Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AQ63_LEIMU

TriTrypDb:

LmxM.15.0650

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.670
CLV_C14_Caspase3-7	213	217	PF00656	0.565
CLV_C14_Caspase3-7	377	381	PF00656	0.558
CLV_C14_Caspase3-7	627	631	PF00656	0.654
CLV_NRD_NRD_1	511	513	PF00675	0.644
CLV_PCSK_FUR_1	509	513	PF00082	0.637
CLV_PCSK_KEX2_1	208	210	PF00082	0.660
CLV_PCSK_KEX2_1	511	513	PF00082	0.644
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.622
CLV_PCSK_SKI1_1	410	414	PF00082	0.689
CLV_PCSK_SKI1_1	58	62	PF00082	0.614
DEG_SCF_FBW7_1	21	28	PF00400	0.713
DEG_SPOP_SBC_1	124	128	PF00917	0.582
DEG_SPOP_SBC_1	301	305	PF00917	0.622
DEG_SPOP_SBC_1	353	357	PF00917	0.650
DEG_SPOP_SBC_1	559	563	PF00917	0.689
DEG_SPOP_SBC_1	73	77	PF00917	0.531
DOC_CKS1_1	22	27	PF01111	0.717
DOC_CKS1_1	343	348	PF01111	0.669
DOC_CYCLIN_RxL_1	55	64	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	398	401	PF00134	0.549
DOC_PP1_RVXF_1	56	62	PF00149	0.649
DOC_PP2B_LxvP_1	246	249	PF13499	0.597
DOC_PP2B_LxvP_1	398	401	PF13499	0.549
DOC_PP2B_LxvP_1	412	415	PF13499	0.532
DOC_PP4_MxPP_1	247	250	PF00568	0.660
DOC_PP4_MxPP_1	298	301	PF00568	0.698
DOC_USP7_MATH_1	118	122	PF00917	0.675
DOC_USP7_MATH_1	135	139	PF00917	0.533
DOC_USP7_MATH_1	162	166	PF00917	0.527
DOC_USP7_MATH_1	194	198	PF00917	0.699
DOC_USP7_MATH_1	239	243	PF00917	0.572
DOC_USP7_MATH_1	301	305	PF00917	0.622
DOC_USP7_MATH_1	319	323	PF00917	0.623
DOC_USP7_MATH_1	386	390	PF00917	0.619
DOC_USP7_MATH_1	624	628	PF00917	0.822
DOC_WW_Pin1_4	139	144	PF00397	0.704
DOC_WW_Pin1_4	163	168	PF00397	0.687
DOC_WW_Pin1_4	17	22	PF00397	0.828
DOC_WW_Pin1_4	183	188	PF00397	0.720
DOC_WW_Pin1_4	198	203	PF00397	0.616
DOC_WW_Pin1_4	222	227	PF00397	0.600
DOC_WW_Pin1_4	25	30	PF00397	0.628
DOC_WW_Pin1_4	250	255	PF00397	0.613
DOC_WW_Pin1_4	257	262	PF00397	0.611
DOC_WW_Pin1_4	270	275	PF00397	0.696
DOC_WW_Pin1_4	288	293	PF00397	0.584
DOC_WW_Pin1_4	296	301	PF00397	0.643
DOC_WW_Pin1_4	326	331	PF00397	0.687
DOC_WW_Pin1_4	342	347	PF00397	0.593
DOC_WW_Pin1_4	354	359	PF00397	0.616
DOC_WW_Pin1_4	45	50	PF00397	0.723
DOC_WW_Pin1_4	53	58	PF00397	0.598
DOC_WW_Pin1_4	675	680	PF00397	0.607
DOC_WW_Pin1_4	69	74	PF00397	0.647
LIG_14-3-3_CanoR_1	129	137	PF00244	0.636
