DRBM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ60_LEIMU

TriTrypDb:

LmxM.15.0620

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	348	350	PF00675	0.529
CLV_NRD_NRD_1	395	397	PF00675	0.550
CLV_NRD_NRD_1	428	430	PF00675	0.473
CLV_PCSK_KEX2_1	260	262	PF00082	0.442
CLV_PCSK_KEX2_1	330	332	PF00082	0.637
CLV_PCSK_KEX2_1	348	350	PF00082	0.544
CLV_PCSK_KEX2_1	395	397	PF00082	0.650
CLV_PCSK_KEX2_1	428	430	PF00082	0.505
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.554
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.637
CLV_PCSK_SKI1_1	117	121	PF00082	0.405
CLV_PCSK_SKI1_1	159	163	PF00082	0.431
CLV_PCSK_SKI1_1	221	225	PF00082	0.425
CLV_PCSK_SKI1_1	239	243	PF00082	0.438
CLV_PCSK_SKI1_1	444	448	PF00082	0.513
DEG_APCC_DBOX_1	116	124	PF00400	0.477
DEG_APCC_DBOX_1	398	406	PF00400	0.430
DEG_SCF_FBW7_1	87	94	PF00400	0.506
DOC_ANK_TNKS_1	162	169	PF00023	0.580
DOC_CKS1_1	152	157	PF01111	0.370
DOC_CKS1_1	24	29	PF01111	0.473
DOC_CKS1_1	351	356	PF01111	0.466
DOC_CYCLIN_RxL_1	236	245	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.680
DOC_MAPK_gen_1	219	228	PF00069	0.422
DOC_MAPK_gen_1	329	337	PF00069	0.630
DOC_PP4_FxxP_1	150	153	PF00568	0.338
DOC_PP4_FxxP_1	24	27	PF00568	0.464
DOC_PP4_FxxP_1	419	422	PF00568	0.491
DOC_USP7_MATH_1	102	106	PF00917	0.606
DOC_USP7_MATH_1	41	45	PF00917	0.689
DOC_USP7_MATH_1	442	446	PF00917	0.546
DOC_USP7_MATH_1	91	95	PF00917	0.795
DOC_WW_Pin1_4	1	6	PF00397	0.530
DOC_WW_Pin1_4	151	156	PF00397	0.368
DOC_WW_Pin1_4	23	28	PF00397	0.680
DOC_WW_Pin1_4	267	272	PF00397	0.547
DOC_WW_Pin1_4	350	355	PF00397	0.472
DOC_WW_Pin1_4	82	87	PF00397	0.694
LIG_14-3-3_CanoR_1	221	226	PF00244	0.428
LIG_14-3-3_CanoR_1	232	236	PF00244	0.388
LIG_14-3-3_CterR_2	444	448	PF00244	0.525
LIG_Actin_WH2_2	219	234	PF00022	0.366
LIG_APCC_ABBA_1	210	215	PF00400	0.548
LIG_BIR_II_1	1	5	PF00653	0.769
LIG_BRCT_BRCA1_1	244	248	PF00533	0.513
LIG_BRCT_BRCA1_1	357	361	PF00533	0.445
LIG_FHA_1	402	408	PF00498	0.442
LIG_FHA_2	24	30	PF00498	0.616
LIG_FHA_2	280	286	PF00498	0.612
LIG_FHA_2	98	104	PF00498	0.674
LIG_LIR_Apic_2	148	153	PF02991	0.360
LIG_LIR_Apic_2	23	27	PF02991	0.464
LIG_LIR_Gen_1	198	205	PF02991	0.612
LIG_LIR_Gen_1	224	233	PF02991	0.389
LIG_LIR_Gen_1	234	242	PF02991	0.384
LIG_LIR_Gen_1	51	61	PF02991	0.460
LIG_LIR_Nem_3	141	147	PF02991	0.501
LIG_LIR_Nem_3	167	173	PF02991	0.598
LIG_LIR_Nem_3	197	203	PF02991	0.628
LIG_LIR_Nem_3	224	228	PF02991	0.428
LIG_LIR_Nem_3	234	238	PF02991	0.377
LIG_LIR_Nem_3	51	56	PF02991	0.453
LIG_Pex14_2	126	130	PF04695	0.357
LIG_Pex14_2	146	150	PF04695	0.489
LIG_SH2_CRK	170	174	PF00017	0.631
LIG_SH2_CRK	352	356	PF00017	0.550
LIG_SH2_NCK_1	352	356	PF00017	0.550
LIG_SH2_NCK_1	63	67	PF00017	0.471
LIG_SH2_STAT5	145	148	PF00017	0.438
LIG_SH2_STAT5	200	203	PF00017	0.483
LIG_SH2_STAT5	225	228	PF00017	0.382
LIG_SH2_STAT5	352	355	PF00017	0.565
LIG_SH2_STAT5	401	404	PF00017	0.411
LIG_SH3_1	348	354	PF00018	0.552
