Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ33_LEIMU

TriTrypDb:

LmxM.15.0310

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.680
CLV_NRD_NRD_1	192	194	PF00675	0.788
CLV_NRD_NRD_1	287	289	PF00675	0.734
CLV_NRD_NRD_1	43	45	PF00675	0.592
CLV_PCSK_FUR_1	190	194	PF00082	0.781
CLV_PCSK_KEX2_1	192	194	PF00082	0.788
CLV_PCSK_KEX2_1	287	289	PF00082	0.734
CLV_PCSK_KEX2_1	43	45	PF00082	0.592
CLV_PCSK_KEX2_1	468	470	PF00082	0.764
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.744
CLV_PCSK_SKI1_1	219	223	PF00082	0.701
CLV_PCSK_SKI1_1	287	291	PF00082	0.616
CLV_PCSK_SKI1_1	43	47	PF00082	0.753
CLV_PCSK_SKI1_1	636	640	PF00082	0.614
DEG_APCC_DBOX_1	635	643	PF00400	0.722
DEG_ODPH_VHL_1	581	592	PF01847	0.738
DEG_SPOP_SBC_1	277	281	PF00917	0.706
DEG_SPOP_SBC_1	282	286	PF00917	0.649
DOC_MAPK_gen_1	375	384	PF00069	0.653
DOC_MAPK_MEF2A_6	377	386	PF00069	0.657
DOC_PP1_RVXF_1	639	645	PF00149	0.640
DOC_PP2B_LxvP_1	51	54	PF13499	0.642
DOC_PP2B_LxvP_1	575	578	PF13499	0.630
DOC_PP2B_LxvP_1	622	625	PF13499	0.691
DOC_USP7_MATH_1	119	123	PF00917	0.686
DOC_USP7_MATH_1	143	147	PF00917	0.739
DOC_USP7_MATH_1	200	204	PF00917	0.706
DOC_USP7_MATH_1	234	238	PF00917	0.602
DOC_USP7_MATH_1	277	281	PF00917	0.763
DOC_USP7_MATH_1	306	310	PF00917	0.652
DOC_USP7_MATH_1	318	322	PF00917	0.546
DOC_USP7_MATH_1	348	352	PF00917	0.722
DOC_USP7_MATH_1	404	408	PF00917	0.833
DOC_USP7_MATH_1	518	522	PF00917	0.537
DOC_USP7_MATH_1	566	570	PF00917	0.752
DOC_WW_Pin1_4	117	122	PF00397	0.664
DOC_WW_Pin1_4	132	137	PF00397	0.529
DOC_WW_Pin1_4	438	443	PF00397	0.810
DOC_WW_Pin1_4	471	476	PF00397	0.764
DOC_WW_Pin1_4	489	494	PF00397	0.773
LIG_14-3-3_CanoR_1	233	241	PF00244	0.736
LIG_14-3-3_CanoR_1	267	275	PF00244	0.658
LIG_14-3-3_CanoR_1	319	327	PF00244	0.601
LIG_14-3-3_CanoR_1	34	42	PF00244	0.602
LIG_14-3-3_CanoR_1	349	358	PF00244	0.831
LIG_14-3-3_CanoR_1	375	384	PF00244	0.731
LIG_14-3-3_CanoR_1	5	15	PF00244	0.650
LIG_14-3-3_CanoR_1	594	601	PF00244	0.598
LIG_Actin_WH2_2	160	176	PF00022	0.670
LIG_Actin_WH2_2	621	638	PF00022	0.759
LIG_AP_GAE_1	526	532	PF02883	0.654
LIG_BIR_II_1	1	5	PF00653	0.756
LIG_EH_1	628	632	PF12763	0.580
LIG_FHA_1	351	357	PF00498	0.757
LIG_FHA_1	377	383	PF00498	0.642
LIG_FHA_1	510	516	PF00498	0.830
LIG_FHA_2	156	162	PF00498	0.537
LIG_FHA_2	465	471	PF00498	0.546
LIG_LIR_Apic_2	239	244	PF02991	0.713
LIG_LIR_Gen_1	152	160	PF02991	0.647
LIG_LIR_Gen_1	526	536	PF02991	0.675
LIG_LIR_Nem_3	152	156	PF02991	0.650
LIG_LIR_Nem_3	526	532	PF02991	0.682
LIG_Pex14_2	644	648	PF04695	0.726
LIG_PTAP_UEV_1	194	199	PF05743	0.714
LIG_RPA_C_Fungi	530	542	PF08784	0.677
LIG_SH2_CRK	153	157	PF00017	0.646
LIG_SH2_CRK	241	245	PF00017	0.707
LIG_SH2_NCK_1	241	245	PF00017	0.707
LIG_SH2_STAP1	325	329	PF00017	0.734
LIG_SH2_STAP1	645	649	PF00017	0.655
LIG_SH2_STAT5	241	244	PF00017	0.808
LIG_SH2_STAT5	643	646	PF00017	0.581
LIG_SH3_1	192	198	PF00018	0.710
LIG_SH3_3	11	17	PF00018	0.739
LIG_SH3_3	192	198	PF00018	0.668
LIG_SH3_3	242	248	PF00018	0.789
LIG_SH3_3	398	404	PF00018	0.739
LIG_SH3_3	451	457	PF00018	0.739
LIG_SH3_3	484	490	PF00018	0.830
LIG_SH3_3	571	577	PF00018	0.732
LIG_SH3_3	64	70	PF00018	0.822
LIG_TRAF2_1	168	171	PF00917	0.671
LIG_TRAF2_1	406	409	PF00917	0.652
LIG_TRFH_1	104	108	PF08558	0.611
LIG_WW_3	346	350	PF00397	0.813
