Smr domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ27_LEIMU

TriTrypDb:

LmxM.15.0260

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AQ27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.487
CLV_C14_Caspase3-7	439	443	PF00656	0.652
CLV_C14_Caspase3-7	84	88	PF00656	0.483
CLV_NRD_NRD_1	115	117	PF00675	0.599
CLV_NRD_NRD_1	151	153	PF00675	0.538
CLV_NRD_NRD_1	205	207	PF00675	0.678
CLV_NRD_NRD_1	272	274	PF00675	0.574
CLV_NRD_NRD_1	296	298	PF00675	0.464
CLV_PCSK_FUR_1	113	117	PF00082	0.487
CLV_PCSK_KEX2_1	115	117	PF00082	0.453
CLV_PCSK_KEX2_1	151	153	PF00082	0.540
CLV_PCSK_KEX2_1	272	274	PF00082	0.574
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.550
CLV_PCSK_PC7_1	147	153	PF00082	0.602
CLV_PCSK_SKI1_1	123	127	PF00082	0.430
CLV_PCSK_SKI1_1	209	213	PF00082	0.495
CLV_PCSK_SKI1_1	226	230	PF00082	0.419
CLV_PCSK_SKI1_1	273	277	PF00082	0.541
CLV_PCSK_SKI1_1	31	35	PF00082	0.531
CLV_PCSK_SKI1_1	312	316	PF00082	0.610
CLV_PCSK_SKI1_1	335	339	PF00082	0.475
CLV_PCSK_SKI1_1	343	347	PF00082	0.361
CLV_PCSK_SKI1_1	374	378	PF00082	0.449
CLV_PCSK_SKI1_1	396	400	PF00082	0.678
DEG_Nend_UBRbox_2	1	3	PF02207	0.549
DOC_MAPK_gen_1	396	404	PF00069	0.466
DOC_USP7_MATH_1	355	359	PF00917	0.548
DOC_USP7_MATH_1	392	396	PF00917	0.455
DOC_USP7_MATH_1	437	441	PF00917	0.725
DOC_WW_Pin1_4	284	289	PF00397	0.657
DOC_WW_Pin1_4	353	358	PF00397	0.545
DOC_WW_Pin1_4	407	412	PF00397	0.748
LIG_14-3-3_CanoR_1	103	111	PF00244	0.589
LIG_14-3-3_CanoR_1	116	122	PF00244	0.395
LIG_14-3-3_CanoR_1	123	129	PF00244	0.398
LIG_14-3-3_CanoR_1	272	282	PF00244	0.573
LIG_14-3-3_CanoR_1	365	369	PF00244	0.552
LIG_Actin_WH2_2	179	197	PF00022	0.537
LIG_BIR_III_2	432	436	PF00653	0.666
LIG_BRCT_BRCA1_1	63	67	PF00533	0.649
LIG_CaM_IQ_9	386	401	PF13499	0.447
LIG_FHA_1	165	171	PF00498	0.458
LIG_FHA_1	466	472	PF00498	0.522
LIG_FHA_2	1	7	PF00498	0.559
LIG_FHA_2	211	217	PF00498	0.437
LIG_FHA_2	274	280	PF00498	0.612
LIG_LIR_Gen_1	236	244	PF02991	0.436
LIG_LIR_LC3C_4	423	427	PF02991	0.668
LIG_LIR_Nem_3	2	7	PF02991	0.567
LIG_LIR_Nem_3	236	240	PF02991	0.471
LIG_LIR_Nem_3	28	33	PF02991	0.496
LIG_Pex14_1	117	121	PF04695	0.414
LIG_Pex14_2	240	244	PF04695	0.552
LIG_SH2_CRK	30	34	PF00017	0.536
LIG_SH2_CRK	475	479	PF00017	0.478
LIG_SH2_NCK_1	438	442	PF00017	0.560
LIG_SH2_STAP1	21	25	PF00017	0.582
LIG_SH2_STAP1	237	241	PF00017	0.417
LIG_SH2_STAT5	21	24	PF00017	0.625
LIG_SH2_STAT5	473	476	PF00017	0.501
LIG_SH3_2	66	71	PF14604	0.502
LIG_SH3_3	282	288	PF00018	0.614
LIG_SH3_3	413	419	PF00018	0.747
LIG_SH3_3	6	12	PF00018	0.662
LIG_SH3_3	63	69	PF00018	0.575
LIG_SUMO_SIM_par_1	166	172	PF11976	0.511
LIG_TRAF2_1	213	216	PF00917	0.581
LIG_TRAF2_1	90	93	PF00917	0.508
LIG_UBA3_1	457	465	PF00899	0.522
LIG_ULM_U2AF65_1	206	211	PF00076	0.518
LIG_WRC_WIRS_1	118	123	PF05994	0.433
MOD_CK1_1	107	113	PF00069	0.411
MOD_CK1_1	19	25	PF00069	0.637
MOD_CK1_1	284	290	PF00069	0.615
MOD_CK1_1	328	334	PF00069	0.581
MOD_CK1_1	70	76	PF00069	0.557
MOD_CK1_1	82	88	PF00069	0.552
MOD_CK2_1	124	130	PF00069	0.505
MOD_CK2_1	210	216	PF00069	0.448
MOD_CK2_1	239	245	PF00069	0.466
MOD_CK2_1	284	290	PF00069	0.609
MOD_Cter_Amidation	295	298	PF01082	0.449
MOD_GlcNHglycan	175	178	PF01048	0.565
MOD_GlcNHglycan	18	21	PF01048	0.616
MOD_GlcNHglycan	330	333	PF01048	0.514
MOD_GlcNHglycan	43	46	PF01048	0.662
MOD_GlcNHglycan	439	442	PF01048	0.643
MOD_GlcNHglycan	447	450	PF01048	0.609
MOD_GlcNHglycan	72	75	PF01048	0.486
MOD_GSK3_1	105	112	PF00069	0.523
MOD_GSK3_1	124	131	PF00069	0.559
MOD_GSK3_1	16	23	PF00069	0.686
MOD_GSK3_1	164	171	PF00069	0.570
MOD_GSK3_1	190	197	PF00069	0.597
MOD_GSK3_1	37	44	PF00069	0.643
MOD_GSK3_1	461	468	PF00069	0.511
MOD_N-GLC_1	173	178	PF02516	0.655
MOD_N-GLC_1	264	269	PF02516	0.480
MOD_N-GLC_1	60	65	PF02516	0.708
MOD_NEK2_1	194	199	PF00069	0.735
MOD_PIKK_1	105	111	PF00454	0.603
MOD_PIKK_1	14	20	PF00454	0.619
MOD_PIKK_1	465	471	PF00454	0.535
MOD_PKA_2	102	108	PF00069	0.611
MOD_PKA_2	364	370	PF00069	0.563
MOD_PKA_2	37	43	PF00069	0.651
MOD_Plk_1	264	270	PF00069	0.542
MOD_Plk_1	60	66	PF00069	0.485
MOD_Plk_4	281	287	PF00069	0.656
MOD_Plk_4	384	390	PF00069	0.620
MOD_ProDKin_1	284	290	PF00069	0.658
MOD_ProDKin_1	353	359	PF00069	0.543
MOD_ProDKin_1	407	413	PF00069	0.746
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.581
TRG_ENDOCYTIC_2	237	240	PF00928	0.420
TRG_ENDOCYTIC_2	30	33	PF00928	0.532
TRG_ENDOCYTIC_2	4	7	PF00928	0.551
TRG_ER_diArg_1	113	116	PF00400	0.545
TRG_ER_diArg_1	271	273	PF00400	0.578
TRG_ER_diArg_1	333	336	PF00400	0.517
TRG_NLS_MonoCore_2	205	210	PF00514	0.517
TRG_NLS_MonoExtN_4	203	210	PF00514	0.500
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P362	Leptomonas seymouri	65%	100%
A0A0S4JPG7	Bodo saltans	34%	98%
A0A1X0NUB6	Trypanosomatidae	41%	100%
A0A3R7NLS4	Trypanosoma rangeli	41%	100%
A0A3S7WTC2	Leishmania donovani	90%	100%
A4H7Z9	Leishmania braziliensis	79%	99%
A4HWC7	Leishmania infantum	90%	100%
C9ZNW9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4QFF4	Leishmania major	90%	100%