LeishMANIAdb
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Methyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltransferase-like protein
Gene product:
Putative methyltransferase, putative
Species:
Leishmania mexicana
UniProt:
E9AQ71_LEIMU
TriTrypDb:
LmxM.15.0730
Length:
560

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ71
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ71

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 1
GO:0032259 methylation 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0008168 methyltransferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016741 transferase activity, transferring one-carbon groups 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 208 212 PF00656 0.761
CLV_C14_Caspase3-7 296 300 PF00656 0.620
CLV_C14_Caspase3-7 460 464 PF00656 0.412
CLV_NRD_NRD_1 402 404 PF00675 0.530
CLV_NRD_NRD_1 49 51 PF00675 0.662
CLV_PCSK_KEX2_1 337 339 PF00082 0.651
CLV_PCSK_KEX2_1 402 404 PF00082 0.530
CLV_PCSK_KEX2_1 49 51 PF00082 0.662
CLV_PCSK_KEX2_1 541 543 PF00082 0.617
CLV_PCSK_PC1ET2_1 337 339 PF00082 0.651
CLV_PCSK_PC1ET2_1 541 543 PF00082 0.617
CLV_PCSK_SKI1_1 280 284 PF00082 0.664
CLV_PCSK_SKI1_1 373 377 PF00082 0.530
CLV_PCSK_SKI1_1 403 407 PF00082 0.530
CLV_PCSK_SKI1_1 50 54 PF00082 0.517
CLV_PCSK_SKI1_1 68 72 PF00082 0.425
CLV_PCSK_SKI1_1 84 88 PF00082 0.502
CLV_Separin_Metazoa 412 416 PF03568 0.238
DEG_APCC_DBOX_1 67 75 PF00400 0.460
DEG_Nend_Nbox_1 1 3 PF02207 0.484
DEG_SCF_FBW7_1 328 335 PF00400 0.799
DEG_SPOP_SBC_1 213 217 PF00917 0.792
DEG_SPOP_SBC_1 233 237 PF00917 0.397
DEG_SPOP_SBC_1 464 468 PF00917 0.660
DEG_SPOP_SBC_1 54 58 PF00917 0.516
DOC_CYCLIN_RxL_1 368 377 PF00134 0.530
DOC_CYCLIN_yCln2_LP_2 127 133 PF00134 0.479
DOC_MAPK_DCC_7 55 64 PF00069 0.495
DOC_MAPK_FxFP_2 191 194 PF00069 0.625
DOC_MAPK_gen_1 137 145 PF00069 0.487
DOC_MAPK_JIP1_4 273 279 PF00069 0.630
DOC_MAPK_MEF2A_6 137 145 PF00069 0.524
DOC_MAPK_MEF2A_6 175 184 PF00069 0.511
DOC_MAPK_MEF2A_6 273 281 PF00069 0.389
DOC_MAPK_MEF2A_6 548 556 PF00069 0.514
DOC_PP1_RVXF_1 123 130 PF00149 0.475
DOC_PP1_RVXF_1 400 407 PF00149 0.530
DOC_PP1_RVXF_1 66 73 PF00149 0.456
DOC_PP4_FxxP_1 101 104 PF00568 0.511
DOC_PP4_FxxP_1 191 194 PF00568 0.625
DOC_PP4_FxxP_1 195 198 PF00568 0.590
DOC_PP4_FxxP_1 229 232 PF00568 0.387
DOC_SPAK_OSR1_1 171 175 PF12202 0.517
DOC_USP7_MATH_1 150 154 PF00917 0.514
DOC_USP7_MATH_1 161 165 PF00917 0.476
DOC_USP7_MATH_1 166 170 PF00917 0.477
DOC_USP7_MATH_1 212 216 PF00917 0.751
DOC_USP7_MATH_1 233 237 PF00917 0.584
DOC_USP7_MATH_1 241 245 PF00917 0.544
DOC_USP7_MATH_1 260 264 PF00917 0.646
DOC_USP7_MATH_1 294 298 PF00917 0.800
DOC_USP7_MATH_1 428 432 PF00917 0.478
DOC_USP7_MATH_1 464 468 PF00917 0.660
DOC_USP7_MATH_2 291 297 PF00917 0.627
DOC_WW_Pin1_4 100 105 PF00397 0.468
DOC_WW_Pin1_4 194 199 PF00397 0.623
DOC_WW_Pin1_4 223 228 PF00397 0.680
DOC_WW_Pin1_4 29 34 PF00397 0.510
