Protein phosphatase 2A regulatory subunit,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2A regulatory subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AQ91_LEIMU

TriTrypDb:

LmxM.15.0920

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	1
GO:0005737	cytoplasm	2	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

E9AQ91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ91

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.609
CLV_MEL_PAP_1	380	386	PF00089	0.465
CLV_NRD_NRD_1	213	215	PF00675	0.676
CLV_NRD_NRD_1	266	268	PF00675	0.434
CLV_NRD_NRD_1	590	592	PF00675	0.503
CLV_NRD_NRD_1	677	679	PF00675	0.746
CLV_NRD_NRD_1	724	726	PF00675	0.577
CLV_NRD_NRD_1	855	857	PF00675	0.491
CLV_PCSK_KEX2_1	213	215	PF00082	0.676
CLV_PCSK_KEX2_1	266	268	PF00082	0.434
CLV_PCSK_KEX2_1	590	592	PF00082	0.503
CLV_PCSK_KEX2_1	677	679	PF00082	0.746
CLV_PCSK_KEX2_1	726	728	PF00082	0.503
CLV_PCSK_KEX2_1	855	857	PF00082	0.492
CLV_PCSK_PC1ET2_1	726	728	PF00082	0.545
CLV_PCSK_SKI1_1	120	124	PF00082	0.513
CLV_PCSK_SKI1_1	266	270	PF00082	0.449
CLV_PCSK_SKI1_1	353	357	PF00082	0.508
CLV_PCSK_SKI1_1	476	480	PF00082	0.421
CLV_PCSK_SKI1_1	497	501	PF00082	0.392
CLV_PCSK_SKI1_1	771	775	PF00082	0.471
CLV_PCSK_SKI1_1	794	798	PF00082	0.521
CLV_Separin_Metazoa	606	610	PF03568	0.513
DEG_APCC_DBOX_1	451	459	PF00400	0.517
DEG_SCF_FBW7_1	147	154	PF00400	0.594
DEG_SCF_FBW7_1	60	65	PF00400	0.518
DEG_SPOP_SBC_1	30	34	PF00917	0.516
DEG_SPOP_SBC_1	354	358	PF00917	0.516
DEG_SPOP_SBC_1	492	496	PF00917	0.545
DEG_SPOP_SBC_1	62	66	PF00917	0.521
DEG_SPOP_SBC_1	664	668	PF00917	0.606
DOC_CKS1_1	148	153	PF01111	0.716
DOC_CKS1_1	42	47	PF01111	0.502
DOC_CYCLIN_RxL_1	473	482	PF00134	0.438
DOC_CYCLIN_RxL_1	493	502	PF00134	0.214
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.503
DOC_MAPK_gen_1	749	757	PF00069	0.426
DOC_MAPK_MEF2A_6	225	234	PF00069	0.775
DOC_PP1_RVXF_1	381	387	PF00149	0.509
DOC_PP2B_LxvP_1	374	377	PF13499	0.384
DOC_USP7_MATH_1	151	155	PF00917	0.694
DOC_USP7_MATH_1	206	210	PF00917	0.785
DOC_USP7_MATH_1	212	216	PF00917	0.647
DOC_USP7_MATH_1	30	34	PF00917	0.568
DOC_USP7_MATH_1	423	427	PF00917	0.465
DOC_USP7_MATH_1	630	634	PF00917	0.472
DOC_USP7_MATH_1	653	657	PF00917	0.657
DOC_USP7_MATH_1	663	667	PF00917	0.473
DOC_USP7_MATH_1	681	685	PF00917	0.649
DOC_USP7_MATH_1	708	712	PF00917	0.680
DOC_USP7_MATH_1	844	848	PF00917	0.450
