Putative ecotin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ecotin

Gene product:

ecotin, putative

Species:

Leishmania mexicana

UniProt:

E9AQ49_LEIMU

TriTrypDb:

LmxM.15.0520

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ49

Function

Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	1
GO:0009607	response to biotic stimulus	2	1
GO:0042783	evasion of host immune response	6	1
GO:0042784	evasion of host immune response via modulation of host complement system	7	1
GO:0043207	response to external biotic stimulus	3	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0050896	response to stimulus	1	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0051707	response to other organism	2	1
GO:0052173	response to defenses of other organism	3	1
GO:0052200	response to host defenses	4	1
GO:0052572	response to host immune response	5	1
GO:0075136	response to host	3	1

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	7
GO:0004866	endopeptidase inhibitor activity	5	7
GO:0004867	serine-type endopeptidase inhibitor activity	6	7
GO:0030234	enzyme regulator activity	2	7
GO:0030414	peptidase inhibitor activity	4	7
GO:0061134	peptidase regulator activity	3	7
GO:0061135	endopeptidase regulator activity	4	7
GO:0098772	molecular function regulator activity	1	7
GO:0140678	molecular function inhibitor activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.324
CLV_NRD_NRD_1	254	256	PF00675	0.653
CLV_NRD_NRD_1	291	293	PF00675	0.632
CLV_NRD_NRD_1	301	303	PF00675	0.786
CLV_NRD_NRD_1	354	356	PF00675	0.658
CLV_NRD_NRD_1	362	364	PF00675	0.613
CLV_PCSK_KEX2_1	177	179	PF00082	0.543
CLV_PCSK_KEX2_1	253	255	PF00082	0.646
CLV_PCSK_KEX2_1	291	293	PF00082	0.714
CLV_PCSK_KEX2_1	301	303	PF00082	0.704
CLV_PCSK_KEX2_1	362	364	PF00082	0.593
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.488
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.602
CLV_PCSK_SKI1_1	152	156	PF00082	0.494
DOC_MAPK_gen_1	177	183	PF00069	0.494
DOC_MAPK_MEF2A_6	111	118	PF00069	0.388
DOC_USP7_MATH_1	107	111	PF00917	0.312
DOC_USP7_MATH_1	213	217	PF00917	0.662
DOC_USP7_MATH_1	300	304	PF00917	0.641
DOC_USP7_MATH_1	328	332	PF00917	0.576
DOC_USP7_MATH_1	357	361	PF00917	0.695
DOC_USP7_MATH_1	84	88	PF00917	0.344
DOC_USP7_MATH_2	245	251	PF00917	0.660
DOC_WW_Pin1_4	100	105	PF00397	0.315
DOC_WW_Pin1_4	268	273	PF00397	0.778
DOC_WW_Pin1_4	284	289	PF00397	0.601
DOC_WW_Pin1_4	290	295	PF00397	0.694
DOC_WW_Pin1_4	350	355	PF00397	0.737
LIG_14-3-3_CanoR_1	127	135	PF00244	0.645
LIG_14-3-3_CanoR_1	152	157	PF00244	0.493
LIG_14-3-3_CanoR_1	178	184	PF00244	0.533
LIG_14-3-3_CanoR_1	276	283	PF00244	0.691
LIG_14-3-3_CanoR_1	301	309	PF00244	0.664
LIG_14-3-3_CanoR_1	321	328	PF00244	0.548
LIG_14-3-3_CanoR_1	348	357	PF00244	0.601
LIG_14-3-3_CanoR_1	86	91	PF00244	0.340
LIG_FHA_1	153	159	PF00498	0.544
LIG_FHA_1	56	62	PF00498	0.388
LIG_FHA_1	93	99	PF00498	0.379
LIG_FHA_2	339	345	PF00498	0.412
LIG_FHA_2	75	81	PF00498	0.431
LIG_LIR_Apic_2	173	179	PF02991	0.492
LIG_LIR_Apic_2	6	10	PF02991	0.438
LIG_LIR_Gen_1	95	105	PF02991	0.340
LIG_LIR_Nem_3	72	76	PF02991	0.378
LIG_LIR_Nem_3	95	100	PF02991	0.385
LIG_MYND_1	194	198	PF01753	0.639
LIG_Pex14_1	69	73	PF04695	0.352
LIG_SH2_CRK	176	180	PF00017	0.490
LIG_SH2_CRK	7	11	PF00017	0.312
