Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AQ75_LEIMU

TriTrypDb:

LmxM.15.0770

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ75

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004713	protein tyrosine kinase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.700
CLV_NRD_NRD_1	151	153	PF00675	0.340
CLV_NRD_NRD_1	463	465	PF00675	0.707
CLV_PCSK_KEX2_1	15	17	PF00082	0.666
CLV_PCSK_KEX2_1	151	153	PF00082	0.340
CLV_PCSK_KEX2_1	261	263	PF00082	0.306
CLV_PCSK_KEX2_1	463	465	PF00082	0.628
CLV_PCSK_KEX2_1	94	96	PF00082	0.306
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.306
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.306
CLV_PCSK_SKI1_1	463	467	PF00082	0.578
CLV_PCSK_SKI1_1	497	501	PF00082	0.738
CLV_PCSK_SKI1_1	63	67	PF00082	0.189
CLV_PCSK_SKI1_1	95	99	PF00082	0.306
DEG_Nend_UBRbox_3	1	3	PF02207	0.710
DEG_SPOP_SBC_1	537	541	PF00917	0.504
DOC_CKS1_1	520	525	PF01111	0.540
DOC_CYCLIN_RxL_1	83	96	PF00134	0.366
DOC_CYCLIN_yCln2_LP_2	282	288	PF00134	0.399
DOC_MAPK_gen_1	194	203	PF00069	0.430
DOC_MAPK_gen_1	294	301	PF00069	0.183
DOC_MAPK_MEF2A_6	131	140	PF00069	0.325
DOC_PP2B_LxvP_1	282	285	PF13499	0.295
DOC_PP4_FxxP_1	249	252	PF00568	0.350
DOC_PP4_MxPP_1	477	480	PF00568	0.521
DOC_USP7_MATH_1	176	180	PF00917	0.325
DOC_USP7_MATH_1	480	484	PF00917	0.776
DOC_USP7_MATH_1	551	555	PF00917	0.739
DOC_WW_Pin1_4	471	476	PF00397	0.724
DOC_WW_Pin1_4	505	510	PF00397	0.692
DOC_WW_Pin1_4	519	524	PF00397	0.642
LIG_14-3-3_CanoR_1	151	161	PF00244	0.392
LIG_14-3-3_CanoR_1	164	170	PF00244	0.355
LIG_14-3-3_CanoR_1	394	402	PF00244	0.524
LIG_14-3-3_CanoR_1	638	647	PF00244	0.649
LIG_AP2alpha_1	500	504	PF02296	0.634
LIG_AP2alpha_1	651	655	PF02296	0.656
LIG_AP2alpha_2	256	258	PF02296	0.430
LIG_AP2alpha_2	536	538	PF02296	0.498
LIG_AP2alpha_2	649	651	PF02296	0.608
LIG_BRCT_BRCA1_1	121	125	PF00533	0.183
LIG_BRCT_BRCA1_1	540	544	PF00533	0.823
LIG_deltaCOP1_diTrp_1	295	301	PF00928	0.413
LIG_deltaCOP1_diTrp_1	357	362	PF00928	0.545
LIG_EVH1_2	615	619	PF00568	0.501
LIG_FHA_1	176	182	PF00498	0.340
LIG_FHA_1	308	314	PF00498	0.381
LIG_FHA_1	391	397	PF00498	0.601
LIG_FHA_1	520	526	PF00498	0.591
LIG_FHA_1	538	544	PF00498	0.581
LIG_FHA_1	618	624	PF00498	0.767
LIG_FHA_1	79	85	PF00498	0.414
LIG_FHA_2	164	170	PF00498	0.430
LIG_FHA_2	190	196	PF00498	0.414
