LeishMANIAdb
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Abhydrolase_3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Abhydrolase_3 domain-containing protein
Gene product:
alpha/beta hydrolase fold, putative
Species:
Leishmania mexicana
UniProt:
E9AQ35_LEIMU
TriTrypDb:
LmxM.15.0330
Length:
989

Annotations

LeishMANIAdb annotations

A hydrolase similar to plant isoprenylcysteine alpha-carbonyl methylesterase (ICME). These might have a very special topology, with 2TMs on the N-terminus.. The family has 2 paralogs in Leishmaniids.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9AQ35
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ35

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016787 hydrolase activity 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 138 142 PF00656 0.707
CLV_C14_Caspase3-7 544 548 PF00656 0.304
CLV_C14_Caspase3-7 933 937 PF00656 0.565
CLV_MEL_PAP_1 60 66 PF00089 0.359
CLV_NRD_NRD_1 121 123 PF00675 0.558
CLV_NRD_NRD_1 212 214 PF00675 0.591
CLV_NRD_NRD_1 300 302 PF00675 0.631
CLV_NRD_NRD_1 304 306 PF00675 0.633
CLV_NRD_NRD_1 394 396 PF00675 0.643
CLV_NRD_NRD_1 403 405 PF00675 0.531
CLV_NRD_NRD_1 407 409 PF00675 0.499
CLV_NRD_NRD_1 429 431 PF00675 0.580
CLV_NRD_NRD_1 488 490 PF00675 0.322
CLV_NRD_NRD_1 62 64 PF00675 0.370
CLV_NRD_NRD_1 673 675 PF00675 0.613
CLV_NRD_NRD_1 727 729 PF00675 0.654
CLV_NRD_NRD_1 736 738 PF00675 0.669
CLV_NRD_NRD_1 743 745 PF00675 0.685
CLV_NRD_NRD_1 779 781 PF00675 0.754
CLV_NRD_NRD_1 92 94 PF00675 0.551
CLV_PCSK_FUR_1 118 122 PF00082 0.560
CLV_PCSK_FUR_1 404 408 PF00082 0.656
CLV_PCSK_FUR_1 486 490 PF00082 0.480
CLV_PCSK_FUR_1 741 745 PF00082 0.675
CLV_PCSK_KEX2_1 118 120 PF00082 0.560
CLV_PCSK_KEX2_1 121 123 PF00082 0.556
CLV_PCSK_KEX2_1 211 213 PF00082 0.589
CLV_PCSK_KEX2_1 304 306 PF00082 0.655
CLV_PCSK_KEX2_1 394 396 PF00082 0.643
CLV_PCSK_KEX2_1 403 405 PF00082 0.531
CLV_PCSK_KEX2_1 406 408 PF00082 0.507
CLV_PCSK_KEX2_1 488 490 PF00082 0.347
CLV_PCSK_KEX2_1 62 64 PF00082 0.370
CLV_PCSK_KEX2_1 673 675 PF00082 0.613
CLV_PCSK_KEX2_1 727 729 PF00082 0.654
CLV_PCSK_KEX2_1 736 738 PF00082 0.669
CLV_PCSK_KEX2_1 743 745 PF00082 0.685
CLV_PCSK_KEX2_1 779 781 PF00082 0.754
CLV_PCSK_PC1ET2_1 490 492 PF00082 0.348
CLV_PCSK_PC7_1 403 409 PF00082 0.586
CLV_PCSK_PC7_1 486 492 PF00082 0.419
CLV_PCSK_PC7_1 723 729 PF00082 0.639
CLV_PCSK_SKI1_1 122 126 PF00082 0.511
CLV_PCSK_SKI1_1 364 368 PF00082 0.529
CLV_PCSK_SKI1_1 693 697 PF00082 0.547
CLV_PCSK_SKI1_1 743 747 PF00082 0.707
CLV_PCSK_SKI1_1 75 79 PF00082 0.453
CLV_PCSK_SKI1_1 89 93 PF00082 0.481
