Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GDP dissociation inhibitor, putative

Species:

Leishmania mexicana

UniProt:

E9AQ80_LEIMU

TriTrypDb:

LmxM.15.0820

Length:

1033

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ80

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	11
GO:0007264	small GTPase mediated signal transduction	4	11
GO:0009987	cellular process	1	11
GO:0035556	intracellular signal transduction	3	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11
GO:0006810	transport	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0005092	GDP-dissociation inhibitor activity	3	11
GO:0030234	enzyme regulator activity	2	11
GO:0030695	GTPase regulator activity	4	11
GO:0060589	nucleoside-triphosphatase regulator activity	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11
GO:0005093	Rab GDP-dissociation inhibitor activity	4	1
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	825	829	PF00656	0.667
CLV_NRD_NRD_1	287	289	PF00675	0.478
CLV_NRD_NRD_1	324	326	PF00675	0.451
CLV_NRD_NRD_1	420	422	PF00675	0.342
CLV_NRD_NRD_1	500	502	PF00675	0.282
CLV_NRD_NRD_1	565	567	PF00675	0.303
CLV_NRD_NRD_1	658	660	PF00675	0.276
CLV_NRD_NRD_1	921	923	PF00675	0.536
CLV_PCSK_FUR_1	418	422	PF00082	0.386
CLV_PCSK_FUR_1	82	86	PF00082	0.502
CLV_PCSK_KEX2_1	102	104	PF00082	0.355
CLV_PCSK_KEX2_1	287	289	PF00082	0.489
CLV_PCSK_KEX2_1	324	326	PF00082	0.468
CLV_PCSK_KEX2_1	418	420	PF00082	0.335
CLV_PCSK_KEX2_1	499	501	PF00082	0.283
CLV_PCSK_KEX2_1	658	660	PF00082	0.276
CLV_PCSK_KEX2_1	84	86	PF00082	0.518
CLV_PCSK_KEX2_1	921	923	PF00082	0.476
CLV_PCSK_KEX2_1	995	997	PF00082	0.512
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.442
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.296
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.491
CLV_PCSK_PC1ET2_1	995	997	PF00082	0.546
CLV_PCSK_PC7_1	80	86	PF00082	0.620
CLV_PCSK_SKI1_1	29	33	PF00082	0.509
CLV_PCSK_SKI1_1	421	425	PF00082	0.283
CLV_PCSK_SKI1_1	43	47	PF00082	0.529
CLV_PCSK_SKI1_1	440	444	PF00082	0.296
CLV_PCSK_SKI1_1	457	461	PF00082	0.329
CLV_PCSK_SKI1_1	504	508	PF00082	0.290
CLV_PCSK_SKI1_1	615	619	PF00082	0.273
CLV_PCSK_SKI1_1	756	760	PF00082	0.465
CLV_PCSK_SKI1_1	995	999	PF00082	0.521
DEG_APCC_DBOX_1	358	366	PF00400	0.521
DEG_APCC_DBOX_1	419	427	PF00400	0.515
DEG_APCC_DBOX_1	65	73	PF00400	0.535
DEG_APCC_DBOX_1	657	665	PF00400	0.524
DEG_SCF_FBW7_1	946	953	PF00400	0.670
DEG_SPOP_SBC_1	588	592	PF00917	0.643
DOC_CDC14_PxL_1	970	978	PF14671	0.459
DOC_CKS1_1	688	693	PF01111	0.593
DOC_CYCLIN_RxL_1	40	50	PF00134	0.281
DOC_CYCLIN_RxL_1	418	425	PF00134	0.498
