Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ31_LEIMU

TriTrypDb:

LmxM.15.0290

Length:

802

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.712
CLV_C14_Caspase3-7	408	412	PF00656	0.336
CLV_MEL_PAP_1	293	299	PF00089	0.368
CLV_NRD_NRD_1	117	119	PF00675	0.484
CLV_NRD_NRD_1	307	309	PF00675	0.402
CLV_NRD_NRD_1	324	326	PF00675	0.378
CLV_NRD_NRD_1	334	336	PF00675	0.446
CLV_NRD_NRD_1	458	460	PF00675	0.483
CLV_NRD_NRD_1	614	616	PF00675	0.593
CLV_NRD_NRD_1	617	619	PF00675	0.602
CLV_NRD_NRD_1	623	625	PF00675	0.526
CLV_NRD_NRD_1	696	698	PF00675	0.513
CLV_NRD_NRD_1	730	732	PF00675	0.645
CLV_NRD_NRD_1	733	735	PF00675	0.664
CLV_NRD_NRD_1	764	766	PF00675	0.588
CLV_NRD_NRD_1	775	777	PF00675	0.697
CLV_NRD_NRD_1	79	81	PF00675	0.595
CLV_PCSK_FUR_1	332	336	PF00082	0.445
CLV_PCSK_FUR_1	614	618	PF00082	0.697
CLV_PCSK_FUR_1	621	625	PF00082	0.622
CLV_PCSK_FUR_1	731	735	PF00082	0.564
CLV_PCSK_FUR_1	773	777	PF00082	0.654
CLV_PCSK_KEX2_1	117	119	PF00082	0.484
CLV_PCSK_KEX2_1	307	309	PF00082	0.409
CLV_PCSK_KEX2_1	334	336	PF00082	0.446
CLV_PCSK_KEX2_1	458	460	PF00082	0.487
CLV_PCSK_KEX2_1	613	615	PF00082	0.601
CLV_PCSK_KEX2_1	616	618	PF00082	0.615
CLV_PCSK_KEX2_1	623	625	PF00082	0.528
CLV_PCSK_KEX2_1	696	698	PF00082	0.513
CLV_PCSK_KEX2_1	729	731	PF00082	0.645
CLV_PCSK_KEX2_1	733	735	PF00082	0.661
CLV_PCSK_KEX2_1	764	766	PF00082	0.596
CLV_PCSK_KEX2_1	773	775	PF00082	0.678
CLV_PCSK_KEX2_1	79	81	PF00082	0.701
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.608
CLV_PCSK_PC7_1	613	619	PF00082	0.571
CLV_PCSK_PC7_1	729	735	PF00082	0.526
CLV_PCSK_PC7_1	770	776	PF00082	0.549
CLV_PCSK_SKI1_1	155	159	PF00082	0.445
CLV_PCSK_SKI1_1	26	30	PF00082	0.539
CLV_PCSK_SKI1_1	285	289	PF00082	0.372
CLV_PCSK_SKI1_1	326	330	PF00082	0.455
CLV_PCSK_SKI1_1	37	41	PF00082	0.540
CLV_PCSK_SKI1_1	4	8	PF00082	0.614
CLV_PCSK_SKI1_1	419	423	PF00082	0.354
CLV_PCSK_SKI1_1	428	432	PF00082	0.418
CLV_PCSK_SKI1_1	558	562	PF00082	0.441
CLV_PCSK_SKI1_1	734	738	PF00082	0.682
DEG_APCC_DBOX_1	714	722	PF00400	0.575
DEG_SPOP_SBC_1	655	659	PF00917	0.791
DEG_SPOP_SBC_1	748	752	PF00917	0.570
DOC_CYCLIN_RxL_1	152	161	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	596	602	PF00134	0.661
DOC_MAPK_DCC_7	155	164	PF00069	0.487
DOC_MAPK_DCC_7	285	295	PF00069	0.358
DOC_MAPK_DCC_7	474	482	PF00069	0.390
DOC_MAPK_gen_1	117	128	PF00069	0.424
DOC_MAPK_gen_1	358	366	PF00069	0.343
DOC_MAPK_gen_1	764	771	PF00069	0.438
DOC_MAPK_MEF2A_6	155	164	PF00069	0.487
DOC_MAPK_MEF2A_6	474	482	PF00069	0.390
DOC_MAPK_MEF2A_6	764	771	PF00069	0.438
DOC_MAPK_NFAT4_5	764	772	PF00069	0.439
DOC_PP1_RVXF_1	294	300	PF00149	0.462
DOC_PP1_RVXF_1	556	563	PF00149	0.572
DOC_PP2B_LxvP_1	113	116	PF13499	0.649
DOC_PP2B_LxvP_1	157	160	PF13499	0.338
DOC_PP2B_LxvP_1	366	369	PF13499	0.375
DOC_PP2B_LxvP_1	596	599	PF13499	0.555
DOC_PP2B_LxvP_1	653	656	PF13499	0.482
DOC_PP2B_LxvP_1	721	724	PF13499	0.575
DOC_PP4_FxxP_1	402	405	PF00568	0.389
DOC_USP7_MATH_1	245	249	PF00917	0.326
DOC_USP7_MATH_1	338	342	PF00917	0.436
DOC_USP7_MATH_1	481	485	PF00917	0.514
DOC_USP7_MATH_1	602	606	PF00917	0.592
DOC_USP7_MATH_1	608	612	PF00917	0.538
DOC_USP7_MATH_1	654	658	PF00917	0.700
DOC_USP7_MATH_1	736	740	PF00917	0.756
DOC_USP7_MATH_1	747	751	PF00917	0.599
DOC_WW_Pin1_4	12	17	PF00397	0.600
DOC_WW_Pin1_4	172	177	PF00397	0.588
DOC_WW_Pin1_4	43	48	PF00397	0.585
DOC_WW_Pin1_4	472	477	PF00397	0.368
DOC_WW_Pin1_4	524	529	PF00397	0.333
DOC_WW_Pin1_4	604	609	PF00397	0.585
DOC_WW_Pin1_4	722	727	PF00397	0.460
DOC_WW_Pin1_4	738	743	PF00397	0.544
DOC_WW_Pin1_4	779	784	PF00397	0.731
LIG_14-3-3_CanoR_1	139	144	PF00244	0.432
LIG_14-3-3_CanoR_1	296	300	PF00244	0.456
LIG_14-3-3_CanoR_1	37	42	PF00244	0.620
LIG_Actin_WH2_2	280	298	PF00022	0.348
LIG_BIR_III_4	106	110	PF00653	0.583
LIG_CNOT1_NIM_1	206	215	PF04054	0.459
LIG_CtBP_PxDLS_1	673	677	PF00389	0.717
LIG_Dynein_DLC8_1	501	507	PF01221	0.517
LIG_eIF4E_1	227	233	PF01652	0.498
LIG_FHA_1	108	114	PF00498	0.565
LIG_FHA_1	144	150	PF00498	0.382
LIG_FHA_1	20	26	PF00498	0.479
LIG_FHA_1	215	221	PF00498	0.439
LIG_FHA_1	272	278	PF00498	0.331
LIG_FHA_1	292	298	PF00498	0.270
LIG_FHA_1	331	337	PF00498	0.563
LIG_FHA_1	38	44	PF00498	0.428
LIG_FHA_1	46	52	PF00498	0.560
LIG_FHA_1	5	11	PF00498	0.682
LIG_FHA_1	57	63	PF00498	0.543
LIG_FHA_2	214	220	PF00498	0.440
LIG_FHA_2	406	412	PF00498	0.327
LIG_FHA_2	687	693	PF00498	0.529
LIG_FHA_2	794	800	PF00498	0.620
LIG_LIR_Gen_1	204	212	PF02991	0.491
LIG_LIR_Nem_3	151	157	PF02991	0.371
LIG_LIR_Nem_3	204	209	PF02991	0.518
LIG_LIR_Nem_3	211	215	PF02991	0.436
LIG_LIR_Nem_3	464	469	PF02991	0.314
LIG_MYND_1	156	160	PF01753	0.347
LIG_PCNA_yPIPBox_3	223	233	PF02747	0.482
LIG_SH2_CRK	212	216	PF00017	0.410
LIG_SH2_NCK_1	735	739	PF00017	0.574
LIG_SH2_PTP2	479	482	PF00017	0.376
LIG_SH2_SRC	574	577	PF00017	0.500
LIG_SH2_SRC	90	93	PF00017	0.500
LIG_SH2_STAP1	206	210	PF00017	0.389
LIG_SH2_STAP1	346	350	PF00017	0.454
LIG_SH2_STAP1	362	366	PF00017	0.333
LIG_SH2_STAT3	346	349	PF00017	0.556
LIG_SH2_STAT3	398	401	PF00017	0.487
LIG_SH2_STAT5	143	146	PF00017	0.333
LIG_SH2_STAT5	240	243	PF00017	0.360
LIG_SH2_STAT5	260	263	PF00017	0.212
LIG_SH2_STAT5	479	482	PF00017	0.376
LIG_SH2_STAT5	549	552	PF00017	0.451
LIG_SH2_STAT5	574	577	PF00017	0.350
LIG_SH2_STAT5	90	93	PF00017	0.500
LIG_SH3_3	475	481	PF00018	0.391
LIG_SH3_3	522	528	PF00018	0.390
LIG_SH3_3	592	598	PF00018	0.472
LIG_SH3_3	780	786	PF00018	0.606
LIG_SH3_3	94	100	PF00018	0.691
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.438
LIG_SUMO_SIM_anti_2	363	368	PF11976	0.309
LIG_SUMO_SIM_anti_2	381	389	PF11976	0.243
LIG_SUMO_SIM_par_1	155	161	PF11976	0.392
LIG_SUMO_SIM_par_1	216	222	PF11976	0.311
LIG_SUMO_SIM_par_1	279	286	PF11976	0.381
LIG_SUMO_SIM_par_1	533	539	PF11976	0.333
LIG_TRAF2_1	100	103	PF00917	0.546
LIG_TRAF2_1	677	680	PF00917	0.697
LIG_TRAF2_1	683	686	PF00917	0.674
LIG_TYR_ITIM	210	215	PF00017	0.437
LIG_WRC_WIRS_1	241	246	PF05994	0.368
LIG_WW_1	476	479	PF00397	0.410
LIG_WW_3	1	5	PF00397	0.582
MOD_CDK_SPK_2	12	17	PF00069	0.600
MOD_CDK_SPK_2	172	177	PF00069	0.568
MOD_CDK_SPxxK_3	524	531	PF00069	0.352
MOD_CDK_SPxxK_3	722	729	PF00069	0.430
MOD_CK1_1	15	21	PF00069	0.452
MOD_CK1_1	170	176	PF00069	0.616
MOD_CK1_1	195	201	PF00069	0.576
MOD_CK1_1	259	265	PF00069	0.307
MOD_CK1_1	470	476	PF00069	0.340
MOD_CK1_1	504	510	PF00069	0.703
MOD_CK1_1	524	530	PF00069	0.262
MOD_CK1_1	628	634	PF00069	0.719
MOD_CK1_1	657	663	PF00069	0.611
MOD_CK1_1	751	757	PF00069	0.742
MOD_CK2_1	198	204	PF00069	0.435
MOD_CK2_1	213	219	PF00069	0.429
MOD_CK2_1	311	317	PF00069	0.295
MOD_CK2_1	533	539	PF00069	0.449
MOD_CK2_1	686	692	PF00069	0.571
MOD_CK2_1	793	799	PF00069	0.556
MOD_GlcNHglycan	169	172	PF01048	0.524
MOD_GlcNHglycan	352	355	PF01048	0.418
MOD_GlcNHglycan	555	558	PF01048	0.449
MOD_GlcNHglycan	571	574	PF01048	0.338
MOD_GlcNHglycan	579	582	PF01048	0.346
MOD_GlcNHglycan	604	607	PF01048	0.707
MOD_GlcNHglycan	627	630	PF01048	0.585
MOD_GlcNHglycan	641	644	PF01048	0.527
MOD_GlcNHglycan	751	754	PF01048	0.745
MOD_GlcNHglycan	94	97	PF01048	0.790
MOD_GSK3_1	127	134	PF00069	0.389
MOD_GSK3_1	139	146	PF00069	0.339
MOD_GSK3_1	15	22	PF00069	0.453
MOD_GSK3_1	188	195	PF00069	0.598
MOD_GSK3_1	291	298	PF00069	0.494
MOD_GSK3_1	338	345	PF00069	0.548
MOD_GSK3_1	497	504	PF00069	0.549
MOD_GSK3_1	598	605	PF00069	0.719
MOD_GSK3_1	624	631	PF00069	0.600
MOD_GSK3_1	654	661	PF00069	0.796
MOD_GSK3_1	747	754	PF00069	0.725
MOD_NEK2_1	194	199	PF00069	0.543
MOD_NEK2_1	385	390	PF00069	0.505
MOD_NEK2_1	62	67	PF00069	0.747
MOD_NEK2_2	127	132	PF00069	0.404
MOD_NEK2_2	6	11	PF00069	0.718
MOD_PIKK_1	107	113	PF00454	0.537
MOD_PIKK_1	338	344	PF00454	0.433
MOD_PIKK_1	386	392	PF00454	0.398
MOD_PIKK_1	502	508	PF00454	0.649
MOD_PIKK_1	608	614	PF00454	0.539
MOD_PKA_1	623	629	PF00069	0.598
MOD_PKA_2	185	191	PF00069	0.542
MOD_PKA_2	192	198	PF00069	0.788
MOD_PKA_2	295	301	PF00069	0.514
MOD_PKA_2	502	508	PF00069	0.681
MOD_PKA_2	623	629	PF00069	0.628
MOD_PKB_1	621	629	PF00069	0.621
MOD_Plk_1	256	262	PF00069	0.301
MOD_Plk_1	362	368	PF00069	0.329
MOD_Plk_1	708	714	PF00069	0.541
MOD_Plk_2-3	794	800	PF00069	0.547
MOD_Plk_4	139	145	PF00069	0.372
MOD_Plk_4	245	251	PF00069	0.289
MOD_Plk_4	256	262	PF00069	0.301
MOD_Plk_4	318	324	PF00069	0.394
MOD_Plk_4	362	368	PF00069	0.332
MOD_Plk_4	467	473	PF00069	0.391
MOD_Plk_4	533	539	PF00069	0.449
MOD_Plk_4	717	723	PF00069	0.551
MOD_ProDKin_1	12	18	PF00069	0.596
MOD_ProDKin_1	172	178	PF00069	0.591
MOD_ProDKin_1	43	49	PF00069	0.588
MOD_ProDKin_1	472	478	PF00069	0.375
MOD_ProDKin_1	524	530	PF00069	0.330
MOD_ProDKin_1	604	610	PF00069	0.581
MOD_ProDKin_1	722	728	PF00069	0.454
MOD_ProDKin_1	738	744	PF00069	0.548
MOD_ProDKin_1	779	785	PF00069	0.734
MOD_SUMO_rev_2	794	802	PF00179	0.591
TRG_DiLeu_BaEn_1	23	28	PF01217	0.584
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.358
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.461
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.527
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.544
TRG_ENDOCYTIC_2	206	209	PF00928	0.519
TRG_ENDOCYTIC_2	212	215	PF00928	0.407
TRG_ENDOCYTIC_2	479	482	PF00928	0.376
TRG_ER_diArg_1	10	13	PF00400	0.682
TRG_ER_diArg_1	116	118	PF00400	0.498
TRG_ER_diArg_1	306	308	PF00400	0.384
TRG_ER_diArg_1	332	335	PF00400	0.447
TRG_ER_diArg_1	358	361	PF00400	0.382
TRG_ER_diArg_1	457	459	PF00400	0.505
TRG_ER_diArg_1	613	615	PF00400	0.578
TRG_ER_diArg_1	617	619	PF00400	0.533
TRG_ER_diArg_1	621	624	PF00400	0.520
TRG_ER_diArg_1	729	731	PF00400	0.645
TRG_ER_diArg_1	732	734	PF00400	0.654
TRG_ER_diArg_1	763	765	PF00400	0.613
TRG_ER_diArg_1	767	770	PF00400	0.632
TRG_ER_diArg_1	772	775	PF00400	0.660
TRG_ER_diArg_1	79	81	PF00400	0.682
TRG_NLS_MonoCore_2	614	619	PF00514	0.570
TRG_NLS_MonoExtN_4	613	620	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.769

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU74	Leptomonas seymouri	63%	100%
A0A1X0NU60	Trypanosomatidae	45%	100%
A0A3S7WTA7	Leishmania donovani	92%	100%
A0A422N3L6	Trypanosoma rangeli	50%	100%
A4H803	Leishmania braziliensis	79%	99%
A4HWD1	Leishmania infantum	92%	100%
C9ZNX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4QFF1	Leishmania major	92%	100%
V5BL46	Trypanosoma cruzi	48%	100%