DEG_APCC_DBOX_1 74 82 PF00400 0.650
DEG_APCC_KENBOX_2 438 442 PF00400 0.602
DEG_MDM2_SWIB_1 47 55 PF02201 0.222
DEG_SCF_FBW7_1 214 219 PF00400 0.725
DEG_SPOP_SBC_1 204 208 PF00917 0.848
DEG_SPOP_SBC_1 757 761 PF00917 0.616
DEG_SPOP_SBC_1 794 798 PF00917 0.415
DEG_SPOP_SBC_1 938 942 PF00917 0.482
DOC_CKS1_1 646 651 PF01111 0.386
DOC_CYCLIN_yClb5_NLxxxL_5 437 446 PF00134 0.673
DOC_CYCLIN_yCln2_LP_2 467 473 PF00134 0.556
DOC_CYCLIN_yCln2_LP_2 646 652 PF00134 0.387
DOC_MAPK_gen_1 430 437 PF00069 0.620
DOC_MAPK_gen_1 486 496 PF00069 0.503
DOC_MAPK_gen_1 71 80 PF00069 0.613
DOC_MAPK_gen_1 863 873 PF00069 0.561
DOC_MAPK_JIP1_4 431 437 PF00069 0.618
DOC_MAPK_MEF2A_6 460 467 PF00069 0.553
DOC_MAPK_MEF2A_6 489 498 PF00069 0.504
DOC_MAPK_MEF2A_6 866 875 PF00069 0.525
DOC_PP1_RVXF_1 5 12 PF00149 0.546
DOC_PP2B_LxvP_1 467 470 PF13499 0.560
DOC_PP2B_LxvP_1 876 879 PF13499 0.417
DOC_PP2B_LxvP_1 969 972 PF13499 0.375
DOC_SPAK_OSR1_1 35 39 PF12202 0.338
DOC_USP7_MATH_1 100 104 PF00917 0.582
DOC_USP7_MATH_1 173 177 PF00917 0.756
DOC_USP7_MATH_1 214 218 PF00917 0.812
DOC_USP7_MATH_1 231 235 PF00917 0.621
DOC_USP7_MATH_1 256 260 PF00917 0.770
DOC_USP7_MATH_1 286 290 PF00917 0.843
DOC_USP7_MATH_1 319 323 PF00917 0.834
DOC_USP7_MATH_1 373 377 PF00917 0.725
DOC_USP7_MATH_1 618 622 PF00917 0.351
DOC_USP7_MATH_1 701 705 PF00917 0.422
DOC_USP7_MATH_1 739 743 PF00917 0.463
DOC_USP7_MATH_1 788 792 PF00917 0.416
DOC_USP7_MATH_1 842 846 PF00917 0.472
DOC_USP7_MATH_1 894 898 PF00917 0.350
DOC_USP7_MATH_1 929 933 PF00917 0.541
DOC_USP7_MATH_2 972 978 PF00917 0.421
DOC_USP7_UBL2_3 350 354 PF12436 0.788
DOC_WW_Pin1_4 109 114 PF00397 0.781
DOC_WW_Pin1_4 160 165 PF00397 0.808
DOC_WW_Pin1_4 212 217 PF00397 0.783
DOC_WW_Pin1_4 272 277 PF00397 0.686
DOC_WW_Pin1_4 332 337 PF00397 0.824
DOC_WW_Pin1_4 54 59 PF00397 0.418
DOC_WW_Pin1_4 645 650 PF00397 0.388
DOC_WW_Pin1_4 853 858 PF00397 0.521
LIG_14-3-3_CanoR_1 121 127 PF00244 0.781
LIG_14-3-3_CanoR_1 154 162 PF00244 0.834
LIG_14-3-3_CanoR_1 181 185 PF00244 0.634
LIG_14-3-3_CanoR_1 218 222 PF00244 0.691
LIG_14-3-3_CanoR_1 460 464 PF00244 0.563
LIG_14-3-3_CanoR_1 62 67 PF00244 0.585
LIG_14-3-3_CanoR_1 723 727 PF00244 0.505
LIG_14-3-3_CanoR_1 882 888 PF00244 0.374
LIG_14-3-3_CanoR_1 981 986 PF00244 0.389
LIG_Actin_WH2_2 73 91 PF00022 0.727
LIG_APCC_ABBA_1 695 700 PF00400 0.385
LIG_APCC_ABBA_1 815 820 PF00400 0.406
LIG_APCC_ABBAyCdc20_2 439 445 PF00400 0.605
LIG_BIR_III_4 787 791 PF00653 0.418
LIG_BRCT_BRCA1_1 883 887 PF00533 0.387
LIG_CtBP_PxDLS_1 870 874 PF00389 0.442
LIG_EH1_1 3 11 PF00400 0.616
LIG_EH1_1 631 639 PF00400 0.346
LIG_eIF4E_1 632 638 PF01652 0.343
LIG_FHA_1 12 18 PF00498 0.411
LIG_FHA_1 23 29 PF00498 0.411
LIG_FHA_1 248 254 PF00498 0.801
LIG_FHA_1 460 466 PF00498 0.555
LIG_FHA_1 540 546 PF00498 0.346
LIG_FHA_1 645 651 PF00498 0.394
LIG_FHA_1 676 682 PF00498 0.386
LIG_FHA_1 938 944 PF00498 0.481
LIG_FHA_2 238 244 PF00498 0.768
LIG_FHA_2 534 540 PF00498 0.304
LIG_FHA_2 794 800 PF00498 0.623
LIG_GBD_Chelix_1 501 509 PF00786 0.436
LIG_GBD_Chelix_1 9 17 PF00786 0.438
LIG_LIR_Apic_2 608 614 PF02991 0.426
LIG_LIR_Gen_1 163 173 PF02991 0.768
LIG_LIR_Gen_1 195 204 PF02991 0.634
LIG_LIR_Gen_1 440 450 PF02991 0.793
LIG_LIR_Gen_1 507 518 PF02991 0.355
LIG_LIR_Gen_1 684 695 PF02991 0.379
LIG_LIR_Gen_1 872 879 PF02991 0.348
LIG_LIR_Nem_3 163 168 PF02991 0.761
LIG_LIR_Nem_3 195 201 PF02991 0.632
LIG_LIR_Nem_3 440 446 PF02991 0.795
LIG_LIR_Nem_3 49 55 PF02991 0.222
LIG_LIR_Nem_3 529 533 PF02991 0.304
LIG_LIR_Nem_3 684 690 PF02991 0.380
LIG_LIR_Nem_3 72 77 PF02991 0.516
LIG_LIR_Nem_3 872 878 PF02991 0.362
LIG_Pex14_2 47 51 PF04695 0.389
LIG_SH2_CRK 349 353 PF00017 0.755
LIG_SH2_CRK 611 615 PF00017 0.388
LIG_SH2_NCK_1 198 202 PF00017 0.762
LIG_SH2_PTP2 625 628 PF00017 0.330
LIG_SH2_SRC 198 201 PF00017 0.764
LIG_SH2_SRC 652 655 PF00017 0.398
LIG_SH2_STAP1 664 668 PF00017 0.384
LIG_SH2_STAP1 906 910 PF00017 0.436
LIG_SH2_STAT3 480 483 PF00017 0.733
LIG_SH2_STAT3 830 833 PF00017 0.475
LIG_SH2_STAT5 480 483 PF00017 0.628
LIG_SH2_STAT5 523 526 PF00017 0.304
LIG_SH2_STAT5 54 57 PF00017 0.434
LIG_SH2_STAT5 625 628 PF00017 0.330
LIG_SH2_STAT5 669 672 PF00017 0.362
LIG_SH2_STAT5 724 727 PF00017 0.420
LIG_SH3_2 300 305 PF14604 0.800
LIG_SH3_3 107 113 PF00018 0.804
LIG_SH3_3 297 303 PF00018 0.804
LIG_SH3_3 379 385 PF00018 0.696
LIG_SH3_3 522 528 PF00018 0.304
LIG_SH3_3 600 606 PF00018 0.461
LIG_SH3_3 854 860 PF00018 0.572
LIG_SH3_3 864 870 PF00018 0.582
LIG_SH3_3 982 988 PF00018 0.284
LIG_SUMO_SIM_anti_2 462 467 PF11976 0.585
LIG_SUMO_SIM_anti_2 845 851 PF11976 0.394
LIG_SUMO_SIM_par_1 492 497 PF11976 0.353
LIG_SUMO_SIM_par_1 541 547 PF11976 0.304
LIG_SUMO_SIM_par_1 848 854 PF11976 0.395
LIG_TRAF2_1 322 325 PF00917 0.840
LIG_TRAF2_1 369 372 PF00917 0.617
LIG_TRAF2_1 719 722 PF00917 0.408
LIG_TYR_ITIM 347 352 PF00017 0.726
MOD_CDC14_SPxK_1 335 338 PF00782 0.764
MOD_CDK_SPxK_1 212 218 PF00069 0.668
MOD_CDK_SPxK_1 332 338 PF00069 0.772
MOD_CK1_1 163 169 PF00069 0.794
MOD_CK1_1 202 208 PF00069 0.758
MOD_CK1_1 217 223 PF00069 0.531
MOD_CK1_1 274 280 PF00069 0.679
MOD_CK1_1 289 295 PF00069 0.832
MOD_CK1_1 376 382 PF00069 0.756
MOD_CK1_1 581 587 PF00069 0.400
MOD_CK1_1 65 71 PF00069 0.467
MOD_CK1_1 759 765 PF00069 0.762
MOD_CK1_1 771 777 PF00069 0.609
MOD_CK1_1 845 851 PF00069 0.694
MOD_CK1_1 930 936 PF00069 0.794
MOD_CK1_1 937 943 PF00069 0.689
MOD_CK2_1 194 200 PF00069 0.744
MOD_CK2_1 237 243 PF00069 0.724
MOD_CK2_1 319 325 PF00069 0.707
MOD_CK2_1 533 539 PF00069 0.353
MOD_CK2_1 793 799 PF00069 0.796
MOD_CK2_1 912 918 PF00069 0.556
MOD_DYRK1A_RPxSP_1 109 113 PF00069 0.526
MOD_GlcNHglycan 14 17 PF01048 0.411
MOD_GlcNHglycan 172 176 PF01048 0.741
MOD_GlcNHglycan 233 236 PF01048 0.745
MOD_GlcNHglycan 257 261 PF01048 0.730
MOD_GlcNHglycan 292 295 PF01048 0.844
MOD_GlcNHglycan 327 330 PF01048 0.805
MOD_GlcNHglycan 388 391 PF01048 0.775
MOD_GlcNHglycan 408 411 PF01048 0.818
MOD_GlcNHglycan 497 501 PF01048 0.513
MOD_GlcNHglycan 571 574 PF01048 0.353
MOD_GlcNHglycan 588 591 PF01048 0.414
MOD_GlcNHglycan 628 631 PF01048 0.388
MOD_GlcNHglycan 702 706 PF01048 0.473
MOD_GlcNHglycan 709 712 PF01048 0.413
MOD_GlcNHglycan 728 731 PF01048 0.646
MOD_GlcNHglycan 790 793 PF01048 0.723
MOD_GlcNHglycan 914 917 PF01048 0.659
MOD_GlcNHglycan 929 932 PF01048 0.772
MOD_GlcNHglycan 943 946 PF01048 0.569
MOD_GSK3_1 133 140 PF00069 0.730
MOD_GSK3_1 160 167 PF00069 0.714
MOD_GSK3_1 180 187 PF00069 0.496
MOD_GSK3_1 199 206 PF00069 0.771
MOD_GSK3_1 212 219 PF00069 0.647
MOD_GSK3_1 226 233 PF00069 0.584
MOD_GSK3_1 256 263 PF00069 0.695
MOD_GSK3_1 272 279 PF00069 0.756
MOD_GSK3_1 286 293 PF00069 0.617
MOD_GSK3_1 376 383 PF00069 0.837
MOD_GSK3_1 474 481 PF00069 0.538
MOD_GSK3_1 504 511 PF00069 0.411
MOD_GSK3_1 539 546 PF00069 0.411
MOD_GSK3_1 62 69 PF00069 0.451
MOD_GSK3_1 701 708 PF00069 0.496
MOD_GSK3_1 722 729 PF00069 0.644
MOD_GSK3_1 757 764 PF00069 0.719
MOD_GSK3_1 771 778 PF00069 0.618
MOD_GSK3_1 914 921 PF00069 0.661
MOD_GSK3_1 930 937 PF00069 0.807
MOD_N-GLC_1 564 569 PF02516 0.411
MOD_NEK2_1 12 17 PF00069 0.411
MOD_NEK2_1 203 208 PF00069 0.761
MOD_NEK2_1 478 483 PF00069 0.539
MOD_NEK2_1 509 514 PF00069 0.411
MOD_NEK2_1 726 731 PF00069 0.599
MOD_NEK2_1 822 827 PF00069 0.771
MOD_NEK2_1 912 917 PF00069 0.517
MOD_NEK2_1 934 939 PF00069 0.706
MOD_NEK2_2 164 169 PF00069 0.717
MOD_NEK2_2 618 623 PF00069 0.422
MOD_NEK2_2 662 667 PF00069 0.426
MOD_OFUCOSY 891 898 PF10250 0.477
MOD_PIKK_1 154 160 PF00454 0.715
MOD_PIKK_1 205 211 PF00454 0.764
MOD_PIKK_1 295 301 PF00454 0.777
MOD_PIKK_1 380 386 PF00454 0.848
MOD_PIKK_1 478 484 PF00454 0.534
MOD_PIKK_1 581 587 PF00454 0.353
MOD_PIKK_1 98 104 PF00454 0.655
MOD_PK_1 93 99 PF00069 0.607
MOD_PKA_1 406 412 PF00069 0.682
MOD_PKA_1 62 68 PF00069 0.451
MOD_PKA_1 93 99 PF00069 0.607
MOD_PKA_2 108 114 PF00069 0.525
