Putative serine/threonine-protein kinase (Putative protein kinase)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AQ15_LEIMU

TriTrypDb:

LmxM.15.0180

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ15

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003712	transcription coregulator activity	2	1
GO:0003713	transcription coactivator activity	3	1
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.519
CLV_C14_Caspase3-7	297	301	PF00656	0.712
CLV_C14_Caspase3-7	345	349	PF00656	0.582
CLV_C14_Caspase3-7	43	47	PF00656	0.787
CLV_C14_Caspase3-7	665	669	PF00656	0.319
CLV_NRD_NRD_1	331	333	PF00675	0.628
CLV_NRD_NRD_1	395	397	PF00675	0.494
CLV_NRD_NRD_1	465	467	PF00675	0.494
CLV_NRD_NRD_1	616	618	PF00675	0.494
CLV_NRD_NRD_1	633	635	PF00675	0.213
CLV_PCSK_FUR_1	631	635	PF00082	0.494
CLV_PCSK_KEX2_1	331	333	PF00082	0.628
CLV_PCSK_KEX2_1	384	386	PF00082	0.494
CLV_PCSK_KEX2_1	395	397	PF00082	0.312
CLV_PCSK_KEX2_1	520	522	PF00082	0.494
CLV_PCSK_KEX2_1	616	618	PF00082	0.494
CLV_PCSK_KEX2_1	633	635	PF00082	0.213
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.494
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.494
CLV_PCSK_SKI1_1	426	430	PF00082	0.494
CLV_PCSK_SKI1_1	667	671	PF00082	0.401
CLV_PCSK_SKI1_1	729	733	PF00082	0.636
DEG_APCC_DBOX_1	547	555	PF00400	0.494
DEG_APCC_DBOX_1	615	623	PF00400	0.494
DEG_SPOP_SBC_1	189	193	PF00917	0.606
DEG_SPOP_SBC_1	212	216	PF00917	0.717
DOC_ANK_TNKS_1	127	134	PF00023	0.699
DOC_CKS1_1	542	547	PF01111	0.494
DOC_CKS1_1	635	640	PF01111	0.494
DOC_MAPK_gen_1	453	462	PF00069	0.494
DOC_MAPK_gen_1	529	539	PF00069	0.494
DOC_MAPK_HePTP_8	526	538	PF00069	0.494
DOC_MAPK_MEF2A_6	307	316	PF00069	0.614
DOC_MAPK_MEF2A_6	401	410	PF00069	0.494
DOC_MAPK_MEF2A_6	456	464	PF00069	0.494
DOC_MAPK_MEF2A_6	529	538	PF00069	0.494
DOC_PP1_RVXF_1	506	513	PF00149	0.494
DOC_PP2B_LxvP_1	352	355	PF13499	0.568
DOC_PP4_FxxP_1	674	677	PF00568	0.590
DOC_USP7_MATH_1	100	104	PF00917	0.703
DOC_USP7_MATH_1	134	138	PF00917	0.598
DOC_USP7_MATH_1	156	160	PF00917	0.700
DOC_USP7_MATH_1	187	191	PF00917	0.606
DOC_USP7_MATH_1	2	6	PF00917	0.762
DOC_USP7_MATH_1	217	221	PF00917	0.617
DOC_USP7_MATH_1	222	226	PF00917	0.639
DOC_USP7_MATH_1	245	249	PF00917	0.725
DOC_USP7_MATH_1	277	281	PF00917	0.590
DOC_USP7_MATH_1	294	298	PF00917	0.629
DOC_USP7_MATH_1	719	723	PF00917	0.577
DOC_USP7_MATH_2	660	666	PF00917	0.319
