DUF667 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ20_LEIMU

TriTrypDb:

LmxM.15.0210

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.450
CLV_C14_Caspase3-7	316	320	PF00656	0.629
CLV_NRD_NRD_1	381	383	PF00675	0.637
CLV_NRD_NRD_1	405	407	PF00675	0.521
CLV_NRD_NRD_1	430	432	PF00675	0.492
CLV_NRD_NRD_1	437	439	PF00675	0.502
CLV_PCSK_FUR_1	434	438	PF00082	0.499
CLV_PCSK_KEX2_1	378	380	PF00082	0.640
CLV_PCSK_KEX2_1	430	432	PF00082	0.489
CLV_PCSK_KEX2_1	436	438	PF00082	0.457
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.583
CLV_PCSK_SKI1_1	256	260	PF00082	0.566
CLV_PCSK_SKI1_1	37	41	PF00082	0.284
CLV_PCSK_SKI1_1	385	389	PF00082	0.519
DEG_SCF_FBW7_1	42	49	PF00400	0.450
DEG_SPOP_SBC_1	167	171	PF00917	0.450
DOC_MAPK_gen_1	127	135	PF00069	0.444
DOC_MAPK_gen_1	430	441	PF00069	0.463
DOC_MAPK_gen_1	55	65	PF00069	0.468
DOC_MAPK_MEF2A_6	127	135	PF00069	0.444
DOC_MAPK_MEF2A_6	33	42	PF00069	0.519
DOC_PP2B_LxvP_1	123	126	PF13499	0.444
DOC_PP4_FxxP_1	145	148	PF00568	0.484
DOC_PP4_FxxP_1	187	190	PF00568	0.389
DOC_USP7_MATH_1	201	205	PF00917	0.586
DOC_USP7_MATH_1	220	224	PF00917	0.521
DOC_USP7_MATH_1	268	272	PF00917	0.684
DOC_USP7_MATH_1	331	335	PF00917	0.607
DOC_USP7_MATH_1	341	345	PF00917	0.553
DOC_USP7_MATH_1	59	63	PF00917	0.539
DOC_USP7_UBL2_3	33	37	PF12436	0.498
DOC_WW_Pin1_4	177	182	PF00397	0.424
DOC_WW_Pin1_4	240	245	PF00397	0.599
DOC_WW_Pin1_4	308	313	PF00397	0.478
DOC_WW_Pin1_4	408	413	PF00397	0.551
DOC_WW_Pin1_4	42	47	PF00397	0.450
LIG_14-3-3_CanoR_1	322	330	PF00244	0.590
LIG_14-3-3_CanoR_1	58	64	PF00244	0.468
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BRCT_BRCA1_1	164	168	PF00533	0.474
LIG_Clathr_ClatBox_1	210	214	PF01394	0.550
LIG_EH1_1	134	142	PF00400	0.431
LIG_FHA_1	116	122	PF00498	0.484
LIG_FHA_1	245	251	PF00498	0.562
LIG_FHA_1	360	366	PF00498	0.569
LIG_FHA_1	94	100	PF00498	0.494
LIG_FHA_2	109	115	PF00498	0.491
LIG_FHA_2	167	173	PF00498	0.467
LIG_FHA_2	304	310	PF00498	0.470
LIG_LIR_Apic_2	143	148	PF02991	0.484
LIG_LIR_Gen_1	294	299	PF02991	0.541
LIG_LIR_Gen_1	350	360	PF02991	0.625
LIG_LIR_LC3C_4	362	365	PF02991	0.567
LIG_LIR_Nem_3	117	123	PF02991	0.474
LIG_LIR_Nem_3	266	270	PF02991	0.573
LIG_LIR_Nem_3	294	298	PF02991	0.543
LIG_LIR_Nem_3	350	355	PF02991	0.658
LIG_LYPXL_yS_3	267	270	PF13949	0.576
LIG_MYND_1	253	257	PF01753	0.516
LIG_NRBOX	206	212	PF00104	0.542
LIG_SH2_PTP2	192	195	PF00017	0.489
LIG_SH2_PTP2	295	298	PF00017	0.525
LIG_SH2_SRC	192	195	PF00017	0.462
LIG_SH2_STAP1	109	113	PF00017	0.458
LIG_SH2_STAT5	120	123	PF00017	0.454
LIG_SH2_STAT5	192	195	PF00017	0.489
LIG_SH2_STAT5	295	298	PF00017	0.525
LIG_SH2_STAT5	488	491	PF00017	0.470
LIG_SH3_1	378	384	PF00018	0.605
LIG_SH3_3	18	24	PF00018	0.413
LIG_SH3_3	247	253	PF00018	0.622
LIG_SH3_3	262	268	PF00018	0.618
LIG_SH3_3	275	281	PF00018	0.487
