Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ43_LEIMU

TriTrypDb:

LmxM.15.0410

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	422	426	PF00656	0.530
CLV_C14_Caspase3-7	536	540	PF00656	0.659
CLV_NRD_NRD_1	161	163	PF00675	0.326
CLV_NRD_NRD_1	212	214	PF00675	0.341
CLV_NRD_NRD_1	3	5	PF00675	0.429
CLV_NRD_NRD_1	306	308	PF00675	0.278
CLV_NRD_NRD_1	38	40	PF00675	0.357
CLV_NRD_NRD_1	480	482	PF00675	0.388
CLV_PCSK_KEX2_1	160	162	PF00082	0.326
CLV_PCSK_KEX2_1	212	214	PF00082	0.341
CLV_PCSK_KEX2_1	260	262	PF00082	0.334
CLV_PCSK_KEX2_1	3	5	PF00082	0.429
CLV_PCSK_KEX2_1	306	308	PF00082	0.278
CLV_PCSK_KEX2_1	38	40	PF00082	0.357
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.374
CLV_PCSK_SKI1_1	353	357	PF00082	0.580
CLV_PCSK_SKI1_1	4	8	PF00082	0.477
CLV_PCSK_SKI1_1	450	454	PF00082	0.581
CLV_PCSK_SKI1_1	637	641	PF00082	0.314
CLV_PCSK_SKI1_1	88	92	PF00082	0.329
CLV_PCSK_SKI1_1	93	97	PF00082	0.320
DEG_APCC_DBOX_1	160	168	PF00400	0.511
DEG_APCC_DBOX_1	195	203	PF00400	0.523
DEG_APCC_DBOX_1	306	314	PF00400	0.487
DEG_Nend_Nbox_1	1	3	PF02207	0.653
DEG_SPOP_SBC_1	437	441	PF00917	0.475
DEG_SPOP_SBC_1	572	576	PF00917	0.783
DOC_CKS1_1	52	57	PF01111	0.538
DOC_CYCLIN_RxL_1	680	692	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.570
DOC_MAPK_gen_1	108	117	PF00069	0.404
DOC_MAPK_gen_1	160	167	PF00069	0.516
DOC_MAPK_gen_1	212	220	PF00069	0.613
DOC_MAPK_gen_1	306	312	PF00069	0.476
DOC_MAPK_gen_1	44	50	PF00069	0.546
DOC_MAPK_gen_1	53	61	PF00069	0.544
DOC_MAPK_gen_1	678	687	PF00069	0.558
DOC_MAPK_gen_1	88	97	PF00069	0.527
DOC_MAPK_MEF2A_6	91	99	PF00069	0.518
DOC_PP1_RVXF_1	684	690	PF00149	0.529
DOC_PP2B_LxvP_1	250	253	PF13499	0.539
DOC_USP7_MATH_1	429	433	PF00917	0.405
DOC_USP7_MATH_1	437	441	PF00917	0.413
DOC_USP7_MATH_1	571	575	PF00917	0.729
DOC_WW_Pin1_4	204	209	PF00397	0.523
DOC_WW_Pin1_4	391	396	PF00397	0.357
DOC_WW_Pin1_4	423	428	PF00397	0.574
DOC_WW_Pin1_4	51	56	PF00397	0.536
DOC_WW_Pin1_4	557	562	PF00397	0.772
DOC_WW_Pin1_4	565	570	PF00397	0.745
LIG_14-3-3_CanoR_1	261	271	PF00244	0.636
LIG_14-3-3_CanoR_1	3	7	PF00244	0.711
LIG_14-3-3_CanoR_1	301	310	PF00244	0.553
LIG_14-3-3_CanoR_1	60	64	PF00244	0.578
LIG_14-3-3_CanoR_1	75	81	PF00244	0.461
LIG_Actin_WH2_2	477	493	PF00022	0.654
LIG_AP2alpha_2	391	393	PF02296	0.382
LIG_APCC_ABBA_1	121	126	PF00400	0.505
LIG_BRCT_BRCA1_1	402	406	PF00533	0.452
LIG_CSL_BTD_1	392	395	PF09270	0.353
LIG_deltaCOP1_diTrp_1	57	61	PF00928	0.566
LIG_EH1_1	181	189	PF00400	0.573
LIG_FHA_1	485	491	PF00498	0.552
LIG_FHA_2	142	148	PF00498	0.547
LIG_FHA_2	272	278	PF00498	0.566
LIG_FHA_2	52	58	PF00498	0.539
LIG_FHA_2	77	83	PF00498	0.575
