Putative flavoprotein monooxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flavoprotein monooxygenase, putative

Species:

Leishmania mexicana

UniProt:

E9AQ70_LEIMU

TriTrypDb:

LmxM.15.0720

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ70

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901661	quinone metabolic process	4	1
GO:1901663	quinone biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004497	monooxygenase activity	3	10
GO:0016491	oxidoreductase activity	2	10
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	563	567	PF00656	0.445
CLV_NRD_NRD_1	141	143	PF00675	0.521
CLV_NRD_NRD_1	196	198	PF00675	0.398
CLV_NRD_NRD_1	256	258	PF00675	0.452
CLV_NRD_NRD_1	3	5	PF00675	0.567
CLV_NRD_NRD_1	333	335	PF00675	0.556
CLV_NRD_NRD_1	344	346	PF00675	0.447
CLV_NRD_NRD_1	410	412	PF00675	0.382
CLV_NRD_NRD_1	580	582	PF00675	0.432
CLV_PCSK_KEX2_1	141	143	PF00082	0.442
CLV_PCSK_KEX2_1	196	198	PF00082	0.385
CLV_PCSK_KEX2_1	256	258	PF00082	0.452
CLV_PCSK_KEX2_1	3	5	PF00082	0.527
CLV_PCSK_KEX2_1	333	335	PF00082	0.617
CLV_PCSK_KEX2_1	409	411	PF00082	0.416
CLV_PCSK_KEX2_1	580	582	PF00082	0.476
CLV_PCSK_PC7_1	137	143	PF00082	0.455
CLV_PCSK_PC7_1	405	411	PF00082	0.372
CLV_PCSK_SKI1_1	196	200	PF00082	0.519
CLV_PCSK_SKI1_1	256	260	PF00082	0.323
CLV_PCSK_SKI1_1	569	573	PF00082	0.420
CLV_Separin_Metazoa	462	466	PF03568	0.481
DEG_APCC_DBOX_1	195	203	PF00400	0.506
DEG_APCC_DBOX_1	464	472	PF00400	0.414
DEG_Nend_Nbox_1	1	3	PF02207	0.533
DEG_SCF_FBW7_1	392	399	PF00400	0.235
DEG_SPOP_SBC_1	168	172	PF00917	0.629
DEG_SPOP_SBC_1	472	476	PF00917	0.493
DOC_CKS1_1	393	398	PF01111	0.236
DOC_CYCLIN_RxL_1	253	261	PF00134	0.361
DOC_MAPK_gen_1	333	342	PF00069	0.458
DOC_MAPK_MEF2A_6	182	189	PF00069	0.429
DOC_MAPK_MEF2A_6	581	590	PF00069	0.380
DOC_USP7_MATH_1	108	112	PF00917	0.668
DOC_USP7_MATH_1	167	171	PF00917	0.753
DOC_USP7_MATH_1	178	182	PF00917	0.594
DOC_USP7_MATH_1	228	232	PF00917	0.435
DOC_USP7_MATH_1	294	298	PF00917	0.374
DOC_USP7_MATH_1	305	309	PF00917	0.613
DOC_USP7_MATH_1	336	340	PF00917	0.486
DOC_USP7_MATH_1	414	418	PF00917	0.498
DOC_USP7_MATH_1	472	476	PF00917	0.529
DOC_USP7_UBL2_3	346	350	PF12436	0.426
DOC_USP7_UBL2_3	639	643	PF12436	0.488
DOC_WW_Pin1_4	120	125	PF00397	0.719
DOC_WW_Pin1_4	174	179	PF00397	0.628
DOC_WW_Pin1_4	181	186	PF00397	0.450
DOC_WW_Pin1_4	25	30	PF00397	0.515