DOC_USP7_MATH_1	926	930	PF00917	0.588
DOC_USP7_UBL2_3	493	497	PF12436	0.509
DOC_WW_Pin1_4	103	108	PF00397	0.612
DOC_WW_Pin1_4	114	119	PF00397	0.801
DOC_WW_Pin1_4	143	148	PF00397	0.749
DOC_WW_Pin1_4	153	158	PF00397	0.637
DOC_WW_Pin1_4	19	24	PF00397	0.694
DOC_WW_Pin1_4	194	199	PF00397	0.727
DOC_WW_Pin1_4	220	225	PF00397	0.631
DOC_WW_Pin1_4	41	46	PF00397	0.774
DOC_WW_Pin1_4	56	61	PF00397	0.745
DOC_WW_Pin1_4	693	698	PF00397	0.715
DOC_WW_Pin1_4	76	81	PF00397	0.673
DOC_WW_Pin1_4	763	768	PF00397	0.507
DOC_WW_Pin1_4	847	852	PF00397	0.485
DOC_WW_Pin1_4	96	101	PF00397	0.603
LIG_14-3-3_CanoR_1	213	217	PF00244	0.649
LIG_14-3-3_CanoR_1	267	275	PF00244	0.483
LIG_14-3-3_CanoR_1	328	336	PF00244	0.537
LIG_14-3-3_CanoR_1	383	387	PF00244	0.517
LIG_14-3-3_CanoR_1	43	49	PF00244	0.588
LIG_14-3-3_CanoR_1	452	456	PF00244	0.489
LIG_14-3-3_CanoR_1	513	522	PF00244	0.427
LIG_14-3-3_CanoR_1	590	597	PF00244	0.496
LIG_14-3-3_CanoR_1	733	742	PF00244	0.514
LIG_14-3-3_CanoR_1	76	80	PF00244	0.674
LIG_14-3-3_CanoR_1	825	830	PF00244	0.504
LIG_14-3-3_CanoR_1	93	97	PF00244	0.705
LIG_Actin_WH2_2	781	799	PF00022	0.486
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BIR_III_2	584	588	PF00653	0.570
LIG_BRCT_BRCA1_1	241	245	PF00533	0.608
LIG_CtBP_PxDLS_1	45	49	PF00389	0.497
LIG_EH1_1	334	342	PF00400	0.447
LIG_FHA_1	281	287	PF00498	0.451
LIG_FHA_1	328	334	PF00498	0.467
LIG_FHA_1	354	360	PF00498	0.512
LIG_FHA_1	379	385	PF00498	0.487
LIG_FHA_1	466	472	PF00498	0.513
LIG_FHA_1	735	741	PF00498	0.566
LIG_FHA_1	772	778	PF00498	0.462
LIG_FHA_1	811	817	PF00498	0.456
LIG_FHA_1	822	828	PF00498	0.432
LIG_FHA_1	861	867	PF00498	0.455
LIG_FHA_1	870	876	PF00498	0.417
LIG_FHA_2	224	230	PF00498	0.729
LIG_FHA_2	294	300	PF00498	0.486
LIG_FHA_2	452	458	PF00498	0.567
LIG_FHA_2	793	799	PF00498	0.548
LIG_FHA_2	809	815	PF00498	0.342
LIG_FHA_2	894	900	PF00498	0.557
LIG_GBD_Chelix_1	351	359	PF00786	0.476
LIG_GBD_Chelix_1	393	401	PF00786	0.453
LIG_LIR_Apic_2	156	161	PF02991	0.748
LIG_LIR_Apic_2	385	390	PF02991	0.399
LIG_LIR_Gen_1	443	450	PF02991	0.481
LIG_LIR_Gen_1	474	484	PF02991	0.473
LIG_LIR_Nem_3	334	339	PF02991	0.402
LIG_LIR_Nem_3	373	378	PF02991	0.522
LIG_LIR_Nem_3	416	422	PF02991	0.473
LIG_LIR_Nem_3	443	447	PF02991	0.467
LIG_LIR_Nem_3	474	480	PF02991	0.475
LIG_LIR_Nem_3	768	773	PF02991	0.404
LIG_LIR_Nem_3	828	834	PF02991	0.489
LIG_LIR_Nem_3	891	895	PF02991	0.423
LIG_LYPXL_SIV_4	902	910	PF13949	0.523
