Abhydrolase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isoprenylcysteine alpha-carbonyl methylesterase, putative

Species:

Leishmania mexicana

UniProt:

E9AQ34_LEIMU

TriTrypDb:

LmxM.15.0320

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AQ34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ34

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.745
CLV_C14_Caspase3-7	379	383	PF00656	0.254
CLV_C14_Caspase3-7	589	593	PF00656	0.373
CLV_C14_Caspase3-7	702	706	PF00656	0.461
CLV_MEL_PAP_1	64	70	PF00089	0.330
CLV_NRD_NRD_1	280	282	PF00675	0.417
CLV_NRD_NRD_1	318	320	PF00675	0.498
CLV_NRD_NRD_1	323	325	PF00675	0.273
CLV_NRD_NRD_1	478	480	PF00675	0.439
CLV_NRD_NRD_1	508	510	PF00675	0.481
CLV_NRD_NRD_1	619	621	PF00675	0.627
CLV_NRD_NRD_1	66	68	PF00675	0.316
CLV_PCSK_KEX2_1	317	319	PF00082	0.616
CLV_PCSK_KEX2_1	325	327	PF00082	0.297
CLV_PCSK_KEX2_1	478	480	PF00082	0.439
CLV_PCSK_KEX2_1	508	510	PF00082	0.479
CLV_PCSK_KEX2_1	619	621	PF00082	0.627
CLV_PCSK_KEX2_1	66	68	PF00082	0.316
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.532
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.177
CLV_PCSK_SKI1_1	181	185	PF00082	0.395
CLV_PCSK_SKI1_1	32	36	PF00082	0.554
CLV_PCSK_SKI1_1	39	43	PF00082	0.445
CLV_PCSK_SKI1_1	483	487	PF00082	0.454
CLV_PCSK_SKI1_1	528	532	PF00082	0.476
CLV_PCSK_SKI1_1	576	580	PF00082	0.591
DEG_APCC_DBOX_1	210	218	PF00400	0.599
DEG_APCC_DBOX_1	482	490	PF00400	0.279
DEG_APCC_DBOX_1	716	724	PF00400	0.453
DEG_SCF_FBW7_1	230	237	PF00400	0.622
DOC_CYCLIN_yClb5_NLxxxL_5	77	85	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	574	580	PF00134	0.401
DOC_MAPK_DCC_7	572	580	PF00069	0.413
DOC_MAPK_gen_1	179	186	PF00069	0.592
DOC_MAPK_gen_1	321	331	PF00069	0.454
DOC_MAPK_gen_1	77	86	PF00069	0.515
DOC_MAPK_HePTP_8	256	268	PF00069	0.524
DOC_MAPK_MEF2A_6	259	268	PF00069	0.506
DOC_MAPK_MEF2A_6	324	333	PF00069	0.454
DOC_PP1_RVXF_1	37	44	PF00149	0.279
DOC_PP2B_LxvP_1	266	269	PF13499	0.514
DOC_USP7_MATH_1	107	111	PF00917	0.754
DOC_USP7_MATH_1	216	220	PF00917	0.778
DOC_USP7_MATH_1	221	225	PF00917	0.670
DOC_USP7_MATH_1	234	238	PF00917	0.729
DOC_USP7_MATH_1	269	273	PF00917	0.602
DOC_USP7_MATH_1	453	457	PF00917	0.282
DOC_USP7_MATH_1	536	540	PF00917	0.279
DOC_USP7_MATH_1	644	648	PF00917	0.567
DOC_USP7_MATH_1	653	657	PF00917	0.520
DOC_USP7_MATH_1	662	666	PF00917	0.428
DOC_USP7_UBL2_3	317	321	PF12436	0.784
DOC_USP7_UBL2_3	572	576	PF12436	0.436
DOC_WW_Pin1_4	103	108	PF00397	0.623
DOC_WW_Pin1_4	114	119	PF00397	0.618
DOC_WW_Pin1_4	126	131	PF00397	0.716
