Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinetoplastid kinetochore protein 22, putative

Species:

Leishmania mexicana

UniProt:

E9AQ81_LEIMU

TriTrypDb:

LmxM.15.0825

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.549
CLV_C14_Caspase3-7	182	186	PF00656	0.734
CLV_C14_Caspase3-7	345	349	PF00656	0.691
CLV_MEL_PAP_1	283	289	PF00089	0.655
CLV_NRD_NRD_1	147	149	PF00675	0.772
CLV_NRD_NRD_1	2	4	PF00675	0.563
CLV_NRD_NRD_1	336	338	PF00675	0.569
CLV_PCSK_KEX2_1	130	132	PF00082	0.716
CLV_PCSK_KEX2_1	147	149	PF00082	0.772
CLV_PCSK_KEX2_1	2	4	PF00082	0.563
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.716
CLV_PCSK_SKI1_1	127	131	PF00082	0.704
CLV_PCSK_SKI1_1	133	137	PF00082	0.637
CLV_PCSK_SKI1_1	21	25	PF00082	0.753
CLV_PCSK_SKI1_1	374	378	PF00082	0.573
DEG_Nend_UBRbox_1	1	4	PF02207	0.667
DOC_CDC14_PxL_1	411	419	PF14671	0.661
DOC_CYCLIN_RxL_1	368	381	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.706
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.685
DOC_MAPK_gen_1	337	343	PF00069	0.536
DOC_PP2B_LxvP_1	319	322	PF13499	0.614
DOC_PP2B_LxvP_1	42	45	PF13499	0.660
DOC_PP4_FxxP_1	70	73	PF00568	0.804
DOC_USP7_MATH_1	155	159	PF00917	0.545
DOC_USP7_MATH_1	177	181	PF00917	0.686
DOC_USP7_MATH_1	236	240	PF00917	0.794
DOC_USP7_MATH_1	336	340	PF00917	0.806
DOC_USP7_MATH_1	6	10	PF00917	0.574
DOC_WW_Pin1_4	167	172	PF00397	0.635
DOC_WW_Pin1_4	175	180	PF00397	0.594
DOC_WW_Pin1_4	2	7	PF00397	0.564
DOC_WW_Pin1_4	265	270	PF00397	0.481
DOC_WW_Pin1_4	296	301	PF00397	0.751
DOC_WW_Pin1_4	69	74	PF00397	0.647
LIG_14-3-3_CanoR_1	119	123	PF00244	0.728
LIG_14-3-3_CanoR_1	147	152	PF00244	0.633
LIG_14-3-3_CanoR_1	255	261	PF00244	0.666
LIG_14-3-3_CanoR_1	286	290	PF00244	0.548
LIG_14-3-3_CanoR_1	308	314	PF00244	0.556
LIG_14-3-3_CanoR_1	385	394	PF00244	0.519
LIG_14-3-3_CanoR_1	406	415	PF00244	0.414
LIG_14-3-3_CanoR_1	57	63	PF00244	0.700
LIG_APCC_ABBAyCdc20_2	391	397	PF00400	0.725
LIG_BIR_III_4	111	115	PF00653	0.531
LIG_BRCT_BRCA1_1	49	53	PF00533	0.678
LIG_EVH1_2	16	20	PF00568	0.540
LIG_FHA_1	232	238	PF00498	0.724
LIG_FHA_2	136	142	PF00498	0.528
LIG_LIR_Apic_2	30	35	PF02991	0.650
LIG_LIR_Gen_1	117	126	PF02991	0.638
LIG_LIR_Nem_3	121	125	PF02991	0.710
LIG_Pex14_1	49	53	PF04695	0.678
LIG_SH2_CRK	60	64	PF00017	0.674
LIG_SH2_SRC	196	199	PF00017	0.522
LIG_SH2_SRC	32	35	PF00017	0.708
LIG_SH2_STAT5	22	25	PF00017	0.750
LIG_SH2_STAT5	386	389	PF00017	0.677
LIG_SH2_STAT5	60	63	PF00017	0.555
LIG_SH3_2	16	21	PF14604	0.542
LIG_SH3_2	333	338	PF14604	0.702
LIG_SH3_3	13	19	PF00018	0.787
LIG_SH3_3	170	176	PF00018	0.588
LIG_SH3_3	263	269	PF00018	0.501
LIG_SH3_3	297	303	PF00018	0.761
LIG_SH3_3	330	336	PF00018	0.814
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.533
LIG_SUMO_SIM_par_1	188	194	PF11976	0.508
LIG_TRAF2_1	100	103	PF00917	0.830
LIG_TRAF2_1	138	141	PF00917	0.526