LIG_Integrin_isoDGR_2	682	684	PF01839	0.427
LIG_LIR_Gen_1	118	129	PF02991	0.510
LIG_LIR_Gen_1	166	176	PF02991	0.516
LIG_LIR_Gen_1	57	66	PF02991	0.557
LIG_LIR_Gen_1	591	600	PF02991	0.516
LIG_LIR_Gen_1	627	636	PF02991	0.494
LIG_LIR_Gen_1	641	650	PF02991	0.535
LIG_LIR_LC3C_4	630	635	PF02991	0.557
LIG_LIR_Nem_3	118	124	PF02991	0.505
LIG_LIR_Nem_3	166	171	PF02991	0.518
LIG_LIR_Nem_3	209	214	PF02991	0.513
LIG_LIR_Nem_3	364	370	PF02991	0.369
LIG_LIR_Nem_3	391	396	PF02991	0.373
LIG_LIR_Nem_3	403	409	PF02991	0.379
LIG_LIR_Nem_3	57	61	PF02991	0.551
LIG_LIR_Nem_3	591	596	PF02991	0.522
LIG_LIR_Nem_3	62	66	PF02991	0.529
LIG_LIR_Nem_3	641	645	PF02991	0.549
LIG_NRBOX	101	107	PF00104	0.553
LIG_Pex14_1	27	31	PF04695	0.555
LIG_PTB_Apo_2	62	69	PF02174	0.546
LIG_PTB_Phospho_1	62	68	PF10480	0.545
LIG_Rb_pABgroove_1	118	126	PF01858	0.508
LIG_SH2_CRK	168	172	PF00017	0.510
LIG_SH2_CRK	63	67	PF00017	0.559
LIG_SH2_NCK_1	112	116	PF00017	0.555
LIG_SH2_SRC	112	115	PF00017	0.629
LIG_SH2_SRC	400	403	PF00017	0.258
LIG_SH2_STAP1	31	35	PF00017	0.574
LIG_SH2_STAP1	323	327	PF00017	0.344
LIG_SH2_STAT5	170	173	PF00017	0.556
LIG_SH2_STAT5	214	217	PF00017	0.494
LIG_SH2_STAT5	235	238	PF00017	0.596
LIG_SH2_STAT5	309	312	PF00017	0.399
LIG_SH2_STAT5	386	389	PF00017	0.307
LIG_SH3_2	392	397	PF14604	0.236
LIG_SH3_3	371	377	PF00018	0.416
LIG_SH3_3	389	395	PF00018	0.334
LIG_SH3_3	49	55	PF00018	0.539
LIG_SH3_3	8	14	PF00018	0.609
LIG_SUMO_SIM_par_1	216	223	PF11976	0.545
LIG_SUMO_SIM_par_1	482	487	PF11976	0.647
LIG_TRAF2_1	172	175	PF00917	0.511
LIG_TRAF2_1	506	509	PF00917	0.670
LIG_UBA3_1	327	336	PF00899	0.397
LIG_UBA3_1	483	491	PF00899	0.594
MOD_CDC14_SPxK_1	394	397	PF00782	0.254
MOD_CDK_SPK_2	51	56	PF00069	0.550
MOD_CDK_SPxK_1	391	397	PF00069	0.244
MOD_CK1_1	138	144	PF00069	0.587
MOD_CK1_1	30	36	PF00069	0.567
MOD_CK1_1	418	424	PF00069	0.525
MOD_CK1_1	439	445	PF00069	0.461
MOD_CK1_1	498	504	PF00069	0.683
MOD_CK1_1	557	563	PF00069	0.724
MOD_CK2_1	141	147	PF00069	0.574
MOD_CK2_1	271	277	PF00069	0.548
MOD_CK2_1	76	82	PF00069	0.523
MOD_GlcNHglycan	188	191	PF01048	0.419
MOD_GlcNHglycan	318	321	PF01048	0.328
MOD_GlcNHglycan	323	326	PF01048	0.323
MOD_GlcNHglycan	359	362	PF01048	0.536
MOD_GlcNHglycan	456	459	PF01048	0.562
MOD_GlcNHglycan	497	500	PF01048	0.534
MOD_GlcNHglycan	502	505	PF01048	0.476
MOD_GlcNHglycan	575	578	PF01048	0.497
MOD_GlcNHglycan	665	668	PF01048	0.401
MOD_GSK3_1	202	209	PF00069	0.530
MOD_GSK3_1	27	34	PF00069	0.461
MOD_GSK3_1	276	283	PF00069	0.546
MOD_GSK3_1	297	304	PF00069	0.607
MOD_GSK3_1	311	318	PF00069	0.384
MOD_GSK3_1	413	420	PF00069	0.502
MOD_GSK3_1	456	463	PF00069	0.734
MOD_GSK3_1	494	501	PF00069	0.708
MOD_GSK3_1	573	580	PF00069	0.743
MOD_GSK3_1	9	16	PF00069	0.625
MOD_N-GLC_1	202	207	PF02516	0.396
MOD_N-GLC_1	577	582	PF02516	0.559
MOD_NEK2_1	202	207	PF00069	0.530
MOD_NEK2_1	220	225	PF00069	0.599
MOD_NEK2_1	254	259	PF00069	0.533
MOD_NEK2_1	297	302	PF00069	0.557
MOD_NEK2_1	315	320	PF00069	0.340
MOD_NEK2_1	356	361	PF00069	0.342
MOD_NEK2_1	59	64	PF00069	0.540
MOD_NEK2_1	644	649	PF00069	0.611
MOD_NEK2_1	663	668	PF00069	0.573
MOD_NEK2_2	2	7	PF00069	0.525
MOD_PIKK_1	401	407	PF00454	0.373
MOD_PIKK_1	415	421	PF00454	0.603
MOD_PIKK_1	504	510	PF00454	0.719
MOD_PIKK_1	644	650	PF00454	0.576
MOD_PK_1	44	50	PF00069	0.571
MOD_PKA_1	44	50	PF00069	0.558
MOD_PKA_2	2	8	PF00069	0.711
MOD_PKA_2	356	362	PF00069	0.326
MOD_PKA_2	572	578	PF00069	0.769
MOD_PKA_2	59	65	PF00069	0.616
MOD_Plk_1	202	208	PF00069	0.594
MOD_Plk_2-3	135	141	PF00069	0.598
MOD_Plk_4	141	147	PF00069	0.527
MOD_Plk_4	206	212	PF00069	0.515
MOD_Plk_4	220	226	PF00069	0.498
MOD_Plk_4	254	260	PF00069	0.538
MOD_Plk_4	280	286	PF00069	0.522
MOD_Plk_4	311	317	PF00069	0.337
MOD_ProDKin_1	204	210	PF00069	0.519
MOD_ProDKin_1	391	397	PF00069	0.359
MOD_ProDKin_1	423	429	PF00069	0.575
MOD_ProDKin_1	51	57	PF00069	0.534
MOD_ProDKin_1	557	563	PF00069	0.772
MOD_ProDKin_1	565	571	PF00069	0.745
MOD_SUMO_rev_2	267	274	PF00179	0.555
TRG_DiLeu_BaEn_2	226	232	PF01217	0.558
TRG_DiLeu_BaEn_4	174	180	PF01217	0.520
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.353
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.547
TRG_ENDOCYTIC_2	112	115	PF00928	0.554
TRG_ENDOCYTIC_2	168	171	PF00928	0.505
TRG_ENDOCYTIC_2	214	217	PF00928	0.575
TRG_ENDOCYTIC_2	309	312	PF00928	0.381
TRG_ENDOCYTIC_2	367	370	PF00928	0.368
TRG_ENDOCYTIC_2	534	537	PF00928	0.672
TRG_ENDOCYTIC_2	63	66	PF00928	0.567
TRG_ENDOCYTIC_2	87	90	PF00928	0.509
TRG_ER_diArg_1	160	162	PF00400	0.526
TRG_ER_diArg_1	2	4	PF00400	0.636
TRG_ER_diArg_1	211	213	PF00400	0.541
TRG_ER_diArg_1	306	308	PF00400	0.466
TRG_ER_diArg_1	678	681	PF00400	0.535
TRG_ER_diArg_1	684	687	PF00400	0.533
TRG_NES_CRM1_1	163	177	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	637	641	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	686	691	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B6	Leptomonas seymouri	75%	100%
A0A0S4JZM2	Bodo saltans	44%	100%
A0A1X0NV52	Trypanosomatidae	54%	97%
A0A3S7WTC9	Leishmania donovani	93%	100%
A0A422NLJ2	Trypanosoma rangeli	56%	100%
A4H813	Leishmania braziliensis	85%	100%
A4HWE3	Leishmania infantum	93%	100%
C9ZNY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q4QFD9	Leishmania major	92%	100%
V5BGN8	Trypanosoma cruzi	55%	100%