Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AQ73_LEIMU

TriTrypDb:

LmxM.15.0750

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.589
CLV_C14_Caspase3-7	415	419	PF00656	0.440
CLV_C14_Caspase3-7	462	466	PF00656	0.677
CLV_C14_Caspase3-7	467	471	PF00656	0.738
CLV_NRD_NRD_1	268	270	PF00675	0.643
CLV_NRD_NRD_1	365	367	PF00675	0.488
CLV_PCSK_KEX2_1	268	270	PF00082	0.643
CLV_PCSK_SKI1_1	366	370	PF00082	0.453
CLV_PCSK_SKI1_1	424	428	PF00082	0.381
DEG_SCF_FBW7_1	134	139	PF00400	0.737
DEG_SPOP_SBC_1	111	115	PF00917	0.609
DEG_SPOP_SBC_1	221	225	PF00917	0.579
DEG_SPOP_SBC_1	71	75	PF00917	0.754
DOC_CKS1_1	215	220	PF01111	0.770
DOC_CKS1_1	353	358	PF01111	0.589
DOC_PP2B_LxvP_1	248	251	PF13499	0.583
DOC_PP2B_LxvP_1	504	507	PF13499	0.721
DOC_PP4_FxxP_1	199	202	PF00568	0.548
DOC_SPAK_OSR1_1	244	248	PF12202	0.681
DOC_USP7_MATH_1	111	115	PF00917	0.517
DOC_USP7_MATH_1	158	162	PF00917	0.565
DOC_USP7_MATH_1	208	212	PF00917	0.566
DOC_USP7_MATH_1	319	323	PF00917	0.712
DOC_USP7_MATH_1	356	360	PF00917	0.426
DOC_USP7_MATH_1	447	451	PF00917	0.706
DOC_USP7_MATH_1	526	530	PF00917	0.664
DOC_USP7_MATH_1	72	76	PF00917	0.733
DOC_WW_Pin1_4	119	124	PF00397	0.751
DOC_WW_Pin1_4	132	137	PF00397	0.643
DOC_WW_Pin1_4	168	173	PF00397	0.791
DOC_WW_Pin1_4	214	219	PF00397	0.693
DOC_WW_Pin1_4	352	357	PF00397	0.657
DOC_WW_Pin1_4	407	412	PF00397	0.617
DOC_WW_Pin1_4	471	476	PF00397	0.559
DOC_WW_Pin1_4	522	527	PF00397	0.590
DOC_WW_Pin1_4	73	78	PF00397	0.696
DOC_WW_Pin1_4	93	98	PF00397	0.801
LIG_APCC_ABBA_1	511	516	PF00400	0.609
LIG_Clathr_ClatBox_1	512	516	PF01394	0.670
LIG_deltaCOP1_diTrp_1	370	379	PF00928	0.497
LIG_EVH1_1	248	252	PF00568	0.578
LIG_EVH1_2	250	254	PF00568	0.558
LIG_FHA_1	113	119	PF00498	0.620
LIG_FHA_1	129	135	PF00498	0.721
LIG_FHA_1	210	216	PF00498	0.566
LIG_FHA_1	221	227	PF00498	0.548
LIG_FHA_1	430	436	PF00498	0.552
LIG_FHA_1	499	505	PF00498	0.693
LIG_FHA_1	525	531	PF00498	0.613
LIG_FHA_2	273	279	PF00498	0.750
LIG_FHA_2	413	419	PF00498	0.594
LIG_FHA_2	460	466	PF00498	0.729
LIG_LIR_Apic_2	489	493	PF02991	0.645
LIG_LIR_Gen_1	255	265	PF02991	0.619
LIG_LIR_Nem_3	255	260	PF02991	0.605
LIG_LIR_Nem_3	370	375	PF02991	0.428
LIG_MYND_1	392	396	PF01753	0.424
LIG_PDZ_Class_2	527	532	PF00595	0.743
LIG_Pex14_2	257	261	PF04695	0.601
LIG_SH2_CRK	365	369	PF00017	0.551
LIG_SH2_CRK	375	379	PF00017	0.464
LIG_SH2_NCK_1	490	494	PF00017	0.640
LIG_SH2_STAP1	375	379	PF00017	0.320
LIG_SH2_STAT5	154	157	PF00017	0.529
LIG_SH2_STAT5	375	378	PF00017	0.357
LIG_SH3_1	146	152	PF00018	0.487
LIG_SH3_3	146	152	PF00018	0.653
LIG_SH3_3	204	210	PF00018	0.756
LIG_SH3_3	212	218	PF00018	0.670
LIG_SH3_3	244	250	PF00018	0.637
LIG_SH3_3	336	342	PF00018	0.582
LIG_SH3_3	61	67	PF00018	0.577
LIG_TRAF2_1	253	256	PF00917	0.388
LIG_TRAF2_1	494	497	PF00917	0.805
LIG_WW_2	207	210	PF00397	0.530
MOD_CK1_1	113	119	PF00069	0.801
MOD_CK1_1	15	21	PF00069	0.766
MOD_CK1_1	271	277	PF00069	0.804
