PseudoU_synth_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania mexicana

UniProt:

E9AQ38_LEIMU

TriTrypDb:

LmxM.15.0360

Length:

1047

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ38

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	6
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009451	RNA modification	5	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0009982	pseudouridine synthase activity	4	6
GO:0016853	isomerase activity	2	6
GO:0016866	intramolecular transferase activity	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.474
CLV_C14_Caspase3-7	268	272	PF00656	0.659
CLV_C14_Caspase3-7	600	604	PF00656	0.559
CLV_C14_Caspase3-7	673	677	PF00656	0.667
CLV_C14_Caspase3-7	88	92	PF00656	0.561
CLV_NRD_NRD_1	182	184	PF00675	0.560
CLV_NRD_NRD_1	209	211	PF00675	0.641
CLV_NRD_NRD_1	239	241	PF00675	0.603
CLV_NRD_NRD_1	392	394	PF00675	0.631
CLV_NRD_NRD_1	452	454	PF00675	0.587
CLV_NRD_NRD_1	474	476	PF00675	0.787
CLV_NRD_NRD_1	502	504	PF00675	0.579
CLV_NRD_NRD_1	515	517	PF00675	0.728
CLV_NRD_NRD_1	591	593	PF00675	0.548
CLV_NRD_NRD_1	640	642	PF00675	0.756
CLV_NRD_NRD_1	759	761	PF00675	0.491
CLV_PCSK_FUR_1	592	596	PF00082	0.550
CLV_PCSK_KEX2_1	182	184	PF00082	0.560
CLV_PCSK_KEX2_1	209	211	PF00082	0.641
CLV_PCSK_KEX2_1	239	241	PF00082	0.603
CLV_PCSK_KEX2_1	392	394	PF00082	0.631
CLV_PCSK_KEX2_1	474	476	PF00082	0.787
CLV_PCSK_KEX2_1	515	517	PF00082	0.758
CLV_PCSK_KEX2_1	591	593	PF00082	0.731
CLV_PCSK_KEX2_1	594	596	PF00082	0.732
CLV_PCSK_KEX2_1	640	642	PF00082	0.700
CLV_PCSK_KEX2_1	759	761	PF00082	0.491
CLV_PCSK_PC1ET2_1	594	596	PF00082	0.734
CLV_PCSK_PC7_1	235	241	PF00082	0.584
CLV_PCSK_PC7_1	511	517	PF00082	0.740
CLV_PCSK_SKI1_1	129	133	PF00082	0.598
CLV_PCSK_SKI1_1	209	213	PF00082	0.623
CLV_PCSK_SKI1_1	242	246	PF00082	0.561
CLV_PCSK_SKI1_1	320	324	PF00082	0.724
CLV_PCSK_SKI1_1	340	344	PF00082	0.440
CLV_PCSK_SKI1_1	55	59	PF00082	0.669
CLV_PCSK_SKI1_1	552	556	PF00082	0.675
CLV_PCSK_SKI1_1	559	563	PF00082	0.728
CLV_PCSK_SKI1_1	591	595	PF00082	0.809
CLV_PCSK_SKI1_1	827	831	PF00082	0.702
CLV_PCSK_SKI1_1	879	883	PF00082	0.309
DEG_APCC_DBOX_1	241	249	PF00400	0.437
DEG_APCC_DBOX_1	702	710	PF00400	0.571
DEG_APCC_DBOX_1	911	919	PF00400	0.542
DEG_SPOP_SBC_1	164	168	PF00917	0.654
DEG_SPOP_SBC_1	189	193	PF00917	0.582
DEG_SPOP_SBC_1	344	348	PF00917	0.593
DEG_SPOP_SBC_1	742	746	PF00917	0.552
DOC_CKS1_1	718	723	PF01111	0.593
DOC_CYCLIN_RxL_1	123	133	PF00134	0.608
