Peroxisomal membrane protein PEX16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisomal membrane protein (Pex16), putative

Species:

Leishmania mexicana

UniProt:

E9AQ78_LEIMU

TriTrypDb:

LmxM.15.0810

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0031903	microbody membrane	5	10
GO:0042579	microbody	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0098588	bounding membrane of organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1

Expansion

Sequence features

E9AQ78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ78

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	10
GO:0007031	peroxisome organization	5	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0071840	cellular component organization or biogenesis	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.658
CLV_NRD_NRD_1	100	102	PF00675	0.269
CLV_NRD_NRD_1	126	128	PF00675	0.254
CLV_NRD_NRD_1	133	135	PF00675	0.254
CLV_NRD_NRD_1	172	174	PF00675	0.398
CLV_NRD_NRD_1	185	187	PF00675	0.484
CLV_NRD_NRD_1	24	26	PF00675	0.549
CLV_NRD_NRD_1	257	259	PF00675	0.486
CLV_PCSK_KEX2_1	100	102	PF00082	0.293
CLV_PCSK_KEX2_1	133	135	PF00082	0.287
CLV_PCSK_KEX2_1	172	174	PF00082	0.407
CLV_PCSK_KEX2_1	184	186	PF00082	0.484
CLV_PCSK_KEX2_1	24	26	PF00082	0.549
CLV_PCSK_KEX2_1	257	259	PF00082	0.486
CLV_PCSK_SKI1_1	155	159	PF00082	0.402
CLV_PCSK_SKI1_1	172	176	PF00082	0.402
CLV_PCSK_SKI1_1	317	321	PF00082	0.501
CLV_PCSK_SKI1_1	326	330	PF00082	0.529
CLV_PCSK_SKI1_1	6	10	PF00082	0.509
CLV_PCSK_SKI1_1	62	66	PF00082	0.333
DEG_APCC_DBOX_1	171	179	PF00400	0.614
DEG_APCC_DBOX_1	29	37	PF00400	0.611
DOC_ANK_TNKS_1	47	54	PF00023	0.467
DOC_CDC14_PxL_1	157	165	PF14671	0.650
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.363
DOC_MAPK_DCC_7	417	426	PF00069	0.597
DOC_MAPK_gen_1	100	110	PF00069	0.525
DOC_MAPK_gen_1	133	141	PF00069	0.502
DOC_MAPK_gen_1	414	423	PF00069	0.549
DOC_MAPK_MEF2A_6	104	112	PF00069	0.598
DOC_MAPK_MEF2A_6	317	324	PF00069	0.333
DOC_MAPK_MEF2A_6	417	426	PF00069	0.597
DOC_MAPK_RevD_3	158	173	PF00069	0.641
DOC_PP2B_LxvP_1	248	251	PF13499	0.594
DOC_PP2B_LxvP_1	343	346	PF13499	0.439
DOC_PP4_FxxP_1	158	161	PF00568	0.592
DOC_USP7_MATH_1	471	475	PF00917	0.736
DOC_USP7_MATH_1	93	97	PF00917	0.520
DOC_USP7_UBL2_3	146	150	PF12436	0.530
DOC_WW_Pin1_4	11	16	PF00397	0.750
DOC_WW_Pin1_4	179	184	PF00397	0.669
DOC_WW_Pin1_4	363	368	PF00397	0.568
LIG_14-3-3_CanoR_1	100	108	PF00244	0.507
LIG_14-3-3_CanoR_1	133	137	PF00244	0.495
