YTH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AQ61_LEIMU

TriTrypDb:

LmxM.15.0630

Length:

921

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.635
CLV_NRD_NRD_1	127	129	PF00675	0.773
CLV_NRD_NRD_1	167	169	PF00675	0.776
CLV_NRD_NRD_1	280	282	PF00675	0.735
CLV_NRD_NRD_1	665	667	PF00675	0.716
CLV_NRD_NRD_1	783	785	PF00675	0.579
CLV_NRD_NRD_1	836	838	PF00675	0.854
CLV_PCSK_FUR_1	833	837	PF00082	0.780
CLV_PCSK_KEX2_1	127	129	PF00082	0.773
CLV_PCSK_KEX2_1	166	168	PF00082	0.771
CLV_PCSK_KEX2_1	279	281	PF00082	0.728
CLV_PCSK_KEX2_1	665	667	PF00082	0.716
CLV_PCSK_KEX2_1	783	785	PF00082	0.579
CLV_PCSK_KEX2_1	835	837	PF00082	0.862
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.576
CLV_PCSK_SKI1_1	224	228	PF00082	0.806
CLV_PCSK_SKI1_1	269	273	PF00082	0.754
CLV_PCSK_SKI1_1	340	344	PF00082	0.768
CLV_PCSK_SKI1_1	903	907	PF00082	0.808
DEG_SCF_FBW7_1	430	437	PF00400	0.574
DEG_SPOP_SBC_1	11	15	PF00917	0.741
DEG_SPOP_SBC_1	260	264	PF00917	0.836
DEG_SPOP_SBC_1	435	439	PF00917	0.776
DEG_SPOP_SBC_1	472	476	PF00917	0.538
DOC_CKS1_1	21	26	PF01111	0.560
DOC_CKS1_1	581	586	PF01111	0.729
DOC_CKS1_1	624	629	PF01111	0.696
DOC_PP2B_LxvP_1	667	670	PF13499	0.471
DOC_PP4_FxxP_1	129	132	PF00568	0.633
DOC_SPAK_OSR1_1	104	108	PF12202	0.637
DOC_USP7_MATH_1	113	117	PF00917	0.687
DOC_USP7_MATH_1	135	139	PF00917	0.646
DOC_USP7_MATH_1	233	237	PF00917	0.754
DOC_USP7_MATH_1	252	256	PF00917	0.835
DOC_USP7_MATH_1	258	262	PF00917	0.723
DOC_USP7_MATH_1	286	290	PF00917	0.791
DOC_USP7_MATH_1	365	369	PF00917	0.528
DOC_USP7_MATH_1	392	396	PF00917	0.615
DOC_USP7_MATH_1	435	439	PF00917	0.869
DOC_USP7_MATH_1	472	476	PF00917	0.538
DOC_USP7_MATH_1	51	55	PF00917	0.714
DOC_USP7_MATH_1	558	562	PF00917	0.757
DOC_USP7_MATH_1	9	13	PF00917	0.848
DOC_USP7_MATH_1	912	916	PF00917	0.764
DOC_WW_Pin1_4	14	19	PF00397	0.845
DOC_WW_Pin1_4	20	25	PF00397	0.737
DOC_WW_Pin1_4	430	435	PF00397	0.775
DOC_WW_Pin1_4	548	553	PF00397	0.655
DOC_WW_Pin1_4	561	566	PF00397	0.730
DOC_WW_Pin1_4	580	585	PF00397	0.696
DOC_WW_Pin1_4	620	625	PF00397	0.724
DOC_WW_Pin1_4	67	72	PF00397	0.833
DOC_WW_Pin1_4	704	709	PF00397	0.541
DOC_WW_Pin1_4	762	767	PF00397	0.651
DOC_WW_Pin1_4	797	802	PF00397	0.591
DOC_WW_Pin1_4	880	885	PF00397	0.834
DOC_WW_Pin1_4	98	103	PF00397	0.742
LIG_14-3-3_CanoR_1	167	176	PF00244	0.845
LIG_14-3-3_CanoR_1	178	188	PF00244	0.650
LIG_14-3-3_CanoR_1	269	276	PF00244	0.742
LIG_14-3-3_CanoR_1	279	285	PF00244	0.583
LIG_14-3-3_CanoR_1	288	297	PF00244	0.509
LIG_14-3-3_CanoR_1	794	803	PF00244	0.594
LIG_14-3-3_CanoR_1	80	90	PF00244	0.581
LIG_14-3-3_CanoR_1	877	884	PF00244	0.847
LIG_AP2alpha_2	893	895	PF02296	0.789