DOC_WW_Pin1_4	311	316	PF00397	0.616
DOC_WW_Pin1_4	340	345	PF00397	0.319
DOC_WW_Pin1_4	392	397	PF00397	0.518
DOC_WW_Pin1_4	55	60	PF00397	0.552
DOC_WW_Pin1_4	582	587	PF00397	0.477
DOC_WW_Pin1_4	90	95	PF00397	0.476
LIG_14-3-3_CanoR_1	208	215	PF00244	0.312
LIG_14-3-3_CanoR_1	334	344	PF00244	0.617
LIG_14-3-3_CanoR_1	485	495	PF00244	0.513
LIG_14-3-3_CanoR_1	589	595	PF00244	0.436
LIG_14-3-3_CanoR_1	604	610	PF00244	0.582
LIG_14-3-3_CanoR_1	629	635	PF00244	0.546
LIG_14-3-3_CterR_2	652	655	PF00244	0.514
LIG_APCC_ABBA_1	272	277	PF00400	0.400
LIG_BIR_III_4	544	548	PF00653	0.277
LIG_BRCT_BRCA1_1	440	444	PF00533	0.379
LIG_BRCT_BRCA1_1	76	80	PF00533	0.380
LIG_Clathr_ClatBox_1	361	365	PF01394	0.432
LIG_Clathr_ClatBox_1	374	378	PF01394	0.350
LIG_EH_1	521	525	PF12763	0.308
LIG_FHA_1	113	119	PF00498	0.550
LIG_FHA_1	232	238	PF00498	0.418
LIG_FHA_1	320	326	PF00498	0.551
LIG_FHA_1	393	399	PF00498	0.461
LIG_FHA_1	410	416	PF00498	0.474
LIG_FHA_1	503	509	PF00498	0.507
LIG_FHA_1	85	91	PF00498	0.379
LIG_FHA_2	26	32	PF00498	0.513
LIG_FHA_2	606	612	PF00498	0.614
LIG_FHA_2	630	636	PF00498	0.521
LIG_FHA_2	86	92	PF00498	0.402
LIG_LIR_Apic_2	47	51	PF02991	0.733
LIG_LIR_Gen_1	184	194	PF02991	0.414
LIG_LIR_Gen_1	357	364	PF02991	0.365
LIG_LIR_Gen_1	441	451	PF02991	0.297
LIG_LIR_Gen_1	500	511	PF02991	0.354
LIG_LIR_Gen_1	585	594	PF02991	0.470
LIG_LIR_Nem_3	181	186	PF02991	0.506
LIG_LIR_Nem_3	188	194	PF02991	0.439
LIG_LIR_Nem_3	357	361	PF02991	0.377
LIG_LIR_Nem_3	432	438	PF02991	0.451
LIG_LIR_Nem_3	47	52	PF02991	0.580
LIG_LIR_Nem_3	500	506	PF02991	0.369
LIG_LIR_Nem_3	585	590	PF02991	0.465
LIG_LIR_Nem_3	593	597	PF02991	0.447
LIG_LIR_Nem_3	628	634	PF02991	0.573
LIG_LYPXL_yS_3	494	497	PF13949	0.388
LIG_NRBOX	254	260	PF00104	0.355
LIG_Pex14_1	347	351	PF04695	0.455
LIG_Pex14_1	606	610	PF04695	0.566
LIG_PTB_Apo_2	36	43	PF02174	0.513
LIG_PTB_Phospho_1	36	42	PF10480	0.514
LIG_SH2_CRK	136	140	PF00017	0.539
LIG_SH2_CRK	191	195	PF00017	0.413
LIG_SH2_CRK	358	362	PF00017	0.313
LIG_SH2_CRK	503	507	PF00017	0.472
LIG_SH2_CRK	551	555	PF00017	0.350
LIG_SH2_CRK	6	10	PF00017	0.657
LIG_SH2_NCK_1	191	195	PF00017	0.441
LIG_SH2_NCK_1	503	507	PF00017	0.472
LIG_SH2_SRC	276	279	PF00017	0.371
LIG_SH2_SRC	634	637	PF00017	0.499
LIG_SH2_STAP1	276	280	PF00017	0.440
LIG_SH2_STAP1	351	355	PF00017	0.391
LIG_SH2_STAP1	358	362	PF00017	0.288