LIG_14-3-3_CanoR_1	176	182	PF00244	0.626
LIG_14-3-3_CanoR_1	252	260	PF00244	0.605
LIG_14-3-3_CanoR_1	62	67	PF00244	0.473
LIG_Actin_RPEL_3	18	37	PF02755	0.651
LIG_AP2alpha_2	507	509	PF02296	0.519
LIG_BIR_III_4	456	460	PF00653	0.655
LIG_Clathr_ClatBox_1	139	143	PF01394	0.530
LIG_FHA_1	103	109	PF00498	0.477
LIG_FHA_1	244	250	PF00498	0.607
LIG_FHA_1	335	341	PF00498	0.466
LIG_FHA_1	463	469	PF00498	0.608
LIG_FHA_1	509	515	PF00498	0.574
LIG_FHA_1	540	546	PF00498	0.360
LIG_FHA_1	59	65	PF00498	0.387
LIG_FHA_1	70	76	PF00498	0.496
LIG_FHA_2	101	107	PF00498	0.403
LIG_FHA_2	223	229	PF00498	0.703
LIG_FHA_2	299	305	PF00498	0.447
LIG_FHA_2	401	407	PF00498	0.378
LIG_LIR_Apic_2	65	71	PF02991	0.502
LIG_LIR_Gen_1	135	144	PF02991	0.495
LIG_LIR_Gen_1	301	310	PF02991	0.320
LIG_LIR_Gen_1	311	321	PF02991	0.276
LIG_LIR_Gen_1	507	518	PF02991	0.559
LIG_LIR_Gen_1	542	552	PF02991	0.407
LIG_LIR_Gen_1	88	95	PF02991	0.519
LIG_LIR_Nem_3	135	139	PF02991	0.469
LIG_LIR_Nem_3	301	305	PF02991	0.344
LIG_LIR_Nem_3	311	316	PF02991	0.347
LIG_LIR_Nem_3	397	402	PF02991	0.212
LIG_LIR_Nem_3	507	513	PF02991	0.521
LIG_LIR_Nem_3	546	552	PF02991	0.332
LIG_LIR_Nem_3	88	92	PF02991	0.519
LIG_NRBOX	407	413	PF00104	0.360
LIG_Pex14_2	522	526	PF04695	0.604
LIG_PTB_Apo_2	496	503	PF02174	0.550
LIG_PTB_Phospho_1	496	502	PF10480	0.593
LIG_SH2_CRK	220	224	PF00017	0.703
LIG_SH2_CRK	550	554	PF00017	0.362
LIG_SH2_STAP1	550	554	PF00017	0.299
LIG_SH2_STAT5	313	316	PF00017	0.400
LIG_SH2_STAT5	425	428	PF00017	0.666
LIG_SH2_STAT5	43	46	PF00017	0.511
LIG_SH2_STAT5	540	543	PF00017	0.307
LIG_SH2_STAT5	544	547	PF00017	0.361
LIG_SH2_STAT5	554	557	PF00017	0.324
LIG_SH3_3	237	243	PF00018	0.681
LIG_SH3_3	339	345	PF00018	0.412
LIG_SH3_3	364	370	PF00018	0.543
LIG_SUMO_SIM_anti_2	105	112	PF11976	0.470
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.295
LIG_SUMO_SIM_anti_2	339	344	PF11976	0.345
LIG_SUMO_SIM_par_1	138	143	PF11976	0.466
LIG_SUMO_SIM_par_1	437	443	PF11976	0.631
LIG_TRAF2_1	348	351	PF00917	0.422
LIG_TRAF2_1	358	361	PF00917	0.408
LIG_UBA3_1	121	128	PF00899	0.506
LIG_UBA3_1	139	146	PF00899	0.447
LIG_WRC_WIRS_1	549	554	PF05994	0.387
LIG_WRC_WIRS_1	86	91	PF05994	0.515
MOD_CDK_SPK_2	179	184	PF00069	0.669
MOD_CDK_SPxK_1	179	185	PF00069	0.673
MOD_CDK_SPxK_1	363	369	PF00069	0.512
MOD_CDK_SPxxK_3	179	186	PF00069	0.677
MOD_CK1_1	16	22	PF00069	0.768
MOD_CK1_1	196	202	PF00069	0.704
MOD_CK1_1	397	403	PF00069	0.201
MOD_CK1_1	429	435	PF00069	0.716
MOD_CK1_1	69	75	PF00069	0.530
