Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ37_LEIMU

TriTrypDb:

LmxM.15.0350

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AQ37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	337	341	PF00656	0.418
CLV_C14_Caspase3-7	84	88	PF00656	0.358
CLV_NRD_NRD_1	28	30	PF00675	0.463
CLV_NRD_NRD_1	663	665	PF00675	0.490
CLV_PCSK_FUR_1	26	30	PF00082	0.489
CLV_PCSK_KEX2_1	26	28	PF00082	0.475
CLV_PCSK_KEX2_1	266	268	PF00082	0.617
CLV_PCSK_KEX2_1	663	665	PF00082	0.480
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.617
CLV_PCSK_PC7_1	22	28	PF00082	0.494
CLV_PCSK_SKI1_1	136	140	PF00082	0.639
CLV_PCSK_SKI1_1	165	169	PF00082	0.596
CLV_PCSK_SKI1_1	229	233	PF00082	0.583
CLV_PCSK_SKI1_1	527	531	PF00082	0.583
CLV_PCSK_SKI1_1	538	542	PF00082	0.517
CLV_PCSK_SKI1_1	57	61	PF00082	0.495
CLV_PCSK_SKI1_1	603	607	PF00082	0.642
DEG_APCC_DBOX_1	89	97	PF00400	0.357
DOC_CDC14_PxL_1	450	458	PF14671	0.324
DOC_CYCLIN_yClb1_LxF_4	489	495	PF00134	0.346
DOC_MAPK_MEF2A_6	619	627	PF00069	0.201
DOC_PP1_RVXF_1	163	170	PF00149	0.493
DOC_PP1_RVXF_1	601	607	PF00149	0.402
DOC_PP2B_LxvP_1	558	561	PF13499	0.359
DOC_PP2B_PxIxI_1	516	522	PF00149	0.335
DOC_PP4_FxxP_1	514	517	PF00568	0.317
DOC_USP7_MATH_1	281	285	PF00917	0.532
DOC_USP7_MATH_1	311	315	PF00917	0.410
DOC_USP7_MATH_1	412	416	PF00917	0.382
DOC_USP7_MATH_1	565	569	PF00917	0.413
DOC_USP7_MATH_1	581	585	PF00917	0.283
DOC_USP7_MATH_1	621	625	PF00917	0.441
DOC_USP7_MATH_1	88	92	PF00917	0.575
DOC_USP7_MATH_1	95	99	PF00917	0.418
DOC_USP7_UBL2_3	266	270	PF12436	0.421
DOC_WW_Pin1_4	148	153	PF00397	0.403
DOC_WW_Pin1_4	190	195	PF00397	0.443
DOC_WW_Pin1_4	198	203	PF00397	0.512
DOC_WW_Pin1_4	483	488	PF00397	0.396
DOC_WW_Pin1_4	614	619	PF00397	0.396
LIG_14-3-3_CanoR_1	118	126	PF00244	0.340
LIG_14-3-3_CanoR_1	28	38	PF00244	0.449
LIG_14-3-3_CanoR_1	282	286	PF00244	0.453
LIG_14-3-3_CanoR_1	404	412	PF00244	0.365
LIG_14-3-3_CanoR_1	493	501	PF00244	0.406
LIG_14-3-3_CanoR_1	506	512	PF00244	0.361
LIG_14-3-3_CanoR_1	52	60	PF00244	0.443
LIG_14-3-3_CanoR_1	527	532	PF00244	0.336
LIG_14-3-3_CanoR_1	68	78	PF00244	0.451
LIG_14-3-3_CanoR_1	90	94	PF00244	0.435
LIG_eIF4E_1	226	232	PF01652	0.328
LIG_eIF4E_1	495	501	PF01652	0.371
LIG_FHA_1	198	204	PF00498	0.438