DOC_CYCLIN_RxL_1	337	347	PF00134	0.669
DOC_CYCLIN_RxL_1	549	558	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	918	924	PF00134	0.574
DOC_MAPK_DCC_7	172	180	PF00069	0.632
DOC_MAPK_DCC_7	371	380	PF00069	0.625
DOC_MAPK_gen_1	239	248	PF00069	0.522
DOC_MAPK_gen_1	879	887	PF00069	0.513
DOC_MAPK_HePTP_8	500	514	PF00069	0.644
DOC_MAPK_MEF2A_6	129	136	PF00069	0.591
DOC_MAPK_MEF2A_6	172	180	PF00069	0.681
DOC_MAPK_MEF2A_6	371	380	PF00069	0.625
DOC_MAPK_MEF2A_6	396	405	PF00069	0.552
DOC_MAPK_MEF2A_6	907	915	PF00069	0.542
DOC_MAPK_NFAT4_5	129	137	PF00069	0.592
DOC_PP1_RVXF_1	102	109	PF00149	0.660
DOC_PP1_RVXF_1	318	325	PF00149	0.653
DOC_PP2B_LxvP_1	687	690	PF13499	0.805
DOC_PP2B_LxvP_1	732	735	PF13499	0.745
DOC_PP2B_LxvP_1	74	77	PF13499	0.649
DOC_PP4_FxxP_1	118	121	PF00568	0.643
DOC_PP4_FxxP_1	211	214	PF00568	0.604
DOC_PP4_FxxP_1	398	401	PF00568	0.567
DOC_USP7_MATH_1	1041	1045	PF00917	0.634
DOC_USP7_MATH_1	195	199	PF00917	0.703
DOC_USP7_MATH_1	23	27	PF00917	0.489
DOC_USP7_MATH_1	252	256	PF00917	0.655
DOC_USP7_MATH_1	310	314	PF00917	0.622
DOC_USP7_MATH_1	41	45	PF00917	0.716
DOC_USP7_MATH_1	496	500	PF00917	0.689
DOC_USP7_MATH_1	528	532	PF00917	0.749
DOC_USP7_MATH_1	566	570	PF00917	0.755
DOC_USP7_MATH_1	624	628	PF00917	0.612
DOC_USP7_MATH_1	645	649	PF00917	0.772
DOC_USP7_MATH_1	688	692	PF00917	0.695
DOC_USP7_MATH_1	742	746	PF00917	0.701
DOC_USP7_MATH_1	840	844	PF00917	0.565
DOC_USP7_MATH_1	946	950	PF00917	0.636
DOC_USP7_MATH_1	954	958	PF00917	0.638
DOC_USP7_MATH_1	962	966	PF00917	0.752
DOC_USP7_UBL2_3	882	886	PF12436	0.413
DOC_WW_Pin1_4	1	6	PF00397	0.581
DOC_WW_Pin1_4	191	196	PF00397	0.589
DOC_WW_Pin1_4	255	260	PF00397	0.630
DOC_WW_Pin1_4	308	313	PF00397	0.544
DOC_WW_Pin1_4	345	350	PF00397	0.620
DOC_WW_Pin1_4	415	420	PF00397	0.659
DOC_WW_Pin1_4	514	519	PF00397	0.661
DOC_WW_Pin1_4	679	684	PF00397	0.772
DOC_WW_Pin1_4	717	722	PF00397	0.680
DOC_WW_Pin1_4	771	776	PF00397	0.790
DOC_WW_Pin1_4	801	806	PF00397	0.712
DOC_WW_Pin1_4	812	817	PF00397	0.687
LIG_14-3-3_CanoR_1	112	117	PF00244	0.721
LIG_14-3-3_CanoR_1	182	188	PF00244	0.608
LIG_14-3-3_CanoR_1	209	214	PF00244	0.586
LIG_14-3-3_CanoR_1	22	31	PF00244	0.542
LIG_14-3-3_CanoR_1	251	259	PF00244	0.601
LIG_14-3-3_CanoR_1	424	430	PF00244	0.489
LIG_14-3-3_CanoR_1	453	458	PF00244	0.581
LIG_14-3-3_CanoR_1	495	501	PF00244	0.660
LIG_14-3-3_CanoR_1	640	646	PF00244	0.762
LIG_14-3-3_CanoR_1	801	805	PF00244	0.725
LIG_14-3-3_CanoR_1	834	839	PF00244	0.524
LIG_14-3-3_CanoR_1	879	888	PF00244	0.506