DOC_WW_Pin1_4	230	235	PF00397	0.697
DOC_WW_Pin1_4	295	300	PF00397	0.718
DOC_WW_Pin1_4	58	63	PF00397	0.370
DOC_WW_Pin1_4	679	684	PF00397	0.511
DOC_WW_Pin1_4	707	712	PF00397	0.401
LIG_14-3-3_CanoR_1	148	155	PF00244	0.703
LIG_14-3-3_CanoR_1	179	186	PF00244	0.670
LIG_14-3-3_CanoR_1	259	263	PF00244	0.530
LIG_14-3-3_CanoR_1	281	289	PF00244	0.635
LIG_14-3-3_CanoR_1	39	44	PF00244	0.316
LIG_14-3-3_CanoR_1	498	502	PF00244	0.332
LIG_14-3-3_CanoR_1	627	631	PF00244	0.423
LIG_14-3-3_CanoR_1	648	653	PF00244	0.527
LIG_14-3-3_CanoR_1	66	71	PF00244	0.560
LIG_14-3-3_CanoR_1	693	697	PF00244	0.466
LIG_14-3-3_CanoR_1	99	104	PF00244	0.607
LIG_APCC_ABBA_1	530	535	PF00400	0.279
LIG_APCC_ABBAyCdc20_2	478	484	PF00400	0.274
LIG_BRCT_BRCA1_1	463	467	PF00533	0.274
LIG_CaM_IQ_9	194	209	PF13499	0.695
LIG_Clathr_ClatBox_1	671	675	PF01394	0.458
LIG_CSL_BTD_1	104	107	PF09270	0.623
LIG_CtBP_PxDLS_1	229	233	PF00389	0.604
LIG_EH1_1	466	474	PF00400	0.254
LIG_eIF4E_1	343	349	PF01652	0.385
LIG_FHA_1	231	237	PF00498	0.665
LIG_FHA_1	259	265	PF00498	0.505
LIG_FHA_1	375	381	PF00498	0.321
LIG_FHA_1	43	49	PF00498	0.230
LIG_FHA_1	511	517	PF00498	0.254
LIG_FHA_1	589	595	PF00498	0.335
LIG_FHA_1	647	653	PF00498	0.511
LIG_FHA_1	693	699	PF00498	0.462
LIG_FHA_1	73	79	PF00498	0.638
LIG_FHA_2	240	246	PF00498	0.738
LIG_FHA_2	302	308	PF00498	0.623
LIG_FHA_2	369	375	PF00498	0.254
LIG_FHA_2	587	593	PF00498	0.385
LIG_FHA_2	700	706	PF00498	0.463
LIG_LIR_Apic_2	47	53	PF02991	0.291
LIG_LIR_Apic_2	691	697	PF02991	0.512
LIG_LIR_Apic_2	725	729	PF02991	0.418
LIG_LIR_Gen_1	42	51	PF02991	0.385
LIG_LIR_Gen_1	5	14	PF02991	0.538
LIG_LIR_Gen_1	519	530	PF02991	0.293
LIG_LIR_Gen_1	579	588	PF02991	0.325
LIG_LIR_Nem_3	263	268	PF02991	0.497
LIG_LIR_Nem_3	364	368	PF02991	0.254
LIG_LIR_Nem_3	5	9	PF02991	0.545
LIG_LIR_Nem_3	519	525	PF02991	0.293
LIG_LIR_Nem_3	579	585	PF02991	0.321
LIG_LIR_Nem_3	607	611	PF02991	0.357
LIG_LIR_Nem_3	695	699	PF02991	0.498
LIG_LRP6_Inhibitor_1	60	66	PF00058	0.331
LIG_NRBOX	80	86	PF00104	0.647
LIG_PCNA_TLS_4	259	266	PF02747	0.503
LIG_PCNA_yPIPBox_3	346	356	PF02747	0.321
LIG_Pex14_2	186	190	PF04695	0.653
LIG_Pex14_2	6	10	PF04695	0.599
LIG_PTB_Apo_2	235	242	PF02174	0.702
LIG_SH2_CRK	446	450	PF00017	0.277
LIG_SH2_CRK	694	698	PF00017	0.498
LIG_SH2_PTP2	460	463	PF00017	0.254
LIG_SH2_PTP2	582	585	PF00017	0.340
LIG_SH2_PTP2	726	729	PF00017	0.418
LIG_SH2_SRC	265	268	PF00017	0.501
LIG_SH2_SRC	487	490	PF00017	0.279
LIG_SH2_STAP1	499	503	PF00017	0.321
LIG_SH2_STAT3	8	11	PF00017	0.526
LIG_SH2_STAT5	265	268	PF00017	0.529
LIG_SH2_STAT5	343	346	PF00017	0.351
