Putative nonspecific lipid-transfer protein (Putative sterol carrier protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sterol carrier protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQ25_LEIMU

TriTrypDb:

LmxM.15.0240

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ25

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.489
CLV_NRD_NRD_1	209	211	PF00675	0.404
CLV_NRD_NRD_1	237	239	PF00675	0.528
CLV_NRD_NRD_1	323	325	PF00675	0.499
CLV_NRD_NRD_1	381	383	PF00675	0.541
CLV_PCSK_KEX2_1	126	128	PF00082	0.509
CLV_PCSK_KEX2_1	155	157	PF00082	0.438
CLV_PCSK_KEX2_1	160	162	PF00082	0.371
CLV_PCSK_KEX2_1	18	20	PF00082	0.511
CLV_PCSK_KEX2_1	185	187	PF00082	0.500
CLV_PCSK_KEX2_1	209	211	PF00082	0.389
CLV_PCSK_KEX2_1	237	239	PF00082	0.539
CLV_PCSK_KEX2_1	323	325	PF00082	0.499
CLV_PCSK_KEX2_1	381	383	PF00082	0.396
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.536
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.438
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.371
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.508
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.503
CLV_PCSK_PC7_1	156	162	PF00082	0.424
CLV_PCSK_SKI1_1	190	194	PF00082	0.251
CLV_PCSK_SKI1_1	26	30	PF00082	0.311
CLV_PCSK_SKI1_1	381	385	PF00082	0.441
DEG_APCC_DBOX_1	160	168	PF00400	0.359
DEG_APCC_DBOX_1	185	193	PF00400	0.506
DEG_APCC_DBOX_1	2	10	PF00400	0.453
DEG_Nend_UBRbox_3	1	3	PF02207	0.546
DEG_SCF_FBW7_1	46	53	PF00400	0.451
DOC_CDC14_PxL_1	164	172	PF14671	0.348
DOC_CKS1_1	47	52	PF01111	0.446
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.496
DOC_MAPK_gen_1	101	111	PF00069	0.465
DOC_MAPK_gen_1	18	24	PF00069	0.436
DOC_MAPK_gen_1	237	244	PF00069	0.510
DOC_MAPK_JIP1_4	238	244	PF00069	0.483
DOC_MAPK_MEF2A_6	101	109	PF00069	0.502
DOC_MAPK_MEF2A_6	26	33	PF00069	0.424
DOC_MAPK_NFAT4_5	26	34	PF00069	0.430
DOC_PP2B_LxvP_1	251	254	PF13499	0.418
DOC_PP4_FxxP_1	348	351	PF00568	0.333
DOC_USP7_MATH_1	125	129	PF00917	0.440
DOC_USP7_MATH_1	48	52	PF00917	0.319
DOC_USP7_MATH_1	71	75	PF00917	0.386
DOC_USP7_MATH_1	88	92	PF00917	0.445
DOC_WW_Pin1_4	131	136	PF00397	0.520
DOC_WW_Pin1_4	258	263	PF00397	0.412
DOC_WW_Pin1_4	376	381	PF00397	0.500
DOC_WW_Pin1_4	46	51	PF00397	0.364
DOC_WW_Pin1_4	84	89	PF00397	0.449
LIG_14-3-3_CanoR_1	184	190	PF00244	0.450
LIG_BIR_III_4	82	86	PF00653	0.218
LIG_BRCT_BRCA1_1	120	124	PF00533	0.452
LIG_BRCT_BRCA1_1	53	57	PF00533	0.397
LIG_BRCT_BRCA1_2	120	126	PF00533	0.547
LIG_FHA_1	229	235	PF00498	0.562
LIG_FHA_1	281	287	PF00498	0.473
LIG_FHA_1	47	53	PF00498	0.452
LIG_FHA_2	254	260	PF00498	0.573
LIG_LIR_Gen_1	97	107	PF02991	0.230
LIG_LIR_Nem_3	285	291	PF02991	0.334
