Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Distal docking complex protein 1

Species:

Leishmania mexicana

UniProt:

E9AQ51_LEIMU

TriTrypDb:

LmxM.15.0540

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005815	microtubule organizing center	2	1
GO:0035253	ciliary rootlet	2	1
GO:0036064	ciliary basal body	3	1
GO:0097542	ciliary tip	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AQ51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ51

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0036158	outer dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	393	397	PF00656	0.714
CLV_C14_Caspase3-7	529	533	PF00656	0.553
CLV_NRD_NRD_1	150	152	PF00675	0.375
CLV_NRD_NRD_1	220	222	PF00675	0.400
CLV_NRD_NRD_1	227	229	PF00675	0.440
CLV_NRD_NRD_1	273	275	PF00675	0.659
CLV_NRD_NRD_1	33	35	PF00675	0.453
CLV_NRD_NRD_1	423	425	PF00675	0.448
CLV_NRD_NRD_1	427	429	PF00675	0.394
CLV_NRD_NRD_1	43	45	PF00675	0.414
CLV_NRD_NRD_1	496	498	PF00675	0.431
CLV_NRD_NRD_1	663	665	PF00675	0.504
CLV_NRD_NRD_1	671	673	PF00675	0.509
CLV_PCSK_KEX2_1	12	14	PF00082	0.415
CLV_PCSK_KEX2_1	150	152	PF00082	0.370
CLV_PCSK_KEX2_1	227	229	PF00082	0.474
CLV_PCSK_KEX2_1	234	236	PF00082	0.522
CLV_PCSK_KEX2_1	272	274	PF00082	0.657
CLV_PCSK_KEX2_1	33	35	PF00082	0.436
CLV_PCSK_KEX2_1	423	425	PF00082	0.441
CLV_PCSK_KEX2_1	427	429	PF00082	0.387
CLV_PCSK_KEX2_1	43	45	PF00082	0.395
CLV_PCSK_KEX2_1	665	667	PF00082	0.610
CLV_PCSK_KEX2_1	671	673	PF00082	0.612
CLV_PCSK_KEX2_1	84	86	PF00082	0.438
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.415
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.429
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.610
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.395
CLV_PCSK_PC7_1	423	429	PF00082	0.425
CLV_PCSK_SKI1_1	227	231	PF00082	0.411
CLV_PCSK_SKI1_1	305	309	PF00082	0.409
CLV_PCSK_SKI1_1	348	352	PF00082	0.549
CLV_PCSK_SKI1_1	428	432	PF00082	0.403
CLV_PCSK_SKI1_1	50	54	PF00082	0.521
CLV_PCSK_SKI1_1	500	504	PF00082	0.484
DEG_APCC_DBOX_1	21	29	PF00400	0.442
DEG_APCC_DBOX_1	644	652	PF00400	0.476
DEG_APCC_KENBOX_2	383	387	PF00400	0.450
DEG_Nend_UBRbox_3	1	3	PF02207	0.561
DEG_SCF_FBW7_1	585	591	PF00400	0.471
DEG_SPOP_SBC_1	598	602	PF00917	0.474
DOC_CKS1_1	585	590	PF01111	0.472
DOC_CYCLIN_RxL_1	423	433	PF00134	0.495
DOC_MAPK_gen_1	11	19	PF00069	0.464
DOC_MAPK_gen_1	240	247	PF00069	0.514
DOC_MAPK_gen_1	296	304	PF00069	0.528
DOC_MAPK_gen_1	321	330	PF00069	0.561
DOC_MAPK_gen_1	423	431	PF00069	0.645
DOC_MAPK_gen_1	43	53	PF00069	0.563
DOC_MAPK_MEF2A_6	240	249	PF00069	0.558
DOC_MAPK_MEF2A_6	44	53	PF00069	0.430
DOC_USP7_MATH_1	204	208	PF00917	0.517