DOC_CYCLIN_RxL_1	454	465	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	722	725	PF00134	0.470
DOC_MAPK_DCC_7	71	79	PF00069	0.529
DOC_MAPK_DCC_7	893	902	PF00069	0.546
DOC_MAPK_gen_1	112	119	PF00069	0.344
DOC_MAPK_gen_1	499	505	PF00069	0.496
DOC_MAPK_gen_1	658	666	PF00069	0.544
DOC_MAPK_gen_1	995	1003	PF00069	0.581
DOC_MAPK_MEF2A_6	71	79	PF00069	0.536
DOC_MIT_MIM_1	62	72	PF04212	0.300
DOC_PP1_RVXF_1	438	444	PF00149	0.481
DOC_PP1_RVXF_1	801	808	PF00149	0.563
DOC_PP2B_LxvP_1	1001	1004	PF13499	0.600
DOC_PP2B_LxvP_1	123	126	PF13499	0.335
DOC_PP2B_LxvP_1	72	75	PF13499	0.545
DOC_PP2B_LxvP_1	722	725	PF13499	0.661
DOC_PP4_FxxP_1	1027	1030	PF00568	0.520
DOC_USP7_MATH_1	392	396	PF00917	0.534
DOC_USP7_MATH_1	531	535	PF00917	0.626
DOC_USP7_MATH_1	588	592	PF00917	0.717
DOC_USP7_MATH_1	923	927	PF00917	0.409
DOC_USP7_MATH_1	941	945	PF00917	0.667
DOC_USP7_MATH_1	950	954	PF00917	0.628
DOC_USP7_MATH_2	899	905	PF00917	0.628
DOC_USP7_UBL2_3	731	735	PF12436	0.804
DOC_USP7_UBL2_3	98	102	PF12436	0.355
DOC_WW_Pin1_4	390	395	PF00397	0.534
DOC_WW_Pin1_4	625	630	PF00397	0.482
DOC_WW_Pin1_4	687	692	PF00397	0.562
DOC_WW_Pin1_4	717	722	PF00397	0.683
DOC_WW_Pin1_4	744	749	PF00397	0.705
DOC_WW_Pin1_4	939	944	PF00397	0.777
DOC_WW_Pin1_4	946	951	PF00397	0.718
LIG_14-3-3_CanoR_1	112	117	PF00244	0.378
LIG_14-3-3_CanoR_1	189	195	PF00244	0.473
LIG_14-3-3_CanoR_1	646	654	PF00244	0.539
LIG_14-3-3_CanoR_1	658	662	PF00244	0.471
LIG_14-3-3_CanoR_1	821	827	PF00244	0.400
LIG_14-3-3_CanoR_1	85	89	PF00244	0.353
LIG_14-3-3_CanoR_1	907	911	PF00244	0.588
LIG_14-3-3_CanoR_1	922	932	PF00244	0.668
LIG_14-3-3_CanoR_1	963	971	PF00244	0.564
LIG_Actin_WH2_2	643	660	PF00022	0.494
LIG_AP2alpha_1	7	11	PF02296	0.592
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_BIR_III_2	940	944	PF00653	0.778
LIG_BIR_III_4	327	331	PF00653	0.424
LIG_BIR_III_4	999	1003	PF00653	0.596
LIG_BRCT_BRCA1_1	335	339	PF00533	0.545
LIG_BRCT_BRCA1_1	402	406	PF00533	0.447
LIG_BRCT_BRCA1_1	964	968	PF00533	0.579
LIG_deltaCOP1_diTrp_1	706	711	PF00928	0.580
LIG_deltaCOP1_diTrp_1	905	914	PF00928	0.568
LIG_eIF4E_1	143	149	PF01652	0.355
LIG_eIF4E_1	20	26	PF01652	0.399
LIG_FHA_1	144	150	PF00498	0.480
LIG_FHA_1	22	28	PF00498	0.508
LIG_FHA_1	344	350	PF00498	0.473
LIG_FHA_1	381	387	PF00498	0.402
LIG_FHA_1	491	497	PF00498	0.571
LIG_FHA_1	559	565	PF00498	0.546
LIG_FHA_1	718	724	PF00498	0.744
LIG_FHA_1	761	767	PF00498	0.438
LIG_FHA_1	800	806	PF00498	0.539
LIG_FHA_2	35	41	PF00498	0.449
LIG_FHA_2	475	481	PF00498	0.553
LIG_FHA_2	55	61	PF00498	0.439
LIG_FHA_2	557	563	PF00498	0.453
LIG_FHA_2	571	577	PF00498	0.470
LIG_FHA_2	688	694	PF00498	0.609
LIG_FHA_2	821	827	PF00498	0.680
LIG_FHA_2	935	941	PF00498	0.751