LIG_SH2_STAP1	618	622	PF00017	0.424
LIG_SH2_STAT3	42	45	PF00017	0.612
LIG_SH2_STAT3	421	424	PF00017	0.494
LIG_SH2_STAT3	449	452	PF00017	0.427
LIG_SH2_STAT3	498	501	PF00017	0.474
LIG_SH2_STAT5	15	18	PF00017	0.550
LIG_SH2_STAT5	33	36	PF00017	0.671
LIG_SH2_STAT5	467	470	PF00017	0.459
LIG_SH2_STAT5	498	501	PF00017	0.458
LIG_SH2_STAT5	631	634	PF00017	0.518
LIG_SH3_3	121	127	PF00018	0.627
LIG_SH3_3	288	294	PF00018	0.365
LIG_SH3_3	445	451	PF00018	0.337
LIG_SH3_3	503	509	PF00018	0.379
LIG_SH3_3	597	603	PF00018	0.466
LIG_SUMO_SIM_par_1	359	365	PF11976	0.216
LIG_SUMO_SIM_par_1	373	378	PF11976	0.352
LIG_TRAF2_1	316	319	PF00917	0.489
LIG_TYR_ITIM	189	194	PF00017	0.445
LIG_TYR_ITIM	274	279	PF00017	0.452
LIG_TYR_ITIM	356	361	PF00017	0.337
LIG_WRC_WIRS_1	484	489	PF05994	0.438
MOD_CDC14_SPxK_1	179	182	PF00782	0.521
MOD_CDC14_SPxK_1	343	346	PF00782	0.317
MOD_CDC14_SPxK_1	58	61	PF00782	0.464
MOD_CDK_SPK_2	25	30	PF00069	0.461
MOD_CDK_SPK_2	340	345	PF00069	0.319
MOD_CDK_SPxK_1	176	182	PF00069	0.547
MOD_CDK_SPxK_1	340	346	PF00069	0.318
MOD_CDK_SPxK_1	55	61	PF00069	0.500
MOD_CDK_SPxxK_3	582	589	PF00069	0.485
MOD_CK1_1	125	131	PF00069	0.677
MOD_CK1_1	153	159	PF00069	0.608
MOD_CK1_1	171	177	PF00069	0.634
MOD_CK1_1	181	187	PF00069	0.482
MOD_CK1_1	231	237	PF00069	0.405
MOD_CK1_1	266	272	PF00069	0.433
MOD_CK1_1	314	320	PF00069	0.528
MOD_CK1_1	417	423	PF00069	0.500
MOD_CK1_1	473	479	PF00069	0.567
MOD_CK1_1	486	492	PF00069	0.371
MOD_CK2_1	474	480	PF00069	0.365
MOD_CK2_1	605	611	PF00069	0.580
MOD_CK2_1	85	91	PF00069	0.374
MOD_GlcNHglycan	17	21	PF01048	0.558
MOD_GlcNHglycan	171	174	PF01048	0.743
MOD_GlcNHglycan	209	212	PF01048	0.334
MOD_GlcNHglycan	268	271	PF01048	0.455
MOD_GlcNHglycan	296	300	PF01048	0.486
MOD_GlcNHglycan	416	419	PF01048	0.671
MOD_GlcNHglycan	477	480	PF01048	0.444
MOD_GlcNHglycan	509	512	PF01048	0.311
MOD_GlcNHglycan	563	566	PF01048	0.399
MOD_GlcNHglycan	66	69	PF01048	0.329
MOD_GlcNHglycan	76	79	PF01048	0.313
MOD_GSK3_1	108	115	PF00069	0.655
MOD_GSK3_1	118	125	PF00069	0.763
MOD_GSK3_1	146	153	PF00069	0.689
MOD_GSK3_1	167	174	PF00069	0.801
MOD_GSK3_1	231	238	PF00069	0.445
MOD_GSK3_1	305	312	PF00069	0.679
MOD_GSK3_1	336	343	PF00069	0.502
MOD_GSK3_1	392	399	PF00069	0.330
MOD_GSK3_1	409	416	PF00069	0.397
MOD_GSK3_1	438	445	PF00069	0.405
MOD_GSK3_1	470	477	PF00069	0.470