LIG_BRCT_BRCA1_1	114	118	PF00533	0.649
LIG_BRCT_BRCA1_1	20	24	PF00533	0.591
LIG_Clathr_ClatBox_1	1035	1039	PF01394	0.712
LIG_deltaCOP1_diTrp_1	314	318	PF00928	0.647
LIG_deltaCOP1_diTrp_1	546	555	PF00928	0.751
LIG_deltaCOP1_diTrp_1	997	1004	PF00928	0.496
LIG_eIF4E_1	1030	1036	PF01652	0.739
LIG_EVH1_1	280	284	PF00568	0.537
LIG_FHA_1	150	156	PF00498	0.584
LIG_FHA_1	191	197	PF00498	0.630
LIG_FHA_1	45	51	PF00498	0.708
LIG_FHA_1	456	462	PF00498	0.571
LIG_FHA_1	624	630	PF00498	0.688
LIG_FHA_1	9	15	PF00498	0.569
LIG_FHA_1	906	912	PF00498	0.542
LIG_FHA_2	1027	1033	PF00498	0.483
LIG_FHA_2	309	315	PF00498	0.469
LIG_FHA_2	46	52	PF00498	0.625
LIG_FHA_2	542	548	PF00498	0.680
LIG_FHA_2	86	92	PF00498	0.770
LIG_Integrin_RGD_1	269	271	PF01839	0.664
LIG_LIR_Apic_2	115	121	PF02991	0.645
LIG_LIR_Apic_2	208	214	PF02991	0.620
LIG_LIR_Apic_2	770	775	PF02991	0.690
LIG_LIR_Apic_2	997	1001	PF02991	0.500
LIG_LIR_Gen_1	138	144	PF02991	0.631
LIG_LIR_Gen_1	33	43	PF02991	0.601
LIG_LIR_Gen_1	413	421	PF02991	0.465
LIG_LIR_Gen_1	546	556	PF02991	0.657
LIG_LIR_Gen_1	925	935	PF02991	0.600
LIG_LIR_Nem_3	138	144	PF02991	0.631
LIG_LIR_Nem_3	33	39	PF02991	0.529
LIG_LIR_Nem_3	413	417	PF02991	0.452
LIG_LIR_Nem_3	546	551	PF02991	0.589
LIG_LIR_Nem_3	925	931	PF02991	0.695
LIG_PCNA_TLS_4	129	136	PF02747	0.591
LIG_Pex14_2	135	139	PF04695	0.595
LIG_SH2_CRK	114	118	PF00017	0.649
LIG_SH2_CRK	497	501	PF00017	0.641
LIG_SH2_NCK_1	890	894	PF00017	0.542
LIG_SH2_PTP2	928	931	PF00017	0.689
LIG_SH2_SRC	1030	1033	PF00017	0.658
LIG_SH2_STAP1	1026	1030	PF00017	0.669
LIG_SH2_STAP1	114	118	PF00017	0.649
LIG_SH2_STAP1	497	501	PF00017	0.754
LIG_SH2_STAP1	612	616	PF00017	0.772
LIG_SH2_STAT3	34	37	PF00017	0.492
LIG_SH2_STAT5	1026	1029	PF00017	0.672
LIG_SH2_STAT5	116	119	PF00017	0.650
LIG_SH2_STAT5	216	219	PF00017	0.561
LIG_SH2_STAT5	34	37	PF00017	0.492
LIG_SH2_STAT5	56	59	PF00017	0.667
LIG_SH2_STAT5	612	615	PF00017	0.773
LIG_SH2_STAT5	696	699	PF00017	0.619
LIG_SH2_STAT5	874	877	PF00017	0.613
LIG_SH2_STAT5	928	931	PF00017	0.590
LIG_SH3_1	565	571	PF00018	0.686
LIG_SH3_3	1035	1041	PF00018	0.618
LIG_SH3_3	150	156	PF00018	0.571
LIG_SH3_3	2	8	PF00018	0.486
LIG_SH3_3	276	282	PF00018	0.647
LIG_SH3_3	333	339	PF00018	0.511
LIG_SH3_3	367	373	PF00018	0.711
LIG_SH3_3	435	441	PF00018	0.642
LIG_SH3_3	442	448	PF00018	0.548
LIG_SH3_3	565	571	PF00018	0.743
LIG_SH3_3	590	596	PF00018	0.828
LIG_SH3_3	680	686	PF00018	0.733
LIG_SH3_3	755	761	PF00018	0.688
