Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ82_LEIMU

TriTrypDb:

LmxM.15.0830

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.588
CLV_C14_Caspase3-7	353	357	PF00656	0.522
CLV_C14_Caspase3-7	471	475	PF00656	0.515
CLV_C14_Caspase3-7	62	66	PF00656	0.559
CLV_C14_Caspase3-7	637	641	PF00656	0.683
CLV_C14_Caspase3-7	788	792	PF00656	0.604
CLV_NRD_NRD_1	103	105	PF00675	0.523
CLV_NRD_NRD_1	160	162	PF00675	0.571
CLV_NRD_NRD_1	184	186	PF00675	0.536
CLV_NRD_NRD_1	192	194	PF00675	0.464
CLV_NRD_NRD_1	200	202	PF00675	0.474
CLV_NRD_NRD_1	264	266	PF00675	0.674
CLV_NRD_NRD_1	377	379	PF00675	0.594
CLV_NRD_NRD_1	465	467	PF00675	0.624
CLV_NRD_NRD_1	52	54	PF00675	0.658
CLV_NRD_NRD_1	529	531	PF00675	0.539
CLV_PCSK_KEX2_1	103	105	PF00082	0.523
CLV_PCSK_KEX2_1	156	158	PF00082	0.531
CLV_PCSK_KEX2_1	160	162	PF00082	0.564
CLV_PCSK_KEX2_1	192	194	PF00082	0.483
CLV_PCSK_KEX2_1	202	204	PF00082	0.538
CLV_PCSK_KEX2_1	264	266	PF00082	0.674
CLV_PCSK_KEX2_1	377	379	PF00082	0.499
CLV_PCSK_KEX2_1	465	467	PF00082	0.600
CLV_PCSK_KEX2_1	52	54	PF00082	0.657
CLV_PCSK_KEX2_1	529	531	PF00082	0.539
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.391
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.535
CLV_PCSK_SKI1_1	156	160	PF00082	0.389
CLV_PCSK_SKI1_1	185	189	PF00082	0.489
CLV_PCSK_SKI1_1	264	268	PF00082	0.511
CLV_PCSK_SKI1_1	324	328	PF00082	0.578
CLV_PCSK_SKI1_1	340	344	PF00082	0.423
CLV_PCSK_SKI1_1	465	469	PF00082	0.573
CLV_PCSK_SKI1_1	580	584	PF00082	0.595
CLV_PCSK_SKI1_1	597	601	PF00082	0.605
CLV_PCSK_SKI1_1	679	683	PF00082	0.629
CLV_PCSK_SKI1_1	807	811	PF00082	0.522
DEG_APCC_DBOX_1	184	192	PF00400	0.612
DEG_APCC_DBOX_1	323	331	PF00400	0.621
DEG_SCF_FBW7_1	231	237	PF00400	0.713
DEG_SPOP_SBC_1	383	387	PF00917	0.558
DEG_SPOP_SBC_1	422	426	PF00917	0.488
DEG_SPOP_SBC_1	627	631	PF00917	0.594
DEG_SPOP_SBC_1	7	11	PF00917	0.725
DOC_CKS1_1	231	236	PF01111	0.712
DOC_CKS1_1	795	800	PF01111	0.614
DOC_CYCLIN_RxL_1	182	189	PF00134	0.486
DOC_MAPK_gen_1	758	765	PF00069	0.707
DOC_PP1_RVXF_1	542	549	PF00149	0.346
DOC_PP1_RVXF_1	633	639	PF00149	0.691
DOC_PP2B_LxvP_1	30	33	PF13499	0.619
DOC_PP2B_LxvP_1	622	625	PF13499	0.682
DOC_PP2B_LxvP_1	712	715	PF13499	0.524
DOC_PP4_FxxP_1	655	658	PF00568	0.669
DOC_USP7_MATH_1	176	180	PF00917	0.585
DOC_USP7_MATH_1	234	238	PF00917	0.718
DOC_USP7_MATH_1	252	256	PF00917	0.589
DOC_USP7_MATH_1	384	388	PF00917	0.697
