UDP-galactose transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleotide-sugar transporter, putative

Species:

Leishmania mexicana

UniProt:

E9AQ83_LEIMU

TriTrypDb:

LmxM.15.0840

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0098588	bounding membrane of organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AQ83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ83

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0008643	carbohydrate transport	5	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0071702	organic substance transport	4	6

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	9
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	9
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.216
CLV_NRD_NRD_1	202	204	PF00675	0.240
CLV_PCSK_KEX2_1	141	143	PF00082	0.216
CLV_PCSK_SKI1_1	134	138	PF00082	0.240
CLV_PCSK_SKI1_1	184	188	PF00082	0.214
CLV_PCSK_SKI1_1	230	234	PF00082	0.320
CLV_PCSK_SKI1_1	405	409	PF00082	0.367
DEG_SPOP_SBC_1	292	296	PF00917	0.296
DOC_CYCLIN_RxL_1	131	138	PF00134	0.542
DOC_CYCLIN_RxL_1	181	188	PF00134	0.214
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.150
DOC_MAPK_gen_1	203	211	PF00069	0.440
DOC_MAPK_gen_1	253	260	PF00069	0.398
DOC_MAPK_HePTP_8	200	212	PF00069	0.481
DOC_MAPK_MEF2A_6	115	122	PF00069	0.243
DOC_MAPK_MEF2A_6	203	212	PF00069	0.415
DOC_MAPK_MEF2A_6	318	327	PF00069	0.240
DOC_PP1_RVXF_1	132	138	PF00149	0.340
DOC_PP1_RVXF_1	182	188	PF00149	0.214
DOC_PP2B_LxvP_1	233	236	PF13499	0.150
DOC_PP2B_LxvP_1	62	65	PF13499	0.558
DOC_USP7_MATH_1	351	355	PF00917	0.231
DOC_USP7_MATH_1	372	376	PF00917	0.240
DOC_USP7_MATH_2	53	59	PF00917	0.623
DOC_WW_Pin1_4	218	223	PF00397	0.231
DOC_WW_Pin1_4	49	54	PF00397	0.621
DOC_WW_Pin1_4	60	65	PF00397	0.684
LIG_14-3-3_CanoR_1	299	308	PF00244	0.140
LIG_14-3-3_CterR_2	405	409	PF00244	0.567
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_BRCT_BRCA1_1	336	340	PF00533	0.400
LIG_BRCT_BRCA1_1	84	88	PF00533	0.348
LIG_FHA_1	131	137	PF00498	0.365
LIG_FHA_1	174	180	PF00498	0.190
LIG_FHA_1	181	187	PF00498	0.207
LIG_FHA_1	222	228	PF00498	0.223
LIG_FHA_1	27	33	PF00498	0.551
LIG_FHA_1	300	306	PF00498	0.337
LIG_FHA_1	359	365	PF00498	0.290
LIG_FHA_2	372	378	PF00498	0.186
LIG_HP1_1	229	233	PF01393	0.150
LIG_HP1_1	322	326	PF01393	0.255
LIG_LIR_Apic_2	217	222	PF02991	0.348
LIG_LIR_Gen_1	159	169	PF02991	0.283
LIG_LIR_Gen_1	176	185	PF02991	0.135
LIG_LIR_Gen_1	267	278	PF02991	0.212
LIG_LIR_LC3C_4	104	108	PF02991	0.150
LIG_LIR_Nem_3	155	161	PF02991	0.283
LIG_LIR_Nem_3	165	169	PF02991	0.207
LIG_LIR_Nem_3	176	180	PF02991	0.223
LIG_LIR_Nem_3	267	273	PF02991	0.221
LIG_LIR_Nem_3	276	281	PF02991	0.204
LIG_NRBOX	355	361	PF00104	0.150
LIG_Pex14_2	274	278	PF04695	0.309
LIG_Pex14_2	340	344	PF04695	0.231
LIG_PTB_Apo_2	160	167	PF02174	0.214
LIG_PTB_Apo_2	272	279	PF02174	0.309
LIG_SH2_CRK	151	155	PF00017	0.207
LIG_SH2_NCK_1	151	155	PF00017	0.290
LIG_SH2_PTP2	270	273	PF00017	0.150
LIG_SH2_STAT5	151	154	PF00017	0.225
LIG_SH2_STAT5	158	161	PF00017	0.262
LIG_SH2_STAT5	270	273	PF00017	0.265
LIG_SH2_STAT5	392	395	PF00017	0.466
LIG_SH2_STAT5	94	97	PF00017	0.287
LIG_SH3_3	58	64	PF00018	0.686
