LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AQ85_LEIMU
TriTrypDb:
LmxM.15.0860
Length:
316

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ85
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ85

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 285 289 PF00656 0.630
CLV_NRD_NRD_1 312 314 PF00675 0.708
CLV_NRD_NRD_1 40 42 PF00675 0.500
CLV_PCSK_KEX2_1 40 42 PF00082 0.500
CLV_PCSK_SKI1_1 54 58 PF00082 0.554
CLV_Separin_Metazoa 51 55 PF03568 0.436
DEG_APCC_DBOX_1 98 106 PF00400 0.426
DEG_SPOP_SBC_1 214 218 PF00917 0.688
DEG_SPOP_SBC_1 60 64 PF00917 0.561
DOC_CYCLIN_RxL_1 88 100 PF00134 0.394
DOC_MAPK_MEF2A_6 29 38 PF00069 0.518
DOC_USP7_MATH_1 122 126 PF00917 0.618
DOC_USP7_MATH_1 185 189 PF00917 0.680
DOC_USP7_MATH_1 203 207 PF00917 0.511
DOC_USP7_MATH_1 214 218 PF00917 0.610
DOC_USP7_MATH_1 264 268 PF00917 0.626
DOC_USP7_MATH_1 60 64 PF00917 0.609
DOC_USP7_MATH_1 65 69 PF00917 0.651
DOC_USP7_UBL2_3 225 229 PF12436 0.636
DOC_USP7_UBL2_3 243 247 PF12436 0.634
DOC_WW_Pin1_4 197 202 PF00397 0.677
DOC_WW_Pin1_4 265 270 PF00397 0.762
DOC_WW_Pin1_4 3 8 PF00397 0.715
DOC_WW_Pin1_4 87 92 PF00397 0.571
LIG_14-3-3_CanoR_1 29 38 PF00244 0.614
LIG_14-3-3_CanoR_1 40 47 PF00244 0.401
LIG_Actin_RPEL_3 34 53 PF02755 0.401
LIG_BIR_II_1 1 5 PF00653 0.632
LIG_FHA_1 30 36 PF00498 0.516
LIG_FHA_1 47 53 PF00498 0.424
LIG_FHA_2 146 152 PF00498 0.555
LIG_FHA_2 250 256 PF00498 0.638
LIG_FHA_2 8 14 PF00498 0.450
LIG_LIR_Gen_1 24 35 PF02991 0.524
LIG_LIR_Gen_1 292 303 PF02991 0.668
LIG_LIR_Nem_3 24 30 PF02991 0.530
LIG_NRP_CendR_1 313 316 PF00754 0.630
LIG_SH2_PTP2 27 30 PF00017 0.514
LIG_SH2_STAT5 27 30 PF00017 0.514
LIG_SH3_3 1 7 PF00018 0.729
LIG_SH3_3 227 233 PF00018 0.678
LIG_SH3_3 234 240 PF00018 0.676
LIG_SH3_3 258 264 PF00018 0.680
LIG_SH3_3 266 272 PF00018 0.664
LIG_SH3_3 74 80 PF00018 0.656
LIG_SUMO_SIM_anti_2 206 213 PF11976 0.501
LIG_SUMO_SIM_anti_2 307 313 PF11976 0.534
LIG_TRAF2_1 18 21 PF00917 0.597
LIG_TRAF2_1 22 25 PF00917 0.533
LIG_TRAF2_1 253 256 PF00917 0.710
LIG_UBA3_1 95 103 PF00899 0.419
LIG_WW_2 271 274 PF00397 0.655
LIG_WW_3 238 242 PF00397 0.654
MOD_CDK_SPxxK_3 87 94 PF00069 0.415
MOD_CK1_1 107 113 PF00069 0.636
MOD_CK1_1 127 133 PF00069 0.709
MOD_CK1_1 134 140 PF00069 0.693
MOD_CK1_1 190 196 PF00069 0.734
MOD_CK1_1 206 212 PF00069 0.614
MOD_CK1_1 213 219 PF00069 0.635
MOD_CK1_1 265 271 PF00069 0.696
MOD_CK1_1 3 9 PF00069 0.539
MOD_CK1_1 59 65 PF00069 0.486
MOD_CK2_1 134 140 PF00069 0.693
MOD_CK2_1 185 191 PF00069 0.506
MOD_CK2_1 19 25 PF00069 0.562
MOD_CK2_1 249 255 PF00069 0.708
MOD_CK2_1 7 13 PF00069 0.487
MOD_CK2_1 87 93 PF00069 0.705
MOD_GlcNHglycan 106 109 PF01048 0.606
MOD_GlcNHglycan 113 116 PF01048 0.594
MOD_GlcNHglycan 121 125 PF01048 0.674
MOD_GlcNHglycan 126 129 PF01048 0.657
MOD_GlcNHglycan 133 136 PF01048 0.714
MOD_GlcNHglycan 140 143 PF01048 0.623
MOD_GlcNHglycan 164 167 PF01048 0.630
MOD_GlcNHglycan 212 215 PF01048 0.645
MOD_GlcNHglycan 217 220 PF01048 0.575
MOD_GlcNHglycan 264 267 PF01048 0.764
MOD_GlcNHglycan 58 61 PF01048 0.431
MOD_GlcNHglycan 7 10 PF01048 0.488
MOD_GlcNHglycan 81 84 PF01048 0.561
MOD_GSK3_1 104 111 PF00069 0.618
MOD_GSK3_1 120 127 PF00069 0.761
MOD_GSK3_1 130 137 PF00069 0.622
MOD_GSK3_1 206 213 PF00069 0.682
MOD_GSK3_1 221 228 PF00069 0.573
MOD_GSK3_1 3 10 PF00069 0.567
MOD_GSK3_1 56 63 PF00069 0.535
MOD_N-GLC_1 250 255 PF02516 0.711
MOD_NEK2_1 61 66 PF00069 0.530
MOD_PIKK_1 122 128 PF00454 0.576
MOD_PIKK_1 29 35 PF00454 0.519
MOD_PKA_1 40 46 PF00069 0.432
MOD_PKA_2 111 117 PF00069 0.716
MOD_PKA_2 28 34 PF00069 0.349
MOD_PKA_2 40 46 PF00069 0.412
MOD_Plk_1 108 114 PF00069 0.465
MOD_Plk_1 156 162 PF00069 0.650
MOD_Plk_1 190 196 PF00069 0.573
MOD_Plk_1 250 256 PF00069 0.711
MOD_Plk_2-3 145 151 PF00069 0.549
MOD_Plk_4 156 162 PF00069 0.650
MOD_Plk_4 203 209 PF00069 0.544
MOD_ProDKin_1 197 203 PF00069 0.677
MOD_ProDKin_1 265 271 PF00069 0.758
MOD_ProDKin_1 3 9 PF00069 0.712
MOD_ProDKin_1 87 93 PF00069 0.570
TRG_DiLeu_BaLyEn_6 91 96 PF01217 0.383
TRG_ENDOCYTIC_2 27 30 PF00928 0.514
TRG_NLS_MonoExtN_4 243 250 PF00514 0.545

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WTH2 Leishmania donovani 75% 98%
A4H858 Leishmania braziliensis 57% 100%
A4HWI4 Leishmania infantum 74% 98%
Q4QF98 Leishmania major 74% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS