Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ36_LEIMU

TriTrypDb:

LmxM.15.0340

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.541
CLV_C14_Caspase3-7	236	240	PF00656	0.760
CLV_C14_Caspase3-7	382	386	PF00656	0.768
CLV_C14_Caspase3-7	434	438	PF00656	0.422
CLV_C14_Caspase3-7	452	456	PF00656	0.492
CLV_MEL_PAP_1	308	314	PF00089	0.453
CLV_NRD_NRD_1	138	140	PF00675	0.693
CLV_NRD_NRD_1	14	16	PF00675	0.505
CLV_NRD_NRD_1	203	205	PF00675	0.642
CLV_NRD_NRD_1	212	214	PF00675	0.494
CLV_NRD_NRD_1	278	280	PF00675	0.590
CLV_NRD_NRD_1	281	283	PF00675	0.601
CLV_NRD_NRD_1	319	321	PF00675	0.614
CLV_NRD_NRD_1	333	335	PF00675	0.664
CLV_NRD_NRD_1	399	401	PF00675	0.763
CLV_NRD_NRD_1	407	409	PF00675	0.644
CLV_NRD_NRD_1	43	45	PF00675	0.616
CLV_PCSK_FUR_1	279	283	PF00082	0.643
CLV_PCSK_KEX2_1	138	140	PF00082	0.691
CLV_PCSK_KEX2_1	14	16	PF00082	0.576
CLV_PCSK_KEX2_1	203	205	PF00082	0.648
CLV_PCSK_KEX2_1	212	214	PF00082	0.494
CLV_PCSK_KEX2_1	278	280	PF00082	0.594
CLV_PCSK_KEX2_1	281	283	PF00082	0.597
CLV_PCSK_KEX2_1	332	334	PF00082	0.517
CLV_PCSK_KEX2_1	349	351	PF00082	0.736
CLV_PCSK_KEX2_1	388	390	PF00082	0.588
CLV_PCSK_KEX2_1	399	401	PF00082	0.714
CLV_PCSK_KEX2_1	409	411	PF00082	0.674
CLV_PCSK_KEX2_1	43	45	PF00082	0.628
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.736
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.674
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.640
CLV_PCSK_SKI1_1	334	338	PF00082	0.648
CLV_PCSK_SKI1_1	377	381	PF00082	0.480
CLV_PCSK_SKI1_1	409	413	PF00082	0.600
CLV_PCSK_SKI1_1	6	10	PF00082	0.387
DEG_SCF_FBW7_1	186	193	PF00400	0.523
DOC_CKS1_1	130	135	PF01111	0.494
DOC_CYCLIN_RxL_1	371	384	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	319	325	PF00134	0.734
DOC_MAPK_gen_1	320	326	PF00069	0.617
DOC_MAPK_RevD_3	317	333	PF00069	0.473
DOC_PP2B_LxvP_1	300	303	PF13499	0.450
DOC_SPAK_OSR1_1	15	19	PF12202	0.510
DOC_USP7_MATH_1	121	125	PF00917	0.731
DOC_USP7_MATH_1	153	157	PF00917	0.721
DOC_USP7_MATH_1	233	237	PF00917	0.742
DOC_USP7_MATH_1	257	261	PF00917	0.640
DOC_USP7_MATH_1	265	269	PF00917	0.624
DOC_USP7_MATH_1	325	329	PF00917	0.758
DOC_USP7_MATH_1	363	367	PF00917	0.487
DOC_USP7_MATH_1	431	435	PF00917	0.727
DOC_WW_Pin1_4	114	119	PF00397	0.743
DOC_WW_Pin1_4	129	134	PF00397	0.690
DOC_WW_Pin1_4	186	191	PF00397	0.687
DOC_WW_Pin1_4	248	253	PF00397	0.755
DOC_WW_Pin1_4	26	31	PF00397	0.649
DOC_WW_Pin1_4	33	38	PF00397	0.682
DOC_WW_Pin1_4	361	366	PF00397	0.650