MOD_CDK_SPxK_1	471	477	PF00069	0.767
MOD_CK1_1	209	215	PF00069	0.763
MOD_CK1_1	246	252	PF00069	0.688
MOD_CK1_1	270	276	PF00069	0.712
MOD_CK1_1	281	287	PF00069	0.688
MOD_CK1_1	308	314	PF00069	0.749
MOD_CK1_1	321	327	PF00069	0.552
MOD_CK1_1	350	356	PF00069	0.754
MOD_CK1_1	464	470	PF00069	0.749
MOD_CK1_1	491	497	PF00069	0.803
MOD_CK1_1	568	574	PF00069	0.844
MOD_CK1_1	602	608	PF00069	0.693
MOD_CK1_1	76	82	PF00069	0.780
MOD_CK2_1	165	171	PF00069	0.734
MOD_CK2_1	209	215	PF00069	0.548
MOD_CK2_1	338	344	PF00069	0.510
MOD_CK2_1	553	559	PF00069	0.789
MOD_GlcNHglycan	1	4	PF01048	0.541
MOD_GlcNHglycan	121	124	PF01048	0.679
MOD_GlcNHglycan	195	198	PF01048	0.678
MOD_GlcNHglycan	208	211	PF01048	0.500
MOD_GlcNHglycan	259	262	PF01048	0.667
MOD_GlcNHglycan	263	266	PF01048	0.656
MOD_GlcNHglycan	275	278	PF01048	0.732
MOD_GlcNHglycan	280	283	PF01048	0.755
MOD_GlcNHglycan	320	323	PF01048	0.658
MOD_GlcNHglycan	340	343	PF01048	0.549
MOD_GlcNHglycan	365	368	PF01048	0.733
MOD_GlcNHglycan	457	460	PF01048	0.830
MOD_GlcNHglycan	480	483	PF01048	0.817
MOD_GlcNHglycan	494	497	PF01048	0.747
MOD_GlcNHglycan	568	571	PF01048	0.786
MOD_GlcNHglycan	601	604	PF01048	0.707
MOD_GlcNHglycan	613	616	PF01048	0.746
MOD_GlcNHglycan	75	78	PF01048	0.731
MOD_GlcNHglycan	84	87	PF01048	0.484
MOD_GSK3_1	180	187	PF00069	0.683
MOD_GSK3_1	200	207	PF00069	0.618
MOD_GSK3_1	239	246	PF00069	0.798
MOD_GSK3_1	257	264	PF00069	0.705
MOD_GSK3_1	273	280	PF00069	0.715
MOD_GSK3_1	305	312	PF00069	0.711
MOD_GSK3_1	317	324	PF00069	0.662
MOD_GSK3_1	32	39	PF00069	0.619
MOD_GSK3_1	347	354	PF00069	0.532
MOD_GSK3_1	376	383	PF00069	0.647
MOD_GSK3_1	411	418	PF00069	0.729
MOD_GSK3_1	457	464	PF00069	0.678
MOD_GSK3_1	488	495	PF00069	0.832
MOD_GSK3_1	590	597	PF00069	0.672
MOD_GSK3_1	78	85	PF00069	0.674
MOD_N-GLC_1	165	170	PF02516	0.477
MOD_NEK2_1	144	149	PF00069	0.477
MOD_NEK2_1	185	190	PF00069	0.671
MOD_NEK2_1	263	268	PF00069	0.756
MOD_NEK2_1	553	558	PF00069	0.709
MOD_NEK2_1	631	636	PF00069	0.646
MOD_NEK2_2	352	357	PF00069	0.546
MOD_PIKK_1	267	273	PF00454	0.711
MOD_PIKK_1	36	42	PF00454	0.573
MOD_PKA_2	246	252	PF00069	0.778
MOD_PKA_2	257	263	PF00069	0.695
MOD_PKA_2	318	324	PF00069	0.609
MOD_PKA_2	348	354	PF00069	0.748
MOD_PKA_2	376	382	PF00069	0.648
MOD_PKA_2	4	10	PF00069	0.756
MOD_PKA_2	499	505	PF00069	0.667
MOD_PKA_2	536	542	PF00069	0.674
MOD_Plk_1	525	531	PF00069	0.668
MOD_Plk_1	620	626	PF00069	0.743
MOD_Plk_4	246	252	PF00069	0.731
MOD_Plk_4	270	276	PF00069	0.730
MOD_ProDKin_1	117	123	PF00069	0.663
MOD_ProDKin_1	132	138	PF00069	0.528
MOD_ProDKin_1	438	444	PF00069	0.809
MOD_ProDKin_1	471	477	PF00069	0.767
MOD_ProDKin_1	489	495	PF00069	0.775
MOD_SUMO_for_1	47	50	PF00179	0.801
TRG_ENDOCYTIC_2	153	156	PF00928	0.647
TRG_ER_diArg_1	189	192	PF00400	0.761
TRG_ER_diArg_1	287	289	PF00400	0.734
TRG_ER_diArg_1	329	332	PF00400	0.627
TRG_ER_diArg_1	374	377	PF00400	0.555
TRG_ER_diArg_1	42	44	PF00400	0.592
TRG_ER_diArg_1	498	501	PF00400	0.680
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.784
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.776

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC10	Leptomonas seymouri	32%	100%
A0A3S7WTB9	Leishmania donovani	81%	100%
A4H805	Leishmania braziliensis	58%	96%
A4HWD3	Leishmania infantum	82%	100%
Q4QFE9	Leishmania major	79%	100%