DOC_WW_Pin1_4	10	15	PF00397	0.692
DOC_WW_Pin1_4	105	110	PF00397	0.702
DOC_WW_Pin1_4	123	128	PF00397	0.587
DOC_WW_Pin1_4	192	197	PF00397	0.582
DOC_WW_Pin1_4	332	337	PF00397	0.659
DOC_WW_Pin1_4	530	535	PF00397	0.494
DOC_WW_Pin1_4	541	546	PF00397	0.312
DOC_WW_Pin1_4	589	594	PF00397	0.494
DOC_WW_Pin1_4	634	639	PF00397	0.494
DOC_WW_Pin1_4	697	702	PF00397	0.529
LIG_14-3-3_CanoR_1	102	109	PF00244	0.643
LIG_14-3-3_CanoR_1	117	127	PF00244	0.690
LIG_14-3-3_CanoR_1	231	235	PF00244	0.539
LIG_14-3-3_CanoR_1	395	401	PF00244	0.494
LIG_14-3-3_CanoR_1	548	552	PF00244	0.494
LIG_14-3-3_CanoR_1	616	620	PF00244	0.494
LIG_14-3-3_CanoR_1	663	670	PF00244	0.319
LIG_14-3-3_CanoR_1	676	685	PF00244	0.339
LIG_14-3-3_CanoR_1	736	744	PF00244	0.721
LIG_APCC_ABBA_1	536	541	PF00400	0.494
LIG_BIR_II_1	1	5	PF00653	0.708
LIG_Clathr_ClatBox_1	476	480	PF01394	0.494
LIG_EH1_1	421	429	PF00400	0.494
LIG_FHA_1	471	477	PF00498	0.359
LIG_FHA_1	678	684	PF00498	0.629
LIG_FHA_1	726	732	PF00498	0.649
LIG_FHA_1	89	95	PF00498	0.717
LIG_FHA_2	127	133	PF00498	0.781
LIG_FHA_2	158	164	PF00498	0.515
LIG_FHA_2	41	47	PF00498	0.718
LIG_FHA_2	542	548	PF00498	0.494
LIG_FHA_2	730	736	PF00498	0.735
LIG_Integrin_isoDGR_2	236	238	PF01839	0.760
LIG_LIR_Apic_2	303	308	PF02991	0.654
LIG_LIR_Apic_2	528	534	PF02991	0.494
LIG_LIR_Apic_2	541	545	PF02991	0.279
LIG_LIR_Gen_1	348	359	PF02991	0.551
LIG_LIR_Gen_1	647	656	PF02991	0.496
LIG_LIR_Nem_3	318	323	PF02991	0.556
LIG_LIR_Nem_3	348	354	PF02991	0.556
LIG_LIR_Nem_3	357	363	PF02991	0.396
LIG_LIR_Nem_3	373	377	PF02991	0.230
LIG_LIR_Nem_3	445	449	PF02991	0.494
LIG_LIR_Nem_3	455	460	PF02991	0.329
LIG_LIR_Nem_3	642	648	PF02991	0.429
LIG_LIR_Nem_3	653	658	PF02991	0.402
LIG_MYND_1	673	677	PF01753	0.494
LIG_NRBOX	407	413	PF00104	0.494
LIG_PCNA_yPIPBox_3	413	424	PF02747	0.494
LIG_Pex14_2	651	655	PF04695	0.494
LIG_PTB_Apo_2	321	328	PF02174	0.602
LIG_PTB_Phospho_1	321	327	PF10480	0.606
LIG_SH2_CRK	305	309	PF00017	0.647
LIG_SH2_CRK	320	324	PF00017	0.347
LIG_SH2_CRK	449	453	PF00017	0.494
LIG_SH2_CRK	542	546	PF00017	0.494
LIG_SH2_NCK_1	305	309	PF00017	0.569
LIG_SH2_NCK_1	75	79	PF00017	0.716
LIG_SH2_STAP1	679	683	PF00017	0.630
LIG_SH2_STAT3	327	330	PF00017	0.618
LIG_SH2_STAT3	363	366	PF00017	0.531
LIG_SH2_STAT5	327	330	PF00017	0.618
LIG_SH2_STAT5	351	354	PF00017	0.551
LIG_SH2_STAT5	363	366	PF00017	0.333
LIG_SH2_STAT5	517	520	PF00017	0.463