LIG_BIR_III_2	159	163	PF00653	0.775
LIG_BRCT_BRCA1_1	222	226	PF00533	0.806
LIG_BRCT_BRCA1_1	474	478	PF00533	0.537
LIG_BRCT_BRCA1_1	616	620	PF00533	0.653
LIG_CSL_BTD_1	555	558	PF09270	0.842
LIG_CtBP_PxDLS_1	120	124	PF00389	0.548
LIG_DLG_GKlike_1	614	621	PF00625	0.651
LIG_Dynein_DLC8_1	78	84	PF01221	0.579
LIG_eIF4E_1	222	228	PF01652	0.804
LIG_FHA_1	34	40	PF00498	0.835
LIG_FHA_1	431	437	PF00498	0.781
LIG_FHA_1	464	470	PF00498	0.765
LIG_FHA_1	71	77	PF00498	0.864
LIG_FHA_1	720	726	PF00498	0.692
LIG_FHA_1	771	777	PF00498	0.668
LIG_FHA_1	812	818	PF00498	0.769
LIG_FHA_1	904	910	PF00498	0.815
LIG_FHA_2	180	186	PF00498	0.705
LIG_FHA_2	270	276	PF00498	0.736
LIG_FHA_2	341	347	PF00498	0.746
LIG_FHA_2	785	791	PF00498	0.575
LIG_FHA_2	823	829	PF00498	0.767
LIG_FHA_2	881	887	PF00498	0.827
LIG_GBD_Chelix_1	659	667	PF00786	0.607
LIG_LIR_Gen_1	26	35	PF02991	0.763
LIG_LIR_Gen_1	551	558	PF02991	0.842
LIG_LIR_LC3C_4	743	746	PF02991	0.606
LIG_LIR_Nem_3	26	32	PF02991	0.800
LIG_LIR_Nem_3	486	490	PF02991	0.731
LIG_LIR_Nem_3	551	557	PF02991	0.844
LIG_LIR_Nem_3	59	63	PF02991	0.827
LIG_LIR_Nem_3	892	898	PF02991	0.785
LIG_PCNA_yPIPBox_3	566	580	PF02747	0.546
LIG_SH2_CRK	60	64	PF00017	0.630
LIG_SH2_GRB2like	601	604	PF00017	0.740
LIG_SH2_NCK_1	668	672	PF00017	0.787
LIG_SH2_SRC	668	671	PF00017	0.489
LIG_SH2_STAP1	601	605	PF00017	0.739
LIG_SH2_STAT3	136	139	PF00017	0.770
LIG_SH2_STAT5	29	32	PF00017	0.766
LIG_SH2_STAT5	425	428	PF00017	0.771
LIG_SH2_STAT5	889	892	PF00017	0.658
LIG_SH3_1	733	739	PF00018	0.733
LIG_SH3_1	753	759	PF00018	0.775
LIG_SH3_3	114	120	PF00018	0.545
LIG_SH3_3	15	21	PF00018	0.580
LIG_SH3_3	368	374	PF00018	0.555
LIG_SH3_3	424	430	PF00018	0.772
LIG_SH3_3	466	472	PF00018	0.559
LIG_SH3_3	578	584	PF00018	0.754
LIG_SH3_3	621	627	PF00018	0.775
LIG_SH3_3	65	71	PF00018	0.842
LIG_SH3_3	693	699	PF00018	0.664
LIG_SH3_3	73	79	PF00018	0.737
LIG_SH3_3	733	739	PF00018	0.733
LIG_SH3_3	753	759	PF00018	0.857
LIG_SH3_3	800	806	PF00018	0.770
LIG_TRAF2_1	343	346	PF00917	0.736
LIG_TRAF2_1	883	886	PF00917	0.821
LIG_WRC_WIRS_1	576	581	PF05994	0.834
MOD_CDC14_SPxK_1	101	104	PF00782	0.763
MOD_CDK_SPK_2	561	566	PF00069	0.764
MOD_CDK_SPxK_1	98	104	PF00069	0.771
MOD_CK1_1	108	114	PF00069	0.657
MOD_CK1_1	12	18	PF00069	0.848
MOD_CK1_1	179	185	PF00069	0.712
MOD_CK1_1	20	26	PF00069	0.733
MOD_CK1_1	236	242	PF00069	0.727
MOD_CK1_1	250	256	PF00069	0.857
MOD_CK1_1	261	267	PF00069	0.646
MOD_CK1_1	295	301	PF00069	0.562
MOD_CK1_1	326	332	PF00069	0.693
MOD_CK1_1	41	47	PF00069	0.674
MOD_CK1_1	438	444	PF00069	0.872
MOD_CK1_1	56	62	PF00069	0.633
MOD_CK1_1	561	567	PF00069	0.764
MOD_CK1_1	591	597	PF00069	0.747
