Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ76_LEIMU

TriTrypDb:

LmxM.15.0780

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ76

PDB structure(s): 7ane_ae

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.466
CLV_NRD_NRD_1	169	171	PF00675	0.383
CLV_NRD_NRD_1	181	183	PF00675	0.413
CLV_NRD_NRD_1	210	212	PF00675	0.442
CLV_NRD_NRD_1	454	456	PF00675	0.487
CLV_NRD_NRD_1	494	496	PF00675	0.403
CLV_PCSK_FUR_1	452	456	PF00082	0.490
CLV_PCSK_KEX2_1	169	171	PF00082	0.383
CLV_PCSK_KEX2_1	181	183	PF00082	0.413
CLV_PCSK_KEX2_1	210	212	PF00082	0.429
CLV_PCSK_KEX2_1	454	456	PF00082	0.523
CLV_PCSK_SKI1_1	182	186	PF00082	0.299
CLV_PCSK_SKI1_1	222	226	PF00082	0.369
CLV_PCSK_SKI1_1	234	238	PF00082	0.319
CLV_PCSK_SKI1_1	436	440	PF00082	0.575
CLV_PCSK_SKI1_1	518	522	PF00082	0.560
DOC_CKS1_1	102	107	PF01111	0.371
DOC_CYCLIN_RxL_1	514	525	PF00134	0.338
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.389
DOC_MAPK_DCC_7	100	108	PF00069	0.379
DOC_MAPK_DCC_7	188	196	PF00069	0.502
DOC_MAPK_DCC_7	222	232	PF00069	0.349
DOC_MAPK_gen_1	185	194	PF00069	0.557
DOC_MAPK_gen_1	279	286	PF00069	0.353
DOC_MAPK_gen_1	312	320	PF00069	0.349
DOC_MAPK_MEF2A_6	188	196	PF00069	0.558
DOC_MAPK_MEF2A_6	90	97	PF00069	0.409
DOC_PP1_RVXF_1	283	289	PF00149	0.326
DOC_PP1_RVXF_1	505	511	PF00149	0.381
DOC_USP7_MATH_1	589	593	PF00917	0.715
DOC_USP7_MATH_1	621	625	PF00917	0.654
DOC_USP7_MATH_1	644	648	PF00917	0.800
DOC_WW_Pin1_4	101	106	PF00397	0.368
DOC_WW_Pin1_4	562	567	PF00397	0.425
DOC_WW_Pin1_4	629	634	PF00397	0.801
LIG_14-3-3_CanoR_1	116	122	PF00244	0.362
LIG_14-3-3_CanoR_1	222	228	PF00244	0.354
LIG_14-3-3_CanoR_1	234	242	PF00244	0.319
LIG_14-3-3_CanoR_1	314	319	PF00244	0.436
LIG_14-3-3_CanoR_1	452	461	PF00244	0.396
LIG_Actin_WH2_2	199	217	PF00022	0.351
LIG_Actin_WH2_2	346	364	PF00022	0.438
LIG_APCC_ABBA_1	250	255	PF00400	0.323
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_BIR_III_4	410	414	PF00653	0.641
LIG_BRCT_BRCA1_1	257	261	PF00533	0.431
LIG_CaM_NSCaTE_8	475	482	PF13499	0.429
LIG_CSL_BTD_1	509	512	PF09270	0.470
LIG_FHA_1	116	122	PF00498	0.441
LIG_FHA_1	364	370	PF00498	0.474
LIG_FHA_1	534	540	PF00498	0.456
LIG_FHA_1	563	569	PF00498	0.484
LIG_FHA_1	614	620	PF00498	0.724
LIG_FHA_1	632	638	PF00498	0.670
LIG_FHA_1	70	76	PF00498	0.506
LIG_FHA_1	77	83	PF00498	0.503
LIG_FHA_2	142	148	PF00498	0.436
LIG_FHA_2	332	338	PF00498	0.452
LIG_FHA_2	399	405	PF00498	0.532
LIG_FHA_2	420	426	PF00498	0.477