LIG_14-3-3_CanoR_1	16	20	PF00244	0.721
LIG_14-3-3_CanoR_1	302	311	PF00244	0.623
LIG_14-3-3_CanoR_1	410	415	PF00244	0.649
LIG_14-3-3_CanoR_1	424	429	PF00244	0.399
LIG_14-3-3_CanoR_1	58	64	PF00244	0.651
LIG_14-3-3_CanoR_1	67	73	PF00244	0.665
LIG_APCC_ABBA_1	655	660	PF00400	0.657
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BRCT_BRCA1_1	346	350	PF00533	0.494
LIG_BRCT_BRCA1_1	434	438	PF00533	0.529
LIG_BRCT_BRCA1_1	651	655	PF00533	0.641
LIG_BRCT_BRCA1_1	660	664	PF00533	0.561
LIG_Clathr_ClatBox_1	279	283	PF01394	0.583
LIG_CtBP_PxDLS_1	249	253	PF00389	0.604
LIG_deltaCOP1_diTrp_1	660	664	PF00928	0.681
LIG_EVH1_1	399	403	PF00568	0.535
LIG_FHA_1	106	112	PF00498	0.705
LIG_FHA_1	171	177	PF00498	0.671
LIG_FHA_1	343	349	PF00498	0.671
LIG_FHA_1	45	51	PF00498	0.832
LIG_FHA_1	484	490	PF00498	0.603
LIG_FHA_1	54	60	PF00498	0.592
LIG_FHA_1	74	80	PF00498	0.675
LIG_FHA_2	114	120	PF00498	0.670
LIG_FHA_2	461	467	PF00498	0.685
LIG_FHA_2	471	477	PF00498	0.668
LIG_IBAR_NPY_1	341	343	PF08397	0.576
LIG_IBAR_NPY_1	656	658	PF08397	0.577
LIG_IRF3_LxIS_1	148	153	PF10401	0.689
LIG_LIR_Gen_1	435	446	PF02991	0.746
LIG_LIR_Gen_1	476	484	PF02991	0.551
LIG_LIR_Nem_3	435	441	PF02991	0.563
LIG_LIR_Nem_3	476	481	PF02991	0.535
LIG_LIR_Nem_3	62	66	PF02991	0.630
LIG_LIR_Nem_3	652	658	PF02991	0.584
LIG_MLH1_MIPbox_1	346	350	PF16413	0.494
LIG_PAM2_1	653	665	PF00658	0.593
LIG_PROFILIN_1	400	406	PF00235	0.617
LIG_PTAP_UEV_1	260	265	PF05743	0.588
LIG_SH2_CRK	314	318	PF00017	0.615
LIG_SH2_CRK	343	347	PF00017	0.669
LIG_SH2_CRK	66	70	PF00017	0.621
LIG_SH2_NCK_1	314	318	PF00017	0.494
LIG_SH2_SRC	658	661	PF00017	0.664
LIG_SH2_STAP1	471	475	PF00017	0.588
LIG_SH2_STAP1	620	624	PF00017	0.689
LIG_SH2_STAP1	658	662	PF00017	0.593
LIG_SH2_STAT3	527	530	PF00017	0.707
LIG_SH2_STAT5	220	223	PF00017	0.625
LIG_SH2_STAT5	428	431	PF00017	0.650
LIG_SH3_1	397	403	PF00018	0.546
LIG_SH3_3	171	177	PF00018	0.542
LIG_SH3_3	19	25	PF00018	0.576
LIG_SH3_3	199	205	PF00018	0.613
LIG_SH3_3	255	261	PF00018	0.627
LIG_SH3_3	327	333	PF00018	0.687
LIG_SH3_3	397	403	PF00018	0.585
LIG_SH3_3	442	448	PF00018	0.613
LIG_SUMO_SIM_par_1	148	153	PF11976	0.613
LIG_SUMO_SIM_par_1	278	283	PF11976	0.630
LIG_TRAF2_1	463	466	PF00917	0.561
LIG_TRAF2_1	87	90	PF00917	0.773