LIG_SH3_3	152	158	PF00018	0.380
LIG_SH3_3	348	354	PF00018	0.457
LIG_SH3_3	366	372	PF00018	0.401
LIG_SH3_3	402	408	PF00018	0.382
LIG_SH3_3	6	12	PF00018	0.713
LIG_SUMO_SIM_par_1	439	445	PF11976	0.470
LIG_TRAF2_1	13	16	PF00917	0.702
LIG_TRAF2_1	27	30	PF00917	0.493
LIG_TRAF2_1	362	365	PF00917	0.440
LIG_TRFH_1	201	205	PF08558	0.610
LIG_UBA3_1	360	366	PF00899	0.467
LIG_UBA3_1	440	447	PF00899	0.551
LIG_WRC_WIRS_1	147	152	PF05994	0.359
MOD_CDK_SPK_2	151	156	PF00069	0.365
MOD_CDK_SPxxK_3	350	357	PF00069	0.462
MOD_CK1_1	31	37	PF00069	0.720
MOD_CK1_1	51	57	PF00069	0.441
MOD_CK1_1	85	91	PF00069	0.616
MOD_CK1_1	94	100	PF00069	0.496
MOD_CK2_1	161	167	PF00069	0.554
MOD_CK2_1	23	29	PF00069	0.471
MOD_CK2_1	279	285	PF00069	0.676
MOD_CK2_1	359	365	PF00069	0.406
MOD_GlcNHglycan	276	279	PF01048	0.664
MOD_GlcNHglycan	285	289	PF01048	0.731
MOD_GlcNHglycan	294	297	PF01048	0.643
MOD_GlcNHglycan	313	316	PF01048	0.710
MOD_GlcNHglycan	33	36	PF01048	0.498
MOD_GlcNHglycan	432	435	PF01048	0.496
MOD_GlcNHglycan	44	47	PF01048	0.583
MOD_GlcNHglycan	53	56	PF01048	0.367
MOD_GlcNHglycan	87	90	PF01048	0.748
MOD_GSK3_1	174	181	PF00069	0.664
MOD_GSK3_1	186	193	PF00069	0.685
MOD_GSK3_1	195	202	PF00069	0.672
MOD_GSK3_1	279	286	PF00069	0.594
MOD_GSK3_1	355	362	PF00069	0.410
MOD_GSK3_1	70	77	PF00069	0.650
MOD_GSK3_1	81	88	PF00069	0.621
MOD_GSK3_1	93	100	PF00069	0.655
MOD_N-GLC_1	195	200	PF02516	0.640
MOD_N-GLC_1	291	296	PF02516	0.701
MOD_N-GLC_1	385	390	PF02516	0.464
MOD_NEK2_1	146	151	PF00069	0.406
MOD_NEK2_1	231	236	PF00069	0.474
MOD_NEK2_1	242	247	PF00069	0.544
MOD_NEK2_1	274	279	PF00069	0.567
MOD_NEK2_2	442	447	PF00069	0.557
MOD_PKA_2	231	237	PF00069	0.421
MOD_Plk_1	102	108	PF00069	0.548
MOD_Plk_1	195	201	PF00069	0.614
MOD_Plk_1	436	442	PF00069	0.521
MOD_Plk_4	436	442	PF00069	0.521
MOD_ProDKin_1	1	7	PF00069	0.528
MOD_ProDKin_1	151	157	PF00069	0.370
MOD_ProDKin_1	23	29	PF00069	0.684
MOD_ProDKin_1	267	273	PF00069	0.545
MOD_ProDKin_1	350	356	PF00069	0.475
MOD_ProDKin_1	82	88	PF00069	0.692
MOD_SUMO_rev_2	103	111	PF00179	0.371
MOD_SUMO_rev_2	240	248	PF00179	0.406
MOD_SUMO_rev_2	358	367	PF00179	0.459
MOD_SUMO_rev_2	77	85	PF00179	0.571
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.477
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.417
TRG_ENDOCYTIC_2	144	147	PF00928	0.471
TRG_ENDOCYTIC_2	170	173	PF00928	0.632
TRG_ENDOCYTIC_2	200	203	PF00928	0.595
TRG_ENDOCYTIC_2	225	228	PF00928	0.375
TRG_ENDOCYTIC_2	352	355	PF00928	0.546
TRG_ER_diArg_1	348	350	PF00400	0.544
TRG_NES_CRM1_1	218	229	PF08389	0.406
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I615	Leptomonas seymouri	71%	100%
A0A1X0NTS1	Trypanosomatidae	36%	100%
A0A3S5H6U7	Leishmania donovani	88%	100%
A0A422NLQ5	Trypanosoma rangeli	40%	100%
A4H835	Leishmania braziliensis	77%	100%
A4HWG0	Leishmania infantum	88%	100%
C9ZP02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QFC3	Leishmania major	90%	100%