DOC_USP7_MATH_1	422	426	PF00917	0.539
DOC_USP7_MATH_1	455	459	PF00917	0.447
DOC_USP7_MATH_1	58	62	PF00917	0.731
DOC_USP7_MATH_1	617	621	PF00917	0.622
DOC_USP7_MATH_1	64	68	PF00917	0.620
DOC_USP7_MATH_1	656	660	PF00917	0.657
DOC_USP7_MATH_1	665	669	PF00917	0.607
DOC_USP7_MATH_1	7	11	PF00917	0.676
DOC_USP7_MATH_1	700	704	PF00917	0.612
DOC_USP7_MATH_1	717	721	PF00917	0.665
DOC_USP7_UBL2_3	186	190	PF12436	0.611
DOC_WW_Pin1_4	13	18	PF00397	0.665
DOC_WW_Pin1_4	225	230	PF00397	0.804
DOC_WW_Pin1_4	277	282	PF00397	0.735
DOC_WW_Pin1_4	60	65	PF00397	0.791
DOC_WW_Pin1_4	628	633	PF00397	0.606
DOC_WW_Pin1_4	661	666	PF00397	0.626
DOC_WW_Pin1_4	669	674	PF00397	0.648
DOC_WW_Pin1_4	70	75	PF00397	0.539
DOC_WW_Pin1_4	718	723	PF00397	0.584
DOC_WW_Pin1_4	773	778	PF00397	0.642
DOC_WW_Pin1_4	794	799	PF00397	0.570
LIG_14-3-3_CanoR_1	219	223	PF00244	0.695
LIG_14-3-3_CanoR_1	378	384	PF00244	0.723
LIG_14-3-3_CanoR_1	444	452	PF00244	0.583
LIG_14-3-3_CanoR_1	456	460	PF00244	0.431
LIG_14-3-3_CanoR_1	465	470	PF00244	0.405
LIG_14-3-3_CanoR_1	515	521	PF00244	0.541
LIG_14-3-3_CanoR_1	59	64	PF00244	0.716
LIG_14-3-3_CanoR_1	635	639	PF00244	0.690
LIG_14-3-3_CanoR_1	667	672	PF00244	0.652
LIG_14-3-3_CanoR_1	68	74	PF00244	0.554
LIG_APCC_ABBAyCdc20_2	456	462	PF00400	0.606
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BIR_III_4	20	24	PF00653	0.775
LIG_CaM_IQ_9	457	472	PF13499	0.455
LIG_EVH1_2	32	36	PF00568	0.621
LIG_FHA_1	226	232	PF00498	0.744
LIG_FHA_1	246	252	PF00498	0.739
LIG_FHA_1	255	261	PF00498	0.665
LIG_FHA_1	362	368	PF00498	0.620
LIG_FHA_2	304	310	PF00498	0.572
LIG_FHA_2	351	357	PF00498	0.612
LIG_FHA_2	407	413	PF00498	0.411
LIG_FHA_2	444	450	PF00498	0.595
LIG_FHA_2	581	587	PF00498	0.601
LIG_FHA_2	635	641	PF00498	0.686
LIG_LIR_Apic_2	653	658	PF02991	0.712
LIG_LIR_Apic_2	659	665	PF02991	0.641
LIG_LIR_Apic_2	776	781	PF02991	0.700
LIG_LIR_Gen_1	133	140	PF02991	0.477
LIG_LIR_Nem_3	133	138	PF02991	0.488
LIG_LIR_Nem_3	806	812	PF02991	0.519
LIG_Pex14_1	169	173	PF04695	0.639
LIG_Pex14_1	805	809	PF04695	0.523
LIG_Pex14_2	266	270	PF04695	0.539
LIG_RPA_C_Fungi	163	175	PF08784	0.567
LIG_SH2_CRK	662	666	PF00017	0.544
LIG_SH2_STAT3	146	149	PF00017	0.473
LIG_SH3_3	257	263	PF00018	0.719
LIG_SH3_3	26	32	PF00018	0.651
LIG_SH3_3	275	281	PF00018	0.552
LIG_SH3_3	52	58	PF00018	0.550
LIG_SH3_3	716	722	PF00018	0.602
LIG_SH3_3	792	798	PF00018	0.624
LIG_SUMO_SIM_anti_2	392	398	PF11976	0.491