LIG_TRFH_1	60	64	PF08558	0.567
MOD_CDK_SPxxK_3	167	174	PF00069	0.683
MOD_CK1_1	214	220	PF00069	0.751
MOD_CK1_1	256	262	PF00069	0.675
MOD_CK1_1	27	33	PF00069	0.613
MOD_CK1_1	309	315	PF00069	0.554
MOD_CK1_1	47	53	PF00069	0.504
MOD_CK1_1	71	77	PF00069	0.650
MOD_CK1_1	81	87	PF00069	0.654
MOD_CK1_1	91	97	PF00069	0.806
MOD_CK2_1	135	141	PF00069	0.520
MOD_CK2_1	147	153	PF00069	0.665
MOD_CK2_1	185	191	PF00069	0.784
MOD_CK2_1	217	223	PF00069	0.626
MOD_CK2_1	97	103	PF00069	0.667
MOD_GlcNHglycan	108	111	PF01048	0.820
MOD_GlcNHglycan	116	119	PF01048	0.562
MOD_GlcNHglycan	157	160	PF01048	0.503
MOD_GlcNHglycan	161	164	PF01048	0.497
MOD_GlcNHglycan	216	219	PF01048	0.520
MOD_GlcNHglycan	255	258	PF01048	0.588
MOD_GlcNHglycan	308	311	PF01048	0.560
MOD_GlcNHglycan	73	76	PF01048	0.692
MOD_GlcNHglycan	90	93	PF01048	0.613
MOD_GSK3_1	114	121	PF00069	0.648
MOD_GSK3_1	129	136	PF00069	0.535
MOD_GSK3_1	155	162	PF00069	0.505
MOD_GSK3_1	175	182	PF00069	0.631
MOD_GSK3_1	2	9	PF00069	0.767
MOD_GSK3_1	207	214	PF00069	0.757
MOD_GSK3_1	217	224	PF00069	0.561
MOD_GSK3_1	23	30	PF00069	0.785
MOD_GSK3_1	236	243	PF00069	0.680
MOD_GSK3_1	251	258	PF00069	0.681
MOD_GSK3_1	71	78	PF00069	0.612
MOD_GSK3_1	90	97	PF00069	0.670
MOD_NEK2_1	209	214	PF00069	0.586
MOD_NEK2_1	253	258	PF00069	0.672
MOD_NEK2_1	387	392	PF00069	0.696
MOD_NEK2_1	395	400	PF00069	0.595
MOD_PIKK_1	406	412	PF00454	0.425
MOD_PIKK_1	6	12	PF00454	0.565
MOD_PK_1	221	227	PF00069	0.654
MOD_PKA_1	147	153	PF00069	0.535
MOD_PKA_2	118	124	PF00069	0.595
MOD_PKA_2	147	153	PF00069	0.623
MOD_PKA_2	285	291	PF00069	0.657
MOD_PKA_2	336	342	PF00069	0.536
MOD_PKA_2	395	401	PF00069	0.618
MOD_PKA_2	58	64	PF00069	0.715
MOD_PKA_2	78	84	PF00069	0.563
MOD_PKB_1	131	139	PF00069	0.587
MOD_PKB_1	383	391	PF00069	0.580
MOD_Plk_1	27	33	PF00069	0.750
MOD_Plk_1	350	356	PF00069	0.582
MOD_Plk_2-3	185	191	PF00069	0.677
MOD_Plk_4	179	185	PF00069	0.688
MOD_Plk_4	390	396	PF00069	0.541
MOD_Plk_4	44	50	PF00069	0.476
MOD_Plk_4	58	64	PF00069	0.715
MOD_ProDKin_1	167	173	PF00069	0.634
MOD_ProDKin_1	175	181	PF00069	0.596
MOD_ProDKin_1	2	8	PF00069	0.566
MOD_ProDKin_1	265	271	PF00069	0.475
MOD_ProDKin_1	296	302	PF00069	0.756
MOD_ProDKin_1	69	75	PF00069	0.649
MOD_SUMO_rev_2	239	246	PF00179	0.510
MOD_SUMO_rev_2	388	393	PF00179	0.709
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.604
TRG_DiLeu_BaLyEn_6	412	417	PF01217	0.651
TRG_ENDOCYTIC_2	126	129	PF00928	0.709
TRG_ENDOCYTIC_2	60	63	PF00928	0.711
TRG_ER_diArg_1	1	3	PF00400	0.673
TRG_ER_diArg_1	146	148	PF00400	0.752
TRG_ER_diArg_1	366	369	PF00400	0.509
TRG_ER_diArg_1	383	386	PF00400	0.531
TRG_ER_diArg_1	57	60	PF00400	0.688
TRG_NLS_MonoExtN_4	336	341	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTN4	Leishmania donovani	80%	97%
A4H855	Leishmania braziliensis	59%	100%
A4HWI0	Leishmania infantum	79%	97%