Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ22_LEIMU

TriTrypDb:

LmxM.15.0223

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.370
CLV_C14_Caspase3-7	190	194	PF00656	0.826
CLV_NRD_NRD_1	179	181	PF00675	0.675
CLV_NRD_NRD_1	77	79	PF00675	0.467
CLV_NRD_NRD_1	9	11	PF00675	0.674
CLV_PCSK_KEX2_1	181	183	PF00082	0.681
CLV_PCSK_KEX2_1	77	79	PF00082	0.398
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.681
CLV_PCSK_SKI1_1	114	118	PF00082	0.483
CLV_PCSK_SKI1_1	122	126	PF00082	0.459
CLV_PCSK_SKI1_1	41	45	PF00082	0.532
DEG_Nend_Nbox_1	1	3	PF02207	0.685
DEG_SCF_FBW7_1	153	159	PF00400	0.658
DOC_CKS1_1	153	158	PF01111	0.660
DOC_CYCLIN_RxL_1	119	130	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.551
DOC_MAPK_DCC_7	91	101	PF00069	0.616
DOC_MAPK_MEF2A_6	91	99	PF00069	0.546
DOC_PP1_RVXF_1	120	127	PF00149	0.493
DOC_PP2B_LxvP_1	49	52	PF13499	0.522
DOC_PP4_FxxP_1	107	110	PF00568	0.626
DOC_USP7_MATH_1	132	136	PF00917	0.469
DOC_USP7_MATH_1	167	171	PF00917	0.612
DOC_USP7_MATH_1	43	47	PF00917	0.448
DOC_WD40_RPTOR_TOS_1	30	35	PF00400	0.485
DOC_WW_Pin1_4	152	157	PF00397	0.597
DOC_WW_Pin1_4	161	166	PF00397	0.557
DOC_WW_Pin1_4	9	14	PF00397	0.527
LIG_14-3-3_CanoR_1	182	187	PF00244	0.741
LIG_Actin_WH2_2	25	43	PF00022	0.610
LIG_Actin_WH2_2	64	79	PF00022	0.533
LIG_BRCT_BRCA1_1	63	67	PF00533	0.488
LIG_LIR_Apic_2	104	110	PF02991	0.640
LIG_LIR_Apic_2	148	153	PF02991	0.623
LIG_LIR_Gen_1	12	20	PF02991	0.660
LIG_LIR_Nem_3	12	17	PF02991	0.661
LIG_LIR_Nem_3	166	171	PF02991	0.616
LIG_LIR_Nem_3	202	208	PF02991	0.628
LIG_SH2_CRK	205	209	PF00017	0.629
LIG_SH2_SRC	205	208	PF00017	0.624
LIG_SH2_STAT5	150	153	PF00017	0.589
LIG_SH3_1	150	156	PF00018	0.637
LIG_SH3_3	150	156	PF00018	0.657
LIG_SH3_3	168	174	PF00018	0.609
LIG_SH3_3	201	207	PF00018	0.749
LIG_SH3_3	49	55	PF00018	0.622
LIG_SH3_3	89	95	PF00018	0.503
LIG_SUMO_SIM_par_1	97	104	PF11976	0.534
LIG_TYR_ITIM	203	208	PF00017	0.629
MOD_CK1_1	12	18	PF00069	0.676
MOD_CK1_1	146	152	PF00069	0.399
MOD_CK1_1	159	165	PF00069	0.668
MOD_CK2_1	12	18	PF00069	0.676
MOD_CK2_1	167	173	PF00069	0.583
MOD_GlcNHglycan	134	137	PF01048	0.472
MOD_GlcNHglycan	139	142	PF01048	0.513
MOD_GlcNHglycan	145	148	PF01048	0.614
MOD_GlcNHglycan	176	179	PF01048	0.772
MOD_GSK3_1	101	108	PF00069	0.578
MOD_GSK3_1	142	149	PF00069	0.336
MOD_GSK3_1	152	159	PF00069	0.626
MOD_GSK3_1	176	183	PF00069	0.712
MOD_GSK3_1	56	63	PF00069	0.518
MOD_GSK3_1	67	74	PF00069	0.510
MOD_N-GLC_1	191	196	PF02516	0.743
MOD_NEK2_1	67	72	PF00069	0.522
MOD_NEK2_2	167	172	PF00069	0.566
MOD_PIKK_1	182	188	PF00454	0.744
MOD_PKA_1	180	186	PF00069	0.701
MOD_PKA_2	127	133	PF00069	0.494
MOD_PKB_1	180	188	PF00069	0.742
MOD_Plk_1	191	197	PF00069	0.738
MOD_Plk_1	60	66	PF00069	0.438
MOD_Plk_4	12	18	PF00069	0.664
MOD_Plk_4	146	152	PF00069	0.481
MOD_Plk_4	156	162	PF00069	0.649
MOD_Plk_4	191	197	PF00069	0.710
MOD_Plk_4	199	205	PF00069	0.585
MOD_Plk_4	61	67	PF00069	0.473
MOD_Plk_4	71	77	PF00069	0.501
MOD_ProDKin_1	152	158	PF00069	0.595
MOD_ProDKin_1	161	167	PF00069	0.545
MOD_ProDKin_1	9	15	PF00069	0.529
MOD_SUMO_rev_2	87	93	PF00179	0.612
TRG_DiLeu_BaEn_1	199	204	PF01217	0.616
TRG_DiLeu_BaEn_4	18	24	PF01217	0.658
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.470
TRG_ENDOCYTIC_2	14	17	PF00928	0.682
TRG_ENDOCYTIC_2	205	208	PF00928	0.599
TRG_ER_diArg_1	120	123	PF00400	0.491
TRG_ER_diArg_1	76	78	PF00400	0.428
TRG_NLS_MonoExtC_3	179	184	PF00514	0.661
TRG_NLS_MonoExtN_4	180	185	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF0	Leptomonas seymouri	49%	100%
A0A3Q8IA55	Leishmania donovani	93%	100%
A4H7Z4	Leishmania braziliensis	71%	100%
A4HWC2	Leishmania infantum	93%	100%
C9ZNV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	85%
Q4QFF9	Leishmania major	92%	100%