LIG_SH3_3	956	962	PF00018	0.707
LIG_SUMO_SIM_anti_2	333	338	PF11976	0.449
LIG_SUMO_SIM_anti_2	626	633	PF11976	0.464
LIG_SUMO_SIM_par_1	1034	1039	PF11976	0.713
LIG_SUMO_SIM_par_1	434	439	PF11976	0.638
LIG_WRC_WIRS_1	9	14	PF05994	0.570
LIG_WW_1	609	612	PF00397	0.693
LIG_WW_2	685	688	PF00397	0.627
MOD_CDK_SPxxK_3	514	521	PF00069	0.671
MOD_CK1_1	163	169	PF00069	0.687
MOD_CK1_1	190	196	PF00069	0.584
MOD_CK1_1	255	261	PF00069	0.705
MOD_CK1_1	306	312	PF00069	0.734
MOD_CK1_1	350	356	PF00069	0.731
MOD_CK1_1	415	421	PF00069	0.649
MOD_CK1_1	44	50	PF00069	0.683
MOD_CK1_1	456	462	PF00069	0.571
MOD_CK1_1	531	537	PF00069	0.679
MOD_CK1_1	722	728	PF00069	0.707
MOD_CK1_1	803	809	PF00069	0.616
MOD_CK1_1	865	871	PF00069	0.600
MOD_CK1_1	880	886	PF00069	0.459
MOD_CK1_1	950	956	PF00069	0.549
MOD_CK1_1	965	971	PF00069	0.714
MOD_CK2_1	308	314	PF00069	0.734
MOD_CK2_1	327	333	PF00069	0.622
MOD_CK2_1	45	51	PF00069	0.592
MOD_CK2_1	456	462	PF00069	0.571
MOD_CK2_1	534	540	PF00069	0.711
MOD_CMANNOS	315	318	PF00535	0.632
MOD_Cter_Amidation	237	240	PF01082	0.585
MOD_Cter_Amidation	589	592	PF01082	0.546
MOD_GlcNHglycan	1008	1011	PF01048	0.635
MOD_GlcNHglycan	162	165	PF01048	0.706
MOD_GlcNHglycan	167	170	PF01048	0.732
MOD_GlcNHglycan	172	175	PF01048	0.755
MOD_GlcNHglycan	201	204	PF01048	0.806
MOD_GlcNHglycan	25	28	PF01048	0.729
MOD_GlcNHglycan	260	263	PF01048	0.705
MOD_GlcNHglycan	271	274	PF01048	0.749
MOD_GlcNHglycan	307	311	PF01048	0.745
MOD_GlcNHglycan	349	352	PF01048	0.734
MOD_GlcNHglycan	365	368	PF01048	0.642
MOD_GlcNHglycan	44	47	PF01048	0.628
MOD_GlcNHglycan	448	451	PF01048	0.630
MOD_GlcNHglycan	522	526	PF01048	0.631
MOD_GlcNHglycan	626	629	PF01048	0.640
MOD_GlcNHglycan	658	664	PF01048	0.760
MOD_GlcNHglycan	70	73	PF01048	0.668
MOD_GlcNHglycan	745	748	PF01048	0.786
MOD_GlcNHglycan	805	808	PF01048	0.763
MOD_GlcNHglycan	842	845	PF01048	0.676
MOD_GlcNHglycan	879	882	PF01048	0.342
MOD_GlcNHglycan	97	100	PF01048	0.572
MOD_GSK3_1	160	167	PF00069	0.694
MOD_GSK3_1	18	25	PF00069	0.501
MOD_GSK3_1	183	190	PF00069	0.688
MOD_GSK3_1	191	198	PF00069	0.678
MOD_GSK3_1	199	206	PF00069	0.540
MOD_GSK3_1	306	313	PF00069	0.728
MOD_GSK3_1	343	350	PF00069	0.691
MOD_GSK3_1	41	48	PF00069	0.584
MOD_GSK3_1	425	432	PF00069	0.647
MOD_GSK3_1	530	537	PF00069	0.764
MOD_GSK3_1	635	642	PF00069	0.641
MOD_GSK3_1	722	729	PF00069	0.688
MOD_GSK3_1	738	745	PF00069	0.526
MOD_GSK3_1	767	774	PF00069	0.790
MOD_GSK3_1	858	865	PF00069	0.758
MOD_GSK3_1	946	953	PF00069	0.712
MOD_LATS_1	825	831	PF00433	0.518
MOD_N-GLC_1	801	806	PF02516	0.751
MOD_NEK2_1	1004	1009	PF00069	0.575
MOD_NEK2_1	144	149	PF00069	0.664
MOD_NEK2_1	18	23	PF00069	0.564
MOD_NEK2_1	343	348	PF00069	0.685
MOD_NEK2_1	800	805	PF00069	0.606
MOD_NEK2_1	972	977	PF00069	0.662
MOD_NEK2_2	610	615	PF00069	0.653
MOD_NEK2_2	874	879	PF00069	0.542
MOD_PIKK_1	560	566	PF00454	0.717
MOD_PIKK_1	722	728	PF00454	0.768
MOD_PK_1	453	459	PF00069	0.578
MOD_PK_1	834	840	PF00069	0.615
MOD_PKA_1	209	215	PF00069	0.610
MOD_PKA_1	453	459	PF00069	0.578
MOD_PKA_2	209	215	PF00069	0.601
MOD_PKA_2	639	645	PF00069	0.698
MOD_PKA_2	68	74	PF00069	0.663
MOD_PKA_2	726	732	PF00069	0.797
MOD_PKA_2	800	806	PF00069	0.608
MOD_PKA_2	857	863	PF00069	0.853
MOD_PKB_1	267	275	PF00069	0.734
MOD_PKB_1	557	565	PF00069	0.790
MOD_Plk_1	351	357	PF00069	0.615
MOD_Plk_1	894	900	PF00069	0.542
MOD_Plk_1	965	971	PF00069	0.667
MOD_Plk_2-3	1034	1040	PF00069	0.710
MOD_Plk_2-3	327	333	PF00069	0.732
MOD_Plk_4	112	118	PF00069	0.653
MOD_Plk_4	183	189	PF00069	0.687
MOD_Plk_4	35	41	PF00069	0.485
MOD_Plk_4	456	462	PF00069	0.571
MOD_Plk_4	496	502	PF00069	0.756
MOD_Plk_4	767	773	PF00069	0.694
MOD_Plk_4	8	14	PF00069	0.475
MOD_Plk_4	894	900	PF00069	0.595
MOD_ProDKin_1	1	7	PF00069	0.578
MOD_ProDKin_1	191	197	PF00069	0.589
MOD_ProDKin_1	255	261	PF00069	0.635
MOD_ProDKin_1	308	314	PF00069	0.542
MOD_ProDKin_1	345	351	PF00069	0.622
MOD_ProDKin_1	415	421	PF00069	0.659
MOD_ProDKin_1	514	520	PF00069	0.666
MOD_ProDKin_1	679	685	PF00069	0.772
MOD_ProDKin_1	717	723	PF00069	0.680
MOD_ProDKin_1	771	777	PF00069	0.787
MOD_ProDKin_1	801	807	PF00069	0.714
MOD_ProDKin_1	812	818	PF00069	0.682
MOD_SUMO_for_1	821	824	PF00179	0.672
TRG_DiLeu_BaEn_1	333	338	PF01217	0.729
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.748
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.790
TRG_ENDOCYTIC_2	114	117	PF00928	0.650
TRG_ENDOCYTIC_2	497	500	PF00928	0.656
TRG_ENDOCYTIC_2	928	931	PF00928	0.590
TRG_ER_diArg_1	209	211	PF00400	0.641
TRG_ER_diArg_1	239	241	PF00400	0.603
TRG_ER_diArg_1	391	393	PF00400	0.650
TRG_ER_diArg_1	474	476	PF00400	0.781
TRG_ER_diArg_1	514	516	PF00400	0.749
TRG_ER_diArg_1	591	593	PF00400	0.548
TRG_ER_diArg_1	758	760	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	936	941	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P442	Leptomonas seymouri	42%	100%
A0A3S7WTI6	Leishmania donovani	81%	100%
A4H810	Leishmania braziliensis	67%	99%
Q4QFE4	Leishmania major	79%	99%