COX assembly mitochondrial protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ66_LEIMU

TriTrypDb:

LmxM.15.0680

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AQ66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.523
CLV_NRD_NRD_1	57	59	PF00675	0.511
CLV_NRD_NRD_1	69	71	PF00675	0.550
CLV_PCSK_FUR_1	179	183	PF00082	0.460
CLV_PCSK_KEX2_1	181	183	PF00082	0.447
CLV_PCSK_KEX2_1	57	59	PF00082	0.496
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.506
CLV_PCSK_SKI1_1	104	108	PF00082	0.649
CLV_PCSK_SKI1_1	182	186	PF00082	0.570
DOC_MAPK_gen_1	129	137	PF00069	0.468
DOC_MAPK_MEF2A_6	129	137	PF00069	0.573
DOC_USP7_MATH_1	177	181	PF00917	0.559
DOC_USP7_UBL2_3	11	15	PF12436	0.624
DOC_USP7_UBL2_3	181	185	PF12436	0.527
DOC_USP7_UBL2_3	22	26	PF12436	0.640
LIG_14-3-3_CanoR_1	104	112	PF00244	0.446
LIG_14-3-3_CanoR_1	29	33	PF00244	0.694
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BRCT_BRCA1_1	179	183	PF00533	0.588
LIG_BRCT_BRCA1_2	179	185	PF00533	0.589
LIG_FHA_2	186	192	PF00498	0.323
LIG_FHA_2	48	54	PF00498	0.628
LIG_Integrin_RGD_1	162	164	PF01839	0.486
LIG_LIR_Gen_1	180	190	PF02991	0.551
LIG_LIR_Nem_3	180	186	PF02991	0.439
LIG_LIR_Nem_3	78	84	PF02991	0.379
LIG_LIR_Nem_3	87	92	PF02991	0.375
LIG_LYPXL_yS_3	89	92	PF13949	0.392
LIG_REV1ctd_RIR_1	99	108	PF16727	0.522
LIG_SH2_STAT5	125	128	PF00017	0.378
LIG_SH2_STAT5	19	22	PF00017	0.657
LIG_SH2_STAT5	62	65	PF00017	0.435
LIG_SH2_STAT5	74	77	PF00017	0.469
LIG_SH2_STAT5	91	94	PF00017	0.311
LIG_TRAF2_1	51	54	PF00917	0.572
MOD_CK2_1	185	191	PF00069	0.531
MOD_CK2_1	47	53	PF00069	0.628
MOD_GlcNHglycan	33	37	PF01048	0.656
MOD_GSK3_1	28	35	PF00069	0.575
MOD_N-GLC_1	64	69	PF02516	0.561
MOD_N-GLC_2	139	141	PF02516	0.407
MOD_PKA_2	110	116	PF00069	0.328
MOD_PKA_2	28	34	PF00069	0.584
MOD_Plk_1	190	196	PF00069	0.539
MOD_Plk_1	64	70	PF00069	0.505
MOD_SUMO_rev_2	161	167	PF00179	0.488
MOD_SUMO_rev_2	191	198	PF00179	0.615
TRG_ENDOCYTIC_2	81	84	PF00928	0.373
TRG_ENDOCYTIC_2	89	92	PF00928	0.372
TRG_ER_diArg_1	57	59	PF00400	0.529
TRG_ER_diLys_1	197	202	PF00400	0.577
TRG_ER_FFAT_1	172	180	PF00635	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B2	Leptomonas seymouri	82%	100%
A0A0S4IW52	Bodo saltans	53%	100%
A0A1X0NTV3	Trypanosomatidae	67%	100%
A0A3R7NUR7	Trypanosoma rangeli	63%	100%
A0A3S7WTG2	Leishmania donovani	94%	100%
A4H838	Leishmania braziliensis	87%	100%
A4HWG5	Leishmania infantum	94%	100%
C9ZXY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	97%
Q4QFB7	Leishmania major	94%	100%
V5BPN5	Trypanosoma cruzi	64%	100%