LIG_SH2_STAT5	52	55	PF00017	0.706
LIG_SH2_STAT5	525	528	PF00017	0.393
LIG_SH2_STAT5	679	682	PF00017	0.627
LIG_SH3_2	698	703	PF14604	0.745
LIG_SH3_3	147	153	PF00018	0.738
LIG_SH3_3	198	204	PF00018	0.653
LIG_SH3_3	237	243	PF00018	0.665
LIG_SH3_3	254	260	PF00018	0.617
LIG_SH3_3	688	694	PF00018	0.675
LIG_SH3_3	695	701	PF00018	0.743
LIG_SH3_4	714	721	PF00018	0.750
LIG_SUMO_SIM_anti_2	407	412	PF11976	0.494
LIG_SUMO_SIM_anti_2	461	466	PF11976	0.494
LIG_SUMO_SIM_par_1	436	442	PF11976	0.494
LIG_UBA3_1	316	321	PF00899	0.597
LIG_UBA3_1	476	483	PF00899	0.353
LIG_WRC_WIRS_1	443	448	PF05994	0.494
MOD_CDC14_SPxK_1	13	16	PF00782	0.679
MOD_CDC14_SPxK_1	700	703	PF00782	0.533
MOD_CDK_SPK_2	123	128	PF00069	0.702
MOD_CDK_SPK_2	589	594	PF00069	0.494
MOD_CDK_SPxK_1	10	16	PF00069	0.690
MOD_CDK_SPxK_1	697	703	PF00069	0.527
MOD_CDK_SPxxK_3	332	339	PF00069	0.663
MOD_CDK_SPxxK_3	541	548	PF00069	0.494
MOD_CK1_1	103	109	PF00069	0.684
MOD_CK1_1	111	117	PF00069	0.669
MOD_CK1_1	123	129	PF00069	0.488
MOD_CK1_1	190	196	PF00069	0.750
MOD_CK1_1	213	219	PF00069	0.709
MOD_CK1_1	225	231	PF00069	0.574
MOD_CK1_1	265	271	PF00069	0.731
MOD_CK1_1	373	379	PF00069	0.494
MOD_CK1_1	399	405	PF00069	0.494
MOD_CK1_1	4	10	PF00069	0.753
MOD_CK1_1	710	716	PF00069	0.826
MOD_CK1_1	734	740	PF00069	0.709
MOD_CK1_1	76	82	PF00069	0.747
MOD_CK2_1	126	132	PF00069	0.701
MOD_CK2_1	238	244	PF00069	0.696
MOD_CK2_1	729	735	PF00069	0.812
MOD_Cter_Amidation	631	634	PF01082	0.494
MOD_GlcNHglycan	110	113	PF01048	0.780
MOD_GlcNHglycan	172	175	PF01048	0.731
MOD_GlcNHglycan	192	195	PF01048	0.743
MOD_GlcNHglycan	205	208	PF01048	0.594
MOD_GlcNHglycan	224	227	PF01048	0.607
MOD_GlcNHglycan	270	273	PF01048	0.784
MOD_GlcNHglycan	281	284	PF01048	0.622
MOD_GlcNHglycan	341	344	PF01048	0.615
MOD_GlcNHglycan	504	507	PF01048	0.378
MOD_GlcNHglycan	513	516	PF01048	0.287
MOD_GlcNHglycan	604	607	PF01048	0.494
MOD_GlcNHglycan	695	698	PF01048	0.616
MOD_GlcNHglycan	739	742	PF01048	0.740
MOD_GlcNHglycan	77	81	PF01048	0.793
MOD_GSK3_1	1	8	PF00069	0.767
MOD_GSK3_1	119	126	PF00069	0.727
MOD_GSK3_1	132	139	PF00069	0.581
MOD_GSK3_1	188	195	PF00069	0.771
MOD_GSK3_1	213	220	PF00069	0.611
MOD_GSK3_1	225	232	PF00069	0.713
MOD_GSK3_1	246	253	PF00069	0.759
MOD_GSK3_1	264	271	PF00069	0.596
MOD_GSK3_1	275	282	PF00069	0.630
MOD_GSK3_1	391	398	PF00069	0.494
MOD_GSK3_1	40	47	PF00069	0.786
MOD_GSK3_1	511	518	PF00069	0.443