LIG_FHA_2	228	234	PF00498	0.430
LIG_FHA_2	352	358	PF00498	0.547
LIG_LIR_Apic_2	382	386	PF02991	0.767
LIG_LIR_Gen_1	327	337	PF02991	0.323
LIG_LIR_Gen_1	34	44	PF02991	0.265
LIG_LIR_Gen_1	498	507	PF02991	0.693
LIG_LIR_Gen_1	649	655	PF02991	0.610
LIG_LIR_Gen_1	72	78	PF02991	0.311
LIG_LIR_Nem_3	327	332	PF02991	0.323
LIG_LIR_Nem_3	335	340	PF02991	0.399
LIG_LIR_Nem_3	34	39	PF02991	0.264
LIG_LIR_Nem_3	498	503	PF02991	0.692
LIG_LIR_Nem_3	649	654	PF02991	0.609
LIG_LIR_Nem_3	72	77	PF02991	0.327
LIG_LIR_Nem_3	96	100	PF02991	0.325
LIG_LYPXL_yS_3	555	558	PF13949	0.703
LIG_MAD2	368	376	PF02301	0.644
LIG_Pex14_1	297	301	PF04695	0.430
LIG_Pex14_2	500	504	PF04695	0.634
LIG_Pex14_2	651	655	PF04695	0.612
LIG_PTB_Apo_2	201	208	PF02174	0.183
LIG_PTB_Apo_2	243	250	PF02174	0.414
LIG_PTB_Apo_2	549	556	PF02174	0.495
LIG_PTB_Phospho_1	201	207	PF10480	0.183
LIG_PTB_Phospho_1	549	555	PF10480	0.495
LIG_SH2_CRK	150	154	PF00017	0.350
LIG_SH2_CRK	207	211	PF00017	0.183
LIG_SH2_CRK	609	613	PF00017	0.748
LIG_SH2_NCK_1	609	613	PF00017	0.742
LIG_SH2_PTP2	74	77	PF00017	0.325
LIG_SH2_SRC	609	612	PF00017	0.753
LIG_SH2_STAP1	309	313	PF00017	0.379
LIG_SH2_STAT3	586	589	PF00017	0.764
LIG_SH2_STAT5	144	147	PF00017	0.306
LIG_SH2_STAT5	183	186	PF00017	0.306
LIG_SH2_STAT5	281	284	PF00017	0.320
LIG_SH2_STAT5	309	312	PF00017	0.306
LIG_SH2_STAT5	74	77	PF00017	0.340
LIG_SH3_1	609	615	PF00018	0.678
LIG_SH3_1	644	650	PF00018	0.604
LIG_SH3_3	282	288	PF00018	0.430
LIG_SH3_3	296	302	PF00018	0.430
LIG_SH3_3	37	43	PF00018	0.514
LIG_SH3_3	373	379	PF00018	0.626
LIG_SH3_3	473	479	PF00018	0.750
LIG_SH3_3	50	56	PF00018	0.455
LIG_SH3_3	506	512	PF00018	0.642
LIG_SH3_3	517	523	PF00018	0.696
LIG_SH3_3	550	556	PF00018	0.700
LIG_SH3_3	588	594	PF00018	0.607
LIG_SH3_3	595	601	PF00018	0.646
LIG_SH3_3	608	614	PF00018	0.708
LIG_SH3_3	644	650	PF00018	0.635
LIG_SH3_3	82	88	PF00018	0.392
LIG_SUMO_SIM_anti_2	109	114	PF11976	0.350
LIG_SUMO_SIM_anti_2	34	41	PF11976	0.379
LIG_TRAF2_1	230	233	PF00917	0.430
LIG_TRAF2_1	428	431	PF00917	0.736
LIG_WRC_WIRS_1	348	353	PF05994	0.474
LIG_WW_1	54	57	PF00397	0.546
MOD_CK1_1	127	133	PF00069	0.337
MOD_CK1_1	308	314	PF00069	0.428
MOD_CK1_1	7	13	PF00069	0.662
MOD_CK2_1	111	117	PF00069	0.482
MOD_CK2_1	127	133	PF00069	0.367
MOD_CK2_1	163	169	PF00069	0.430