LIG_SUMO_SIM_anti_2	571	577	PF11976	0.503
LIG_SUMO_SIM_par_1	136	142	PF11976	0.461
LIG_SUMO_SIM_par_1	370	376	PF11976	0.447
LIG_SUMO_SIM_par_1	392	398	PF11976	0.587
LIG_UBA3_1	183	190	PF00899	0.576
MOD_CDC14_SPxK_1	664	667	PF00782	0.754
MOD_CDK_SPxK_1	661	667	PF00069	0.629
MOD_CDK_SPxK_1	773	779	PF00069	0.528
MOD_CDK_SPxxK_3	628	635	PF00069	0.607
MOD_CDK_SPxxK_3	794	801	PF00069	0.564
MOD_CK1_1	13	19	PF00069	0.692
MOD_CK1_1	179	185	PF00069	0.641
MOD_CK1_1	221	227	PF00069	0.678
MOD_CK1_1	245	251	PF00069	0.770
MOD_CK1_1	291	297	PF00069	0.553
MOD_CK1_1	311	317	PF00069	0.559
MOD_CK1_1	331	337	PF00069	0.458
MOD_CK1_1	382	388	PF00069	0.633
MOD_CK1_1	423	429	PF00069	0.695
MOD_CK1_1	6	12	PF00069	0.674
MOD_CK1_1	66	72	PF00069	0.756
MOD_CK1_1	702	708	PF00069	0.636
MOD_CK1_1	73	79	PF00069	0.648
MOD_CK2_1	273	279	PF00069	0.520
MOD_CK2_1	303	309	PF00069	0.574
MOD_CK2_1	395	401	PF00069	0.650
MOD_CK2_1	443	449	PF00069	0.612
MOD_CK2_1	529	535	PF00069	0.461
MOD_CK2_1	568	574	PF00069	0.461
MOD_CK2_1	580	586	PF00069	0.590
MOD_GlcNHglycan	10	13	PF01048	0.756
MOD_GlcNHglycan	128	131	PF01048	0.549
MOD_GlcNHglycan	216	219	PF01048	0.768
MOD_GlcNHglycan	223	226	PF01048	0.703
MOD_GlcNHglycan	236	239	PF01048	0.739
MOD_GlcNHglycan	295	298	PF01048	0.783
MOD_GlcNHglycan	381	384	PF01048	0.550
MOD_GlcNHglycan	397	400	PF01048	0.619
MOD_GlcNHglycan	418	421	PF01048	0.666
MOD_GlcNHglycan	425	428	PF01048	0.668
MOD_GlcNHglycan	5	8	PF01048	0.709
MOD_GlcNHglycan	531	534	PF01048	0.455
MOD_GlcNHglycan	604	607	PF01048	0.539
MOD_GlcNHglycan	619	622	PF01048	0.640
MOD_GlcNHglycan	652	655	PF01048	0.735
MOD_GlcNHglycan	702	705	PF01048	0.732
MOD_GlcNHglycan	708	711	PF01048	0.699
MOD_GlcNHglycan	715	718	PF01048	0.746
MOD_GlcNHglycan	735	739	PF01048	0.540
MOD_GlcNHglycan	754	757	PF01048	0.668
MOD_GlcNHglycan	77	80	PF01048	0.801
MOD_GlcNHglycan	787	790	PF01048	0.554
MOD_GSK3_1	1	8	PF00069	0.679
MOD_GSK3_1	122	129	PF00069	0.516
MOD_GSK3_1	214	221	PF00069	0.690
MOD_GSK3_1	225	232	PF00069	0.609
MOD_GSK3_1	273	280	PF00069	0.644
MOD_GSK3_1	379	386	PF00069	0.631
MOD_GSK3_1	402	409	PF00069	0.472
MOD_GSK3_1	416	423	PF00069	0.655
MOD_GSK3_1	465	472	PF00069	0.356
MOD_GSK3_1	525	532	PF00069	0.588
MOD_GSK3_1	59	66	PF00069	0.732
MOD_GSK3_1	598	605	PF00069	0.470
MOD_GSK3_1	657	664	PF00069	0.634
MOD_GSK3_1	665	672	PF00069	0.627
MOD_GSK3_1	698	705	PF00069	0.779