LIG_SH2_STAT5	358	361	PF00017	0.203
LIG_SH2_STAT5	460	463	PF00017	0.254
LIG_SH2_STAT5	499	502	PF00017	0.265
LIG_SH2_STAT5	50	53	PF00017	0.291
LIG_SH2_STAT5	504	507	PF00017	0.243
LIG_SH2_STAT5	550	553	PF00017	0.351
LIG_SH2_STAT5	58	61	PF00017	0.363
LIG_SH2_STAT5	582	585	PF00017	0.340
LIG_SH2_STAT5	694	697	PF00017	0.563
LIG_SH2_STAT5	726	729	PF00017	0.425
LIG_SH2_STAT5	8	11	PF00017	0.526
LIG_SH3_1	694	700	PF00018	0.499
LIG_SH3_3	129	135	PF00018	0.747
LIG_SH3_3	223	229	PF00018	0.731
LIG_SH3_3	357	363	PF00018	0.254
LIG_SH3_3	435	441	PF00018	0.321
LIG_SH3_3	694	700	PF00018	0.499
LIG_SH3_3	708	714	PF00018	0.471
LIG_SUMO_SIM_par_1	228	233	PF11976	0.665
LIG_SUMO_SIM_par_1	327	332	PF11976	0.291
LIG_SUMO_SIM_par_1	376	382	PF11976	0.254
LIG_TRFH_1	58	62	PF08558	0.466
LIG_TRFH_1	582	586	PF08558	0.322
LIG_TYR_ITIM	609	614	PF00017	0.407
LIG_UBA3_1	23	32	PF00899	0.291
LIG_UBA3_1	273	282	PF00899	0.578
LIG_UBA3_1	671	679	PF00899	0.409
LIG_Vh1_VBS_1	34	52	PF01044	0.179
MOD_CDK_SPK_2	295	300	PF00069	0.659
MOD_CK1_1	106	112	PF00069	0.691
MOD_CK1_1	119	125	PF00069	0.682
MOD_CK1_1	126	132	PF00069	0.623
MOD_CK1_1	174	180	PF00069	0.727
MOD_CK1_1	237	243	PF00069	0.751
MOD_CK1_1	283	289	PF00069	0.659
MOD_CK1_1	416	422	PF00069	0.274
MOD_CK1_1	647	653	PF00069	0.542
MOD_CK1_1	656	662	PF00069	0.567
MOD_CK1_1	69	75	PF00069	0.548
MOD_CK1_1	715	721	PF00069	0.515
MOD_CK1_1	90	96	PF00069	0.618
MOD_CK2_1	107	113	PF00069	0.624
MOD_CK2_1	216	222	PF00069	0.747
MOD_CK2_1	241	247	PF00069	0.751
MOD_CK2_1	301	307	PF00069	0.622
MOD_CK2_1	368	374	PF00069	0.254
MOD_CK2_1	590	596	PF00069	0.375
MOD_GlcNHglycan	118	121	PF01048	0.603
MOD_GlcNHglycan	125	128	PF01048	0.551
MOD_GlcNHglycan	150	153	PF01048	0.423
MOD_GlcNHglycan	406	409	PF01048	0.467
MOD_GlcNHglycan	423	426	PF01048	0.471
MOD_GlcNHglycan	463	466	PF01048	0.461
MOD_GlcNHglycan	537	541	PF01048	0.467
MOD_GlcNHglycan	544	547	PF01048	0.467
MOD_GlcNHglycan	655	658	PF01048	0.805
MOD_GlcNHglycan	663	667	PF01048	0.711
MOD_GlcNHglycan	688	691	PF01048	0.592
MOD_GSK3_1	119	126	PF00069	0.735
MOD_GSK3_1	182	189	PF00069	0.664
MOD_GSK3_1	216	223	PF00069	0.685
MOD_GSK3_1	230	237	PF00069	0.712
MOD_GSK3_1	374	381	PF00069	0.339
MOD_GSK3_1	536	543	PF00069	0.279
MOD_GSK3_1	586	593	PF00069	0.398
MOD_GSK3_1	622	629	PF00069	0.389
MOD_GSK3_1	644	651	PF00069	0.563
MOD_GSK3_1	652	659	PF00069	0.612
MOD_GSK3_1	66	73	PF00069	0.548
MOD_GSK3_1	675	682	PF00069	0.511
MOD_GSK3_1	99	106	PF00069	0.670
MOD_LATS_1	646	652	PF00433	0.526
MOD_N-GLC_1	186	191	PF02516	0.494
MOD_N-GLC_1	237	242	PF02516	0.536