LIG_TRAF2_1	92	95	PF00917	0.708
LIG_WW_2	403	406	PF00397	0.609
LIG_WW_3	299	303	PF00397	0.624
MOD_CDC14_SPxK_1	299	302	PF00782	0.622
MOD_CDK_SPK_2	53	58	PF00069	0.593
MOD_CDK_SPxK_1	296	302	PF00069	0.626
MOD_CK1_1	106	112	PF00069	0.629
MOD_CK1_1	139	145	PF00069	0.681
MOD_CK1_1	170	176	PF00069	0.762
MOD_CK1_1	186	192	PF00069	0.703
MOD_CK1_1	197	203	PF00069	0.562
MOD_CK1_1	2	8	PF00069	0.656
MOD_CK1_1	227	233	PF00069	0.592
MOD_CK1_1	303	309	PF00069	0.745
MOD_CK1_1	315	321	PF00069	0.591
MOD_CK1_1	324	330	PF00069	0.696
MOD_CK1_1	389	395	PF00069	0.603
MOD_CK1_1	44	50	PF00069	0.543
MOD_CK1_1	450	456	PF00069	0.689
MOD_CK1_1	459	465	PF00069	0.644
MOD_CK1_1	507	513	PF00069	0.751
MOD_CK1_1	515	521	PF00069	0.723
MOD_CK1_1	53	59	PF00069	0.578
MOD_CK1_1	618	624	PF00069	0.638
MOD_CK1_1	665	671	PF00069	0.661
MOD_CK1_1	72	78	PF00069	0.598
MOD_CK2_1	113	119	PF00069	0.786
MOD_CK2_1	459	465	PF00069	0.569
MOD_GlcNHglycan	1	4	PF01048	0.609
MOD_GlcNHglycan	119	123	PF01048	0.719
MOD_GlcNHglycan	133	136	PF01048	0.615
MOD_GlcNHglycan	138	141	PF01048	0.557
MOD_GlcNHglycan	152	155	PF01048	0.733
MOD_GlcNHglycan	169	172	PF01048	0.558
MOD_GlcNHglycan	202	205	PF01048	0.673
MOD_GlcNHglycan	212	215	PF01048	0.634
MOD_GlcNHglycan	261	264	PF01048	0.589
MOD_GlcNHglycan	314	317	PF01048	0.564
MOD_GlcNHglycan	326	329	PF01048	0.805
MOD_GlcNHglycan	334	337	PF01048	0.619
MOD_GlcNHglycan	390	394	PF01048	0.623
MOD_GlcNHglycan	506	509	PF01048	0.624
MOD_GlcNHglycan	52	55	PF01048	0.632
MOD_GlcNHglycan	520	523	PF01048	0.740
MOD_GlcNHglycan	535	538	PF01048	0.654
MOD_GlcNHglycan	602	605	PF01048	0.788
MOD_GlcNHglycan	617	620	PF01048	0.591
MOD_GlcNHglycan	626	629	PF01048	0.813
MOD_GlcNHglycan	664	667	PF01048	0.634
MOD_GlcNHglycan	76	79	PF01048	0.707
MOD_GSK3_1	103	110	PF00069	0.630
MOD_GSK3_1	113	120	PF00069	0.642
MOD_GSK3_1	124	131	PF00069	0.612
MOD_GSK3_1	135	142	PF00069	0.629
MOD_GSK3_1	163	170	PF00069	0.723
MOD_GSK3_1	17	24	PF00069	0.725
MOD_GSK3_1	194	201	PF00069	0.623
MOD_GSK3_1	25	32	PF00069	0.630
MOD_GSK3_1	250	257	PF00069	0.609
MOD_GSK3_1	284	291	PF00069	0.600
MOD_GSK3_1	296	303	PF00069	0.690
MOD_GSK3_1	315	322	PF00069	0.506
MOD_GSK3_1	349	356	PF00069	0.700
MOD_GSK3_1	37	44	PF00069	0.577
MOD_GSK3_1	448	455	PF00069	0.654