LIG_Pex14_2	148	152	PF04695	0.460
LIG_Pex14_2	295	299	PF04695	0.358
LIG_Pex14_2	348	352	PF04695	0.337
LIG_SH2_NCK_1	275	279	PF00017	0.438
LIG_SH2_NCK_1	358	362	PF00017	0.455
LIG_SH2_STAP1	146	150	PF00017	0.340
LIG_SH2_STAT5	240	243	PF00017	0.468
LIG_SH2_STAT5	62	65	PF00017	0.418
LIG_SH3_3	129	135	PF00018	0.461
LIG_SH3_3	137	143	PF00018	0.342
LIG_SH3_3	173	179	PF00018	0.438
LIG_SH3_3	247	253	PF00018	0.432
LIG_SUMO_SIM_anti_2	395	403	PF11976	0.350
LIG_TRAF2_1	256	259	PF00917	0.583
MOD_CDK_SPK_2	376	381	PF00069	0.532
MOD_CDK_SPxK_1	376	382	PF00069	0.529
MOD_CK1_1	128	134	PF00069	0.440
MOD_CK1_1	172	178	PF00069	0.472
MOD_CK1_1	51	57	PF00069	0.384
MOD_CK1_1	87	93	PF00069	0.440
MOD_CK2_1	185	191	PF00069	0.445
MOD_CK2_1	253	259	PF00069	0.524
MOD_Cter_Amidation	235	238	PF01082	0.548
MOD_GlcNHglycan	171	174	PF01048	0.462
MOD_GlcNHglycan	246	250	PF01048	0.428
MOD_GlcNHglycan	392	395	PF01048	0.337
MOD_GlcNHglycan	53	56	PF01048	0.442
MOD_GlcNHglycan	72	76	PF01048	0.285
MOD_GSK3_1	115	122	PF00069	0.461
MOD_GSK3_1	46	53	PF00069	0.444
MOD_GSK3_1	67	74	PF00069	0.444
MOD_GSK3_1	84	91	PF00069	0.344
MOD_N-GLC_1	128	133	PF02516	0.466
MOD_NEK2_1	392	397	PF00069	0.331
MOD_PK_1	18	24	PF00069	0.347
MOD_PKA_1	18	24	PF00069	0.444
MOD_PKA_1	185	191	PF00069	0.514
MOD_PKA_2	18	24	PF00069	0.444
MOD_PKA_2	185	191	PF00069	0.514
MOD_Plk_1	128	134	PF00069	0.440
MOD_Plk_1	71	77	PF00069	0.286
MOD_ProDKin_1	131	137	PF00069	0.515
MOD_ProDKin_1	258	264	PF00069	0.407
MOD_ProDKin_1	376	382	PF00069	0.496
MOD_ProDKin_1	46	52	PF00069	0.365
MOD_ProDKin_1	84	90	PF00069	0.449
MOD_SUMO_for_1	159	162	PF00179	0.396
TRG_ENDOCYTIC_2	292	295	PF00928	0.321
TRG_ER_diArg_1	184	187	PF00400	0.483
TRG_ER_diArg_1	237	239	PF00400	0.531
TRG_ER_diArg_1	3	6	PF00400	0.435
TRG_ER_diArg_1	322	324	PF00400	0.528
TRG_ER_diArg_1	380	382	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUB7	Leptomonas seymouri	79%	100%
A0A0S4JDZ8	Bodo saltans	59%	100%
A0A3S5H6U0	Leishmania donovani	93%	100%
A0A422NT95	Trypanosoma rangeli	57%	100%
A4H7Z7	Leishmania braziliensis	90%	100%
A4HWC5	Leishmania infantum	93%	100%
C9ZUV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	99%
D1AB74	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9)	25%	100%
I6Y3T7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	24%	100%
O26884	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	29%	100%
O62742	Oryctolagus cuniculus	31%	74%
P07857	Bos taurus	28%	75%
P11915	Rattus norvegicus	27%	74%
P22307	Homo sapiens	29%	74%
P32020	Mus musculus	26%	74%
Q07598	Gallus gallus	26%	74%
Q4QFF6	Leishmania major	93%	100%
Q58944	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	100%
V5BHW0	Trypanosoma cruzi	60%	87%