MOD_CK1_1	612	618	PF00069	0.763
MOD_CK1_1	623	629	PF00069	0.727
MOD_CK1_1	70	76	PF00069	0.687
MOD_CK1_1	714	720	PF00069	0.564
MOD_CK1_1	797	803	PF00069	0.859
MOD_CK1_1	857	863	PF00069	0.565
MOD_CK1_1	915	921	PF00069	0.773
MOD_CK1_1	96	102	PF00069	0.720
MOD_CK2_1	269	275	PF00069	0.747
MOD_CK2_1	340	346	PF00069	0.757
MOD_CK2_1	784	790	PF00069	0.574
MOD_CK2_1	822	828	PF00069	0.764
MOD_CK2_1	880	886	PF00069	0.833
MOD_Cter_Amidation	833	836	PF01082	0.780
MOD_GlcNHglycan	235	239	PF01048	0.705
MOD_GlcNHglycan	297	300	PF01048	0.708
MOD_GlcNHglycan	328	331	PF01048	0.734
MOD_GlcNHglycan	367	370	PF01048	0.539
MOD_GlcNHglycan	399	402	PF01048	0.849
MOD_GlcNHglycan	404	407	PF01048	0.762
MOD_GlcNHglycan	409	412	PF01048	0.666
MOD_GlcNHglycan	416	419	PF01048	0.551
MOD_GlcNHglycan	443	446	PF01048	0.636
MOD_GlcNHglycan	45	48	PF01048	0.796
MOD_GlcNHglycan	461	464	PF01048	0.678
MOD_GlcNHglycan	534	537	PF01048	0.798
MOD_GlcNHglycan	55	58	PF01048	0.554
MOD_GlcNHglycan	590	593	PF01048	0.799
MOD_GlcNHglycan	614	617	PF01048	0.786
MOD_GlcNHglycan	729	732	PF01048	0.624
MOD_GlcNHglycan	797	800	PF01048	0.657
MOD_GlcNHglycan	828	832	PF01048	0.762
MOD_GlcNHglycan	856	859	PF01048	0.794
MOD_GSK3_1	108	115	PF00069	0.706
MOD_GSK3_1	19	26	PF00069	0.720
MOD_GSK3_1	216	223	PF00069	0.808
MOD_GSK3_1	260	267	PF00069	0.665
MOD_GSK3_1	280	287	PF00069	0.513
MOD_GSK3_1	288	295	PF00069	0.682
MOD_GSK3_1	308	315	PF00069	0.518
MOD_GSK3_1	33	40	PF00069	0.592
MOD_GSK3_1	387	394	PF00069	0.581
MOD_GSK3_1	41	48	PF00069	0.700
MOD_GSK3_1	414	421	PF00069	0.784
MOD_GSK3_1	430	437	PF00069	0.599
MOD_GSK3_1	441	448	PF00069	0.611
MOD_GSK3_1	459	466	PF00069	0.671
MOD_GSK3_1	479	486	PF00069	0.573
MOD_GSK3_1	548	555	PF00069	0.768
MOD_GSK3_1	557	564	PF00069	0.695
MOD_GSK3_1	591	598	PF00069	0.745
MOD_GSK3_1	612	619	PF00069	0.723
MOD_GSK3_1	63	70	PF00069	0.678
MOD_GSK3_1	679	686	PF00069	0.659
MOD_GSK3_1	694	701	PF00069	0.827
MOD_GSK3_1	793	800	PF00069	0.774
MOD_GSK3_1	853	860	PF00069	0.589
MOD_GSK3_1	876	883	PF00069	0.806
MOD_GSK3_1	889	896	PF00069	0.541
MOD_GSK3_1	9	16	PF00069	0.828
MOD_GSK3_1	908	915	PF00069	0.598
MOD_GSK3_1	92	99	PF00069	0.733
MOD_LATS_1	792	798	PF00433	0.661
MOD_N-GLC_1	108	113	PF02516	0.720
MOD_N-GLC_1	307	312	PF02516	0.609
MOD_N-GLC_1	323	328	PF02516	0.784
MOD_N-GLC_1	392	397	PF02516	0.758
MOD_N-GLC_1	42	47	PF02516	0.831
MOD_N-GLC_1	446	451	PF02516	0.676
MOD_N-GLC_1	532	537	PF02516	0.744
MOD_N-GLC_1	558	563	PF02516	0.723
MOD_N-GLC_1	679	684	PF02516	0.567
MOD_N-GLC_1	822	827	PF02516	0.682
MOD_N-GLC_1	851	856	PF02516	0.628
MOD_N-GLC_2	876	878	PF02516	0.869
MOD_NEK2_1	105	110	PF00069	0.789
MOD_NEK2_1	112	117	PF00069	0.779