DOC_WW_Pin1_4 310 315 PF00397 0.571
DOC_WW_Pin1_4 324 329 PF00397 0.546
DOC_WW_Pin1_4 332 337 PF00397 0.675
DOC_WW_Pin1_4 439 444 PF00397 0.540
DOC_WW_Pin1_4 55 60 PF00397 0.509
LIG_14-3-3_CanoR_1 140 146 PF00244 0.507
LIG_14-3-3_CanoR_1 175 179 PF00244 0.513
LIG_14-3-3_CanoR_1 280 289 PF00244 0.441
LIG_14-3-3_CanoR_1 415 420 PF00244 0.238
LIG_14-3-3_CanoR_1 43 48 PF00244 0.520
LIG_14-3-3_CanoR_1 49 55 PF00244 0.508
LIG_14-3-3_CanoR_1 84 93 PF00244 0.524
LIG_APCC_ABBAyCdc20_2 402 408 PF00400 0.452
LIG_BRCT_BRCA1_1 163 167 PF00533 0.531
LIG_BRCT_BRCA1_1 168 172 PF00533 0.532
LIG_BRCT_BRCA1_1 225 229 PF00533 0.405
LIG_CSL_BTD_1 229 232 PF09270 0.679
LIG_deltaCOP1_diTrp_1 453 459 PF00928 0.577
LIG_EVH1_1 30 34 PF00568 0.513
LIG_FHA_1 122 128 PF00498 0.473
LIG_FHA_1 140 146 PF00498 0.493
LIG_FHA_1 175 181 PF00498 0.552
LIG_FHA_1 270 276 PF00498 0.690
LIG_FHA_1 439 445 PF00498 0.701
LIG_FHA_1 505 511 PF00498 0.557
LIG_FHA_2 206 212 PF00498 0.839
LIG_FHA_2 247 253 PF00498 0.549
LIG_FHA_2 310 316 PF00498 0.637
LIG_FHA_2 471 477 PF00498 0.318
LIG_GBD_Chelix_1 493 501 PF00786 0.554
LIG_HP1_1 241 245 PF01393 0.630
LIG_LIR_Apic_2 226 232 PF02991 0.391
LIG_LIR_Gen_1 164 174 PF02991 0.511
LIG_LIR_Gen_1 239 250 PF02991 0.630
LIG_LIR_Gen_1 3 11 PF02991 0.475
LIG_LIR_Gen_1 453 460 PF02991 0.429
LIG_LIR_Gen_1 472 479 PF02991 0.576
LIG_LIR_Nem_3 164 170 PF02991 0.533
LIG_LIR_Nem_3 237 243 PF02991 0.631
LIG_LIR_Nem_3 3 7 PF02991 0.477
LIG_LIR_Nem_3 453 457 PF02991 0.476
LIG_LIR_Nem_3 472 477 PF02991 0.589
LIG_NRBOX 107 113 PF00104 0.479
LIG_NRBOX 69 75 PF00104 0.463
LIG_Pex14_1 253 257 PF04695 0.516
LIG_Pex14_1 500 504 PF04695 0.397
LIG_Pex14_1 72 76 PF04695 0.469
LIG_Pex14_2 129 133 PF04695 0.476
LIG_Pex14_2 191 195 PF04695 0.800
LIG_SH2_CRK 349 353 PF00017 0.530
LIG_SH2_CRK 372 376 PF00017 0.530
LIG_SH2_CRK 4 8 PF00017 0.476
LIG_SH2_STAT3 41 44 PF00017 0.524
LIG_SH2_STAT5 2 5 PF00017 0.621
LIG_SH2_STAT5 257 260 PF00017 0.602
LIG_SH2_STAT5 364 367 PF00017 0.369
LIG_SH2_STAT5 41 44 PF00017 0.524
LIG_SH2_STAT5 45 48 PF00017 0.510
LIG_SH2_STAT5 504 507 PF00017 0.538
LIG_SH2_STAT5 516 519 PF00017 0.436
LIG_SH2_STAT5 523 526 PF00017 0.423
LIG_SH3_3 157 163 PF00018 0.597
LIG_SH3_3 221 227 PF00018 0.734
LIG_SH3_3 25 31 PF00018 0.506
LIG_SUMO_SIM_anti_2 107 113 PF11976 0.481
LIG_SUMO_SIM_anti_2 60 66 PF11976 0.469
LIG_SUMO_SIM_par_1 107 113 PF11976 0.493
LIG_TRAF2_1 249 252 PF00917 0.425
LIG_WRC_WIRS_1 471 476 PF05994 0.329
LIG_WW_2 160 163 PF00397 0.494
LIG_WW_2 28 31 PF00397 0.510
MOD_CDC14_SPxK_1 197 200 PF00782 0.509
MOD_CDC14_SPxK_1 335 338 PF00782 0.474
MOD_CDK_SPK_2 332 337 PF00069 0.500
MOD_CDK_SPxK_1 194 200 PF00069 0.508
MOD_CDK_SPxK_1 332 338 PF00069 0.491
MOD_CK1_1 115 121 PF00069 0.490
MOD_CK1_1 215 221 PF00069 0.697
MOD_CK1_1 236 242 PF00069 0.629
MOD_CK1_1 244 250 PF00069 0.490
MOD_CK1_1 268 274 PF00069 0.611
MOD_CK1_1 458 464 PF00069 0.599
MOD_CK1_1 481 487 PF00069 0.563