LIG_SH3_3	378	384	PF00018	0.564
LIG_SH3_3	48	54	PF00018	0.484
LIG_SH3_3	488	494	PF00018	0.518
LIG_SUMO_SIM_anti_2	362	368	PF11976	0.550
LIG_SUMO_SIM_par_1	361	368	PF11976	0.599
LIG_TRAF2_1	325	328	PF00917	0.790
LIG_UBA3_1	251	259	PF00899	0.568
LIG_WW_1	264	267	PF00397	0.526
LIG_WW_3	379	383	PF00397	0.587
MOD_CDK_SPK_2	408	413	PF00069	0.516
MOD_CK1_1	223	229	PF00069	0.554
MOD_CK1_1	240	246	PF00069	0.623
MOD_CK1_1	272	278	PF00069	0.715
MOD_CK1_1	288	294	PF00069	0.561
MOD_CK1_1	311	317	PF00069	0.573
MOD_CK1_1	416	422	PF00069	0.592
MOD_CK1_1	426	432	PF00069	0.524
MOD_CK2_1	109	115	PF00069	0.307
MOD_CK2_1	167	173	PF00069	0.404
MOD_CK2_1	270	276	PF00069	0.719
MOD_CK2_1	303	309	PF00069	0.483
MOD_CK2_1	347	353	PF00069	0.618
MOD_CK2_1	391	397	PF00069	0.704
MOD_CK2_1	513	519	PF00069	0.559
MOD_GlcNHglycan	216	219	PF01048	0.494
MOD_GlcNHglycan	272	275	PF01048	0.676
MOD_GlcNHglycan	287	290	PF01048	0.674
MOD_GlcNHglycan	349	352	PF01048	0.609
MOD_GlcNHglycan	367	370	PF01048	0.472
MOD_GlcNHglycan	418	421	PF01048	0.584
MOD_GSK3_1	154	161	PF00069	0.327
MOD_GSK3_1	162	169	PF00069	0.312
MOD_GSK3_1	196	203	PF00069	0.525
MOD_GSK3_1	236	243	PF00069	0.569
MOD_GSK3_1	268	275	PF00069	0.621
MOD_GSK3_1	284	291	PF00069	0.517
MOD_GSK3_1	42	49	PF00069	0.282
MOD_N-GLC_1	426	431	PF02516	0.540
MOD_N-GLC_1	449	454	PF02516	0.454
MOD_N-GLC_2	345	347	PF02516	0.654
MOD_NEK2_1	158	163	PF00069	0.307
MOD_NEK2_1	258	263	PF00069	0.769
MOD_NEK2_1	65	70	PF00069	0.329
MOD_NEK2_2	59	64	PF00069	0.407
MOD_PIKK_1	288	294	PF00454	0.561
MOD_PIKK_1	323	329	PF00454	0.570
MOD_PIKK_1	44	50	PF00454	0.316
MOD_PIKK_1	463	469	PF00454	0.602
MOD_PIKK_1	86	92	PF00454	0.329
MOD_PK_1	25	31	PF00069	0.282
MOD_Plk_1	172	178	PF00069	0.440
MOD_Plk_1	223	229	PF00069	0.573
MOD_Plk_4	140	146	PF00069	0.329
MOD_Plk_4	206	212	PF00069	0.542
MOD_Plk_4	246	252	PF00069	0.688
MOD_Plk_4	359	365	PF00069	0.756
MOD_Plk_4	510	516	PF00069	0.596
MOD_Plk_4	65	71	PF00069	0.329
MOD_ProDKin_1	177	183	PF00069	0.429
MOD_ProDKin_1	240	246	PF00069	0.600
MOD_ProDKin_1	308	314	PF00069	0.479
MOD_ProDKin_1	408	414	PF00069	0.554
MOD_ProDKin_1	42	48	PF00069	0.282
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.273
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.358
TRG_ENDOCYTIC_2	120	123	PF00928	0.397
TRG_ENDOCYTIC_2	267	270	PF00928	0.576
TRG_ENDOCYTIC_2	295	298	PF00928	0.549
TRG_ENDOCYTIC_2	488	491	PF00928	0.470
TRG_ER_diArg_1	434	437	PF00400	0.621
TRG_ER_diArg_1	438	441	PF00400	0.482
TRG_NLS_MonoCore_2	381	386	PF00514	0.593
TRG_NLS_MonoExtN_4	379	386	PF00514	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P363	Leptomonas seymouri	49%	91%
A0A3Q8IIK6	Leishmania donovani	92%	100%
A0A3R7KIM5	Trypanosoma rangeli	29%	83%
A4H7Z2	Leishmania braziliensis	74%	100%
A4HWC0	Leishmania infantum	92%	100%
Q4QFG1	Leishmania major	92%	100%