Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ56_LEIMU

TriTrypDb:

LmxM.15.0590

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.690
CLV_NRD_NRD_1	210	212	PF00675	0.635
CLV_NRD_NRD_1	216	218	PF00675	0.572
CLV_PCSK_KEX2_1	209	211	PF00082	0.675
CLV_PCSK_PC7_1	206	212	PF00082	0.653
CLV_PCSK_SKI1_1	152	156	PF00082	0.569
CLV_PCSK_SKI1_1	5	9	PF00082	0.620
DEG_SPOP_SBC_1	116	120	PF00917	0.646
DEG_SPOP_SBC_1	133	137	PF00917	0.508
DOC_USP7_MATH_1	116	120	PF00917	0.793
DOC_USP7_MATH_1	193	197	PF00917	0.675
DOC_WW_Pin1_4	118	123	PF00397	0.728
DOC_WW_Pin1_4	142	147	PF00397	0.621
DOC_WW_Pin1_4	200	205	PF00397	0.691
DOC_WW_Pin1_4	230	235	PF00397	0.591
LIG_14-3-3_CanoR_1	149	155	PF00244	0.581
LIG_14-3-3_CanoR_1	164	169	PF00244	0.547
LIG_14-3-3_CanoR_1	174	183	PF00244	0.625
LIG_14-3-3_CanoR_1	192	198	PF00244	0.757
LIG_FHA_2	124	130	PF00498	0.714
LIG_LIR_Apic_2	85	90	PF02991	0.716
LIG_LIR_Gen_1	95	105	PF02991	0.588
LIG_LIR_Nem_3	202	208	PF02991	0.572
LIG_LIR_Nem_3	95	100	PF02991	0.658
LIG_Pex14_1	55	59	PF04695	0.580
LIG_SH2_CRK	205	209	PF00017	0.577
LIG_SH2_CRK	97	101	PF00017	0.661
LIG_SH2_GRB2like	87	90	PF00017	0.685
LIG_SH2_PTP2	87	90	PF00017	0.711
LIG_SH2_SRC	87	90	PF00017	0.711
LIG_SH2_STAP1	97	101	PF00017	0.584
LIG_SH2_STAT3	59	62	PF00017	0.611
LIG_SH2_STAT5	158	161	PF00017	0.574
LIG_SH2_STAT5	232	235	PF00017	0.510
LIG_SH2_STAT5	87	90	PF00017	0.685
LIG_SH3_3	170	176	PF00018	0.688
MOD_CDC14_SPxK_1	203	206	PF00782	0.652
MOD_CDK_SPK_2	230	235	PF00069	0.591
MOD_CDK_SPxK_1	200	206	PF00069	0.651
MOD_CDK_SPxxK_3	142	149	PF00069	0.518
MOD_CK1_1	107	113	PF00069	0.654
MOD_CK1_1	118	124	PF00069	0.705
MOD_CK1_1	194	200	PF00069	0.699
MOD_CK1_1	34	40	PF00069	0.593
MOD_CK2_1	123	129	PF00069	0.753
MOD_CK2_1	193	199	PF00069	0.767
MOD_GlcNHglycan	193	196	PF01048	0.509
MOD_GSK3_1	132	139	PF00069	0.695
MOD_GSK3_1	187	194	PF00069	0.569
MOD_GSK3_1	30	37	PF00069	0.630
MOD_NEK2_1	198	203	PF00069	0.670
MOD_NEK2_1	31	36	PF00069	0.580
MOD_NEK2_1	96	101	PF00069	0.518
MOD_PIKK_1	152	158	PF00454	0.609
MOD_PIKK_1	31	37	PF00454	0.656
MOD_PKA_2	191	197	PF00069	0.743
MOD_PKB_1	162	170	PF00069	0.733
MOD_Plk_1	55	61	PF00069	0.461
MOD_Plk_4	96	102	PF00069	0.564
MOD_ProDKin_1	118	124	PF00069	0.732
MOD_ProDKin_1	142	148	PF00069	0.622
MOD_ProDKin_1	200	206	PF00069	0.693
TRG_ENDOCYTIC_2	205	208	PF00928	0.580
TRG_ENDOCYTIC_2	97	100	PF00928	0.659
TRG_ER_diArg_1	208	211	PF00400	0.671
TRG_NLS_MonoExtN_4	2	7	PF00514	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F5	Leptomonas seymouri	50%	100%
A0A3Q8IDE0	Leishmania donovani	90%	100%
A0A3R7KEI8	Trypanosoma rangeli	31%	100%
A4H831	Leishmania braziliensis	74%	100%
A4HWF7	Leishmania infantum	90%	100%
C9ZNZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QFC6	Leishmania major	89%	100%