MOD_GSK3_1	556	563	PF00069	0.353
MOD_GSK3_1	625	632	PF00069	0.613
MOD_GSK3_1	9	16	PF00069	0.586
MOD_LATS_1	408	414	PF00433	0.445
MOD_N-GLC_1	25	30	PF02516	0.474
MOD_N-GLC_2	599	601	PF02516	0.457
MOD_NEK2_1	304	309	PF00069	0.476
MOD_NEK2_1	471	476	PF00069	0.565
MOD_NEK2_1	502	507	PF00069	0.416
MOD_NEK2_1	590	595	PF00069	0.418
MOD_NEK2_1	625	630	PF00069	0.598
MOD_NEK2_1	74	79	PF00069	0.484
MOD_NEK2_1	8	13	PF00069	0.534
MOD_NEK2_2	605	610	PF00069	0.614
MOD_PKA_1	409	415	PF00069	0.480
MOD_PKA_2	13	19	PF00069	0.570
MOD_PKA_2	207	213	PF00069	0.383
MOD_PKA_2	409	415	PF00069	0.453
MOD_PKA_2	560	566	PF00069	0.446
MOD_Plk_1	295	301	PF00069	0.399
MOD_Plk_1	305	311	PF00069	0.447
MOD_Plk_4	228	234	PF00069	0.392
MOD_Plk_4	493	499	PF00069	0.359
MOD_Plk_4	605	611	PF00069	0.588
MOD_Plk_4	85	91	PF00069	0.394
MOD_ProDKin_1	120	126	PF00069	0.717
MOD_ProDKin_1	174	180	PF00069	0.621
MOD_ProDKin_1	181	187	PF00069	0.442
MOD_ProDKin_1	25	31	PF00069	0.513
MOD_ProDKin_1	311	317	PF00069	0.607
MOD_ProDKin_1	340	346	PF00069	0.318
MOD_ProDKin_1	392	398	PF00069	0.515
MOD_ProDKin_1	55	61	PF00069	0.537
MOD_ProDKin_1	582	588	PF00069	0.477
MOD_ProDKin_1	90	96	PF00069	0.476
MOD_SUMO_for_1	99	102	PF00179	0.458
MOD_SUMO_rev_2	343	352	PF00179	0.450
TRG_DiLeu_BaEn_2	482	488	PF01217	0.418
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.394
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.564
TRG_ENDOCYTIC_2	183	186	PF00928	0.409
TRG_ENDOCYTIC_2	191	194	PF00928	0.346
TRG_ENDOCYTIC_2	276	279	PF00928	0.446
TRG_ENDOCYTIC_2	358	361	PF00928	0.317
TRG_ENDOCYTIC_2	494	497	PF00928	0.411
TRG_ENDOCYTIC_2	503	506	PF00928	0.407
TRG_ENDOCYTIC_2	551	554	PF00928	0.343
TRG_ENDOCYTIC_2	594	597	PF00928	0.477
TRG_ENDOCYTIC_2	6	9	PF00928	0.657
TRG_ER_diArg_1	140	142	PF00400	0.436
TRG_ER_diArg_1	2	4	PF00400	0.577
TRG_ER_diArg_1	255	257	PF00400	0.442
TRG_ER_diArg_1	332	334	PF00400	0.635
TRG_ER_diArg_1	409	411	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	30	35	PF00026	0.705
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTW3	Leptomonas seymouri	72%	100%
A0A0S4JRA1	Bodo saltans	48%	100%
A0A1X0NTX5	Trypanosomatidae	47%	100%
A0A3S5H6U9	Leishmania donovani	95%	100%
A4HWG9	Leishmania infantum	95%	100%
C9ZXY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
Q4QFB3	Leishmania major	95%	100%
V5DL32	Trypanosoma cruzi	53%	100%