MOD_GSK3_1	713	720	PF00069	0.546
MOD_GSK3_1	86	93	PF00069	0.550
MOD_LATS_1	57	63	PF00433	0.732
MOD_N-GLC_1	229	234	PF02516	0.625
MOD_N-GLC_1	273	278	PF02516	0.697
MOD_N-GLC_1	345	350	PF02516	0.628
MOD_N-GLC_1	580	585	PF02516	0.595
MOD_NEK2_1	1	6	PF00069	0.542
MOD_NEK2_1	372	377	PF00069	0.557
MOD_NEK2_1	389	394	PF00069	0.730
MOD_NEK2_1	416	421	PF00069	0.638
MOD_NEK2_1	513	518	PF00069	0.584
MOD_NEK2_1	568	573	PF00069	0.480
MOD_NEK2_2	23	28	PF00069	0.613
MOD_NEK2_2	455	460	PF00069	0.372
MOD_PKA_1	465	471	PF00069	0.448
MOD_PKA_1	529	535	PF00069	0.461
MOD_PKA_2	218	224	PF00069	0.737
MOD_PKA_2	252	258	PF00069	0.522
MOD_PKA_2	331	337	PF00069	0.458
MOD_PKA_2	443	449	PF00069	0.612
MOD_PKA_2	455	461	PF00069	0.392
MOD_PKA_2	465	471	PF00069	0.436
MOD_PKA_2	516	522	PF00069	0.539
MOD_PKA_2	529	535	PF00069	0.427
MOD_PKA_2	558	564	PF00069	0.362
MOD_PKA_2	58	64	PF00069	0.731
MOD_PKA_2	634	640	PF00069	0.692
MOD_PKA_2	650	656	PF00069	0.703
MOD_PKA_2	67	73	PF00069	0.558
MOD_PKA_2	752	758	PF00069	0.533
MOD_Plk_1	273	279	PF00069	0.651
MOD_Plk_4	179	185	PF00069	0.444
MOD_Plk_4	389	395	PF00069	0.556
MOD_Plk_4	402	408	PF00069	0.554
MOD_Plk_4	455	461	PF00069	0.370
MOD_Plk_4	535	541	PF00069	0.538
MOD_Plk_4	657	663	PF00069	0.558
MOD_Plk_4	726	732	PF00069	0.597
MOD_ProDKin_1	13	19	PF00069	0.664
MOD_ProDKin_1	225	231	PF00069	0.805
MOD_ProDKin_1	277	283	PF00069	0.733
MOD_ProDKin_1	60	66	PF00069	0.792
MOD_ProDKin_1	628	634	PF00069	0.606
MOD_ProDKin_1	661	667	PF00069	0.629
MOD_ProDKin_1	669	675	PF00069	0.644
MOD_ProDKin_1	70	76	PF00069	0.539
MOD_ProDKin_1	718	724	PF00069	0.585
MOD_ProDKin_1	773	779	PF00069	0.643
MOD_ProDKin_1	794	800	PF00069	0.566
MOD_SUMO_for_1	494	497	PF00179	0.584
MOD_SUMO_for_1	555	558	PF00179	0.508
MOD_SUMO_rev_2	605	613	PF00179	0.653
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.525
TRG_ENDOCYTIC_2	135	138	PF00928	0.479
TRG_ER_diArg_1	147	150	PF00400	0.476
TRG_ER_diArg_1	159	161	PF00400	0.510
TRG_ER_diArg_1	191	193	PF00400	0.495
TRG_ER_diArg_1	200	203	PF00400	0.528
TRG_ER_diArg_1	263	265	PF00400	0.674
TRG_ER_diArg_1	465	467	PF00400	0.361
TRG_NLS_Bipartite_1	185	205	PF00514	0.573
TRG_NLS_MonoExtN_4	200	205	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C2	Leptomonas seymouri	28%	88%
A0A3Q8IIQ6	Leishmania donovani	81%	99%
A4H856	Leishmania braziliensis	52%	99%
A4HWI1	Leishmania infantum	81%	99%
Q4QFA0	Leishmania major	80%	100%