DOC_USP7_MATH_1	259	263	PF00917	0.678
DOC_USP7_MATH_1	350	354	PF00917	0.577
DOC_USP7_MATH_1	365	369	PF00917	0.528
DOC_USP7_MATH_1	487	491	PF00917	0.590
DOC_USP7_MATH_1	618	622	PF00917	0.715
DOC_USP7_UBL2_3	138	142	PF12436	0.372
DOC_USP7_UBL2_3	193	197	PF12436	0.475
DOC_WW_Pin1_4	284	289	PF00397	0.576
DOC_WW_Pin1_4	524	529	PF00397	0.657
DOC_WW_Pin1_4	575	580	PF00397	0.780
DOC_WW_Pin1_4	584	589	PF00397	0.675
LIG_14-3-3_CanoR_1	13	17	PF00244	0.560
LIG_14-3-3_CanoR_1	150	154	PF00244	0.368
LIG_14-3-3_CanoR_1	258	264	PF00244	0.751
LIG_14-3-3_CanoR_1	277	286	PF00244	0.582
LIG_14-3-3_CanoR_1	497	507	PF00244	0.469
LIG_14-3-3_CanoR_1	605	614	PF00244	0.512
LIG_14-3-3_CanoR_1	61	66	PF00244	0.559
LIG_Actin_WH2_2	35	52	PF00022	0.501
LIG_Actin_WH2_2	83	101	PF00022	0.549
LIG_BRCT_BRCA1_1	610	614	PF00533	0.451
LIG_CaM_IQ_9	25	40	PF13499	0.488
LIG_CtBP_PxDLS_1	589	593	PF00389	0.512
LIG_FHA_1	468	474	PF00498	0.360
LIG_FHA_1	506	512	PF00498	0.515
LIG_FHA_1	580	586	PF00498	0.570
LIG_FHA_2	153	159	PF00498	0.401
LIG_FHA_2	2	8	PF00498	0.718
LIG_FHA_2	331	337	PF00498	0.445
LIG_FHA_2	372	378	PF00498	0.466
LIG_GLEBS_BUB3_1	525	533	PF00400	0.548
LIG_IRF3_LxIS_1	469	476	PF10401	0.475
LIG_LIR_Gen_1	152	160	PF02991	0.409
LIG_LIR_Gen_1	353	362	PF02991	0.520
LIG_LIR_Nem_3	152	156	PF02991	0.408
LIG_LIR_Nem_3	353	358	PF02991	0.456
LIG_LIR_Nem_3	415	420	PF02991	0.707
LIG_NRBOX	454	460	PF00104	0.476
LIG_PDZ_Class_3	673	678	PF00595	0.600
LIG_SH2_CRK	417	421	PF00017	0.554
LIG_SH2_STAP1	153	157	PF00017	0.333
LIG_SH2_STAT5	301	304	PF00017	0.548
LIG_SH2_STAT5	468	471	PF00017	0.542
LIG_SH3_3	547	553	PF00018	0.682
LIG_SH3_3	582	588	PF00018	0.582
LIG_SUMO_SIM_anti_2	508	513	PF11976	0.481
LIG_SUMO_SIM_par_1	15	20	PF11976	0.367
LIG_TRAF2_1	104	107	PF00917	0.401
LIG_TRAF2_1	250	253	PF00917	0.505
LIG_TRAF2_1	527	530	PF00917	0.555
LIG_TRAF2_1	70	73	PF00917	0.526
MOD_CK1_1	278	284	PF00069	0.695
MOD_CK1_1	490	496	PF00069	0.575
MOD_CK1_1	599	605	PF00069	0.546
MOD_CK1_1	608	614	PF00069	0.561
MOD_CK1_1	652	658	PF00069	0.438
MOD_CK2_1	1	7	PF00069	0.534
MOD_CK2_1	152	158	PF00069	0.401
MOD_CK2_1	169	175	PF00069	0.417
MOD_CK2_1	330	336	PF00069	0.447
MOD_CK2_1	350	356	PF00069	0.293
MOD_CK2_1	524	530	PF00069	0.532
MOD_GlcNHglycan	120	125	PF01048	0.438
MOD_GlcNHglycan	193	196	PF01048	0.516
MOD_GlcNHglycan	266	269	PF01048	0.761
MOD_GlcNHglycan	281	284	PF01048	0.760
MOD_GlcNHglycan	367	370	PF01048	0.599
MOD_GlcNHglycan	379	382	PF01048	0.650
MOD_GlcNHglycan	475	478	PF01048	0.521
MOD_GlcNHglycan	483	486	PF01048	0.537
MOD_GlcNHglycan	488	492	PF01048	0.549
MOD_GlcNHglycan	500	503	PF01048	0.613
MOD_GlcNHglycan	570	573	PF01048	0.710
MOD_GlcNHglycan	620	623	PF01048	0.598
MOD_GSK3_1	145	152	PF00069	0.440
MOD_GSK3_1	166	173	PF00069	0.427
MOD_GSK3_1	264	271	PF00069	0.706
MOD_GSK3_1	275	282	PF00069	0.693
MOD_GSK3_1	467	474	PF00069	0.332
MOD_GSK3_1	498	505	PF00069	0.532
MOD_GSK3_1	575	582	PF00069	0.709
MOD_GSK3_1	584	591	PF00069	0.614
MOD_GSK3_1	606	613	PF00069	0.666
MOD_LATS_1	496	502	PF00433	0.524
MOD_N-GLC_1	1	6	PF02516	0.675
MOD_N-GLC_1	330	335	PF02516	0.323
MOD_N-GLC_1	385	390	PF02516	0.465
MOD_N-GLC_1	61	66	PF02516	0.610
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	230	235	PF00069	0.411
MOD_NEK2_1	330	335	PF00069	0.452
MOD_NEK2_1	337	342	PF00069	0.467
MOD_NEK2_1	473	478	PF00069	0.508
MOD_NEK2_1	53	58	PF00069	0.535
MOD_NEK2_1	83	88	PF00069	0.393
MOD_PIKK_1	166	172	PF00454	0.411
MOD_PIKK_1	490	496	PF00454	0.549
MOD_PIKK_1	500	506	PF00454	0.472
MOD_PK_1	12	18	PF00069	0.425
MOD_PK_1	61	67	PF00069	0.561
MOD_PKA_1	12	18	PF00069	0.414
MOD_PKA_2	12	18	PF00069	0.562
MOD_PKA_2	149	155	PF00069	0.368
MOD_PKA_2	278	284	PF00069	0.687
MOD_PKA_2	377	383	PF00069	0.429
MOD_PKB_1	277	285	PF00069	0.575
MOD_PKB_1	303	311	PF00069	0.544
MOD_Plk_1	120	126	PF00069	0.532
MOD_Plk_1	305	311	PF00069	0.409
MOD_Plk_1	337	343	PF00069	0.538
MOD_Plk_1	384	390	PF00069	0.460
MOD_Plk_1	61	67	PF00069	0.597
MOD_Plk_4	12	18	PF00069	0.465
MOD_Plk_4	152	158	PF00069	0.400
MOD_Plk_4	652	658	PF00069	0.337
MOD_ProDKin_1	284	290	PF00069	0.569
MOD_ProDKin_1	524	530	PF00069	0.656
MOD_ProDKin_1	575	581	PF00069	0.780
MOD_ProDKin_1	584	590	PF00069	0.678
MOD_SUMO_for_1	202	205	PF00179	0.397
MOD_SUMO_for_1	70	73	PF00179	0.549
MOD_SUMO_rev_2	205	211	PF00179	0.447
MOD_SUMO_rev_2	41	49	PF00179	0.414
MOD_SUMO_rev_2	641	651	PF00179	0.504
TRG_DiLeu_BaEn_1	184	189	PF01217	0.513
TRG_DiLeu_BaEn_2	105	111	PF01217	0.494
TRG_DiLeu_BaEn_3	225	231	PF01217	0.466
TRG_ENDOCYTIC_2	153	156	PF00928	0.408
TRG_ENDOCYTIC_2	301	304	PF00928	0.403
TRG_ENDOCYTIC_2	417	420	PF00928	0.559
TRG_ER_diArg_1	149	151	PF00400	0.368
TRG_ER_diArg_1	227	229	PF00400	0.558
TRG_ER_diArg_1	272	274	PF00400	0.663
TRG_ER_diArg_1	302	305	PF00400	0.477
TRG_ER_diArg_1	32	34	PF00400	0.459
TRG_ER_diArg_1	42	44	PF00400	0.426
TRG_ER_diArg_1	427	429	PF00400	0.405
TRG_NLS_MonoExtN_4	662	668	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	427	432	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF92	Leptomonas seymouri	65%	100%
A0A0S4JUS3	Bodo saltans	28%	100%
A0A1X0NV64	Trypanosomatidae	39%	96%
A0A3Q8IA72	Leishmania donovani	90%	100%
A0A422NLI6	Trypanosoma rangeli	40%	100%
A4H826	Leishmania braziliensis	81%	100%
C9ZNZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
Q4QFD1	Leishmania major	89%	100%
V5BBE7	Trypanosoma cruzi	42%	100%