LIG_GBD_Chelix_1	247	255	PF00786	0.413
LIG_LIR_Apic_2	38	44	PF02991	0.479
LIG_LIR_Apic_2	867	873	PF02991	0.476
LIG_LIR_Apic_2	905	911	PF02991	0.610
LIG_LIR_Gen_1	226	237	PF02991	0.365
LIG_LIR_Gen_1	278	286	PF02991	0.459
LIG_LIR_Gen_1	336	343	PF02991	0.363
LIG_LIR_Gen_1	47	56	PF02991	0.519
LIG_LIR_Gen_1	5	14	PF02991	0.548
LIG_LIR_Gen_1	628	637	PF02991	0.530
LIG_LIR_Gen_1	706	716	PF02991	0.575
LIG_LIR_Gen_1	965	976	PF02991	0.553
LIG_LIR_Nem_3	226	232	PF02991	0.377
LIG_LIR_Nem_3	236	242	PF02991	0.396
LIG_LIR_Nem_3	278	282	PF02991	0.424
LIG_LIR_Nem_3	336	342	PF02991	0.363
LIG_LIR_Nem_3	40	45	PF02991	0.484
LIG_LIR_Nem_3	47	52	PF02991	0.475
LIG_LIR_Nem_3	5	10	PF02991	0.648
LIG_LIR_Nem_3	648	654	PF02991	0.562
LIG_LIR_Nem_3	672	677	PF02991	0.553
LIG_LIR_Nem_3	706	712	PF02991	0.563
LIG_LIR_Nem_3	965	971	PF02991	0.529
LIG_LIR_Nem_3	991	997	PF02991	0.510
LIG_LYPXL_SIV_4	993	1001	PF13949	0.462
LIG_LYPXL_yS_3	300	303	PF13949	0.446
LIG_MAD2	996	1004	PF02301	0.585
LIG_MYND_1	974	978	PF01753	0.533
LIG_NRBOX	250	256	PF00104	0.443
LIG_NRBOX	559	565	PF00104	0.507
LIG_PCNA_yPIPBox_3	550	564	PF02747	0.566
LIG_PCNA_yPIPBox_3	845	856	PF02747	0.454
LIG_Pex14_1	651	655	PF04695	0.482
LIG_Pex14_1	707	711	PF04695	0.608
LIG_Pex14_1	908	912	PF04695	0.578
LIG_Pex14_2	7	11	PF04695	0.592
LIG_PTB_Apo_2	976	983	PF02174	0.538
LIG_PTB_Phospho_1	976	982	PF10480	0.540
LIG_REV1ctd_RIR_1	279	288	PF16727	0.391
LIG_SH2_CRK	1025	1029	PF00017	0.561
LIG_SH2_CRK	229	233	PF00017	0.464
LIG_SH2_CRK	273	277	PF00017	0.481
LIG_SH2_CRK	674	678	PF00017	0.550
LIG_SH2_CRK	709	713	PF00017	0.629
LIG_SH2_CRK	870	874	PF00017	0.547
LIG_SH2_CRK	994	998	PF00017	0.523
LIG_SH2_NCK_1	326	330	PF00017	0.517
LIG_SH2_NCK_1	786	790	PF00017	0.596
LIG_SH2_SRC	229	232	PF00017	0.466
LIG_SH2_SRC	874	877	PF00017	0.482
LIG_SH2_STAP1	229	233	PF00017	0.464
LIG_SH2_STAP1	373	377	PF00017	0.553
LIG_SH2_STAP1	786	790	PF00017	0.596
LIG_SH2_STAP1	874	878	PF00017	0.446
LIG_SH2_STAT3	20	23	PF00017	0.511
LIG_SH2_STAT3	388	391	PF00017	0.562
LIG_SH2_STAT5	222	225	PF00017	0.367
LIG_SH2_STAT5	264	267	PF00017	0.353
LIG_SH2_STAT5	388	391	PF00017	0.496
LIG_SH2_STAT5	41	44	PF00017	0.530
LIG_SH2_STAT5	422	425	PF00017	0.503
LIG_SH2_STAT5	630	633	PF00017	0.562
LIG_SH2_STAT5	699	702	PF00017	0.529
LIG_SH2_STAT5	786	789	PF00017	0.590
LIG_SH2_STAT5	855	858	PF00017	0.515
LIG_SH2_STAT5	860	863	PF00017	0.510
LIG_SH2_STAT5	870	873	PF00017	0.337
LIG_SH2_STAT5	986	989	PF00017	0.407
LIG_SH2_STAT5	99	102	PF00017	0.403
LIG_SH3_3	15	21	PF00018	0.546
LIG_SH3_3	310	316	PF00018	0.510
LIG_SH3_3	718	724	PF00018	0.709
LIG_SH3_3	893	899	PF00018	0.598
LIG_SH3_3	968	974	PF00018	0.415