LIG_FHA_1	220	226	PF00498	0.331
LIG_FHA_1	235	241	PF00498	0.333
LIG_FHA_1	371	377	PF00498	0.350
LIG_FHA_1	445	451	PF00498	0.372
LIG_FHA_1	472	478	PF00498	0.325
LIG_FHA_1	495	501	PF00498	0.371
LIG_FHA_1	528	534	PF00498	0.326
LIG_FHA_1	618	624	PF00498	0.238
LIG_FHA_1	634	640	PF00498	0.372
LIG_FHA_2	375	381	PF00498	0.412
LIG_FHA_2	82	88	PF00498	0.340
LIG_Integrin_RGD_1	338	340	PF01839	0.593
LIG_LIR_Apic_2	196	202	PF02991	0.494
LIG_LIR_Apic_2	512	517	PF02991	0.325
LIG_LIR_Gen_1	143	154	PF02991	0.436
LIG_LIR_Gen_1	316	327	PF02991	0.379
LIG_LIR_Gen_1	41	50	PF02991	0.335
LIG_LIR_Gen_1	58	67	PF02991	0.349
LIG_LIR_Gen_1	588	598	PF02991	0.403
LIG_LIR_Gen_1	620	629	PF02991	0.286
LIG_LIR_Nem_3	143	149	PF02991	0.397
LIG_LIR_Nem_3	221	226	PF02991	0.305
LIG_LIR_Nem_3	316	322	PF02991	0.356
LIG_LIR_Nem_3	41	45	PF02991	0.497
LIG_LIR_Nem_3	58	63	PF02991	0.334
LIG_LIR_Nem_3	588	593	PF02991	0.431
LIG_LIR_Nem_3	620	625	PF02991	0.318
LIG_PCNA_yPIPBox_3	68	78	PF02747	0.292
LIG_Pex14_2	605	609	PF04695	0.301
LIG_SH2_CRK	199	203	PF00017	0.487
LIG_SH2_CRK	372	376	PF00017	0.320
LIG_SH2_CRK	590	594	PF00017	0.390
LIG_SH2_PTP2	622	625	PF00017	0.270
LIG_SH2_SRC	452	455	PF00017	0.247
LIG_SH2_STAP1	174	178	PF00017	0.422
LIG_SH2_STAP1	251	255	PF00017	0.476
LIG_SH2_STAP1	372	376	PF00017	0.378
LIG_SH2_STAP1	607	611	PF00017	0.395
LIG_SH2_STAT5	101	104	PF00017	0.360
LIG_SH2_STAT5	199	202	PF00017	0.445
LIG_SH2_STAT5	330	333	PF00017	0.356
LIG_SH2_STAT5	372	375	PF00017	0.401
LIG_SH2_STAT5	440	443	PF00017	0.361
LIG_SH2_STAT5	452	455	PF00017	0.247
LIG_SH2_STAT5	557	560	PF00017	0.296
LIG_SH2_STAT5	598	601	PF00017	0.411
LIG_SH2_STAT5	622	625	PF00017	0.298
LIG_SH3_3	208	214	PF00018	0.402
LIG_SH3_3	305	311	PF00018	0.559
LIG_SUMO_SIM_par_1	3	9	PF11976	0.680
LIG_SUMO_SIM_par_1	454	459	PF11976	0.309
LIG_SUMO_SIM_par_1	529	534	PF11976	0.369
LIG_TYR_ITIM	555	560	PF00017	0.427
LIG_TYR_ITSM	618	625	PF00017	0.270
LIG_WRC_WIRS_1	39	44	PF05994	0.270
LIG_WRC_WIRS_1	606	611	PF05994	0.484
MOD_CDK_SPK_2	614	619	PF00069	0.481
MOD_CK1_1	160	166	PF00069	0.624
MOD_CK1_1	218	224	PF00069	0.468
MOD_CK1_1	265	271	PF00069	0.656
MOD_CK1_1	274	280	PF00069	0.628
MOD_CK1_1	288	294	PF00069	0.770
MOD_CK1_1	333	339	PF00069	0.600
MOD_CK1_1	430	436	PF00069	0.410