MOD_CK2_1	100	106	PF00069	0.523
MOD_CK2_1	16	22	PF00069	0.691
MOD_CK2_1	222	228	PF00069	0.572
MOD_CK2_1	345	351	PF00069	0.403
MOD_CK2_1	52	58	PF00069	0.502
MOD_CMANNOS	396	399	PF00535	0.465
MOD_Cter_Amidation	98	101	PF01082	0.265
MOD_GlcNHglycan	196	199	PF01048	0.592
MOD_GlcNHglycan	201	204	PF01048	0.559
MOD_GlcNHglycan	428	431	PF01048	0.481
MOD_GlcNHglycan	452	455	PF01048	0.554
MOD_GlcNHglycan	96	99	PF01048	0.350
MOD_GSK3_1	10	17	PF00069	0.743
MOD_GSK3_1	102	109	PF00069	0.560
MOD_GSK3_1	163	170	PF00069	0.634
MOD_GSK3_1	199	206	PF00069	0.719
MOD_GSK3_1	2	9	PF00069	0.633
MOD_GSK3_1	359	366	PF00069	0.410
MOD_GSK3_1	388	395	PF00069	0.398
MOD_GSK3_1	446	453	PF00069	0.678
MOD_GSK3_1	459	466	PF00069	0.701
MOD_GSK3_1	535	542	PF00069	0.463
MOD_GSK3_1	548	555	PF00069	0.348
MOD_GSK3_1	58	65	PF00069	0.496
MOD_GSK3_1	66	73	PF00069	0.599
MOD_NEK2_1	163	168	PF00069	0.640
MOD_NEK2_1	392	397	PF00069	0.396
MOD_NEK2_1	461	466	PF00069	0.665
MOD_NEK2_1	532	537	PF00069	0.308
MOD_NEK2_1	539	544	PF00069	0.358
MOD_NEK2_1	552	557	PF00069	0.288
MOD_NEK2_1	60	65	PF00069	0.550
MOD_PIKK_1	222	228	PF00454	0.779
MOD_PIKK_1	447	453	PF00454	0.577
MOD_PKA_1	100	106	PF00069	0.530
MOD_PKA_2	132	138	PF00069	0.530
MOD_PKA_2	251	257	PF00069	0.578
MOD_PKA_2	99	105	PF00069	0.544
MOD_Plk_1	6	12	PF00069	0.588
MOD_Plk_2-3	289	295	PF00069	0.643
MOD_Plk_4	106	112	PF00069	0.513
MOD_Plk_4	388	394	PF00069	0.381
MOD_Plk_4	548	554	PF00069	0.318
MOD_Plk_4	62	68	PF00069	0.530
MOD_Plk_4	70	76	PF00069	0.439
MOD_ProDKin_1	11	17	PF00069	0.750
MOD_ProDKin_1	179	185	PF00069	0.673
MOD_ProDKin_1	363	369	PF00069	0.571
MOD_SUMO_rev_2	360	364	PF00179	0.542
TRG_DiLeu_BaEn_1	106	111	PF01217	0.571
TRG_DiLeu_BaEn_1	117	122	PF01217	0.428
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.364
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.530
TRG_ENDOCYTIC_2	313	316	PF00928	0.368
TRG_ENDOCYTIC_2	502	505	PF00928	0.556
TRG_ENDOCYTIC_2	519	522	PF00928	0.453
TRG_ENDOCYTIC_2	544	547	PF00928	0.356
TRG_ENDOCYTIC_2	549	552	PF00928	0.268
TRG_ER_diArg_1	171	173	PF00400	0.601
TRG_ER_diArg_1	183	186	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R8	Leptomonas seymouri	56%	100%
A0A1X0NUI4	Trypanosomatidae	34%	100%
A0A3Q8ICA1	Leishmania donovani	88%	99%
A4H843	Leishmania braziliensis	76%	99%
A4HWH7	Leishmania infantum	88%	99%
C9ZXX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QFA4	Leishmania major	88%	100%
V5DL46	Trypanosoma cruzi	35%	100%