LIG_FHA_2	483	489	PF00498	0.580
LIG_LIR_Gen_1	334	344	PF02991	0.434
LIG_LIR_Nem_3	124	128	PF02991	0.477
LIG_LIR_Nem_3	162	168	PF02991	0.530
LIG_LIR_Nem_3	231	236	PF02991	0.314
LIG_LIR_Nem_3	334	339	PF02991	0.429
LIG_NRBOX	319	325	PF00104	0.309
LIG_PDZ_Class_1	650	655	PF00595	0.606
LIG_SH2_CRK	233	237	PF00017	0.302
LIG_SH2_CRK	336	340	PF00017	0.350
LIG_SH2_CRK	531	535	PF00017	0.495
LIG_SH2_GRB2like	298	301	PF00017	0.360
LIG_SH2_SRC	298	301	PF00017	0.360
LIG_SH2_STAP1	298	302	PF00017	0.391
LIG_SH2_STAP1	336	340	PF00017	0.375
LIG_SH2_STAP1	395	399	PF00017	0.482
LIG_SH2_STAT3	554	557	PF00017	0.591
LIG_SH2_STAT5	128	131	PF00017	0.490
LIG_SH2_STAT5	179	182	PF00017	0.371
LIG_SH2_STAT5	24	27	PF00017	0.413
LIG_SH2_STAT5	262	265	PF00017	0.311
LIG_SH2_STAT5	322	325	PF00017	0.335
LIG_SH2_STAT5	338	341	PF00017	0.359
LIG_SH2_STAT5	398	401	PF00017	0.504
LIG_SH2_STAT5	468	471	PF00017	0.345
LIG_SH2_STAT5	493	496	PF00017	0.528
LIG_SH2_STAT5	554	557	PF00017	0.538
LIG_SH3_2	31	36	PF14604	0.433
LIG_SH3_3	142	148	PF00018	0.411
LIG_SH3_3	28	34	PF00018	0.439
LIG_SH3_3	583	589	PF00018	0.693
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.418
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.474
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.298
LIG_SUMO_SIM_anti_2	76	84	PF11976	0.509
LIG_SUMO_SIM_par_1	104	110	PF11976	0.378
LIG_SUMO_SIM_par_1	192	198	PF11976	0.476
LIG_TRAF2_1	217	220	PF00917	0.354
LIG_TRAF2_1	328	331	PF00917	0.469
LIG_TRAF2_1	401	404	PF00917	0.578
LIG_TRAF2_1	485	488	PF00917	0.502
MOD_CK1_1	107	113	PF00069	0.357
MOD_CK1_1	17	23	PF00069	0.542
MOD_CK1_1	497	503	PF00069	0.490
MOD_CK1_1	580	586	PF00069	0.613
MOD_CK1_1	609	615	PF00069	0.656
MOD_CK1_1	642	648	PF00069	0.661
MOD_CK1_1	65	71	PF00069	0.473
MOD_CK1_1	78	84	PF00069	0.452
MOD_CK1_1	96	102	PF00069	0.470
MOD_CK2_1	192	198	PF00069	0.488
MOD_CK2_1	398	404	PF00069	0.456
MOD_CK2_1	482	488	PF00069	0.523
MOD_GlcNHglycan	109	112	PF01048	0.385
MOD_GlcNHglycan	480	483	PF01048	0.585
MOD_GlcNHglycan	579	582	PF01048	0.621
MOD_GlcNHglycan	591	594	PF01048	0.608
MOD_GlcNHglycan	608	611	PF01048	0.615
MOD_GlcNHglycan	613	616	PF01048	0.641
MOD_GlcNHglycan	625	628	PF01048	0.685
MOD_GlcNHglycan	637	640	PF01048	0.542
MOD_GlcNHglycan	64	67	PF01048	0.437
MOD_GlcNHglycan	642	645	PF01048	0.555
MOD_GlcNHglycan	646	649	PF01048	0.610
MOD_GSK3_1	10	17	PF00069	0.480
MOD_GSK3_1	419	426	PF00069	0.483
MOD_GSK3_1	478	485	PF00069	0.549
MOD_GSK3_1	609	616	PF00069	0.628
