ER membrane protein complex subunit 6

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ44_LEIMU

TriTrypDb:

LmxM.15.0420

Length:

146


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

E9AQ44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ44


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.453
CLV_NRD_NRD_1	84	86	PF00675	0.695
CLV_PCSK_KEX2_1	130	132	PF00082	0.457
CLV_PCSK_PC7_1	126	132	PF00082	0.525
CLV_PCSK_SKI1_1	131	135	PF00082	0.497
CLV_PCSK_SKI1_1	86	90	PF00082	0.621
DOC_MAPK_DCC_7	60	70	PF00069	0.561
DOC_MAPK_RevD_3	72	86	PF00069	0.444
DOC_WW_Pin1_4	36	41	PF00397	0.752
DOC_WW_Pin1_4	90	95	PF00397	0.354
LIG_14-3-3_CanoR_1	130	139	PF00244	0.716
LIG_14-3-3_CanoR_1	85	95	PF00244	0.488
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_FHA_1	132	138	PF00498	0.712
LIG_FHA_1	87	93	PF00498	0.482
LIG_LIR_Gen_1	75	83	PF02991	0.466
LIG_PCNA_PIPBox_1	48	57	PF02747	0.684
LIG_SH2_STAT5	3	6	PF00017	0.535
LIG_SH2_STAT5	54	57	PF00017	0.614
LIG_SH3_2	5	10	PF14604	0.688
LIG_SH3_3	14	20	PF00018	0.623
LIG_SH3_3	2	8	PF00018	0.698
LIG_SH3_3	31	37	PF00018	0.765
LIG_TRAF2_1	24	27	PF00917	0.770
LIG_UBA3_1	105	114	PF00899	0.335
LIG_UBA3_1	51	60	PF00899	0.655
MOD_CK1_1	132	138	PF00069	0.712
MOD_CK2_1	21	27	PF00069	0.719
MOD_CK2_1	84	90	PF00069	0.318
MOD_GSK3_1	36	43	PF00069	0.566
MOD_GSK3_1	84	91	PF00069	0.497
MOD_NEK2_1	72	77	PF00069	0.425
MOD_NEK2_1	88	93	PF00069	0.356
MOD_PIKK_1	22	28	PF00454	0.723
MOD_PIKK_1	46	52	PF00454	0.732
MOD_PIKK_1	60	66	PF00454	0.502
MOD_PKA_2	129	135	PF00069	0.713
MOD_PKA_2	84	90	PF00069	0.318
MOD_Plk_1	46	52	PF00069	0.733
MOD_Plk_4	54	60	PF00069	0.674
MOD_Plk_4	72	78	PF00069	0.264
MOD_ProDKin_1	36	42	PF00069	0.750
MOD_ProDKin_1	90	96	PF00069	0.354
TRG_ENDOCYTIC_2	78	81	PF00928	0.418
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.491


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK1	Leptomonas seymouri	71%	100%
A0A1X0NVE4	Trypanosomatidae	45%	100%
A0A3R7RL81	Trypanosoma rangeli	44%	90%
A0A3S7WTD5	Leishmania donovani	86%	100%
A4H814	Leishmania braziliensis	77%	100%
A4HWE4	Leishmania infantum	86%	100%
C9ZNY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QFD8	Leishmania major	84%	100%