Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ53_LEIMU

TriTrypDb:

LmxM.15.0560

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.660
CLV_NRD_NRD_1	139	141	PF00675	0.618
CLV_NRD_NRD_1	2	4	PF00675	0.601
CLV_NRD_NRD_1	243	245	PF00675	0.615
CLV_NRD_NRD_1	246	248	PF00675	0.534
CLV_NRD_NRD_1	342	344	PF00675	0.575
CLV_NRD_NRD_1	386	388	PF00675	0.509
CLV_PCSK_FUR_1	244	248	PF00082	0.642
CLV_PCSK_KEX2_1	139	141	PF00082	0.542
CLV_PCSK_KEX2_1	243	245	PF00082	0.610
CLV_PCSK_KEX2_1	246	248	PF00082	0.538
CLV_PCSK_KEX2_1	342	344	PF00082	0.662
CLV_PCSK_KEX2_1	504	506	PF00082	0.477
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.477
CLV_PCSK_SKI1_1	139	143	PF00082	0.569
CLV_PCSK_SKI1_1	217	221	PF00082	0.681
CLV_PCSK_SKI1_1	269	273	PF00082	0.367
CLV_PCSK_SKI1_1	297	301	PF00082	0.458
CLV_PCSK_SKI1_1	462	466	PF00082	0.434
CLV_PCSK_SKI1_1	48	52	PF00082	0.664
CLV_PCSK_SKI1_1	6	10	PF00082	0.534
DEG_APCC_DBOX_1	253	261	PF00400	0.477
DEG_APCC_KENBOX_2	496	500	PF00400	0.443
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DEG_SPOP_SBC_1	143	147	PF00917	0.656
DEG_SPOP_SBC_1	195	199	PF00917	0.686
DEG_SPOP_SBC_1	234	238	PF00917	0.679
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.582
DOC_MAPK_gen_1	169	178	PF00069	0.462
DOC_MAPK_gen_1	3	12	PF00069	0.490
DOC_MAPK_gen_1	32	42	PF00069	0.556
DOC_MAPK_MEF2A_6	3	12	PF00069	0.490
DOC_PP1_RVXF_1	519	525	PF00149	0.440
DOC_PP2B_LxvP_1	210	213	PF13499	0.583
DOC_PP2B_LxvP_1	411	414	PF13499	0.578
DOC_USP7_MATH_1	116	120	PF00917	0.444
DOC_USP7_MATH_1	143	147	PF00917	0.707
DOC_USP7_MATH_1	194	198	PF00917	0.697
DOC_USP7_MATH_1	352	356	PF00917	0.459
DOC_USP7_MATH_1	533	537	PF00917	0.682
DOC_USP7_MATH_1	87	91	PF00917	0.583
DOC_USP7_UBL2_3	179	183	PF12436	0.459
DOC_USP7_UBL2_3	51	55	PF12436	0.653
DOC_USP7_UBL2_3	99	103	PF12436	0.486
DOC_WW_Pin1_4	531	536	PF00397	0.515
LIG_14-3-3_CanoR_1	269	278	PF00244	0.416
LIG_14-3-3_CanoR_1	295	300	PF00244	0.455
LIG_14-3-3_CanoR_1	473	481	PF00244	0.489
LIG_EVH1_2	418	422	PF00568	0.458
LIG_FHA_1	129	135	PF00498	0.543
LIG_FHA_1	237	243	PF00498	0.669
LIG_FHA_1	270	276	PF00498	0.366
LIG_FHA_1	31	37	PF00498	0.523
LIG_FHA_1	7	13	PF00498	0.522
LIG_FHA_2	317	323	PF00498	0.578
LIG_LIR_Gen_1	425	433	PF02991	0.562
LIG_LIR_Nem_3	425	430	PF02991	0.560
LIG_PCNA_yPIPBox_3	112	121	PF02747	0.466
LIG_SH2_CRK	97	101	PF00017	0.453
LIG_SH2_STAT5	309	312	PF00017	0.445
LIG_SH3_2	415	420	PF14604	0.561
LIG_SH3_3	239	245	PF00018	0.676
LIG_SH3_3	404	410	PF00018	0.529
LIG_SH3_3	412	418	PF00018	0.616
LIG_SUMO_SIM_anti_2	173	180	PF11976	0.452
LIG_SUMO_SIM_par_1	173	180	PF11976	0.431
