Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ45_LEIMU

TriTrypDb:

LmxM.15.0430

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.529
CLV_C14_Caspase3-7	55	59	PF00656	0.698
CLV_NRD_NRD_1	160	162	PF00675	0.548
CLV_NRD_NRD_1	76	78	PF00675	0.735
CLV_PCSK_KEX2_1	76	78	PF00082	0.735
CLV_PCSK_SKI1_1	33	37	PF00082	0.584
DEG_Nend_UBRbox_1	1	4	PF02207	0.462
DEG_SPOP_SBC_1	105	109	PF00917	0.688
DOC_USP7_MATH_1	105	109	PF00917	0.705
DOC_USP7_MATH_1	111	115	PF00917	0.682
DOC_USP7_MATH_1	157	161	PF00917	0.561
DOC_USP7_MATH_1	193	197	PF00917	0.712
DOC_USP7_MATH_1	277	281	PF00917	0.692
DOC_USP7_MATH_1	295	299	PF00917	0.603
DOC_USP7_UBL2_3	49	53	PF12436	0.696
DOC_WW_Pin1_4	114	119	PF00397	0.666
DOC_WW_Pin1_4	205	210	PF00397	0.745
DOC_WW_Pin1_4	281	286	PF00397	0.704
LIG_14-3-3_CanoR_1	136	144	PF00244	0.758
LIG_14-3-3_CanoR_1	177	181	PF00244	0.645
LIG_14-3-3_CanoR_1	243	248	PF00244	0.640
LIG_BIR_III_2	282	286	PF00653	0.522
LIG_BIR_III_4	58	62	PF00653	0.541
LIG_eIF4E_1	4	10	PF01652	0.648
LIG_FHA_1	105	111	PF00498	0.807
LIG_FHA_1	130	136	PF00498	0.696
LIG_FHA_1	15	21	PF00498	0.665
LIG_FHA_1	211	217	PF00498	0.813
LIG_FHA_1	218	224	PF00498	0.692
LIG_FHA_1	286	292	PF00498	0.777
LIG_FHA_1	308	314	PF00498	0.532
LIG_FHA_1	340	346	PF00498	0.606
LIG_FHA_1	43	49	PF00498	0.610
LIG_FHA_1	55	61	PF00498	0.801
LIG_FHA_2	226	232	PF00498	0.647
LIG_FHA_2	299	305	PF00498	0.704
LIG_FHA_2	315	321	PF00498	0.452
LIG_LIR_Gen_1	91	101	PF02991	0.643
LIG_LIR_Nem_3	117	122	PF02991	0.650
LIG_LIR_Nem_3	30	35	PF02991	0.538
LIG_LIR_Nem_3	91	96	PF02991	0.715
LIG_SH2_STAP1	106	110	PF00017	0.646
LIG_SH2_STAT5	106	109	PF00017	0.683
LIG_SH2_STAT5	4	7	PF00017	0.654
LIG_SH3_1	183	189	PF00018	0.793
LIG_SH3_2	257	262	PF14604	0.539
LIG_SH3_3	183	189	PF00018	0.739
LIG_SH3_3	254	260	PF00018	0.539
LIG_SH3_3	93	99	PF00018	0.709
LIG_SUMO_SIM_anti_2	107	115	PF11976	0.724
MOD_CK1_1	114	120	PF00069	0.753
MOD_CK1_1	152	158	PF00069	0.555
MOD_CK1_1	205	211	PF00069	0.633
MOD_CK1_1	298	304	PF00069	0.623
MOD_CK1_1	319	325	PF00069	0.436
MOD_CK2_1	298	304	PF00069	0.623
MOD_CK2_1	314	320	PF00069	0.579
MOD_GlcNHglycan	139	142	PF01048	0.738
MOD_GlcNHglycan	151	154	PF01048	0.739
MOD_GlcNHglycan	166	169	PF01048	0.784
MOD_GlcNHglycan	195	198	PF01048	0.729
MOD_GlcNHglycan	204	207	PF01048	0.711
MOD_GlcNHglycan	251	254	PF01048	0.828
MOD_GlcNHglycan	279	282	PF01048	0.644
MOD_GlcNHglycan	297	300	PF01048	0.728
MOD_GlcNHglycan	64	67	PF01048	0.697
MOD_GlcNHglycan	85	88	PF01048	0.708
MOD_GSK3_1	101	108	PF00069	0.751
MOD_GSK3_1	14	21	PF00069	0.781
MOD_GSK3_1	208	215	PF00069	0.735
MOD_GSK3_1	241	248	PF00069	0.706
MOD_GSK3_1	277	284	PF00069	0.756
MOD_GSK3_1	339	346	PF00069	0.683
MOD_GSK3_1	88	95	PF00069	0.693
MOD_N-GLC_1	164	169	PF02516	0.719
MOD_N-GLC_1	216	221	PF02516	0.808
MOD_N-GLC_1	91	96	PF02516	0.767
MOD_N-GLC_2	169	171	PF02516	0.710
MOD_NEK2_1	122	127	PF00069	0.660
MOD_NEK2_1	245	250	PF00069	0.755
MOD_NEK2_1	314	319	PF00069	0.580
MOD_NEK2_1	338	343	PF00069	0.672
MOD_NEK2_2	42	47	PF00069	0.504
MOD_PKA_2	176	182	PF00069	0.645
MOD_Plk_1	101	107	PF00069	0.679
MOD_Plk_1	319	325	PF00069	0.727
MOD_Plk_1	91	97	PF00069	0.690
MOD_Plk_4	92	98	PF00069	0.699
MOD_ProDKin_1	114	120	PF00069	0.665
MOD_ProDKin_1	205	211	PF00069	0.744
MOD_ProDKin_1	281	287	PF00069	0.706
MOD_SUMO_for_1	52	55	PF00179	0.733
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.596
TRG_ENDOCYTIC_2	119	122	PF00928	0.620
TRG_ENDOCYTIC_2	32	35	PF00928	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU81	Leptomonas seymouri	45%	100%
A0A3S5H6U3	Leishmania donovani	87%	100%
A4H815	Leishmania braziliensis	65%	91%
A4HWE5	Leishmania infantum	87%	100%
Q4QFD7	Leishmania major	84%	99%