LIG_MYND_3	638	642	PF01753	0.459
LIG_PCNA_yPIPBox_3	280	291	PF02747	0.397
LIG_PDZ_Class_3	936	941	PF00595	0.489
LIG_Pex14_1	512	516	PF04695	0.369
LIG_Pex14_1	889	893	PF04695	0.494
LIG_Pex3_1	287	298	PF04882	0.546
LIG_SH2_GRB2like	257	260	PF00017	0.428
LIG_SH2_NCK_1	516	520	PF00017	0.444
LIG_SH2_STAT5	335	338	PF00017	0.420
LIG_SH2_STAT5	400	403	PF00017	0.462
LIG_SH2_STAT5	477	480	PF00017	0.398
LIG_SH2_STAT5	498	501	PF00017	0.397
LIG_SH2_STAT5	516	519	PF00017	0.254
LIG_SH2_STAT5	870	873	PF00017	0.485
LIG_SH3_3	101	107	PF00018	0.674
LIG_SH3_3	142	148	PF00018	0.814
LIG_SH3_3	17	23	PF00018	0.573
LIG_SH3_3	54	60	PF00018	0.729
LIG_SH3_3	761	767	PF00018	0.473
LIG_SH3_3	838	844	PF00018	0.470
LIG_SUMO_SIM_anti_2	533	541	PF11976	0.501
LIG_SUMO_SIM_anti_2	915	920	PF11976	0.498
LIG_SUMO_SIM_par_1	141	146	PF11976	0.731
LIG_TRAF2_1	262	265	PF00917	0.542
LIG_TRAF2_1	625	628	PF00917	0.548
LIG_TRFH_1	220	224	PF08558	0.671
LIG_TYR_ITIM	398	403	PF00017	0.307
LIG_TYR_ITIM	475	480	PF00017	0.394
LIG_WRC_WIRS_1	500	505	PF05994	0.485
LIG_WRC_WIRS_1	732	737	PF05994	0.572
MOD_CDK_SPK_2	220	225	PF00069	0.643
MOD_CDK_SPK_2	58	63	PF00069	0.515
MOD_CDK_SPK_2	847	852	PF00069	0.513
MOD_CDK_SPxK_1	114	120	PF00069	0.799
MOD_CDK_SPxxK_3	56	63	PF00069	0.517
MOD_CDK_SPxxK_3	76	83	PF00069	0.599
MOD_CK1_1	126	132	PF00069	0.664
MOD_CK1_1	146	152	PF00069	0.677
MOD_CK1_1	202	208	PF00069	0.670
MOD_CK1_1	223	229	PF00069	0.729
MOD_CK1_1	32	38	PF00069	0.560
MOD_CK1_1	385	391	PF00069	0.396
MOD_CK1_1	411	417	PF00069	0.428
MOD_CK1_1	427	433	PF00069	0.526
MOD_CK1_1	465	471	PF00069	0.546
MOD_CK1_1	667	673	PF00069	0.803
MOD_CK1_1	686	692	PF00069	0.656
MOD_CK1_1	734	740	PF00069	0.559
MOD_CK1_1	847	853	PF00069	0.434
MOD_CK1_1	929	935	PF00069	0.734
MOD_CK1_1	95	101	PF00069	0.680
MOD_CK2_1	130	136	PF00069	0.810
MOD_CK2_1	225	231	PF00069	0.738
MOD_CK2_1	259	265	PF00069	0.545
MOD_CK2_1	293	299	PF00069	0.473
MOD_CK2_1	35	41	PF00069	0.567
MOD_CK2_1	451	457	PF00069	0.484
MOD_CK2_1	622	628	PF00069	0.465
MOD_CK2_1	792	798	PF00069	0.503
MOD_CK2_1	847	853	PF00069	0.514
MOD_CK2_1	893	899	PF00069	0.482
MOD_CMANNOS	889	892	PF00535	0.499
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.656
MOD_GlcNHglycan	111	114	PF01048	0.709
MOD_GlcNHglycan	153	156	PF01048	0.749
MOD_GlcNHglycan	162	166	PF01048	0.816
MOD_GlcNHglycan	176	179	PF01048	0.665
MOD_GlcNHglycan	188	191	PF01048	0.713