LIG_TRAF2_1	28	31	PF00917	0.537
LIG_TRAF2_1	334	337	PF00917	0.450
MOD_CK1_1	147	153	PF00069	0.621
MOD_CK1_1	232	238	PF00069	0.586
MOD_CK1_1	43	49	PF00069	0.504
MOD_CK1_1	485	491	PF00069	0.588
MOD_CK2_1	194	200	PF00069	0.628
MOD_CK2_1	316	322	PF00069	0.431
MOD_CK2_1	422	428	PF00069	0.582
MOD_CK2_1	77	83	PF00069	0.714
MOD_GlcNHglycan	146	149	PF01048	0.660
MOD_GlcNHglycan	158	161	PF01048	0.583
MOD_GlcNHglycan	222	225	PF01048	0.618
MOD_GlcNHglycan	257	260	PF01048	0.557
MOD_GlcNHglycan	289	292	PF01048	0.573
MOD_GlcNHglycan	354	357	PF01048	0.600
MOD_GlcNHglycan	366	369	PF01048	0.580
MOD_GlcNHglycan	45	48	PF01048	0.532
MOD_GlcNHglycan	452	455	PF01048	0.495
MOD_GlcNHglycan	487	490	PF01048	0.598
MOD_GlcNHglycan	535	538	PF01048	0.470
MOD_GlcNHglycan	55	58	PF01048	0.705
MOD_GlcNHglycan	74	77	PF01048	0.686
MOD_GlcNHglycan	79	82	PF01048	0.558
MOD_GlcNHglycan	89	92	PF01048	0.437
MOD_GSK3_1	139	146	PF00069	0.580
MOD_GSK3_1	208	215	PF00069	0.746
MOD_GSK3_1	229	236	PF00069	0.631
MOD_GSK3_1	298	305	PF00069	0.479
MOD_GSK3_1	418	425	PF00069	0.619
MOD_GSK3_1	483	490	PF00069	0.714
MOD_NEK2_1	12	17	PF00069	0.502
MOD_NEK2_1	177	182	PF00069	0.430
MOD_NEK2_1	287	292	PF00069	0.579
MOD_NEK2_1	314	319	PF00069	0.427
MOD_NEK2_1	364	369	PF00069	0.592
MOD_NEK2_1	422	427	PF00069	0.555
MOD_NEK2_1	523	528	PF00069	0.387
MOD_PIKK_1	12	18	PF00454	0.493
MOD_PIKK_1	237	243	PF00454	0.573
MOD_PIKK_1	30	36	PF00454	0.542
MOD_PKA_1	139	145	PF00069	0.523
MOD_PKA_2	139	145	PF00069	0.570
MOD_PKA_2	255	261	PF00069	0.477
MOD_PKA_2	287	293	PF00069	0.533
MOD_PKA_2	472	478	PF00069	0.463
MOD_PKB_1	505	513	PF00069	0.437
MOD_Plk_1	6	12	PF00069	0.488
MOD_Plk_4	309	315	PF00069	0.448
MOD_Plk_4	490	496	PF00069	0.568
MOD_ProDKin_1	531	537	PF00069	0.521
MOD_SUMO_for_1	299	302	PF00179	0.452
MOD_SUMO_rev_2	124	134	PF00179	0.562
TRG_DiLeu_BaEn_1	133	138	PF01217	0.538
TRG_DiLeu_BaEn_1	173	178	PF01217	0.450
TRG_DiLeu_BaEn_4	173	179	PF01217	0.529
TRG_DiLeu_LyEn_5	133	138	PF01217	0.566
TRG_ENDOCYTIC_2	427	430	PF00928	0.480
TRG_ENDOCYTIC_2	97	100	PF00928	0.456
TRG_ER_diArg_1	138	140	PF00400	0.731
TRG_ER_diArg_1	168	171	PF00400	0.489
TRG_ER_diArg_1	242	244	PF00400	0.622
TRG_ER_diArg_1	245	247	PF00400	0.560
TRG_ER_diArg_1	341	343	PF00400	0.669
TRG_NLS_MonoExtC_3	502	507	PF00514	0.430
TRG_NLS_MonoExtN_4	503	508	PF00514	0.430
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	269	274	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I948	Leptomonas seymouri	44%	86%
A0A3Q8IA19	Leishmania donovani	88%	99%
A4H828	Leishmania braziliensis	70%	100%
A4HWF4	Leishmania infantum	87%	99%
Q4QFC9	Leishmania major	89%	100%