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.365
LIG_SUMO_SIM_anti_2	573	579	PF11976	0.463
LIG_SUMO_SIM_par_1	230	236	PF11976	0.353
LIG_SUMO_SIM_par_1	573	579	PF11976	0.490
LIG_SUMO_SIM_par_1	776	782	PF11976	0.585
LIG_SUMO_SIM_par_1	898	906	PF11976	0.629
LIG_SUMO_SIM_par_1	969	975	PF11976	0.559
LIG_TRAF2_1	57	60	PF00917	0.565
LIG_TYR_ITIM	290	295	PF00017	0.463
LIG_TYR_ITIM	872	877	PF00017	0.474
LIG_WRC_WIRS_1	377	382	PF05994	0.562
MOD_CK1_1	351	357	PF00069	0.513
MOD_CK1_1	393	399	PF00069	0.573
MOD_CK1_1	400	406	PF00069	0.582
MOD_CK1_1	472	478	PF00069	0.552
MOD_CK1_1	51	57	PF00069	0.615
MOD_CK1_1	591	597	PF00069	0.685
MOD_CK1_1	765	771	PF00069	0.476
MOD_CK1_1	812	818	PF00069	0.451
MOD_CK2_1	112	118	PF00069	0.355
MOD_CK2_1	474	480	PF00069	0.531
MOD_CK2_1	54	60	PF00069	0.508
MOD_CK2_1	556	562	PF00069	0.496
MOD_CK2_1	687	693	PF00069	0.586
MOD_CK2_1	923	929	PF00069	0.569
MOD_Cter_Amidation	210	213	PF01082	0.515
MOD_GlcNHglycan	1010	1013	PF01048	0.780
MOD_GlcNHglycan	190	193	PF01048	0.576
MOD_GlcNHglycan	225	228	PF01048	0.399
MOD_GlcNHglycan	353	356	PF01048	0.286
MOD_GlcNHglycan	399	402	PF01048	0.378
MOD_GlcNHglycan	443	446	PF01048	0.369
MOD_GlcNHglycan	53	56	PF01048	0.598
MOD_GlcNHglycan	569	573	PF01048	0.578
MOD_GlcNHglycan	591	594	PF01048	0.523
MOD_GlcNHglycan	647	650	PF01048	0.347
MOD_GlcNHglycan	744	747	PF01048	0.741
MOD_GlcNHglycan	943	946	PF01048	0.587
MOD_GlcNHglycan	952	955	PF01048	0.678
MOD_GSK3_1	351	358	PF00069	0.449
MOD_GSK3_1	376	383	PF00069	0.574
MOD_GSK3_1	392	399	PF00069	0.528
MOD_GSK3_1	465	472	PF00069	0.543
MOD_GSK3_1	50	57	PF00069	0.579
MOD_GSK3_1	526	533	PF00069	0.633
MOD_GSK3_1	587	594	PF00069	0.723
MOD_GSK3_1	625	632	PF00069	0.555
MOD_GSK3_1	740	747	PF00069	0.733
MOD_GSK3_1	758	765	PF00069	0.436
MOD_GSK3_1	946	953	PF00069	0.668
MOD_N-GLC_1	490	495	PF02516	0.353
MOD_N-GLC_1	531	536	PF02516	0.671
MOD_N-GLC_1	923	928	PF02516	0.565
MOD_N-GLC_2	643	645	PF02516	0.296
MOD_NEK2_1	220	225	PF00069	0.455
MOD_NEK2_1	247	252	PF00069	0.367
MOD_NEK2_1	333	338	PF00069	0.484
MOD_NEK2_1	343	348	PF00069	0.459
MOD_NEK2_1	380	385	PF00069	0.391
MOD_NEK2_1	397	402	PF00069	0.510
MOD_NEK2_1	441	446	PF00069	0.569
MOD_NEK2_1	489	494	PF00069	0.483
MOD_NEK2_1	570	575	PF00069	0.544
MOD_NEK2_1	617	622	PF00069	0.495
MOD_NEK2_1	631	636	PF00069	0.562
MOD_NEK2_1	657	662	PF00069	0.513
MOD_NEK2_2	21	26	PF00069	0.419
MOD_NEK2_2	914	919	PF00069	0.611
MOD_PIKK_1	595	601	PF00454	0.594
MOD_PIKK_1	669	675	PF00454	0.562
MOD_PIKK_1	845	851	PF00454	0.556
MOD_PK_1	112	118	PF00069	0.480
MOD_PK_1	48	54	PF00069	0.292
MOD_PKA_1	84	90	PF00069	0.355
MOD_PKA_2	188	194	PF00069	0.432
MOD_PKA_2	645	651	PF00069	0.517