DOC_WW_Pin1_4	484	489	PF00397	0.577
LIG_14-3-3_CanoR_1	123	129	PF00244	0.685
LIG_14-3-3_CanoR_1	138	145	PF00244	0.723
LIG_14-3-3_CanoR_1	159	164	PF00244	0.760
LIG_14-3-3_CanoR_1	177	186	PF00244	0.696
LIG_14-3-3_CanoR_1	287	296	PF00244	0.503
LIG_14-3-3_CanoR_1	299	303	PF00244	0.574
LIG_14-3-3_CanoR_1	332	339	PF00244	0.626
LIG_14-3-3_CanoR_1	356	361	PF00244	0.775
LIG_14-3-3_CanoR_1	410	419	PF00244	0.745
LIG_14-3-3_CanoR_1	43	47	PF00244	0.830
LIG_14-3-3_CanoR_1	66	75	PF00244	0.585
LIG_Actin_WH2_2	166	181	PF00022	0.631
LIG_APCC_ABBA_1	16	21	PF00400	0.643
LIG_APCC_ABBAyCdc20_2	15	21	PF00400	0.641
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_FHA_1	295	301	PF00498	0.477
LIG_FHA_1	446	452	PF00498	0.617
LIG_FHA_1	52	58	PF00498	0.660
LIG_FHA_2	380	386	PF00498	0.763
LIG_FHA_2	450	456	PF00498	0.494
LIG_LIR_Gen_1	122	133	PF02991	0.787
LIG_LIR_Gen_1	61	70	PF02991	0.607
LIG_LIR_Nem_3	122	128	PF02991	0.795
LIG_LIR_Nem_3	61	65	PF02991	0.537
LIG_MYND_1	227	231	PF01753	0.591
LIG_PDZ_Class_1	484	489	PF00595	0.388
LIG_REV1ctd_RIR_1	409	418	PF16727	0.475
LIG_RPA_C_Fungi	276	288	PF08784	0.383
LIG_RPA_C_Fungi	328	340	PF08784	0.503
LIG_SH2_CRK	125	129	PF00017	0.643
LIG_SH2_CRK	323	327	PF00017	0.746
LIG_SH2_NCK_1	125	129	PF00017	0.793
LIG_SH2_SRC	172	175	PF00017	0.644
LIG_SH2_STAP1	19	23	PF00017	0.659
LIG_SH2_STAT5	172	175	PF00017	0.644
LIG_SH2_STAT5	194	197	PF00017	0.529
LIG_SH2_STAT5	64	67	PF00017	0.786
LIG_SH3_2	118	123	PF14604	0.770
LIG_SH3_3	115	121	PF00018	0.736
LIG_SH3_3	127	133	PF00018	0.506
LIG_SH3_3	29	35	PF00018	0.642
LIG_SH3_3	319	325	PF00018	0.734
LIG_WW_3	30	34	PF00397	0.765
MOD_CDK_SPxxK_3	248	255	PF00069	0.489
MOD_CDK_SPxxK_3	26	33	PF00069	0.651
MOD_CK1_1	100	106	PF00069	0.731
MOD_CK1_1	124	130	PF00069	0.793
MOD_CK1_1	244	250	PF00069	0.714
MOD_CK1_1	290	296	PF00069	0.617
MOD_CK1_1	298	304	PF00069	0.712
MOD_CK1_1	315	321	PF00069	0.575
MOD_CK1_1	328	334	PF00069	0.630
MOD_CK1_1	359	365	PF00069	0.771
MOD_CK1_1	413	419	PF00069	0.682
MOD_CK1_1	81	87	PF00069	0.521
MOD_CK2_1	424	430	PF00069	0.693
MOD_DYRK1A_RPxSP_1	33	37	PF00069	0.798
MOD_GlcNHglycan	100	103	PF01048	0.540
MOD_GlcNHglycan	155	158	PF01048	0.690
MOD_GlcNHglycan	179	182	PF01048	0.673
MOD_GlcNHglycan	246	249	PF01048	0.722
MOD_GlcNHglycan	351	354	PF01048	0.684
MOD_GlcNHglycan	361	364	PF01048	0.639
MOD_GlcNHglycan	425	429	PF01048	0.649
MOD_GlcNHglycan	68	71	PF01048	0.727
MOD_GlcNHglycan	83	86	PF01048	0.498
MOD_GlcNHglycan	89	92	PF01048	0.564
MOD_GSK3_1	137	144	PF00069	0.792
MOD_GSK3_1	148	155	PF00069	0.596
MOD_GSK3_1	186	193	PF00069	0.639
MOD_GSK3_1	22	29	PF00069	0.560
MOD_GSK3_1	244	251	PF00069	0.648
MOD_GSK3_1	290	297	PF00069	0.598
MOD_GSK3_1	324	331	PF00069	0.651
MOD_GSK3_1	359	366	PF00069	0.746
MOD_GSK3_1	371	378	PF00069	0.628
MOD_GSK3_1	445	452	PF00069	0.491
MOD_GSK3_1	47	54	PF00069	0.746
MOD_GSK3_1	97	104	PF00069	0.609
MOD_N-GLC_1	244	249	PF02516	0.761
MOD_N-GLC_1	288	293	PF02516	0.705
MOD_NEK2_1	221	226	PF00069	0.395
MOD_NEK2_1	288	293	PF00069	0.638
MOD_NEK2_1	411	416	PF00069	0.754
MOD_NEK2_2	475	480	PF00069	0.440
MOD_PIKK_1	194	200	PF00454	0.511
MOD_PIKK_1	265	271	PF00454	0.662
MOD_PKA_1	138	144	PF00069	0.756
MOD_PKA_1	332	338	PF00069	0.509
MOD_PKA_1	349	355	PF00069	0.743
MOD_PKA_2	137	143	PF00069	0.759
MOD_PKA_2	298	304	PF00069	0.498
MOD_PKA_2	332	338	PF00069	0.634
MOD_PKA_2	349	355	PF00069	0.739
MOD_PKA_2	42	48	PF00069	0.535
MOD_PKA_2	445	451	PF00069	0.466
MOD_PKA_2	65	71	PF00069	0.501
MOD_PKA_2	81	87	PF00069	0.521
MOD_PKB_1	183	191	PF00069	0.551
MOD_PKB_1	332	340	PF00069	0.507
MOD_PKB_1	356	364	PF00069	0.651
MOD_PKB_1	408	416	PF00069	0.632
MOD_Plk_1	190	196	PF00069	0.571
MOD_Plk_1	221	227	PF00069	0.671
MOD_Plk_1	257	263	PF00069	0.599
MOD_Plk_1	424	430	PF00069	0.622
MOD_Plk_4	190	196	PF00069	0.430
MOD_Plk_4	47	53	PF00069	0.530
MOD_ProDKin_1	114	120	PF00069	0.743
MOD_ProDKin_1	129	135	PF00069	0.688
MOD_ProDKin_1	186	192	PF00069	0.678
MOD_ProDKin_1	248	254	PF00069	0.754
MOD_ProDKin_1	26	32	PF00069	0.654
MOD_ProDKin_1	33	39	PF00069	0.681
MOD_ProDKin_1	361	367	PF00069	0.648
MOD_SUMO_rev_2	2	8	PF00179	0.389
MOD_SUMO_rev_2	20	30	PF00179	0.587
MOD_SUMO_rev_2	214	221	PF00179	0.644
TRG_DiLeu_BaEn_1	216	221	PF01217	0.368
TRG_DiLeu_BaEn_1	4	9	PF01217	0.655
TRG_ENDOCYTIC_2	125	128	PF00928	0.796
TRG_ENDOCYTIC_2	19	22	PF00928	0.589
TRG_ENDOCYTIC_2	323	326	PF00928	0.742
TRG_ER_diArg_1	14	16	PF00400	0.471
TRG_ER_diArg_1	202	204	PF00400	0.647
TRG_ER_diArg_1	211	213	PF00400	0.492
TRG_ER_diArg_1	278	281	PF00400	0.604
TRG_ER_diArg_1	332	334	PF00400	0.517
TRG_ER_diArg_1	398	400	PF00400	0.777
TRG_ER_diArg_1	405	408	PF00400	0.644
TRG_NLS_MonoExtN_4	405	412	PF00514	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIM0	Leishmania donovani	79%	99%
A0A3R7M601	Trypanosoma rangeli	28%	100%
A4HWD6	Leishmania infantum	79%	99%
Q4QFE6	Leishmania major	79%	100%
V5DCS2	Trypanosoma cruzi	27%	100%