MOD_GSK3_1	456	463	PF00069	0.595
MOD_GSK3_1	658	665	PF00069	0.634
MOD_GSK3_1	68	75	PF00069	0.635
MOD_N-GLC_1	111	116	PF02516	0.643
MOD_N-GLC_1	162	167	PF02516	0.512
MOD_N-GLC_1	25	30	PF02516	0.674
MOD_N-GLC_1	250	255	PF02516	0.613
MOD_N-GLC_1	284	289	PF02516	0.813
MOD_N-GLC_1	459	464	PF02516	0.743
MOD_N-GLC_1	67	72	PF02516	0.698
MOD_NEK2_1	1	6	PF00069	0.711
MOD_NEK2_1	150	155	PF00069	0.618
MOD_NEK2_1	169	174	PF00069	0.650
MOD_NEK2_1	349	354	PF00069	0.762
MOD_NEK2_1	664	669	PF00069	0.694
MOD_PIKK_1	29	35	PF00454	0.673
MOD_PIKK_1	512	518	PF00454	0.724
MOD_PIKK_1	693	699	PF00454	0.668
MOD_PIKK_1	8	14	PF00454	0.709
MOD_PK_1	344	350	PF00069	0.613
MOD_PKA_1	208	214	PF00069	0.583
MOD_PKA_2	128	134	PF00069	0.751
MOD_PKA_2	15	21	PF00069	0.713
MOD_PKA_2	208	214	PF00069	0.588
MOD_PKA_2	301	307	PF00069	0.815
MOD_PKA_2	600	606	PF00069	0.730
MOD_PKA_2	692	698	PF00069	0.648
MOD_Plk_4	321	327	PF00069	0.646
MOD_Plk_4	344	350	PF00069	0.580
MOD_Plk_4	41	47	PF00069	0.638
MOD_Plk_4	424	430	PF00069	0.453
MOD_ProDKin_1	139	145	PF00069	0.704
MOD_ProDKin_1	163	169	PF00069	0.689
MOD_ProDKin_1	17	23	PF00069	0.829
MOD_ProDKin_1	183	189	PF00069	0.718
MOD_ProDKin_1	198	204	PF00069	0.615
MOD_ProDKin_1	222	228	PF00069	0.599
MOD_ProDKin_1	25	31	PF00069	0.630
MOD_ProDKin_1	250	256	PF00069	0.614
MOD_ProDKin_1	257	263	PF00069	0.612
MOD_ProDKin_1	270	276	PF00069	0.696
MOD_ProDKin_1	288	294	PF00069	0.586
MOD_ProDKin_1	296	302	PF00069	0.644
MOD_ProDKin_1	326	332	PF00069	0.687
MOD_ProDKin_1	342	348	PF00069	0.594
MOD_ProDKin_1	354	360	PF00069	0.618
MOD_ProDKin_1	45	51	PF00069	0.721
MOD_ProDKin_1	53	59	PF00069	0.597
MOD_ProDKin_1	675	681	PF00069	0.604
MOD_ProDKin_1	69	75	PF00069	0.649
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.547
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.612
TRG_ENDOCYTIC_2	314	317	PF00928	0.719
TRG_ENDOCYTIC_2	66	69	PF00928	0.619
TRG_ENDOCYTIC_2	711	714	PF00928	0.704
TRG_ER_diArg_1	509	512	PF00400	0.635
TRG_ER_diArg_1	538	541	PF00400	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J0	Leptomonas seymouri	39%	99%
A0A3S5H6U8	Leishmania donovani	87%	100%
A4HWG3	Leishmania infantum	87%	100%
E9AI50	Leishmania braziliensis	76%	97%
Q4QFC0	Leishmania major	85%	95%