CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQ59_LEIMU

TriTrypDb:

LmxM.15.0610

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.439
CLV_NRD_NRD_1	113	115	PF00675	0.464
CLV_NRD_NRD_1	254	256	PF00675	0.424
CLV_NRD_NRD_1	511	513	PF00675	0.637
CLV_PCSK_KEX2_1	113	115	PF00082	0.520
CLV_PCSK_KEX2_1	195	197	PF00082	0.496
CLV_PCSK_KEX2_1	215	217	PF00082	0.166
CLV_PCSK_KEX2_1	254	256	PF00082	0.424
CLV_PCSK_KEX2_1	511	513	PF00082	0.486
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.496
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.166
CLV_PCSK_SKI1_1	179	183	PF00082	0.604
CLV_PCSK_SKI1_1	313	317	PF00082	0.387
CLV_PCSK_SKI1_1	36	40	PF00082	0.494
CLV_PCSK_SKI1_1	364	368	PF00082	0.395
CLV_PCSK_SKI1_1	415	419	PF00082	0.587
CLV_PCSK_SKI1_1	89	93	PF00082	0.442
DEG_APCC_DBOX_1	243	251	PF00400	0.392
DEG_SCF_FBW7_1	234	239	PF00400	0.424
DOC_CYCLIN_RxL_1	314	328	PF00134	0.496
DOC_MAPK_gen_1	113	119	PF00069	0.514
DOC_MAPK_gen_1	195	201	PF00069	0.496
DOC_MAPK_gen_1	313	324	PF00069	0.496
DOC_MAPK_gen_1	86	94	PF00069	0.489
DOC_PP2B_LxvP_1	92	95	PF13499	0.564
DOC_SPAK_OSR1_1	108	112	PF12202	0.466
DOC_USP7_MATH_1	487	491	PF00917	0.483
DOC_USP7_MATH_1	500	504	PF00917	0.544
DOC_USP7_MATH_1	64	68	PF00917	0.548
DOC_USP7_UBL2_3	313	317	PF12436	0.387
DOC_WW_Pin1_4	167	172	PF00397	0.716
DOC_WW_Pin1_4	232	237	PF00397	0.382
DOC_WW_Pin1_4	384	389	PF00397	0.659
DOC_WW_Pin1_4	441	446	PF00397	0.616
LIG_14-3-3_CanoR_1	320	325	PF00244	0.496
LIG_14-3-3_CterR_2	512	517	PF00244	0.470
LIG_Actin_RPEL_3	106	125	PF02755	0.477
LIG_BIR_II_1	1	5	PF00653	0.499
LIG_BRCT_BRCA1_1	443	447	PF00533	0.632
LIG_CtBP_PxDLS_1	331	335	PF00389	0.393
LIG_CtBP_PxDLS_1	77	81	PF00389	0.598
LIG_deltaCOP1_diTrp_1	496	501	PF00928	0.627
LIG_FHA_1	119	125	PF00498	0.544
LIG_FHA_1	176	182	PF00498	0.658
LIG_FHA_1	292	298	PF00498	0.371
LIG_FHA_1	35	41	PF00498	0.312
LIG_FHA_2	283	289	PF00498	0.422
LIG_FHA_2	73	79	PF00498	0.536
LIG_LIR_Gen_1	230	238	PF02991	0.441
LIG_LIR_Gen_1	37	45	PF02991	0.324
LIG_LIR_Gen_1	496	504	PF02991	0.610
LIG_LIR_Nem_3	104	110	PF02991	0.398
LIG_LIR_Nem_3	146	152	PF02991	0.622
LIG_LIR_Nem_3	214	220	PF02991	0.418
LIG_LIR_Nem_3	230	234	PF02991	0.424
LIG_LIR_Nem_3	235	241	PF02991	0.422
LIG_LIR_Nem_3	348	353	PF02991	0.207
LIG_LIR_Nem_3	37	42	PF02991	0.302
LIG_LIR_Nem_3	444	450	PF02991	0.426
LIG_LIR_Nem_3	496	501	PF02991	0.627
LIG_MYND_1	355	359	PF01753	0.424
LIG_MYND_1	475	479	PF01753	0.581
LIG_Pex14_2	346	350	PF04695	0.424
LIG_Pex14_2	430	434	PF04695	0.517
LIG_PTB_Apo_2	225	232	PF02174	0.404
LIG_PTB_Apo_2	338	345	PF02174	0.424
LIG_PTB_Apo_2	456	463	PF02174	0.656
LIG_PTB_Phospho_1	456	462	PF10480	0.627
LIG_REV1ctd_RIR_1	347	354	PF16727	0.310
LIG_SH2_CRK	107	111	PF00017	0.402
LIG_SH2_CRK	202	206	PF00017	0.424
LIG_SH2_CRK	238	242	PF00017	0.496
LIG_SH2_GRB2like	238	241	PF00017	0.424
LIG_SH2_SRC	219	222	PF00017	0.496
LIG_SH2_STAP1	11	15	PF00017	0.574
LIG_SH2_STAP1	238	242	PF00017	0.424
LIG_SH2_STAT3	262	265	PF00017	0.404
LIG_SH2_STAT5	127	130	PF00017	0.456