MOD_GlcNHglycan	204	207	PF01048	0.688
MOD_GlcNHglycan	208	211	PF01048	0.726
MOD_GlcNHglycan	345	348	PF01048	0.466
MOD_GlcNHglycan	387	390	PF01048	0.431
MOD_GlcNHglycan	410	413	PF01048	0.418
MOD_GlcNHglycan	428	432	PF01048	0.473
MOD_GlcNHglycan	48	51	PF01048	0.710
MOD_GlcNHglycan	591	594	PF01048	0.466
MOD_GlcNHglycan	655	658	PF01048	0.643
MOD_GlcNHglycan	660	663	PF01048	0.686
MOD_GlcNHglycan	673	676	PF01048	0.698
MOD_GlcNHglycan	683	686	PF01048	0.635
MOD_GlcNHglycan	704	707	PF01048	0.775
MOD_GlcNHglycan	710	713	PF01048	0.755
MOD_GlcNHglycan	928	931	PF01048	0.668
MOD_GSK3_1	109	116	PF00069	0.747
MOD_GSK3_1	125	132	PF00069	0.724
MOD_GSK3_1	143	150	PF00069	0.685
MOD_GSK3_1	15	22	PF00069	0.705
MOD_GSK3_1	194	201	PF00069	0.686
MOD_GSK3_1	202	209	PF00069	0.660
MOD_GSK3_1	25	32	PF00069	0.651
MOD_GSK3_1	327	334	PF00069	0.481
MOD_GSK3_1	378	385	PF00069	0.385
MOD_GSK3_1	423	430	PF00069	0.504
MOD_GSK3_1	44	51	PF00069	0.669
MOD_GSK3_1	465	472	PF00069	0.441
MOD_GSK3_1	58	65	PF00069	0.705
MOD_GSK3_1	663	670	PF00069	0.749
MOD_GSK3_1	679	686	PF00069	0.620
MOD_GSK3_1	693	700	PF00069	0.641
MOD_GSK3_1	727	734	PF00069	0.393
MOD_GSK3_1	783	790	PF00069	0.462
MOD_GSK3_1	817	824	PF00069	0.554
MOD_GSK3_1	91	98	PF00069	0.730
MOD_N-GLC_1	181	186	PF02516	0.798
MOD_N-GLC_1	199	204	PF02516	0.776
MOD_N-GLC_1	331	336	PF02516	0.491
MOD_N-GLC_1	668	673	PF02516	0.804
MOD_N-GLC_1	719	724	PF02516	0.564
MOD_N-GLC_1	919	924	PF02516	0.568
MOD_NEK2_1	130	135	PF00069	0.737
MOD_NEK2_1	168	173	PF00069	0.734
MOD_NEK2_1	25	30	PF00069	0.558
MOD_NEK2_1	378	383	PF00069	0.358
MOD_NEK2_1	408	413	PF00069	0.504
MOD_NEK2_1	46	51	PF00069	0.644
MOD_NEK2_1	462	467	PF00069	0.487
MOD_NEK2_1	471	476	PF00069	0.463
MOD_NEK2_1	499	504	PF00069	0.373
MOD_NEK2_1	641	646	PF00069	0.479
MOD_NEK2_1	721	726	PF00069	0.363
MOD_NEK2_1	742	747	PF00069	0.488
MOD_NEK2_1	859	864	PF00069	0.508
MOD_NEK2_1	919	924	PF00069	0.526
MOD_NEK2_1	92	97	PF00069	0.646
MOD_NEK2_2	784	789	PF00069	0.539
MOD_NEK2_2	792	797	PF00069	0.469
MOD_PIKK_1	280	286	PF00454	0.457
MOD_PIKK_1	579	585	PF00454	0.570
MOD_PIKK_1	787	793	PF00454	0.498
MOD_PKA_2	212	218	PF00069	0.678
MOD_PKA_2	327	333	PF00069	0.544
MOD_PKA_2	382	388	PF00069	0.505
MOD_PKA_2	451	457	PF00069	0.520
MOD_PKA_2	514	520	PF00069	0.396
MOD_PKA_2	589	595	PF00069	0.452
MOD_PKA_2	62	68	PF00069	0.713
MOD_PKA_2	671	677	PF00069	0.682