MOD_GSK3_1	693	700	PF00069	0.520
MOD_GSK3_1	719	726	PF00069	0.752
MOD_GSK3_1	727	734	PF00069	0.664
MOD_GSK3_1	98	105	PF00069	0.694
MOD_N-GLC_1	502	507	PF02516	0.494
MOD_N-GLC_1	601	606	PF02516	0.494
MOD_NEK2_1	1	6	PF00069	0.767
MOD_NEK2_1	120	125	PF00069	0.728
MOD_NEK2_1	264	269	PF00069	0.527
MOD_NEK2_1	391	396	PF00069	0.494
MOD_NEK2_1	472	477	PF00069	0.494
MOD_PIKK_1	251	257	PF00454	0.590
MOD_PIKK_1	399	405	PF00454	0.494
MOD_PIKK_1	40	46	PF00454	0.787
MOD_PIKK_1	704	710	PF00454	0.815
MOD_PKA_1	395	401	PF00069	0.494
MOD_PKA_2	101	107	PF00069	0.574
MOD_PKA_2	118	124	PF00069	0.741
MOD_PKA_2	230	236	PF00069	0.540
MOD_PKA_2	395	401	PF00069	0.494
MOD_PKA_2	547	553	PF00069	0.494
MOD_PKA_2	615	621	PF00069	0.494
MOD_PKA_2	662	668	PF00069	0.319
MOD_PKA_2	737	743	PF00069	0.735
MOD_PKA_2	88	94	PF00069	0.713
MOD_PKB_1	117	125	PF00069	0.741
MOD_Plk_1	577	583	PF00069	0.494
MOD_Plk_2-3	615	621	PF00069	0.494
MOD_Plk_4	373	379	PF00069	0.494
MOD_Plk_4	472	478	PF00069	0.494
MOD_Plk_4	618	624	PF00069	0.494
MOD_ProDKin_1	10	16	PF00069	0.690
MOD_ProDKin_1	105	111	PF00069	0.703
MOD_ProDKin_1	123	129	PF00069	0.587
MOD_ProDKin_1	192	198	PF00069	0.582
MOD_ProDKin_1	332	338	PF00069	0.662
MOD_ProDKin_1	530	536	PF00069	0.494
MOD_ProDKin_1	541	547	PF00069	0.312
MOD_ProDKin_1	589	595	PF00069	0.494
MOD_ProDKin_1	634	640	PF00069	0.494
MOD_ProDKin_1	697	703	PF00069	0.532
MOD_SUMO_for_1	404	407	PF00179	0.494
MOD_SUMO_for_1	492	495	PF00179	0.494
MOD_SUMO_for_1	575	578	PF00179	0.494
TRG_DiLeu_BaEn_1	407	412	PF01217	0.494
TRG_DiLeu_BaEn_2	534	540	PF01217	0.494
TRG_DiLeu_BaEn_2	646	652	PF01217	0.310
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.494
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.494
TRG_ENDOCYTIC_2	320	323	PF00928	0.604
TRG_ENDOCYTIC_2	351	354	PF00928	0.551
TRG_ENDOCYTIC_2	449	452	PF00928	0.494
TRG_ENDOCYTIC_2	645	648	PF00928	0.494
TRG_ER_diArg_1	117	120	PF00400	0.777
TRG_ER_diArg_1	331	333	PF00400	0.628
TRG_ER_diArg_1	630	633	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	654	659	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTA3	Leishmania donovani	92%	100%
A4H7Y7	Leishmania braziliensis	75%	100%
A4HWB5	Leishmania infantum	91%	100%
E9AVG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4QC19	Leishmania major	31%	100%
Q4QFG6	Leishmania major	92%	100%
Q5U4C9	Mus musculus	36%	100%
Q92630	Homo sapiens	36%	100%