LIG_SH2_STAP1	338	342	PF00017	0.521
LIG_SH2_STAP1	71	75	PF00017	0.304
LIG_SH2_STAT3	171	174	PF00017	0.630
LIG_SH2_STAT3	24	27	PF00017	0.327
LIG_SH2_STAT5	117	120	PF00017	0.414
LIG_SH2_STAT5	171	174	PF00017	0.630
LIG_SH2_STAT5	24	27	PF00017	0.312
LIG_SH2_STAT5	74	77	PF00017	0.502
LIG_SH3_3	113	119	PF00018	0.300
LIG_SH3_3	140	146	PF00018	0.599
LIG_SH3_3	183	189	PF00018	0.585
LIG_SH3_3	192	198	PF00018	0.633
LIG_SH3_3	269	275	PF00018	0.710
LIG_SH3_3	351	357	PF00018	0.630
LIG_SH3_3	6	12	PF00018	0.469
LIG_SUMO_SIM_par_1	74	80	PF11976	0.315
LIG_TRAF2_1	182	185	PF00917	0.639
LIG_TRAF2_1	308	311	PF00917	0.661
MOD_CDC14_SPxK_1	353	356	PF00782	0.696
MOD_CDK_SPK_2	284	289	PF00069	0.526
MOD_CDK_SPK_2	350	355	PF00069	0.671
MOD_CDK_SPxK_1	350	356	PF00069	0.677
MOD_CDK_SPxxK_3	284	291	PF00069	0.593
MOD_CK1_1	256	262	PF00069	0.702
MOD_CK1_1	270	276	PF00069	0.620
MOD_CK1_1	287	293	PF00069	0.519
MOD_CK1_1	303	309	PF00069	0.608
MOD_CK1_1	323	329	PF00069	0.835
MOD_CK1_1	358	364	PF00069	0.654
MOD_CK2_1	179	185	PF00069	0.632
MOD_CK2_1	201	207	PF00069	0.658
MOD_CK2_1	263	269	PF00069	0.694
MOD_CK2_1	275	281	PF00069	0.657
MOD_CK2_1	57	63	PF00069	0.312
MOD_CK2_1	86	92	PF00069	0.291
MOD_DYRK1A_RPxSP_1	350	354	PF00069	0.716
MOD_GlcNHglycan	198	201	PF01048	0.650
MOD_GlcNHglycan	215	218	PF01048	0.536
MOD_GlcNHglycan	294	297	PF01048	0.650
MOD_GlcNHglycan	305	308	PF01048	0.721
MOD_GlcNHglycan	314	317	PF01048	0.808
MOD_GlcNHglycan	323	326	PF01048	0.556
MOD_GlcNHglycan	357	360	PF01048	0.720
MOD_GlcNHglycan	363	366	PF01048	0.727
MOD_GSK3_1	127	134	PF00069	0.504
MOD_GSK3_1	166	173	PF00069	0.534
MOD_GSK3_1	253	260	PF00069	0.663
MOD_GSK3_1	263	270	PF00069	0.683
MOD_GSK3_1	290	297	PF00069	0.669
MOD_GSK3_1	319	326	PF00069	0.665
MOD_GSK3_1	357	364	PF00069	0.668
MOD_LATS_1	274	280	PF00433	0.562
MOD_N-GLC_1	263	268	PF02516	0.616
MOD_N-GLC_1	319	324	PF02516	0.710
MOD_N-GLC_1	328	333	PF02516	0.606
MOD_N-GLC_1	365	370	PF02516	0.653
MOD_NEK2_1	135	140	PF00069	0.585
MOD_NEK2_1	57	62	PF00069	0.388
MOD_NEK2_2	154	159	PF00069	0.492
MOD_NEK2_2	338	343	PF00069	0.548
MOD_PIKK_1	170	176	PF00454	0.568
MOD_PIKK_1	294	300	PF00454	0.530
MOD_PKA_1	177	183	PF00069	0.494
MOD_PKA_1	253	259	PF00069	0.828
MOD_PKA_1	301	307	PF00069	0.711
MOD_PKA_1	355	361	PF00069	0.661
MOD_PKA_2	177	183	PF00069	0.560
MOD_PKA_2	187	193	PF00069	0.635
MOD_PKA_2	253	259	PF00069	0.657
MOD_PKA_2	275	281	PF00069	0.730
MOD_PKA_2	300	306	PF00069	0.700
MOD_PKA_2	320	326	PF00069	0.675
MOD_PKA_2	361	367	PF00069	0.569
MOD_PKA_2	85	91	PF00069	0.340
MOD_PKB_1	125	133	PF00069	0.340
MOD_Plk_1	131	137	PF00069	0.511
MOD_Plk_1	338	344	PF00069	0.548
MOD_Plk_1	62	68	PF00069	0.312
MOD_Plk_4	57	63	PF00069	0.260
MOD_Plk_4	69	75	PF00069	0.325
MOD_Plk_4	93	99	PF00069	0.340
MOD_ProDKin_1	100	106	PF00069	0.315
MOD_ProDKin_1	268	274	PF00069	0.779
MOD_ProDKin_1	284	290	PF00069	0.608
MOD_ProDKin_1	350	356	PF00069	0.743
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.645
TRG_ENDOCYTIC_2	73	76	PF00928	0.388
TRG_ER_diArg_1	300	302	PF00400	0.808
TRG_NLS_Bipartite_1	301	322	PF00514	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ51	Leptomonas seymouri	32%	100%
A0A3S7WTD9	Leishmania donovani	80%	98%
A4H824	Leishmania braziliensis	45%	84%
A4HWF0	Leishmania infantum	80%	98%
Q4QFD3	Leishmania major	82%	100%