Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ43_LEIMU

TriTrypDb:

LmxM.15.0410

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AQ43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ43

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	422	426	PF00656	0.530
CLV_C14_Caspase3-7	536	540	PF00656	0.659
CLV_NRD_NRD_1	161	163	PF00675	0.326
CLV_NRD_NRD_1	212	214	PF00675	0.341
CLV_NRD_NRD_1	3	5	PF00675	0.429
CLV_NRD_NRD_1	306	308	PF00675	0.278
CLV_NRD_NRD_1	38	40	PF00675	0.357
CLV_NRD_NRD_1	480	482	PF00675	0.388
CLV_PCSK_KEX2_1	160	162	PF00082	0.326
CLV_PCSK_KEX2_1	212	214	PF00082	0.341

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B6	Leptomonas seymouri	75%	100%
A0A0S4JZM2	Bodo saltans	44%	100%
A0A1X0NV52	Trypanosomatidae	54%	97%
A0A3S7WTC9	Leishmania donovani	93%	100%
A0A422NLJ2	Trypanosoma rangeli	56%	100%
A4H813	Leishmania braziliensis	85%	100%
A4HWE3	Leishmania infantum	93%	100%
C9ZNY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q4QFD9	Leishmania major	92%	100%
V5BGN8	Trypanosoma cruzi	55%	100%

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