MOD_N-GLC_1	399	404	PF02516	0.521
MOD_NEK2_1	16	21	PF00069	0.364
MOD_NEK2_1	34	39	PF00069	0.404
MOD_NEK2_1	652	657	PF00069	0.502
MOD_NEK2_2	269	274	PF00069	0.602
MOD_NEK2_2	453	458	PF00069	0.281
MOD_PIKK_1	171	177	PF00454	0.605
MOD_PIKK_1	202	208	PF00454	0.722
MOD_PIKK_1	221	227	PF00454	0.779
MOD_PIKK_1	416	422	PF00454	0.254
MOD_PKA_1	66	72	PF00069	0.547
MOD_PKA_2	142	148	PF00069	0.702
MOD_PKA_2	258	264	PF00069	0.532
MOD_PKA_2	280	286	PF00069	0.681
MOD_PKA_2	453	459	PF00069	0.265
MOD_PKA_2	497	503	PF00069	0.279
MOD_PKA_2	626	632	PF00069	0.505
MOD_PKA_2	647	653	PF00069	0.525
MOD_PKA_2	66	72	PF00069	0.526
MOD_PKA_2	692	698	PF00069	0.464
MOD_PKA_2	73	79	PF00069	0.566
MOD_PKA_2	90	96	PF00069	0.509
MOD_PKA_2	98	104	PF00069	0.579
MOD_Plk_1	186	192	PF00069	0.727
MOD_Plk_1	221	227	PF00069	0.635
MOD_Plk_1	237	243	PF00069	0.756
MOD_Plk_1	399	405	PF00069	0.254
MOD_Plk_2-3	142	148	PF00069	0.686
MOD_Plk_2-3	239	245	PF00069	0.743
MOD_Plk_2-3	280	286	PF00069	0.619
MOD_Plk_2-3	374	380	PF00069	0.321
MOD_Plk_4	119	125	PF00069	0.593
MOD_Plk_4	156	162	PF00069	0.694
MOD_Plk_4	269	275	PF00069	0.616
MOD_Plk_4	399	405	PF00069	0.266
MOD_Plk_4	410	416	PF00069	0.236
MOD_Plk_4	468	474	PF00069	0.179
MOD_Plk_4	590	596	PF00069	0.428
MOD_Plk_4	722	728	PF00069	0.410
MOD_Plk_4	99	105	PF00069	0.566
MOD_ProDKin_1	103	109	PF00069	0.624
MOD_ProDKin_1	114	120	PF00069	0.619
MOD_ProDKin_1	126	132	PF00069	0.718
MOD_ProDKin_1	230	236	PF00069	0.697
MOD_ProDKin_1	295	301	PF00069	0.719
MOD_ProDKin_1	58	64	PF00069	0.364
MOD_ProDKin_1	679	685	PF00069	0.511
MOD_ProDKin_1	707	713	PF00069	0.406
MOD_SUMO_rev_2	278	283	PF00179	0.558
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.606
TRG_ENDOCYTIC_2	265	268	PF00928	0.501
TRG_ENDOCYTIC_2	358	361	PF00928	0.254
TRG_ENDOCYTIC_2	365	368	PF00928	0.254
TRG_ENDOCYTIC_2	460	463	PF00928	0.270
TRG_ENDOCYTIC_2	482	485	PF00928	0.254
TRG_ENDOCYTIC_2	582	585	PF00928	0.340
TRG_ENDOCYTIC_2	611	614	PF00928	0.422
TRG_ER_diArg_1	201	204	PF00400	0.743
TRG_ER_diArg_1	324	327	PF00400	0.521
TRG_ER_diArg_1	65	67	PF00400	0.515
TRG_NLS_MonoExtC_3	316	321	PF00514	0.791
TRG_NLS_MonoExtC_3	323	328	PF00514	0.391
TRG_NLS_MonoExtN_4	314	321	PF00514	0.783
TRG_Pf-PMV_PEXEL_1	479	484	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ74	Leptomonas seymouri	65%	100%
A0A1X0NTZ0	Trypanosomatidae	42%	100%
A0A3Q8IC72	Leishmania donovani	89%	96%
A0A3R7K197	Trypanosoma rangeli	49%	100%
A4H806	Leishmania braziliensis	78%	100%
A4HWD4	Leishmania infantum	89%	96%
Q4QFE8	Leishmania major	89%	100%