Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ89_LEIMU

TriTrypDb:

LmxM.15.0900

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.335
CLV_NRD_NRD_1	106	108	PF00675	0.481
CLV_NRD_NRD_1	257	259	PF00675	0.393
CLV_NRD_NRD_1	330	332	PF00675	0.461
CLV_NRD_NRD_1	366	368	PF00675	0.356
CLV_NRD_NRD_1	458	460	PF00675	0.401
CLV_NRD_NRD_1	487	489	PF00675	0.422
CLV_NRD_NRD_1	98	100	PF00675	0.388
CLV_PCSK_FUR_1	327	331	PF00082	0.466
CLV_PCSK_KEX2_1	105	107	PF00082	0.509
CLV_PCSK_KEX2_1	256	258	PF00082	0.393
CLV_PCSK_KEX2_1	327	329	PF00082	0.441
CLV_PCSK_KEX2_1	330	332	PF00082	0.449
CLV_PCSK_KEX2_1	458	460	PF00082	0.375
CLV_PCSK_KEX2_1	487	489	PF00082	0.481
CLV_PCSK_SKI1_1	107	111	PF00082	0.397
CLV_PCSK_SKI1_1	125	129	PF00082	0.308
CLV_PCSK_SKI1_1	209	213	PF00082	0.441
CLV_PCSK_SKI1_1	217	221	PF00082	0.492
CLV_PCSK_SKI1_1	349	353	PF00082	0.435
DEG_APCC_DBOX_1	255	263	PF00400	0.437
DEG_SCF_FBW7_1	420	425	PF00400	0.504
DEG_SPOP_SBC_1	167	171	PF00917	0.692
DEG_SPOP_SBC_1	3	7	PF00917	0.601
DOC_CKS1_1	142	147	PF01111	0.460
DOC_CYCLIN_RxL_1	228	239	PF00134	0.370
DOC_MAPK_FxFP_2	411	414	PF00069	0.455
DOC_MAPK_gen_1	367	376	PF00069	0.331
DOC_MAPK_MEF2A_6	367	375	PF00069	0.280
DOC_PP1_RVXF_1	205	211	PF00149	0.420
DOC_PP1_RVXF_1	298	304	PF00149	0.307
DOC_PP1_RVXF_1	34	40	PF00149	0.459
DOC_PP1_RVXF_1	480	487	PF00149	0.407
DOC_PP2B_LxvP_1	134	137	PF13499	0.507
DOC_PP2B_LxvP_1	468	471	PF13499	0.416
DOC_PP4_FxxP_1	411	414	PF00568	0.455
DOC_USP7_MATH_1	166	170	PF00917	0.712
DOC_USP7_MATH_1	2	6	PF00917	0.663
DOC_USP7_MATH_1	265	269	PF00917	0.515
DOC_USP7_MATH_1	407	411	PF00917	0.447
DOC_USP7_MATH_1	450	454	PF00917	0.552
DOC_USP7_MATH_1	505	509	PF00917	0.640
DOC_USP7_MATH_2	356	362	PF00917	0.368
DOC_WW_Pin1_4	141	146	PF00397	0.730
DOC_WW_Pin1_4	149	154	PF00397	0.676
DOC_WW_Pin1_4	200	205	PF00397	0.425
DOC_WW_Pin1_4	274	279	PF00397	0.522
DOC_WW_Pin1_4	287	292	PF00397	0.456
DOC_WW_Pin1_4	402	407	PF00397	0.431
DOC_WW_Pin1_4	418	423	PF00397	0.473
LIG_14-3-3_CanoR_1	111	119	PF00244	0.412
LIG_14-3-3_CanoR_1	209	214	PF00244	0.428
LIG_14-3-3_CanoR_1	231	236	PF00244	0.376
LIG_14-3-3_CanoR_1	24	32	PF00244	0.382
LIG_14-3-3_CanoR_1	349	356	PF00244	0.344
LIG_14-3-3_CanoR_1	389	395	PF00244	0.342
LIG_14-3-3_CanoR_1	91	95	PF00244	0.455
LIG_APCC_ABBA_1	376	381	PF00400	0.387
LIG_APCC_ABBAyCdc20_2	217	223	PF00400	0.392
LIG_EVH1_1	134	138	PF00568	0.517
LIG_FHA_1	242	248	PF00498	0.454
LIG_FHA_1	330	336	PF00498	0.495
LIG_FHA_1	357	363	PF00498	0.407
LIG_FHA_1	39	45	PF00498	0.386
LIG_FHA_2	111	117	PF00498	0.425
LIG_FHA_2	220	226	PF00498	0.424
LIG_FXI_DFP_1	221	225	PF00024	0.546
LIG_Integrin_isoDGR_2	298	300	PF01839	0.314
LIG_LIR_Apic_2	131	136	PF02991	0.355
LIG_LIR_Apic_2	410	414	PF02991	0.459
LIG_LIR_Gen_1	190	201	PF02991	0.522
LIG_LIR_Gen_1	222	232	PF02991	0.456
LIG_LIR_Gen_1	350	356	PF02991	0.436
LIG_LIR_Gen_1	65	73	PF02991	0.472
LIG_LIR_Nem_3	190	196	PF02991	0.534
LIG_LIR_Nem_3	212	216	PF02991	0.359
LIG_LIR_Nem_3	350	354	PF02991	0.440
LIG_LIR_Nem_3	410	416	PF02991	0.459
LIG_LIR_Nem_3	425	430	PF02991	0.491
LIG_LIR_Nem_3	65	70	PF02991	0.460
LIG_LYPXL_yS_3	413	416	PF13949	0.508
LIG_MYND_1	132	136	PF01753	0.482
LIG_MYND_1	492	496	PF01753	0.679
LIG_PCNA_PIPBox_1	385	394	PF02747	0.353
LIG_Pex14_1	39	43	PF04695	0.365
LIG_Pex14_2	347	351	PF04695	0.450
LIG_Pex14_2	411	415	PF04695	0.477
LIG_SH2_CRK	193	197	PF00017	0.502
LIG_SH2_SRC	133	136	PF00017	0.458
LIG_SH2_SRC	43	46	PF00017	0.359
LIG_SH2_SRC	467	470	PF00017	0.415
LIG_SH2_STAP1	243	247	PF00017	0.431
LIG_SH2_STAP1	456	460	PF00017	0.475
LIG_SH2_STAT3	182	185	PF00017	0.576
LIG_SH2_STAT5	133	136	PF00017	0.552
LIG_SH2_STAT5	236	239	PF00017	0.523
LIG_SH2_STAT5	243	246	PF00017	0.464
LIG_SH2_STAT5	254	257	PF00017	0.334
LIG_SH2_STAT5	43	46	PF00017	0.359
LIG_SH2_STAT5	460	463	PF00017	0.454
LIG_SH2_STAT5	467	470	PF00017	0.434
LIG_SH2_STAT5	86	89	PF00017	0.390
LIG_SH3_3	129	135	PF00018	0.518
LIG_SH3_3	148	154	PF00018	0.694
LIG_SH3_3	198	204	PF00018	0.454
LIG_SH3_3	315	321	PF00018	0.363
LIG_SH3_3	486	492	PF00018	0.502
LIG_SUMO_SIM_par_1	137	144	PF11976	0.519
LIG_SUMO_SIM_par_1	358	364	PF11976	0.460
LIG_SUMO_SIM_par_1	372	377	PF11976	0.433
LIG_TRAF2_1	174	177	PF00917	0.528
LIG_TRAF2_1	189	192	PF00917	0.581
LIG_TRFH_1	128	132	PF08558	0.463
LIG_WRC_WIRS_1	283	288	PF05994	0.517
LIG_WRC_WIRS_1	408	413	PF05994	0.454
LIG_WRC_WIRS_1	415	420	PF05994	0.475
MOD_CDK_SPxxK_3	141	148	PF00069	0.482
MOD_CDK_SPxxK_3	200	207	PF00069	0.420
MOD_CK1_1	169	175	PF00069	0.731
MOD_CK1_1	508	514	PF00069	0.592
MOD_CK1_1	7	13	PF00069	0.508
MOD_CK1_1	84	90	PF00069	0.494
MOD_CK2_1	171	177	PF00069	0.727
MOD_CK2_1	260	266	PF00069	0.369
MOD_CK2_1	390	396	PF00069	0.338
MOD_CK2_1	504	510	PF00069	0.697
MOD_GlcNHglycan	157	160	PF01048	0.753
MOD_GlcNHglycan	171	174	PF01048	0.641
MOD_GlcNHglycan	307	310	PF01048	0.395
MOD_GlcNHglycan	46	49	PF01048	0.489
MOD_GlcNHglycan	462	467	PF01048	0.403
MOD_GlcNHglycan	497	500	PF01048	0.597
MOD_GlcNHglycan	9	12	PF01048	0.651
MOD_GSK3_1	155	162	PF00069	0.597
MOD_GSK3_1	167	174	PF00069	0.680
MOD_GSK3_1	219	226	PF00069	0.498
MOD_GSK3_1	3	10	PF00069	0.531
MOD_GSK3_1	414	421	PF00069	0.494
MOD_GSK3_1	504	511	PF00069	0.729
MOD_N-GLC_1	305	310	PF02516	0.328
MOD_N-GLC_2	472	474	PF02516	0.420
MOD_N-GLC_2	90	92	PF02516	0.451
MOD_NEK2_1	155	160	PF00069	0.684
MOD_NEK2_1	305	310	PF00069	0.406
MOD_NEK2_1	347	352	PF00069	0.613
MOD_NEK2_2	390	395	PF00069	0.366
MOD_PIKK_1	187	193	PF00454	0.523
MOD_PIKK_1	450	456	PF00454	0.533
MOD_PKA_1	329	335	PF00069	0.561
MOD_PKA_2	110	116	PF00069	0.466
MOD_PKA_2	23	29	PF00069	0.409
MOD_PKA_2	329	335	PF00069	0.561
MOD_PKA_2	90	96	PF00069	0.453
MOD_PKB_1	105	113	PF00069	0.459
MOD_PKB_1	207	215	PF00069	0.347
MOD_PKB_1	327	335	PF00069	0.557
MOD_Plk_1	265	271	PF00069	0.475
MOD_Plk_1	462	468	PF00069	0.394
MOD_Plk_1	84	90	PF00069	0.383
MOD_Plk_2-3	260	266	PF00069	0.285
MOD_Plk_2-3	358	364	PF00069	0.343
MOD_Plk_4	231	237	PF00069	0.378
MOD_Plk_4	265	271	PF00069	0.573
MOD_Plk_4	423	429	PF00069	0.512
MOD_Plk_4	84	90	PF00069	0.383
MOD_ProDKin_1	141	147	PF00069	0.731
MOD_ProDKin_1	149	155	PF00069	0.678
MOD_ProDKin_1	200	206	PF00069	0.421
MOD_ProDKin_1	274	280	PF00069	0.524
MOD_ProDKin_1	287	293	PF00069	0.446
MOD_ProDKin_1	402	408	PF00069	0.435
MOD_ProDKin_1	418	424	PF00069	0.477
TRG_DiLeu_BaEn_1	289	294	PF01217	0.243
TRG_ENDOCYTIC_2	181	184	PF00928	0.513
TRG_ENDOCYTIC_2	193	196	PF00928	0.424
TRG_ENDOCYTIC_2	391	394	PF00928	0.447
TRG_ENDOCYTIC_2	413	416	PF00928	0.508
TRG_ENDOCYTIC_2	67	70	PF00928	0.433
TRG_ER_diArg_1	105	107	PF00400	0.514
TRG_ER_diArg_1	207	210	PF00400	0.352
TRG_ER_diArg_1	255	258	PF00400	0.330
TRG_ER_diArg_1	327	330	PF00400	0.501
TRG_ER_diArg_1	458	460	PF00400	0.455
TRG_ER_diArg_1	486	488	PF00400	0.453
TRG_NES_CRM1_1	225	239	PF08389	0.427
TRG_NLS_MonoExtC_3	366	371	PF00514	0.344
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J4	Leptomonas seymouri	70%	99%
A0A1X0NTX1	Trypanosomatidae	48%	100%
A0A3Q8IA36	Leishmania donovani	92%	100%
A4H863	Leishmania braziliensis	82%	100%
A4HWI8	Leishmania infantum	92%	86%
C9ZXV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4QF94	Leishmania major	91%	100%
V5AMI4	Trypanosoma cruzi	49%	100%