LIG_SH2_STAT5	219	222	PF00017	0.424
LIG_SH2_STAT5	246	249	PF00017	0.424
LIG_SH2_STAT5	266	269	PF00017	0.413
LIG_SH2_STAT5	425	428	PF00017	0.527
LIG_SH3_3	231	237	PF00018	0.496
LIG_SH3_3	439	445	PF00018	0.681
LIG_SH3_3	447	453	PF00018	0.624
LIG_SH3_3	71	77	PF00018	0.666
LIG_SH3_3	79	85	PF00018	0.570
LIG_SUMO_SIM_par_1	294	301	PF11976	0.371
LIG_SUMO_SIM_par_1	320	325	PF11976	0.413
LIG_SUMO_SIM_par_1	364	369	PF11976	0.424
LIG_TRAF2_1	494	497	PF00917	0.499
LIG_TYR_ITIM	105	110	PF00017	0.450
LIG_UBA3_1	124	133	PF00899	0.466
LIG_UBA3_1	23	28	PF00899	0.411
LIG_UBA3_1	91	99	PF00899	0.564
LIG_WRC_WIRS_1	346	351	PF05994	0.207
MOD_CDK_SPxxK_3	167	174	PF00069	0.639
MOD_CK1_1	135	141	PF00069	0.480
MOD_CK1_1	282	288	PF00069	0.439
MOD_CK1_1	305	311	PF00069	0.508
MOD_CK1_1	380	386	PF00069	0.722
MOD_CK1_1	389	395	PF00069	0.723
MOD_CK1_1	67	73	PF00069	0.662
MOD_CK2_1	491	497	PF00069	0.650
MOD_CK2_1	72	78	PF00069	0.541
MOD_CMANNOS	186	189	PF00535	0.496
MOD_Cter_Amidation	252	255	PF01082	0.424
MOD_GlcNHglycan	368	371	PF01048	0.414
MOD_GlcNHglycan	396	400	PF01048	0.552
MOD_GlcNHglycan	70	73	PF01048	0.672
MOD_GSK3_1	232	239	PF00069	0.424
MOD_GSK3_1	278	285	PF00069	0.479
MOD_GSK3_1	298	305	PF00069	0.311
MOD_GSK3_1	368	375	PF00069	0.430
MOD_GSK3_1	377	384	PF00069	0.652
MOD_GSK3_1	487	494	PF00069	0.539
MOD_GSK3_1	64	71	PF00069	0.674
MOD_N-GLC_1	16	21	PF02516	0.559
MOD_N-GLC_1	332	337	PF02516	0.393
MOD_N-GLC_1	34	39	PF02516	0.314
MOD_N-GLC_1	392	397	PF02516	0.742
MOD_N-GLC_1	78	83	PF02516	0.573
MOD_NEK2_1	307	312	PF00069	0.389
MOD_NEK2_1	322	327	PF00069	0.452
MOD_NEK2_1	368	373	PF00069	0.397
MOD_NEK2_2	34	39	PF00069	0.264
MOD_PIKK_1	358	364	PF00454	0.424
MOD_PIKK_1	386	392	PF00454	0.721
MOD_PIKK_1	491	497	PF00454	0.504
MOD_PKA_1	166	172	PF00069	0.427
MOD_PKA_1	254	260	PF00069	0.424
MOD_PKA_2	254	260	PF00069	0.424
MOD_Plk_1	332	338	PF00069	0.393
MOD_Plk_1	34	40	PF00069	0.318
MOD_Plk_1	381	387	PF00069	0.498
MOD_Plk_1	78	84	PF00069	0.566
MOD_Plk_2-3	132	138	PF00069	0.425
MOD_Plk_2-3	78	84	PF00069	0.658
MOD_Plk_4	135	141	PF00069	0.587
MOD_Plk_4	282	288	PF00069	0.444
MOD_Plk_4	325	331	PF00069	0.439
MOD_Plk_4	345	351	PF00069	0.166
MOD_Plk_4	430	436	PF00069	0.467
MOD_Plk_4	505	511	PF00069	0.432
MOD_ProDKin_1	167	173	PF00069	0.723
MOD_ProDKin_1	232	238	PF00069	0.382
MOD_ProDKin_1	384	390	PF00069	0.664
MOD_ProDKin_1	441	447	PF00069	0.622
MOD_SUMO_for_1	27	30	PF00179	0.399
MOD_SUMO_rev_2	394	404	PF00179	0.541
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.573
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.424
TRG_ENDOCYTIC_2	107	110	PF00928	0.397
TRG_ENDOCYTIC_2	127	130	PF00928	0.204
TRG_ENDOCYTIC_2	238	241	PF00928	0.371
TRG_ER_diArg_1	113	115	PF00400	0.520
TRG_ER_diArg_1	254	256	PF00400	0.424
TRG_ER_diArg_1	469	472	PF00400	0.602
TRG_ER_diArg_1	510	512	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ3	Leptomonas seymouri	67%	100%
A0A0S4JI39	Bodo saltans	25%	78%
A0A3Q8IC92	Leishmania donovani	90%	100%
A4H834	Leishmania braziliensis	78%	100%
Q4QFC4	Leishmania major	88%	100%