MOD_GSK3_1	62	69	PF00069	0.426
MOD_GSK3_1	631	638	PF00069	0.648
MOD_GSK3_1	640	647	PF00069	0.608
MOD_N-GLC_1	141	146	PF02516	0.448
MOD_NEK2_1	180	185	PF00069	0.427
MOD_NEK2_1	323	328	PF00069	0.473
MOD_NEK2_1	377	382	PF00069	0.418
MOD_NEK2_1	453	458	PF00069	0.596
MOD_NEK2_1	478	483	PF00069	0.441
MOD_NEK2_1	494	499	PF00069	0.310
MOD_NEK2_1	598	603	PF00069	0.592
MOD_NEK2_1	604	609	PF00069	0.605
MOD_NEK2_1	650	655	PF00069	0.606
MOD_NEK2_1	75	80	PF00069	0.493
MOD_NEK2_2	615	620	PF00069	0.589
MOD_PIKK_1	377	383	PF00454	0.552
MOD_PKA_1	454	460	PF00069	0.483
MOD_PKA_2	10	16	PF00069	0.532
MOD_PKA_2	115	121	PF00069	0.356
MOD_PKA_2	180	186	PF00069	0.427
MOD_PKA_2	453	459	PF00069	0.540
MOD_PKA_2	494	500	PF00069	0.390
MOD_PKA_2	639	645	PF00069	0.667
MOD_PKB_1	312	320	PF00069	0.437
MOD_PKB_1	452	460	PF00069	0.473
MOD_Plk_1	141	147	PF00069	0.441
MOD_Plk_1	175	181	PF00069	0.243
MOD_Plk_1	539	545	PF00069	0.456
MOD_Plk_1	546	552	PF00069	0.505
MOD_Plk_1	75	81	PF00069	0.460
MOD_Plk_1	93	99	PF00069	0.434
MOD_Plk_2-3	141	147	PF00069	0.441
MOD_Plk_2-3	331	337	PF00069	0.359
MOD_Plk_4	104	110	PF00069	0.387
MOD_Plk_4	14	20	PF00069	0.440
MOD_Plk_4	175	181	PF00069	0.243
MOD_Plk_4	489	495	PF00069	0.480
MOD_Plk_4	598	604	PF00069	0.619
MOD_Plk_4	78	84	PF00069	0.396
MOD_ProDKin_1	101	107	PF00069	0.372
MOD_ProDKin_1	562	568	PF00069	0.421
MOD_ProDKin_1	629	635	PF00069	0.802
MOD_SUMO_for_1	84	87	PF00179	0.412
MOD_SUMO_rev_2	337	345	PF00179	0.461
TRG_DiLeu_BaEn_2	86	92	PF01217	0.524
TRG_ENDOCYTIC_2	165	168	PF00928	0.388
TRG_ENDOCYTIC_2	233	236	PF00928	0.306
TRG_ENDOCYTIC_2	290	293	PF00928	0.421
TRG_ENDOCYTIC_2	298	301	PF00928	0.360
TRG_ENDOCYTIC_2	336	339	PF00928	0.335
TRG_ER_diArg_1	161	164	PF00400	0.371
TRG_ER_diArg_1	168	170	PF00400	0.399
TRG_ER_diArg_1	180	182	PF00400	0.470
TRG_ER_diArg_1	26	29	PF00400	0.413
TRG_ER_diArg_1	283	286	PF00400	0.337
TRG_ER_diArg_1	453	455	PF00400	0.490
TRG_NLS_MonoExtC_3	494	499	PF00514	0.396
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.477
TRG_PTS1	652	655	PF00515	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I655	Leptomonas seymouri	76%	99%
A0A0S4JKP6	Bodo saltans	54%	100%
A0A1X0NU53	Trypanosomatidae	65%	95%
A0A3R7NKZ5	Trypanosoma rangeli	60%	96%
A0A3S7WTG4	Leishmania donovani	96%	100%
A4H846	Leishmania braziliensis	89%	100%
A4HWH4	Leishmania infantum	96%	100%
C9ZXX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	98%
Q4QFA7	Leishmania major	95%	100%