MOD_PKA_2 180 186 PF00069 0.534
MOD_PKA_2 192 198 PF00069 0.818
MOD_PKA_2 217 223 PF00069 0.621
MOD_PKA_2 406 412 PF00069 0.789
MOD_PKA_2 459 465 PF00069 0.447
MOD_PKA_2 618 624 PF00069 0.419
MOD_PKA_2 62 68 PF00069 0.451
MOD_PKA_2 662 668 PF00069 0.463
MOD_PKA_2 722 728 PF00069 0.555
MOD_PKA_2 845 851 PF00069 0.595
MOD_PKA_2 881 887 PF00069 0.447
MOD_PKB_1 120 128 PF00069 0.634
MOD_PKB_1 404 412 PF00069 0.743
MOD_Plk_1 152 158 PF00069 0.740
MOD_Plk_1 199 205 PF00069 0.756
MOD_Plk_1 376 382 PF00069 0.756
MOD_Plk_1 564 570 PF00069 0.353
MOD_Plk_1 906 912 PF00069 0.590
MOD_Plk_1 974 980 PF00069 0.434
MOD_Plk_2-3 194 200 PF00069 0.744
MOD_Plk_2-3 539 545 PF00069 0.411
MOD_Plk_4 199 205 PF00069 0.752
MOD_Plk_4 217 223 PF00069 0.760
MOD_Plk_4 509 515 PF00069 0.362
MOD_Plk_4 564 570 PF00069 0.381
MOD_Plk_4 575 581 PF00069 0.312
MOD_Plk_4 709 715 PF00069 0.588
MOD_Plk_4 845 851 PF00069 0.668
MOD_Plk_4 934 940 PF00069 0.786
MOD_Plk_4 981 987 PF00069 0.474
MOD_ProDKin_1 109 115 PF00069 0.741
MOD_ProDKin_1 160 166 PF00069 0.777
MOD_ProDKin_1 212 218 PF00069 0.746
MOD_ProDKin_1 272 278 PF00069 0.608
MOD_ProDKin_1 332 338 PF00069 0.801
MOD_ProDKin_1 54 60 PF00069 0.412
MOD_ProDKin_1 645 651 PF00069 0.462
MOD_ProDKin_1 853 859 PF00069 0.660
TRG_DiLeu_BaEn_1 709 714 PF01217 0.587
TRG_DiLeu_BaEn_1 872 877 PF01217 0.598
TRG_DiLeu_BaLyEn_6 741 746 PF01217 0.595
TRG_ENDOCYTIC_2 198 201 PF00928 0.542
TRG_ENDOCYTIC_2 349 352 PF00928 0.726
TRG_ENDOCYTIC_2 523 526 PF00928 0.353
TRG_ENDOCYTIC_2 530 533 PF00928 0.353
TRG_ENDOCYTIC_2 625 628 PF00928 0.373
TRG_ER_diArg_1 118 121 PF00400 0.710
TRG_ER_diArg_1 211 213 PF00400 0.752
TRG_ER_diArg_1 266 269 PF00400 0.756
TRG_ER_diArg_1 303 305 PF00400 0.843
TRG_ER_diArg_1 393 395 PF00400 0.772
TRG_ER_diArg_1 403 406 PF00400 0.738
TRG_ER_diArg_1 486 489 PF00400 0.549
TRG_ER_diArg_1 61 63 PF00400 0.440
TRG_ER_diArg_1 726 728 PF00400 0.490
TRG_ER_diArg_1 741 744 PF00400 0.612
TRG_NLS_MonoCore_2 300 305 PF00514 0.669
TRG_NLS_MonoExtC_3 300 305 PF00514 0.669
TRG_NLS_MonoExtC_3 488 493 PF00514 0.345
TRG_NLS_MonoExtN_4 300 305 PF00514 0.669
TRG_NLS_MonoExtN_4 486 493 PF00514 0.353
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.745
TRG_Pf-PMV_PEXEL_1 516 520 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 79 84 PF00026 0.553

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P440 Leptomonas seymouri 52% 85%
A0A3S5H6U1 Leishmania donovani 86% 97%
A4H807 Leishmania braziliensis 67% 100%
A4HWD5 Leishmania infantum 86% 97%
Q4QFE7 Leishmania major 85% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS