GPI-anchored protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AQ54_LEIMU

TriTrypDb:

LmxM.15.0570

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.576
CLV_C14_Caspase3-7	273	277	PF00656	0.513
CLV_NRD_NRD_1	231	233	PF00675	0.585
CLV_NRD_NRD_1	74	76	PF00675	0.689
CLV_PCSK_KEX2_1	74	76	PF00082	0.596
CLV_PCSK_SKI1_1	295	299	PF00082	0.701
CLV_PCSK_SKI1_1	316	320	PF00082	0.424
DEG_SPOP_SBC_1	108	112	PF00917	0.515
DEG_SPOP_SBC_1	137	141	PF00917	0.524
DOC_CDC14_PxL_1	13	21	PF14671	0.603
DOC_CKS1_1	178	183	PF01111	0.395
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.581
DOC_MAPK_gen_1	232	240	PF00069	0.456
DOC_PP2B_LxvP_1	241	244	PF13499	0.480
DOC_PP2B_LxvP_1	9	12	PF13499	0.586
DOC_USP7_MATH_1	107	111	PF00917	0.512
DOC_USP7_MATH_1	220	224	PF00917	0.476
DOC_USP7_MATH_1	226	230	PF00917	0.468
DOC_USP7_MATH_1	271	275	PF00917	0.496
DOC_USP7_MATH_1	30	34	PF00917	0.534
DOC_WW_Pin1_4	115	120	PF00397	0.521
DOC_WW_Pin1_4	177	182	PF00397	0.569
DOC_WW_Pin1_4	306	311	PF00397	0.597
LIG_14-3-3_CanoR_1	316	321	PF00244	0.436
LIG_14-3-3_CanoR_1	44	52	PF00244	0.492
LIG_14-3-3_CanoR_1	61	67	PF00244	0.367
LIG_APCC_ABBA_1	196	201	PF00400	0.578
LIG_APCC_ABBAyCdc20_2	295	301	PF00400	0.359
LIG_BRCT_BRCA1_1	117	121	PF00533	0.550
LIG_CSL_BTD_1	119	122	PF09270	0.550
LIG_FHA_1	178	184	PF00498	0.486
LIG_FHA_1	20	26	PF00498	0.689
LIG_FHA_1	229	235	PF00498	0.541
LIG_FHA_1	61	67	PF00498	0.412
LIG_FHA_1	97	103	PF00498	0.499
LIG_FHA_2	137	143	PF00498	0.527
LIG_LIR_Gen_1	202	211	PF02991	0.360
LIG_LIR_Nem_3	202	208	PF02991	0.358
LIG_MYND_1	181	185	PF01753	0.544
LIG_PCNA_yPIPBox_3	188	199	PF02747	0.524
LIG_SH2_CRK	205	209	PF00017	0.514
LIG_SH2_NCK_1	106	110	PF00017	0.451
LIG_SH2_NCK_1	205	209	PF00017	0.517
LIG_SH2_SRC	52	55	PF00017	0.457
LIG_SH2_STAP1	199	203	PF00017	0.470
LIG_SH2_STAP1	52	56	PF00017	0.580
LIG_SH2_STAT5	199	202	PF00017	0.502
LIG_SH2_STAT5	203	206	PF00017	0.498
LIG_SH2_STAT5	291	294	PF00017	0.474
LIG_SH3_3	116	122	PF00018	0.550
LIG_SH3_3	141	147	PF00018	0.495
LIG_SH3_3	304	310	PF00018	0.545
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.609
LIG_SUMO_SIM_par_1	16	22	PF11976	0.598
LIG_TRAF2_1	153	156	PF00917	0.549
LIG_WRC_WIRS_1	92	97	PF05994	0.421
MOD_CK1_1	110	116	PF00069	0.427
MOD_CK1_1	158	164	PF00069	0.529
MOD_CK1_1	306	312	PF00069	0.535
MOD_CK1_1	47	53	PF00069	0.401
MOD_CK1_1	96	102	PF00069	0.560
MOD_CK2_1	136	142	PF00069	0.553
MOD_CK2_1	150	156	PF00069	0.507
MOD_CK2_1	221	227	PF00069	0.559
MOD_GlcNHglycan	160	163	PF01048	0.756
MOD_GlcNHglycan	224	227	PF01048	0.690
MOD_GlcNHglycan	256	259	PF01048	0.633
MOD_GlcNHglycan	282	285	PF01048	0.699
MOD_GlcNHglycan	32	35	PF01048	0.609
MOD_GlcNHglycan	48	52	PF01048	0.752
MOD_GlcNHglycan	5	8	PF01048	0.716
MOD_GSK3_1	107	114	PF00069	0.562
MOD_GSK3_1	151	158	PF00069	0.516
MOD_GSK3_1	222	229	PF00069	0.538
MOD_GSK3_1	276	283	PF00069	0.555
MOD_GSK3_1	287	294	PF00069	0.476
MOD_GSK3_1	299	306	PF00069	0.461
MOD_GSK3_1	40	47	PF00069	0.370
MOD_N-GLC_2	260	262	PF02516	0.605
MOD_N-GLC_2	69	71	PF02516	0.593
MOD_NEK2_1	19	24	PF00069	0.595
MOD_NEK2_1	204	209	PF00069	0.359
MOD_NEK2_1	221	226	PF00069	0.562
MOD_NEK2_1	287	292	PF00069	0.520
MOD_NEK2_1	3	8	PF00069	0.604
MOD_NEK2_1	70	75	PF00069	0.496
MOD_NEK2_1	90	95	PF00069	0.494
MOD_PIKK_1	121	127	PF00454	0.585
MOD_PKA_2	60	66	PF00069	0.416
MOD_Plk_1	47	53	PF00069	0.462
MOD_Plk_1	90	96	PF00069	0.463
MOD_Plk_4	199	205	PF00069	0.532
MOD_Plk_4	321	327	PF00069	0.406
MOD_ProDKin_1	115	121	PF00069	0.522
MOD_ProDKin_1	177	183	PF00069	0.569
MOD_ProDKin_1	306	312	PF00069	0.596
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.681
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.338
TRG_ENDOCYTIC_2	205	208	PF00928	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P748	Leptomonas seymouri	38%	100%
A0A3S7WTK4	Leishmania donovani	81%	100%
A4H829	Leishmania braziliensis	63%	100%
A4HWF5	Leishmania infantum	81%	100%
Q4QFC8	Leishmania major	80%	100%