MOD_CK1_1	464	470	PF00069	0.450
MOD_CK1_1	473	479	PF00069	0.344
MOD_CK1_1	483	489	PF00069	0.379
MOD_CK1_1	496	502	PF00069	0.358
MOD_CK1_1	568	574	PF00069	0.399
MOD_CK2_1	374	380	PF00069	0.489
MOD_CK2_1	464	470	PF00069	0.495
MOD_CK2_1	496	502	PF00069	0.365
MOD_GlcNHglycan	111	114	PF01048	0.601
MOD_GlcNHglycan	251	254	PF01048	0.316
MOD_GlcNHglycan	258	261	PF01048	0.460
MOD_GlcNHglycan	273	276	PF01048	0.714
MOD_GlcNHglycan	287	290	PF01048	0.597
MOD_GlcNHglycan	332	335	PF01048	0.607
MOD_GlcNHglycan	48	51	PF01048	0.360
MOD_GlcNHglycan	53	56	PF01048	0.510
MOD_GlcNHglycan	535	538	PF01048	0.516
MOD_GlcNHglycan	583	586	PF01048	0.359
MOD_GlcNHglycan	8	11	PF01048	0.601
MOD_GlcNHglycan	84	87	PF01048	0.469
MOD_GSK3_1	156	163	PF00069	0.475
MOD_GSK3_1	215	222	PF00069	0.460
MOD_GSK3_1	234	241	PF00069	0.393
MOD_GSK3_1	265	272	PF00069	0.661
MOD_GSK3_1	281	288	PF00069	0.669
MOD_GSK3_1	325	332	PF00069	0.495
MOD_GSK3_1	34	41	PF00069	0.363
MOD_GSK3_1	347	354	PF00069	0.429
MOD_GSK3_1	370	377	PF00069	0.459
MOD_GSK3_1	394	401	PF00069	0.462
MOD_GSK3_1	430	437	PF00069	0.343
MOD_GSK3_1	461	468	PF00069	0.415
MOD_GSK3_1	479	486	PF00069	0.477
MOD_GSK3_1	527	534	PF00069	0.398
MOD_GSK3_1	561	568	PF00069	0.375
MOD_GSK3_1	581	588	PF00069	0.466
MOD_GSK3_1	610	617	PF00069	0.404
MOD_GSK3_1	66	73	PF00069	0.603
MOD_GSK3_1	78	85	PF00069	0.414
MOD_LATS_1	654	660	PF00433	0.384
MOD_N-GLC_1	188	193	PF02516	0.603
MOD_N-GLC_1	219	224	PF02516	0.415
MOD_N-GLC_1	268	273	PF02516	0.650
MOD_N-GLC_1	404	409	PF02516	0.625
MOD_N-GLC_1	427	432	PF02516	0.501
MOD_N-GLC_1	461	466	PF02516	0.391
MOD_N-GLC_1	471	476	PF02516	0.397
MOD_N-GLC_1	70	75	PF02516	0.348
MOD_N-GLC_2	594	596	PF02516	0.358
MOD_NEK2_1	103	108	PF00069	0.389
MOD_NEK2_1	156	161	PF00069	0.543
MOD_NEK2_1	178	183	PF00069	0.500
MOD_NEK2_1	209	214	PF00069	0.575
MOD_NEK2_1	225	230	PF00069	0.298
MOD_NEK2_1	329	334	PF00069	0.459
MOD_NEK2_1	38	43	PF00069	0.306
MOD_NEK2_1	444	449	PF00069	0.449
MOD_NEK2_1	456	461	PF00069	0.366
MOD_NEK2_1	479	484	PF00069	0.525
MOD_NEK2_1	494	499	PF00069	0.346
MOD_NEK2_1	589	594	PF00069	0.366
MOD_NEK2_1	605	610	PF00069	0.515
MOD_NEK2_1	67	72	PF00069	0.432
MOD_NEK2_1	89	94	PF00069	0.505
MOD_NEK2_2	585	590	PF00069	0.298
MOD_NEK2_2	621	626	PF00069	0.270