MOD_PKA_2	75	81	PF00069	0.798
MOD_PKA_2	92	98	PF00069	0.593
MOD_PKB_1	725	733	PF00069	0.292
MOD_Plk_1	126	132	PF00069	0.798
MOD_Plk_1	181	187	PF00069	0.798
MOD_Plk_1	230	236	PF00069	0.735
MOD_Plk_1	238	244	PF00069	0.663
MOD_Plk_1	331	337	PF00069	0.422
MOD_Plk_1	427	433	PF00069	0.510
MOD_Plk_1	719	725	PF00069	0.417
MOD_Plk_4	331	337	PF00069	0.435
MOD_Plk_4	382	388	PF00069	0.404
MOD_Plk_4	499	505	PF00069	0.372
MOD_Plk_4	727	733	PF00069	0.318
MOD_Plk_4	825	831	PF00069	0.525
MOD_Plk_4	888	894	PF00069	0.448
MOD_ProDKin_1	103	109	PF00069	0.615
MOD_ProDKin_1	114	120	PF00069	0.789
MOD_ProDKin_1	143	149	PF00069	0.750
MOD_ProDKin_1	153	159	PF00069	0.635
MOD_ProDKin_1	19	25	PF00069	0.697
MOD_ProDKin_1	194	200	PF00069	0.728
MOD_ProDKin_1	220	226	PF00069	0.631
MOD_ProDKin_1	41	47	PF00069	0.773
MOD_ProDKin_1	56	62	PF00069	0.739
MOD_ProDKin_1	693	699	PF00069	0.701
MOD_ProDKin_1	76	82	PF00069	0.675
MOD_ProDKin_1	763	769	PF00069	0.508
MOD_ProDKin_1	847	853	PF00069	0.485
MOD_ProDKin_1	96	102	PF00069	0.605
TRG_DiLeu_BaEn_1	367	372	PF01217	0.452
TRG_DiLeu_BaEn_3	264	270	PF01217	0.529
TRG_DiLeu_BaEn_4	481	487	PF01217	0.473
TRG_DiLeu_BaEn_4	87	93	PF01217	0.546
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.710
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.549
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.495
TRG_DiLeu_BaLyEn_6	862	867	PF01217	0.512
TRG_ENDOCYTIC_2	257	260	PF00928	0.459
TRG_ENDOCYTIC_2	400	403	PF00928	0.467
TRG_ENDOCYTIC_2	477	480	PF00928	0.415
TRG_ENDOCYTIC_2	597	600	PF00928	0.444
TRG_ENDOCYTIC_2	890	893	PF00928	0.520
TRG_ER_diArg_1	212	214	PF00400	0.688
TRG_ER_diArg_1	512	515	PF00400	0.344
TRG_ER_diArg_1	589	591	PF00400	0.499
TRG_ER_diArg_1	748	751	PF00400	0.402
TRG_ER_diArg_1	854	856	PF00400	0.492
TRG_NES_CRM1_1	360	373	PF08389	0.490
TRG_NES_CRM1_1	469	482	PF08389	0.498
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	476	481	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	616	620	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	794	798	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA72	Leptomonas seymouri	65%	96%
A0A3Q8IDF8	Leishmania donovani	94%	100%
A0A3R7N5C8	Trypanosoma rangeli	36%	100%
A4H865	Leishmania braziliensis	79%	98%
A4HWJ0	Leishmania infantum	94%	100%
C9ZXV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4QF92	Leishmania major	93%	100%
V5DL61	Trypanosoma cruzi	37%	100%