MOD_CK1_1 60 66 PF00069 0.469
MOD_CK2_1 246 252 PF00069 0.557
MOD_CK2_1 309 315 PF00069 0.516
MOD_CK2_1 371 377 PF00069 0.530
MOD_DYRK1A_RPxSP_1 55 59 PF00069 0.513
MOD_GlcNHglycan 114 117 PF01048 0.489
MOD_GlcNHglycan 185 189 PF01048 0.798
MOD_GlcNHglycan 24 27 PF01048 0.499
MOD_GlcNHglycan 283 286 PF01048 0.683
MOD_GlcNHglycan 296 299 PF01048 0.654
MOD_GlcNHglycan 332 335 PF01048 0.701
MOD_GlcNHglycan 467 470 PF01048 0.524
MOD_GlcNHglycan 528 531 PF01048 0.589
MOD_GSK3_1 100 107 PF00069 0.440
MOD_GSK3_1 110 117 PF00069 0.488
MOD_GSK3_1 150 157 PF00069 0.552
MOD_GSK3_1 161 168 PF00069 0.497
MOD_GSK3_1 194 201 PF00069 0.785
MOD_GSK3_1 212 219 PF00069 0.609
MOD_GSK3_1 232 239 PF00069 0.339
MOD_GSK3_1 265 272 PF00069 0.474
MOD_GSK3_1 318 325 PF00069 0.574
MOD_GSK3_1 328 335 PF00069 0.642
MOD_GSK3_1 428 435 PF00069 0.535
MOD_GSK3_1 50 57 PF00069 0.629
MOD_GSK3_1 84 91 PF00069 0.524
MOD_N-GLC_1 428 433 PF02516 0.567
MOD_NEK2_1 110 115 PF00069 0.488
MOD_NEK2_1 131 136 PF00069 0.505
MOD_NEK2_1 173 178 PF00069 0.637
MOD_NEK2_1 184 189 PF00069 0.726
MOD_NEK2_1 432 437 PF00069 0.673
MOD_NEK2_1 524 529 PF00069 0.473
MOD_NEK2_1 554 559 PF00069 0.584
MOD_NEK2_2 166 171 PF00069 0.512
MOD_PIKK_1 161 167 PF00454 0.505
MOD_PIKK_1 174 180 PF00454 0.520
MOD_PIKK_1 299 305 PF00454 0.448
MOD_PIKK_1 322 328 PF00454 0.748
MOD_PIKK_1 415 421 PF00454 0.261
MOD_PIKK_1 458 464 PF00454 0.673
MOD_PIKK_1 88 94 PF00454 0.521
MOD_PKA_2 139 145 PF00069 0.504
MOD_PKA_2 174 180 PF00069 0.513
MOD_PKA_2 36 42 PF00069 0.527
MOD_PKA_2 48 54 PF00069 0.494
MOD_PKA_2 554 560 PF00069 0.604
MOD_PKA_2 88 94 PF00069 0.513
MOD_Plk_1 428 434 PF00069 0.575
MOD_Plk_1 455 461 PF00069 0.606
MOD_Plk_1 481 487 PF00069 0.440
MOD_Plk_2-3 246 252 PF00069 0.557
MOD_Plk_2-3 470 476 PF00069 0.343
MOD_Plk_4 104 110 PF00069 0.463
MOD_Plk_4 150 156 PF00069 0.514
MOD_Plk_4 60 66 PF00069 0.469
MOD_Plk_4 78 84 PF00069 0.449
MOD_ProDKin_1 100 106 PF00069 0.468
MOD_ProDKin_1 194 200 PF00069 0.624
MOD_ProDKin_1 223 229 PF00069 0.681
MOD_ProDKin_1 29 35 PF00069 0.512
MOD_ProDKin_1 310 316 PF00069 0.567
MOD_ProDKin_1 324 330 PF00069 0.551
MOD_ProDKin_1 332 338 PF00069 0.666
MOD_ProDKin_1 439 445 PF00069 0.518
MOD_ProDKin_1 55 61 PF00069 0.505
MOD_SUMO_for_1 336 339 PF00179 0.663
TRG_DiLeu_BaLyEn_6 122 127 PF01217 0.557
TRG_DiLeu_BaLyEn_6 440 445 PF01217 0.611
TRG_ENDOCYTIC_2 349 352 PF00928 0.565
TRG_ENDOCYTIC_2 372 375 PF00928 0.530
TRG_ENDOCYTIC_2 4 7 PF00928 0.478
TRG_ENDOCYTIC_2 523 526 PF00928 0.438
TRG_ENDOCYTIC_2 79 82 PF00928 0.477
TRG_ER_diArg_1 17 20 PF00400 0.480
TRG_ER_diArg_1 402 404 PF00400 0.530
TRG_NES_CRM1_1 470 482 PF08389 0.302
TRG_Pf-PMV_PEXEL_1 373 377 PF00026 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WTG3 Leishmania donovani 84% 100%
A4H852 Leishmania braziliensis 82% 100%
A4HWH0 Leishmania infantum 79% 100%
Q4QFB2 Leishmania major 90% 99%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS