LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

PPM-type phosphatase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PPM-type phosphatase domain-containing protein
Gene product:
protein phosphatase 2C, putative
Species:
Leishmania mexicana
UniProt:
E9AQ14_LEIMU
TriTrypDb:
LmxM.15.0170
Length:
404

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AQ14
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ14

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 22
GO:0006793 phosphorus metabolic process 3 22
GO:0006796 phosphate-containing compound metabolic process 4 22
GO:0006807 nitrogen compound metabolic process 2 22
GO:0008152 metabolic process 1 22
GO:0009987 cellular process 1 22
GO:0016311 dephosphorylation 5 22
GO:0019538 protein metabolic process 3 22
GO:0036211 protein modification process 4 22
GO:0043170 macromolecule metabolic process 3 22
GO:0043412 macromolecule modification 4 22
GO:0044237 cellular metabolic process 2 22
GO:0044238 primary metabolic process 2 22
GO:0071704 organic substance metabolic process 2 22
GO:1901564 organonitrogen compound metabolic process 3 22
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 22
GO:0004721 phosphoprotein phosphatase activity 3 22
GO:0004722 protein serine/threonine phosphatase activity 4 22
GO:0016787 hydrolase activity 2 22
GO:0016788 hydrolase activity, acting on ester bonds 3 22
GO:0016791 phosphatase activity 5 22
GO:0042578 phosphoric ester hydrolase activity 4 22
GO:0140096 catalytic activity, acting on a protein 2 22
GO:0017018 myosin phosphatase activity 5 4
GO:0005488 binding 1 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 126 130 PF00656 0.529
CLV_C14_Caspase3-7 330 334 PF00656 0.427
CLV_C14_Caspase3-7 391 395 PF00656 0.380
CLV_NRD_NRD_1 328 330 PF00675 0.193
CLV_NRD_NRD_1 7 9 PF00675 0.729
CLV_NRD_NRD_1 71 73 PF00675 0.540
CLV_PCSK_KEX2_1 306 308 PF00082 0.427
CLV_PCSK_KEX2_1 310 312 PF00082 0.404
CLV_PCSK_KEX2_1 328 330 PF00082 0.491
CLV_PCSK_KEX2_1 6 8 PF00082 0.729
CLV_PCSK_PC1ET2_1 306 308 PF00082 0.420
CLV_PCSK_PC1ET2_1 310 312 PF00082 0.404
CLV_PCSK_PC1ET2_1 6 8 PF00082 0.729
CLV_PCSK_SKI1_1 117 121 PF00082 0.450
CLV_PCSK_SKI1_1 194 198 PF00082 0.345
CLV_PCSK_SKI1_1 210 214 PF00082 0.326
CLV_PCSK_SKI1_1 217 221 PF00082 0.338
CLV_PCSK_SKI1_1 251 255 PF00082 0.340
CLV_PCSK_SKI1_1 311 315 PF00082 0.365
CLV_PCSK_SKI1_1 60 64 PF00082 0.537
DEG_Nend_UBRbox_1 1 4 PF02207 0.585
DOC_CKS1_1 195 200 PF01111 0.323
DOC_PP2B_LxvP_1 317 320 PF13499 0.255
DOC_USP7_MATH_1 113 117 PF00917 0.609
DOC_USP7_MATH_1 331 335 PF00917 0.458
DOC_USP7_UBL2_3 2 6 PF12436 0.656
DOC_USP7_UBL2_3 306 310 PF12436 0.317
DOC_WW_Pin1_4 194 199 PF00397 0.323
DOC_WW_Pin1_4 235 240 PF00397 0.340
DOC_WW_Pin1_4 379 384 PF00397 0.358
LIG_14-3-3_CanoR_1 328 336 PF00244 0.228
LIG_14-3-3_CanoR_1 94 99 PF00244 0.632
LIG_BRCT_BRCA1_1 184 188 PF00533 0.278
LIG_FHA_1 232 238 PF00498 0.276
LIG_FHA_1 312 318 PF00498 0.298
LIG_FHA_1 395 401 PF00498 0.376
LIG_FHA_1 82 88 PF00498 0.501
LIG_FHA_2 124 130 PF00498 0.509
LIG_FHA_2 307 313 PF00498 0.320
LIG_LIR_Apic_2 193 198 PF02991 0.255
LIG_LIR_Apic_2 234 239 PF02991 0.255
LIG_LIR_Gen_1 209 219 PF02991 0.315
LIG_LIR_Gen_1 333 343 PF02991 0.335
LIG_LIR_Gen_1 36 46 PF02991 0.525
LIG_LIR_LC3C_4 314 319 PF02991 0.363
LIG_LIR_Nem_3 166 172 PF02991 0.333
LIG_LIR_Nem_3 209 215 PF02991 0.327
LIG_LIR_Nem_3 333 338 PF02991 0.334
LIG_LIR_Nem_3 341 347 PF02991 0.336
LIG_LIR_Nem_3 36 42 PF02991 0.526
LIG_NRBOX 99 105 PF00104 0.534
LIG_PCNA_yPIPBox_3 94 108 PF02747 0.504
LIG_Pex14_2 208 212 PF04695 0.370
LIG_PTB_Apo_2 127 134 PF02174 0.418
LIG_PTB_Apo_2 151 158 PF02174 0.278
LIG_RPA_C_Fungi 89 101 PF08784 0.453
LIG_SH2_CRK 195 199 PF00017 0.278
LIG_SH2_NCK_1 195 199 PF00017 0.371
LIG_SH2_PTP2 236 239 PF00017 0.431
LIG_SH2_PTP2 335 338 PF00017 0.431
LIG_SH2_STAT5 168 171 PF00017 0.486
LIG_SH2_STAT5 236 239 PF00017 0.483
LIG_SH2_STAT5 335 338 PF00017 0.431
LIG_SH3_3 316 322 PF00018 0.399
LIG_SH3_3 377 383 PF00018 0.278
LIG_SUMO_SIM_anti_2 348 358 PF11976 0.267
LIG_SUMO_SIM_anti_2 397 402 PF11976 0.393
LIG_SUMO_SIM_par_1 396 402 PF11976 0.387
LIG_TRAF2_1 238 241 PF00917 0.403
LIG_TRAF2_1 348 351 PF00917 0.350
LIG_UBA3_1 352 360 PF00899 0.431
LIG_UBA3_1 399 404 PF00899 0.381
MOD_CK1_1 12 18 PF00069 0.624
MOD_CK1_1 182 188 PF00069 0.405
MOD_CK1_1 228 234 PF00069 0.375
MOD_CK1_1 44 50 PF00069 0.556
MOD_CK2_1 187 193 PF00069 0.492
MOD_CK2_1 235 241 PF00069 0.411
MOD_CK2_1 306 312 PF00069 0.314
MOD_CK2_1 345 351 PF00069 0.316
MOD_CK2_1 378 384 PF00069 0.417
MOD_CK2_1 50 56 PF00069 0.500
MOD_CK2_1 80 86 PF00069 0.593
MOD_GlcNHglycan 108 111 PF01048 0.568
MOD_GlcNHglycan 14 17 PF01048 0.764
MOD_GlcNHglycan 158 161 PF01048 0.361
MOD_GlcNHglycan 175 178 PF01048 0.313
MOD_GlcNHglycan 179 182 PF01048 0.305
MOD_GlcNHglycan 227 230 PF01048 0.376
MOD_GlcNHglycan 329 332 PF01048 0.419
MOD_GlcNHglycan 52 55 PF01048 0.421
MOD_GSK3_1 113 120 PF00069 0.542
MOD_GSK3_1 121 128 PF00069 0.526
MOD_GSK3_1 173 180 PF00069 0.513
MOD_GSK3_1 182 189 PF00069 0.451
MOD_GSK3_1 227 234 PF00069 0.313
MOD_GSK3_1 323 330 PF00069 0.469
MOD_GSK3_1 390 397 PF00069 0.446
MOD_GSK3_1 46 53 PF00069 0.581
MOD_N-GLC_1 12 17 PF02516 0.627
MOD_N-GLC_1 394 399 PF02516 0.376
MOD_N-GLC_1 47 52 PF02516 0.406
MOD_N-GLC_2 375 377 PF02516 0.471
MOD_NEK2_1 294 299 PF00069 0.345
MOD_NEK2_1 46 51 PF00069 0.658
MOD_PIKK_1 182 188 PF00454 0.407
MOD_PIKK_1 311 317 PF00454 0.335
MOD_PKA_1 306 312 PF00069 0.389
MOD_PKA_1 7 13 PF00069 0.599
MOD_PKA_2 306 312 PF00069 0.221
MOD_PKA_2 327 333 PF00069 0.261
MOD_PKA_2 50 56 PF00069 0.452
MOD_PKA_2 7 13 PF00069 0.560
MOD_PKA_2 81 87 PF00069 0.625
MOD_Plk_1 394 400 PF00069 0.374
MOD_Plk_4 231 237 PF00069 0.396
MOD_Plk_4 331 337 PF00069 0.315
MOD_Plk_4 394 400 PF00069 0.374
MOD_ProDKin_1 194 200 PF00069 0.323
MOD_ProDKin_1 235 241 PF00069 0.340
MOD_ProDKin_1 379 385 PF00069 0.358
MOD_SUMO_rev_2 262 269 PF00179 0.338
MOD_SUMO_rev_2 354 361 PF00179 0.255
MOD_SUMO_rev_2 59 67 PF00179 0.425
TRG_DiLeu_BaEn_1 148 153 PF01217 0.340
TRG_DiLeu_BaEn_1 351 356 PF01217 0.340
TRG_ENDOCYTIC_2 168 171 PF00928 0.269
TRG_ENDOCYTIC_2 335 338 PF00928 0.431
TRG_NLS_MonoExtC_3 71 77 PF00514 0.590
TRG_NLS_MonoExtN_4 4 10 PF00514 0.722
TRG_Pf-PMV_PEXEL_1 60 64 PF00026 0.727

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C7 Leptomonas seymouri 71% 100%
A0A0N0P8F8 Leptomonas seymouri 38% 100%
A0A0N1I0H9 Leptomonas seymouri 39% 100%
A0A0N1I8W9 Leptomonas seymouri 28% 93%
A0A0N1IHU6 Leptomonas seymouri 31% 99%
A0A0N1PAL8 Leptomonas seymouri 31% 100%
A0A0N1PET0 Leptomonas seymouri 35% 69%
A0A0S4IY95 Bodo saltans 35% 100%
A0A0S4J0A6 Bodo saltans 29% 99%
A0A0S4JHB4 Bodo saltans 34% 100%
A0A0S4JPC3 Bodo saltans 42% 100%
A0A0S4JPM8 Bodo saltans 46% 100%
A0A0S4KIS4 Bodo saltans 35% 89%
A0A0S4KJV9 Bodo saltans 39% 93%
A0A1X0NRG3 Trypanosomatidae 37% 100%
A0A1X0NVC4 Trypanosomatidae 53% 98%
A0A1X0P568 Trypanosomatidae 31% 99%
A0A1X0P991 Trypanosomatidae 40% 100%
A0A1X0PAN4 Trypanosomatidae 27% 100%
A0A3Q8IEK6 Leishmania donovani 40% 100%
A0A3Q8IFG7 Leishmania donovani 32% 100%
A0A3Q8IGS1 Leishmania donovani 35% 72%
A0A3Q8IK65 Leishmania donovani 41% 100%
A0A3S7WTA2 Leishmania donovani 92% 100%
A0A3S7WZ14 Leishmania donovani 30% 100%
A0A3S7X808 Leishmania donovani 28% 90%
A0A422N8D7 Trypanosoma rangeli 27% 100%
A0A422NAJ1 Trypanosoma rangeli 37% 100%
A0A422NBV9 Trypanosoma rangeli 32% 99%
A0A422NL94 Trypanosoma rangeli 38% 92%
A0A422NML6 Trypanosoma rangeli 32% 100%
A0A422NS77 Trypanosoma rangeli 51% 98%
A0A422P293 Trypanosoma rangeli 41% 100%
A0BLX0 Paramecium tetraurelia 34% 100%
A0BQL0 Paramecium tetraurelia 36% 100%
A0CUB5 Paramecium tetraurelia 31% 100%
A0DSB3 Paramecium tetraurelia 32% 100%
A0DTY1 Paramecium tetraurelia 34% 100%
A3A8W2 Oryza sativa subsp. japonica 30% 100%
A3A8W6 Oryza sativa subsp. japonica 27% 70%
A4H7Y6 Leishmania braziliensis 79% 100%
A4HAW6 Leishmania braziliensis 27% 90%
A4HE10 Leishmania braziliensis 30% 100%
A4HG10 Leishmania braziliensis 40% 100%
A4HHY5 Leishmania braziliensis 32% 100%
A4HKF6 Leishmania braziliensis 35% 71%
A4HNR1 Leishmania braziliensis 40% 99%
A4HWB4 Leishmania infantum 92% 100%
A4I1B7 Leishmania infantum 30% 100%
A4I329 Leishmania infantum 40% 100%
A4I565 Leishmania infantum 32% 100%
A4I7Y4 Leishmania infantum 35% 72%
A4IA26 Leishmania infantum 28% 90%
A4ICT4 Leishmania infantum 41% 100%
A5PJZ2 Bos taurus 32% 100%
C9ZJK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
C9ZMJ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZNW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 95%
D0A2L9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
D0A5L0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 99%
E9ACV0 Leishmania major 40% 100%
E9ASH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9AXF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AZD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9B0G2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B2U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 72%
E9B541 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
O04719 Arabidopsis thaliana 31% 96%
O62829 Bos taurus 35% 100%
O62830 Bos taurus 37% 83%
O75688 Homo sapiens 37% 84%
O80871 Arabidopsis thaliana 26% 100%
O81716 Arabidopsis thaliana 32% 100%
P20650 Rattus norvegicus 35% 100%
P34221 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 86%
P35182 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
P35813 Homo sapiens 35% 100%
P35814 Oryctolagus cuniculus 35% 100%
P35815 Rattus norvegicus 37% 100%
P36982 Leishmania chagasi 30% 100%
P36993 Mus musculus 37% 100%
P38089 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P39966 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 87%
P40371 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
P49443 Mus musculus 35% 100%
P49444 Paramecium tetraurelia 35% 100%
P49593 Homo sapiens 30% 89%
P49594 Caenorhabditis elegans 25% 90%
P49596 Caenorhabditis elegans 39% 100%
P49599 Arabidopsis thaliana 28% 100%
Q09172 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 100%
Q09173 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 98%
Q0IIF0 Bos taurus 31% 100%
Q0J2L7 Oryza sativa subsp. japonica 33% 100%
Q0J2R1 Oryza sativa subsp. japonica 26% 100%
Q0JL75 Oryza sativa subsp. japonica 31% 100%
Q0JLP9 Oryza sativa subsp. japonica 33% 87%
Q10MX1 Oryza sativa subsp. japonica 29% 100%
Q19775 Caenorhabditis elegans 34% 86%
Q2QWE3 Oryza sativa subsp. japonica 28% 96%
Q2R637 Oryza sativa subsp. japonica 29% 94%
Q4Q225 Leishmania major 39% 99%
Q4Q2U5 Leishmania major 28% 90%
Q4Q2U6 Leishmania major 26% 100%
Q4Q5B1 Leishmania major 35% 72%
Q4Q7S1 Leishmania major 31% 100%
Q4QA19 Leishmania major 32% 100%
Q4QFG7 Leishmania major 91% 100%
Q53Q11 Oryza sativa subsp. japonica 30% 100%
Q5SGD2 Homo sapiens 32% 100%
Q5SN75 Oryza sativa subsp. japonica 30% 100%
Q653S3 Oryza sativa subsp. japonica 32% 100%
Q65XG6 Oryza sativa subsp. japonica 34% 97%
Q67UP9 Oryza sativa subsp. japonica 35% 100%
Q67UX7 Oryza sativa subsp. japonica 33% 100%
Q69QZ0 Oryza sativa subsp. japonica 28% 100%
Q69VD9 Oryza sativa subsp. japonica 29% 100%
Q6AUQ4 Oryza sativa subsp. japonica 30% 100%
Q6ETK3 Oryza sativa subsp. japonica 33% 100%
Q6K1U4 Oryza sativa subsp. japonica 26% 78%
Q6K5I0 Oryza sativa subsp. japonica 26% 78%
Q6L4R7 Oryza sativa subsp. japonica 30% 91%
Q6L5H6 Oryza sativa subsp. japonica 33% 100%
Q7XJ53 Arabidopsis thaliana 28% 100%
Q7XU84 Oryza sativa subsp. japonica 30% 100%
Q8BHN0 Mus musculus 32% 100%
Q8CGA0 Mus musculus 31% 89%
Q8LAY8 Arabidopsis thaliana 31% 100%
Q8R0F6 Mus musculus 31% 100%
Q9CAJ0 Arabidopsis thaliana 33% 79%
Q9H0C8 Homo sapiens 32% 100%
Q9LMT1 Arabidopsis thaliana 25% 100%
Q9LNF4 Arabidopsis thaliana 28% 100%
Q9LNP9 Arabidopsis thaliana 31% 79%
Q9M1V8 Arabidopsis thaliana 25% 96%
Q9SLA1 Arabidopsis thaliana 32% 100%
Q9SZ53 Arabidopsis thaliana 32% 100%
Q9WVR7 Rattus norvegicus 32% 90%
Q9Z1Z6 Rattus norvegicus 31% 100%
V5AZJ4 Trypanosoma cruzi 37% 100%
V5BA03 Trypanosoma cruzi 42% 100%
V5BCX6 Trypanosoma cruzi 35% 100%
V5BH00 Trypanosoma cruzi 32% 100%
V5BSS7 Trypanosoma cruzi 33% 99%
V5DCR6 Trypanosoma cruzi 51% 98%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS