Putative myo-inositol-1 phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myo-inositol-1 phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AQ87_LEIMU

TriTrypDb:

LmxM.15.0880

Length:

471

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ87

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0006066	alcohol metabolic process	3	7
GO:0006629	lipid metabolic process	3	5
GO:0006644	phospholipid metabolic process	4	5
GO:0006650	glycerophospholipid metabolic process	5	5
GO:0006661	phosphatidylinositol biosynthetic process	6	5
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	5
GO:0008654	phospholipid biosynthetic process	5	5
GO:0009056	catabolic process	2	7
GO:0009058	biosynthetic process	2	5
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019751	polyol metabolic process	4	7
GO:0043647	inositol phosphate metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	5
GO:0044255	cellular lipid metabolic process	3	5
GO:0044262	obsolete cellular carbohydrate metabolic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0044282	small molecule catabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	5
GO:0046164	alcohol catabolic process	4	7
GO:0046174	polyol catabolic process	5	7
GO:0046434	organophosphate catabolic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	5
GO:0046486	glycerolipid metabolic process	4	5
GO:0046488	phosphatidylinositol metabolic process	6	5
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	7
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	5
GO:0046855	obsolete inositol phosphate dephosphorylation	5	7
GO:0071545	inositol phosphate catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	5
GO:1901575	organic substance catabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	5
GO:1901615	organic hydroxy compound metabolic process	3	7
GO:1901616	organic hydroxy compound catabolic process	4	7
GO:0006020	inositol metabolic process	4	1
GO:0007165	signal transduction	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0008934	inositol monophosphate 1-phosphatase activity	8	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0052745	inositol phosphate phosphatase activity	6	5
GO:0052832	inositol monophosphate 3-phosphatase activity	8	4
GO:0052833	inositol monophosphate 4-phosphatase activity	8	4
GO:0052834	inositol monophosphate phosphatase activity	7	5
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.310
CLV_NRD_NRD_1	355	357	PF00675	0.356
CLV_NRD_NRD_1	48	50	PF00675	0.396
CLV_PCSK_KEX2_1	355	357	PF00082	0.333
CLV_PCSK_KEX2_1	47	49	PF00082	0.425
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.425
CLV_PCSK_SKI1_1	114	118	PF00082	0.383
CLV_PCSK_SKI1_1	268	272	PF00082	0.517
CLV_Separin_Metazoa	371	375	PF03568	0.383
DEG_APCC_DBOX_1	368	376	PF00400	0.383
DEG_Kelch_Keap1_1	15	20	PF01344	0.512
DEG_SCF_FBW7_1	168	175	PF00400	0.383
DEG_SPOP_SBC_1	11	15	PF00917	0.608
DEG_SPOP_SBC_1	324	328	PF00917	0.308
DOC_CKS1_1	169	174	PF01111	0.310
DOC_CKS1_1	230	235	PF01111	0.604
DOC_CKS1_1	256	261	PF01111	0.653
DOC_CKS1_1	6	11	PF01111	0.571
DOC_CYCLIN_yCln2_LP_2	373	379	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	429	435	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.482
DOC_MAPK_gen_1	108	115	PF00069	0.351
DOC_MAPK_gen_1	161	168	PF00069	0.310
DOC_MAPK_HePTP_8	158	170	PF00069	0.310
DOC_MAPK_MEF2A_6	108	115	PF00069	0.310
DOC_MAPK_MEF2A_6	161	170	PF00069	0.310
DOC_MAPK_MEF2A_6	369	377	PF00069	0.409
DOC_PP1_RVXF_1	37	43	PF00149	0.433
DOC_PP2B_LxvP_1	373	376	PF13499	0.383
DOC_PP4_FxxP_1	332	335	PF00568	0.383
DOC_USP7_MATH_1	11	15	PF00917	0.608
DOC_USP7_MATH_1	221	225	PF00917	0.495
DOC_USP7_MATH_1	263	267	PF00917	0.658
DOC_USP7_MATH_1	274	278	PF00917	0.565
DOC_USP7_MATH_1	325	329	PF00917	0.319
DOC_WW_Pin1_4	168	173	PF00397	0.310
DOC_WW_Pin1_4	205	210	PF00397	0.622
DOC_WW_Pin1_4	226	231	PF00397	0.585
DOC_WW_Pin1_4	255	260	PF00397	0.747
DOC_WW_Pin1_4	276	281	PF00397	0.740
DOC_WW_Pin1_4	287	292	PF00397	0.611
DOC_WW_Pin1_4	344	349	PF00397	0.306
DOC_WW_Pin1_4	5	10	PF00397	0.634
LIG_14-3-3_CanoR_1	179	183	PF00244	0.310
LIG_14-3-3_CanoR_1	374	383	PF00244	0.270
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_CtBP_PxDLS_1	432	436	PF00389	0.320
LIG_EVH1_1	255	259	PF00568	0.658
LIG_FHA_1	117	123	PF00498	0.274
LIG_FHA_1	131	137	PF00498	0.340
LIG_FHA_1	16	22	PF00498	0.427
LIG_FHA_1	169	175	PF00498	0.351
LIG_FHA_1	208	214	PF00498	0.765
LIG_FHA_1	237	243	PF00498	0.722
LIG_FHA_1	250	256	PF00498	0.573
LIG_FHA_1	288	294	PF00498	0.637
LIG_FHA_1	324	330	PF00498	0.326
LIG_FHA_1	437	443	PF00498	0.324
LIG_FHA_1	79	85	PF00498	0.294
LIG_FHA_1	94	100	PF00498	0.262
LIG_FHA_2	230	236	PF00498	0.630
LIG_Integrin_isoDGR_2	313	315	PF01839	0.310
LIG_LIR_Apic_2	399	404	PF02991	0.310
LIG_LIR_Gen_1	129	139	PF02991	0.321
LIG_LIR_Gen_1	300	310	PF02991	0.310
LIG_LIR_Nem_3	129	135	PF02991	0.321
LIG_LIR_Nem_3	261	267	PF02991	0.655
LIG_LIR_Nem_3	300	305	PF02991	0.310
LIG_Pex14_2	462	466	PF04695	0.363
LIG_RPA_C_Fungi	44	56	PF08784	0.345
LIG_SH2_SRC	401	404	PF00017	0.310
LIG_SH2_STAP1	102	106	PF00017	0.439
LIG_SH2_STAP1	132	136	PF00017	0.312
LIG_SH2_STAT3	160	163	PF00017	0.383
LIG_SH2_STAT3	87	90	PF00017	0.236
LIG_SH2_STAT5	132	135	PF00017	0.310
LIG_SH2_STAT5	401	404	PF00017	0.351
LIG_SH3_3	132	138	PF00018	0.322
LIG_SH3_3	166	172	PF00018	0.310
LIG_SH3_3	203	209	PF00018	0.594
LIG_SH3_3	210	216	PF00018	0.689
LIG_SH3_3	227	233	PF00018	0.613
LIG_SH3_3	253	259	PF00018	0.619
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.675
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.278
LIG_SUMO_SIM_par_1	208	214	PF11976	0.704
LIG_TRAF2_1	445	448	PF00917	0.294
LIG_UBA3_1	301	306	PF00899	0.383
MOD_CK1_1	15	21	PF00069	0.466
MOD_CK1_1	266	272	PF00069	0.605
MOD_CK1_1	279	285	PF00069	0.636
MOD_CK1_1	4	10	PF00069	0.633
MOD_CK2_1	19	25	PF00069	0.434
MOD_GlcNHglycan	175	178	PF01048	0.310
MOD_GlcNHglycan	218	221	PF01048	0.652
MOD_GlcNHglycan	276	279	PF01048	0.601
MOD_GlcNHglycan	61	64	PF01048	0.420
MOD_GlcNHglycan	78	81	PF01048	0.383
MOD_GSK3_1	1	8	PF00069	0.634
MOD_GSK3_1	11	18	PF00069	0.542
MOD_GSK3_1	126	133	PF00069	0.341
MOD_GSK3_1	152	159	PF00069	0.310
MOD_GSK3_1	168	175	PF00069	0.310
MOD_GSK3_1	205	212	PF00069	0.596
MOD_GSK3_1	222	229	PF00069	0.486
MOD_GSK3_1	382	389	PF00069	0.333
MOD_GSK3_1	412	419	PF00069	0.315
MOD_GSK3_1	78	85	PF00069	0.317
MOD_NEK2_1	1	6	PF00069	0.663
MOD_NEK2_1	173	178	PF00069	0.310
MOD_NEK2_1	211	216	PF00069	0.577
MOD_NEK2_1	222	227	PF00069	0.664
MOD_NEK2_1	234	239	PF00069	0.543
MOD_PIKK_1	443	449	PF00454	0.345
MOD_PIKK_1	82	88	PF00454	0.310
MOD_PKA_2	178	184	PF00069	0.311
MOD_PKA_2	91	97	PF00069	0.366
MOD_Plk_1	130	136	PF00069	0.310
MOD_Plk_1	19	25	PF00069	0.434
MOD_Plk_1	362	368	PF00069	0.383
MOD_Plk_4	123	129	PF00069	0.331
MOD_Plk_4	130	136	PF00069	0.327
MOD_Plk_4	183	189	PF00069	0.362
MOD_Plk_4	19	25	PF00069	0.421
MOD_Plk_4	289	295	PF00069	0.580
MOD_Plk_4	325	331	PF00069	0.328
MOD_Plk_4	412	418	PF00069	0.344
MOD_ProDKin_1	168	174	PF00069	0.310
MOD_ProDKin_1	205	211	PF00069	0.625
MOD_ProDKin_1	226	232	PF00069	0.584
MOD_ProDKin_1	255	261	PF00069	0.746
MOD_ProDKin_1	276	282	PF00069	0.740
MOD_ProDKin_1	287	293	PF00069	0.608
MOD_ProDKin_1	344	350	PF00069	0.306
MOD_ProDKin_1	5	11	PF00069	0.634
MOD_SUMO_rev_2	71	79	PF00179	0.319
TRG_DiLeu_BaEn_1	448	453	PF01217	0.383
TRG_DiLeu_BaEn_4	370	376	PF01217	0.299
TRG_ENDOCYTIC_2	132	135	PF00928	0.310
TRG_ENDOCYTIC_2	465	468	PF00928	0.471
TRG_ER_diArg_1	48	50	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZI7	Leptomonas seymouri	55%	100%
A0A3Q8IA90	Leishmania donovani	90%	100%
A4H860	Leishmania braziliensis	75%	100%
A4HWI6	Leishmania infantum	89%	100%
Q4QF96	Leishmania major	87%	99%