MOD_CK2_1	227	233	PF00069	0.457
MOD_CK2_1	351	357	PF00069	0.510
MOD_CK2_1	379	385	PF00069	0.690
MOD_GlcNHglycan	155	158	PF01048	0.428
MOD_GlcNHglycan	178	181	PF01048	0.350
MOD_GlcNHglycan	20	23	PF01048	0.416
MOD_GlcNHglycan	481	485	PF01048	0.823
MOD_GlcNHglycan	505	508	PF01048	0.726
MOD_GlcNHglycan	546	549	PF01048	0.660
MOD_GlcNHglycan	575	578	PF01048	0.656
MOD_GlcNHglycan	9	12	PF01048	0.658
MOD_GSK3_1	300	307	PF00069	0.443
MOD_GSK3_1	347	354	PF00069	0.510
MOD_GSK3_1	503	510	PF00069	0.722
MOD_GSK3_1	512	519	PF00069	0.635
MOD_GSK3_1	538	545	PF00069	0.748
MOD_N-GLC_1	119	124	PF02516	0.183
MOD_N-GLC_1	219	224	PF02516	0.422
MOD_NEK2_1	136	141	PF00069	0.319
MOD_NEK2_1	175	180	PF00069	0.344
MOD_NEK2_1	332	337	PF00069	0.371
MOD_NEK2_1	351	356	PF00069	0.539
MOD_NEK2_1	4	9	PF00069	0.671
MOD_NEK2_1	503	508	PF00069	0.728
MOD_NEK2_1	543	548	PF00069	0.747
MOD_NEK2_1	557	562	PF00069	0.485
MOD_NEK2_1	93	98	PF00069	0.350
MOD_NEK2_2	309	314	PF00069	0.277
MOD_PIKK_1	183	189	PF00454	0.295
MOD_PIKK_1	300	306	PF00454	0.283
MOD_PIKK_1	395	401	PF00454	0.562
MOD_PIKK_1	512	518	PF00454	0.684
MOD_PIKK_1	629	635	PF00454	0.811
MOD_PKA_2	153	159	PF00069	0.472
MOD_PKA_2	163	169	PF00069	0.376
MOD_Plk_1	119	125	PF00069	0.271
MOD_Plk_4	516	522	PF00069	0.564
MOD_Plk_4	70	76	PF00069	0.363
MOD_ProDKin_1	471	477	PF00069	0.728
MOD_ProDKin_1	505	511	PF00069	0.693
MOD_ProDKin_1	519	525	PF00069	0.643
MOD_SUMO_rev_2	111	121	PF00179	0.435
MOD_SUMO_rev_2	360	370	PF00179	0.563
TRG_DiLeu_BaEn_1	35	40	PF01217	0.357
TRG_ENDOCYTIC_2	150	153	PF00928	0.350
TRG_ENDOCYTIC_2	277	280	PF00928	0.306
TRG_ENDOCYTIC_2	281	284	PF00928	0.306
TRG_ENDOCYTIC_2	337	340	PF00928	0.511
TRG_ENDOCYTIC_2	555	558	PF00928	0.732
TRG_ENDOCYTIC_2	74	77	PF00928	0.348
TRG_ER_diArg_1	150	152	PF00400	0.338
TRG_ER_diArg_1	462	464	PF00400	0.655
TRG_NLS_MonoExtC_3	259	265	PF00514	0.430
TRG_NLS_MonoExtN_4	257	264	PF00514	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7R8	Leptomonas seymouri	61%	93%
A0A1X0NUC1	Trypanosomatidae	45%	87%
A0A3S7WTG9	Leishmania donovani	87%	100%
A0A422NRC0	Trypanosoma rangeli	42%	96%
A4H848	Leishmania braziliensis	64%	99%
A4HWH3	Leishmania infantum	87%	99%
C9ZXX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4QFA8	Leishmania major	82%	100%
V5BK24	Trypanosoma cruzi	41%	96%