MOD_CK1_1	281	287	PF00069	0.655
MOD_CK1_1	34	40	PF00069	0.561
MOD_CK1_1	351	357	PF00069	0.714
MOD_CK1_1	471	477	PF00069	0.818
MOD_CK1_1	483	489	PF00069	0.655
MOD_CK1_1	521	527	PF00069	0.787
MOD_CK1_1	87	93	PF00069	0.692
MOD_CK2_1	272	278	PF00069	0.748
MOD_CK2_1	317	323	PF00069	0.768
MOD_CK2_1	351	357	PF00069	0.676
MOD_CK2_1	37	43	PF00069	0.806
MOD_CK2_1	378	384	PF00069	0.572
MOD_CK2_1	471	477	PF00069	0.817
MOD_CK2_1	491	497	PF00069	0.474
MOD_GlcNHglycan	160	163	PF01048	0.745
MOD_GlcNHglycan	165	168	PF01048	0.790
MOD_GlcNHglycan	184	187	PF01048	0.571
MOD_GlcNHglycan	226	229	PF01048	0.556
MOD_GlcNHglycan	270	273	PF01048	0.730
MOD_GlcNHglycan	301	304	PF01048	0.820
MOD_GlcNHglycan	357	361	PF01048	0.539
MOD_GlcNHglycan	493	496	PF01048	0.568
MOD_GlcNHglycan	520	523	PF01048	0.783
MOD_GlcNHglycan	89	92	PF01048	0.785
MOD_GSK3_1	109	116	PF00069	0.701
MOD_GSK3_1	128	135	PF00069	0.501
MOD_GSK3_1	13	20	PF00069	0.816
MOD_GSK3_1	197	204	PF00069	0.766
MOD_GSK3_1	216	223	PF00069	0.708
MOD_GSK3_1	268	275	PF00069	0.688
MOD_GSK3_1	277	284	PF00069	0.669
MOD_GSK3_1	33	40	PF00069	0.586
MOD_GSK3_1	348	355	PF00069	0.714
MOD_GSK3_1	459	466	PF00069	0.644
MOD_GSK3_1	471	478	PF00069	0.753
MOD_GSK3_1	518	525	PF00069	0.693
MOD_GSK3_1	66	73	PF00069	0.819
MOD_GSK3_1	80	87	PF00069	0.724
MOD_N-GLC_1	263	268	PF02516	0.673
MOD_N-GLC_1	475	480	PF02516	0.693
MOD_N-GLC_1	87	92	PF02516	0.639
MOD_NEK2_1	118	123	PF00069	0.726
MOD_NEK2_1	128	133	PF00069	0.508
MOD_NEK2_1	260	265	PF00069	0.724
MOD_NEK2_1	317	322	PF00069	0.675
MOD_NEK2_1	378	383	PF00069	0.339
MOD_NEK2_1	500	505	PF00069	0.790
MOD_NEK2_1	515	520	PF00069	0.553
MOD_PIKK_1	349	355	PF00454	0.529
MOD_PIKK_1	98	104	PF00454	0.760
MOD_PKA_1	268	274	PF00069	0.622
MOD_PKA_2	268	274	PF00069	0.703
MOD_PKA_2	299	305	PF00069	0.779
MOD_PKA_2	317	323	PF00069	0.713
MOD_PKA_2	447	453	PF00069	0.619
MOD_PKA_2	478	484	PF00069	0.527
MOD_PKB_1	346	354	PF00069	0.516
MOD_Plk_1	342	348	PF00069	0.740
MOD_Plk_1	515	521	PF00069	0.682
MOD_Plk_4	113	119	PF00069	0.752
MOD_Plk_4	373	379	PF00069	0.560
MOD_Plk_4	429	435	PF00069	0.534
MOD_Plk_4	80	86	PF00069	0.824
MOD_ProDKin_1	119	125	PF00069	0.742
MOD_ProDKin_1	132	138	PF00069	0.644
MOD_ProDKin_1	168	174	PF00069	0.787
MOD_ProDKin_1	214	220	PF00069	0.691
MOD_ProDKin_1	352	358	PF00069	0.649
MOD_ProDKin_1	407	413	PF00069	0.620
MOD_ProDKin_1	471	477	PF00069	0.560
MOD_ProDKin_1	522	528	PF00069	0.594
MOD_ProDKin_1	73	79	PF00069	0.698
MOD_ProDKin_1	93	99	PF00069	0.799
TRG_DiLeu_BaEn_4	255	261	PF01217	0.419
TRG_ENDOCYTIC_2	154	157	PF00928	0.529
TRG_ENDOCYTIC_2	365	368	PF00928	0.567
TRG_ENDOCYTIC_2	375	378	PF00928	0.451
TRG_ER_diArg_1	444	447	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P755	Leptomonas seymouri	29%	94%
A0A3S7WTM2	Leishmania donovani	75%	80%
A4H850	Leishmania braziliensis	54%	100%
A4HWH2	Leishmania infantum	74%	80%
Q4QFB0	Leishmania major	73%	100%