MOD_NEK2_1	227	232	PF00069	0.805
MOD_NEK2_1	259	264	PF00069	0.754
MOD_NEK2_1	387	392	PF00069	0.654
MOD_NEK2_1	458	463	PF00069	0.712
MOD_NEK2_1	479	484	PF00069	0.822
MOD_NEK2_1	532	537	PF00069	0.756
MOD_NEK2_1	606	611	PF00069	0.797
MOD_NEK2_1	63	68	PF00069	0.550
MOD_PIKK_1	135	141	PF00454	0.645
MOD_PIKK_1	23	29	PF00454	0.759
MOD_PIKK_1	247	253	PF00454	0.860
MOD_PIKK_1	288	294	PF00454	0.811
MOD_PIKK_1	418	424	PF00454	0.755
MOD_PIKK_1	631	637	PF00454	0.738
MOD_PIKK_1	79	85	PF00454	0.815
MOD_PK_1	318	324	PF00069	0.536
MOD_PKA_1	166	172	PF00069	0.756
MOD_PKA_1	280	286	PF00069	0.755
MOD_PKA_2	166	172	PF00069	0.804
MOD_PKA_2	280	286	PF00069	0.755
MOD_PKA_2	458	464	PF00069	0.714
MOD_PKA_2	493	499	PF00069	0.831
MOD_PKA_2	79	85	PF00069	0.578
MOD_PKA_2	793	799	PF00069	0.577
MOD_PKA_2	876	882	PF00069	0.701
MOD_PKA_2	92	98	PF00069	0.564
MOD_PKB_1	835	843	PF00069	0.775
MOD_PKB_1	91	99	PF00069	0.583
MOD_Plk_1	108	114	PF00069	0.721
MOD_Plk_1	245	251	PF00069	0.862
MOD_Plk_1	34	40	PF00069	0.835
MOD_Plk_1	532	538	PF00069	0.620
MOD_Plk_2-3	775	781	PF00069	0.657
MOD_Plk_4	217	223	PF00069	0.808
MOD_Plk_4	292	298	PF00069	0.705
MOD_Plk_4	312	318	PF00069	0.509
MOD_Plk_4	34	40	PF00069	0.835
MOD_Plk_4	479	485	PF00069	0.532
MOD_Plk_4	616	622	PF00069	0.736
MOD_Plk_4	721	727	PF00069	0.620
MOD_Plk_4	799	805	PF00069	0.775
MOD_ProDKin_1	14	20	PF00069	0.843
MOD_ProDKin_1	430	436	PF00069	0.778
MOD_ProDKin_1	548	554	PF00069	0.657
MOD_ProDKin_1	561	567	PF00069	0.729
MOD_ProDKin_1	580	586	PF00069	0.699
MOD_ProDKin_1	620	626	PF00069	0.719
MOD_ProDKin_1	67	73	PF00069	0.837
MOD_ProDKin_1	704	710	PF00069	0.541
MOD_ProDKin_1	762	768	PF00069	0.651
MOD_ProDKin_1	797	803	PF00069	0.592
MOD_ProDKin_1	880	886	PF00069	0.833
MOD_ProDKin_1	98	104	PF00069	0.742
MOD_SUMO_rev_2	881	890	PF00179	0.825
TRG_DiLeu_BaEn_1	346	351	PF01217	0.646
TRG_DiLeu_BaEn_1	655	660	PF01217	0.514
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.789
TRG_ENDOCYTIC_2	29	32	PF00928	0.848
TRG_ENDOCYTIC_2	60	63	PF00928	0.837
TRG_ER_diArg_1	127	129	PF00400	0.567
TRG_ER_diArg_1	279	281	PF00400	0.728
TRG_ER_diArg_1	665	667	PF00400	0.716
TRG_ER_diArg_1	732	735	PF00400	0.742
TRG_ER_diArg_1	833	836	PF00400	0.855
TRG_ER_diArg_1	90	93	PF00400	0.588
TRG_NLS_MonoExtC_3	165	171	PF00514	0.562
TRG_NLS_MonoExtN_4	164	170	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	269	274	PF00026	0.754
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.764

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIP4	Leishmania donovani	79%	96%
A4H836	Leishmania braziliensis	59%	97%
A4HWG1	Leishmania infantum	79%	96%
Q4QFC2	Leishmania major	78%	100%