MOD_PKA_2	657	663	PF00069	0.461
MOD_PKA_2	752	758	PF00069	0.420
MOD_PKA_2	820	826	PF00069	0.678
MOD_PKA_2	84	90	PF00069	0.355
MOD_PKA_2	906	912	PF00069	0.578
MOD_PKA_2	962	968	PF00069	0.580
MOD_Plk_1	333	339	PF00069	0.510
MOD_Plk_1	380	386	PF00069	0.506
MOD_Plk_1	490	496	PF00069	0.548
MOD_Plk_1	531	537	PF00069	0.693
MOD_Plk_1	914	920	PF00069	0.538
MOD_Plk_4	112	118	PF00069	0.355
MOD_Plk_4	21	27	PF00069	0.585
MOD_Plk_4	250	256	PF00069	0.333
MOD_Plk_4	348	354	PF00069	0.496
MOD_Plk_4	570	576	PF00069	0.462
MOD_Plk_4	762	768	PF00069	0.490
MOD_Plk_4	84	90	PF00069	0.343
MOD_Plk_4	972	978	PF00069	0.439
MOD_ProDKin_1	390	396	PF00069	0.534
MOD_ProDKin_1	625	631	PF00069	0.482
MOD_ProDKin_1	687	693	PF00069	0.562
MOD_ProDKin_1	717	723	PF00069	0.682
MOD_ProDKin_1	744	750	PF00069	0.697
MOD_ProDKin_1	939	945	PF00069	0.777
MOD_ProDKin_1	946	952	PF00069	0.707
MOD_SUMO_for_1	169	172	PF00179	0.564
MOD_SUMO_for_1	864	867	PF00179	0.580
MOD_SUMO_rev_2	620	629	PF00179	0.530
MOD_SUMO_rev_2	667	672	PF00179	0.557
TRG_DiLeu_BaEn_1	60	65	PF01217	0.418
TRG_DiLeu_BaEn_1	966	971	PF01217	0.583
TRG_DiLeu_BaEn_1	972	977	PF01217	0.453
TRG_DiLeu_BaEn_4	915	921	PF01217	0.545
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.404
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.535
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.562
TRG_DiLeu_BaLyEn_6	718	723	PF01217	0.700
TRG_ENDOCYTIC_2	1025	1028	PF00928	0.445
TRG_ENDOCYTIC_2	229	232	PF00928	0.466
TRG_ENDOCYTIC_2	264	267	PF00928	0.353
TRG_ENDOCYTIC_2	273	276	PF00928	0.377
TRG_ENDOCYTIC_2	292	295	PF00928	0.329
TRG_ENDOCYTIC_2	300	303	PF00928	0.416
TRG_ENDOCYTIC_2	630	633	PF00928	0.530
TRG_ENDOCYTIC_2	674	677	PF00928	0.519
TRG_ENDOCYTIC_2	708	711	PF00928	0.569
TRG_ENDOCYTIC_2	874	877	PF00928	0.506
TRG_ENDOCYTIC_2	994	997	PF00928	0.435
TRG_ER_diArg_1	199	202	PF00400	0.510
TRG_ER_diArg_1	286	288	PF00400	0.489
TRG_ER_diArg_1	324	326	PF00400	0.469
TRG_ER_diArg_1	418	421	PF00400	0.517
TRG_ER_diArg_1	500	502	PF00400	0.483
TRG_ER_diArg_1	65	68	PF00400	0.593
TRG_ER_diArg_1	657	659	PF00400	0.482
TRG_ER_diArg_1	920	922	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	448	453	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	457	462	PF00026	0.279

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXX4	Leptomonas seymouri	65%	100%
A0A0S4JKJ3	Bodo saltans	37%	100%
A0A1X0NTW1	Trypanosomatidae	38%	100%
A0A3R7KR10	Trypanosoma rangeli	41%	100%
A0A3S7WTI0	Leishmania donovani	91%	99%
A4H854	Leishmania braziliensis	81%	100%
A4HWH9	Leishmania infantum	91%	99%
C9ZXW9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4QFA2	Leishmania major	90%	100%