LIG_SUMO_SIM_anti_2	354	361	PF11976	0.154
LIG_TRFH_1	192	196	PF08558	0.255
LIG_UBA3_1	210	218	PF00899	0.344
LIG_UBA3_1	341	350	PF00899	0.146
LIG_WRC_WIRS_1	153	158	PF05994	0.231
MOD_CK1_1	221	227	PF00069	0.281
MOD_CK1_1	7	13	PF00069	0.728
MOD_CK2_1	351	357	PF00069	0.231
MOD_CK2_1	49	55	PF00069	0.617
MOD_CK2_1	7	13	PF00069	0.541
MOD_GlcNHglycan	137	140	PF01048	0.261
MOD_GlcNHglycan	318	321	PF01048	0.418
MOD_GlcNHglycan	336	339	PF01048	0.244
MOD_GlcNHglycan	353	356	PF01048	0.145
MOD_GlcNHglycan	57	60	PF01048	0.492
MOD_GlcNHglycan	73	76	PF01048	0.170
MOD_GSK3_1	152	159	PF00069	0.255
MOD_GSK3_1	214	221	PF00069	0.348
MOD_GSK3_1	22	29	PF00069	0.713
MOD_GSK3_1	291	298	PF00069	0.310
MOD_GSK3_1	51	58	PF00069	0.676
MOD_GSK3_1	60	67	PF00069	0.659
MOD_GSK3_1	88	95	PF00069	0.257
MOD_N-GLC_1	162	167	PF02516	0.146
MOD_N-GLC_1	26	31	PF02516	0.395
MOD_NEK2_1	116	121	PF00069	0.252
MOD_NEK2_1	156	161	PF00069	0.400
MOD_NEK2_1	164	169	PF00069	0.262
MOD_NEK2_1	180	185	PF00069	0.208
MOD_NEK2_1	239	244	PF00069	0.220
MOD_NEK2_1	273	278	PF00069	0.237
MOD_NEK2_1	291	296	PF00069	0.207
MOD_NEK2_1	334	339	PF00069	0.273
MOD_NEK2_1	390	395	PF00069	0.313
MOD_NEK2_1	71	76	PF00069	0.471
MOD_NEK2_1	82	87	PF00069	0.220
MOD_NEK2_1	88	93	PF00069	0.192
MOD_PK_1	256	262	PF00069	0.481
MOD_PK_1	33	39	PF00069	0.530
MOD_PKA_2	298	304	PF00069	0.140
MOD_PKA_2	92	98	PF00069	0.199
MOD_Plk_1	162	168	PF00069	0.146
MOD_Plk_1	26	32	PF00069	0.619
MOD_Plk_1	65	71	PF00069	0.566
MOD_Plk_4	152	158	PF00069	0.243
MOD_Plk_4	273	279	PF00069	0.310
MOD_Plk_4	329	335	PF00069	0.228
MOD_Plk_4	82	88	PF00069	0.262
MOD_ProDKin_1	218	224	PF00069	0.231
MOD_ProDKin_1	49	55	PF00069	0.622
MOD_ProDKin_1	60	66	PF00069	0.681
MOD_SUMO_for_1	252	255	PF00179	0.415
MOD_SUMO_rev_2	7	15	PF00179	0.540
TRG_DiLeu_BaEn_2	125	131	PF01217	0.440
TRG_ENDOCYTIC_2	161	164	PF00928	0.223
TRG_ENDOCYTIC_2	177	180	PF00928	0.214
TRG_ENDOCYTIC_2	270	273	PF00928	0.245
TRG_NES_CRM1_1	112	126	PF08389	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R3	Leptomonas seymouri	61%	100%
A0A0N0P7L9	Leptomonas seymouri	24%	93%
A0A0S4JKR6	Bodo saltans	44%	100%
A0A1X0NTU7	Trypanosomatidae	44%	100%
A0A3S7WTI2	Leishmania donovani	81%	89%
A0A422NRC3	Trypanosoma rangeli	43%	100%
A4H9E4	Leishmania braziliensis	23%	73%
A4HWI2	Leishmania infantum	80%	89%
A4IHW3	Xenopus tropicalis	24%	100%
B8A7Q8	Oryza sativa subsp. indica	25%	100%
B8B350	Oryza sativa subsp. indica	26%	100%
B8B7Q4	Oryza sativa subsp. indica	26%	100%
O08520	Cricetulus griseus	25%	100%
O77592	Canis lupus familiaris	26%	100%
P78381	Homo sapiens	25%	100%
P78382	Homo sapiens	25%	100%
Q02334	Caenorhabditis elegans	24%	100%
Q5N855	Oryza sativa subsp. japonica	25%	100%
Q61420	Mus musculus	25%	100%
Q654D9	Oryza sativa subsp. japonica	26%	100%
Q6AXR5	Rattus norvegicus	25%	100%
Q6YC49	Bos taurus	26%	100%
Q6ZL17	Oryza sativa subsp. japonica	26%	100%
Q8LGE9	Arabidopsis thaliana	24%	100%
Q8R1T4	Mus musculus	25%	100%
Q91ZR7	Rattus norvegicus	24%	100%
Q93890	Caenorhabditis elegans	22%	100%
Q9VMU8	Drosophila melanogaster	32%	100%
Q9Y2D2	Homo sapiens	27%	100%
V5B4K3	Trypanosoma cruzi	43%	100%
V5BRN3	Trypanosoma cruzi	24%	100%