MOD_OFUCOSY	171	176	PF10250	0.521
MOD_PIKK_1	281	287	PF00454	0.550
MOD_PIKK_1	291	297	PF00454	0.527
MOD_PIKK_1	399	405	PF00454	0.487
MOD_PIKK_1	427	433	PF00454	0.502
MOD_PIKK_1	656	662	PF00454	0.334
MOD_PIKK_1	78	84	PF00454	0.391
MOD_PK_1	461	467	PF00069	0.405
MOD_PKA_2	117	123	PF00069	0.390
MOD_PKA_2	281	287	PF00069	0.531
MOD_PKA_2	507	513	PF00069	0.541
MOD_PKA_2	51	57	PF00069	0.573
MOD_PKA_2	561	567	PF00069	0.429
MOD_PKA_2	67	73	PF00069	0.342
MOD_PKA_2	89	95	PF00069	0.441
MOD_PKB_1	27	35	PF00069	0.585
MOD_Plk_1	157	163	PF00069	0.620
MOD_Plk_1	178	184	PF00069	0.572
MOD_Plk_1	195	201	PF00069	0.480
MOD_Plk_1	219	225	PF00069	0.408
MOD_Plk_1	347	353	PF00069	0.409
MOD_Plk_1	363	369	PF00069	0.356
MOD_Plk_1	445	451	PF00069	0.436
MOD_Plk_1	461	467	PF00069	0.405
MOD_Plk_1	568	574	PF00069	0.391
MOD_Plk_1	70	76	PF00069	0.358
MOD_Plk_1	78	84	PF00069	0.361
MOD_Plk_4	12	18	PF00069	0.654
MOD_Plk_4	140	146	PF00069	0.495
MOD_Plk_4	157	163	PF00069	0.491
MOD_Plk_4	178	184	PF00069	0.572
MOD_Plk_4	219	225	PF00069	0.408
MOD_Plk_4	325	331	PF00069	0.515
MOD_Plk_4	34	40	PF00069	0.395
MOD_Plk_4	363	369	PF00069	0.506
MOD_Plk_4	394	400	PF00069	0.351
MOD_Plk_4	412	418	PF00069	0.442
MOD_Plk_4	445	451	PF00069	0.400
MOD_Plk_4	461	467	PF00069	0.405
MOD_Plk_4	496	502	PF00069	0.373
MOD_Plk_4	585	591	PF00069	0.558
MOD_Plk_4	621	627	PF00069	0.294
MOD_Plk_4	635	641	PF00069	0.294
MOD_Plk_4	97	103	PF00069	0.473
MOD_ProDKin_1	148	154	PF00069	0.494
MOD_ProDKin_1	190	196	PF00069	0.551
MOD_ProDKin_1	198	204	PF00069	0.634
MOD_ProDKin_1	483	489	PF00069	0.482
MOD_ProDKin_1	614	620	PF00069	0.488
MOD_SUMO_for_1	650	653	PF00179	0.410
MOD_SUMO_rev_2	407	415	PF00179	0.585
TRG_DiLeu_BaEn_1	653	658	PF01217	0.419
TRG_DiLeu_LyEn_5	653	658	PF01217	0.408
TRG_ENDOCYTIC_2	251	254	PF00928	0.588
TRG_ENDOCYTIC_2	372	375	PF00928	0.374
TRG_ENDOCYTIC_2	557	560	PF00928	0.422
TRG_ENDOCYTIC_2	590	593	PF00928	0.516
TRG_ENDOCYTIC_2	622	625	PF00928	0.270
TRG_ER_diArg_1	26	29	PF00400	0.578
TRG_ER_diArg_1	643	646	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W1	Leptomonas seymouri	45%	100%
A0A3S5H6U2	Leishmania donovani	82%	100%
A4H809	Leishmania braziliensis	66%	100%
A4HWD7	Leishmania infantum	82%	100%
Q4QFE5	Leishmania major	83%	100%