C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger (CCCH type) protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQ13_LEIMU

TriTrypDb:

LmxM.15.0160

Length:

832

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ13

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.526
CLV_C14_Caspase3-7	331	335	PF00656	0.508
CLV_NRD_NRD_1	115	117	PF00675	0.691
CLV_NRD_NRD_1	165	167	PF00675	0.684
CLV_NRD_NRD_1	284	286	PF00675	0.794
CLV_NRD_NRD_1	5	7	PF00675	0.539
CLV_NRD_NRD_1	682	684	PF00675	0.616
CLV_NRD_NRD_1	704	706	PF00675	0.642
CLV_NRD_NRD_1	755	757	PF00675	0.702
CLV_NRD_NRD_1	813	815	PF00675	0.578
CLV_PCSK_FUR_1	814	818	PF00082	0.669
CLV_PCSK_KEX2_1	115	117	PF00082	0.796
CLV_PCSK_KEX2_1	165	167	PF00082	0.683
CLV_PCSK_KEX2_1	284	286	PF00082	0.771
CLV_PCSK_KEX2_1	5	7	PF00082	0.539
CLV_PCSK_KEX2_1	681	683	PF00082	0.626
CLV_PCSK_KEX2_1	704	706	PF00082	0.646
CLV_PCSK_KEX2_1	754	756	PF00082	0.707
CLV_PCSK_KEX2_1	816	818	PF00082	0.666
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.796
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.605
CLV_PCSK_PC1ET2_1	816	818	PF00082	0.671
CLV_PCSK_SKI1_1	34	38	PF00082	0.415
CLV_PCSK_SKI1_1	767	771	PF00082	0.534
CLV_PCSK_SKI1_1	817	821	PF00082	0.666
DEG_APCC_DBOX_1	816	824	PF00400	0.599
DEG_SCF_TRCP1_1	430	435	PF00400	0.713
DEG_SPOP_SBC_1	270	274	PF00917	0.686
DEG_SPOP_SBC_1	279	283	PF00917	0.623
DEG_SPOP_SBC_1	472	476	PF00917	0.591
DEG_SPOP_SBC_1	505	509	PF00917	0.641
DEG_SPOP_SBC_1	516	520	PF00917	0.585
DEG_SPOP_SBC_1	673	677	PF00917	0.548
DEG_SPOP_SBC_1	761	765	PF00917	0.640
DOC_CKS1_1	196	201	PF01111	0.625
DOC_CKS1_1	336	341	PF01111	0.669
DOC_CKS1_1	437	442	PF01111	0.570
DOC_CKS1_1	795	800	PF01111	0.621
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.511
DOC_MAPK_MEF2A_6	651	659	PF00069	0.488
DOC_PP2B_LxvP_1	169	172	PF13499	0.631
DOC_PP2B_LxvP_1	187	190	PF13499	0.790
DOC_PP2B_LxvP_1	670	673	PF13499	0.667
DOC_PP4_FxxP_1	453	456	PF00568	0.588
DOC_PP4_MxPP_1	263	266	PF00568	0.502
DOC_USP7_MATH_1	104	108	PF00917	0.613
DOC_USP7_MATH_1	141	145	PF00917	0.716
DOC_USP7_MATH_1	179	183	PF00917	0.571
DOC_USP7_MATH_1	271	275	PF00917	0.714
DOC_USP7_MATH_1	326	330	PF00917	0.569
DOC_USP7_MATH_1	365	369	PF00917	0.615
DOC_USP7_MATH_1	381	385	PF00917	0.572
DOC_USP7_MATH_1	413	417	PF00917	0.621
DOC_USP7_MATH_1	418	422	PF00917	0.589
DOC_USP7_MATH_1	426	430	PF00917	0.593
DOC_USP7_MATH_1	442	446	PF00917	0.545
DOC_USP7_MATH_1	460	464	PF00917	0.493
DOC_USP7_MATH_1	472	476	PF00917	0.637
DOC_USP7_MATH_1	499	503	PF00917	0.574
DOC_USP7_MATH_1	505	509	PF00917	0.628
DOC_USP7_MATH_1	511	515	PF00917	0.678
DOC_USP7_MATH_1	516	520	PF00917	0.753
DOC_USP7_MATH_1	559	563	PF00917	0.438
DOC_USP7_MATH_1	628	632	PF00917	0.594
DOC_USP7_MATH_1	649	653	PF00917	0.635
DOC_USP7_MATH_1	65	69	PF00917	0.521
DOC_USP7_MATH_1	666	670	PF00917	0.568
DOC_USP7_MATH_1	673	677	PF00917	0.611
DOC_USP7_UBL2_3	115	119	PF12436	0.624
DOC_USP7_UBL2_3	710	714	PF12436	0.608
DOC_WW_Pin1_4	137	142	PF00397	0.544
DOC_WW_Pin1_4	195	200	PF00397	0.661
DOC_WW_Pin1_4	335	340	PF00397	0.597
DOC_WW_Pin1_4	353	358	PF00397	0.609
DOC_WW_Pin1_4	414	419	PF00397	0.644
DOC_WW_Pin1_4	432	437	PF00397	0.515
DOC_WW_Pin1_4	49	54	PF00397	0.605
DOC_WW_Pin1_4	599	604	PF00397	0.610
DOC_WW_Pin1_4	617	622	PF00397	0.611
DOC_WW_Pin1_4	72	77	PF00397	0.635
DOC_WW_Pin1_4	748	753	PF00397	0.642
DOC_WW_Pin1_4	794	799	PF00397	0.604
LIG_14-3-3_CanoR_1	158	163	PF00244	0.537
LIG_14-3-3_CanoR_1	309	317	PF00244	0.599
LIG_14-3-3_CanoR_1	420	426	PF00244	0.647
LIG_14-3-3_CanoR_1	814	820	PF00244	0.591
LIG_BIR_III_2	153	157	PF00653	0.519
LIG_BIR_III_2	293	297	PF00653	0.649
LIG_BRCT_BRCA1_1	204	208	PF00533	0.622
LIG_BRCT_BRCA1_1	77	81	PF00533	0.652
LIG_Clathr_ClatBox_1	656	660	PF01394	0.539
LIG_deltaCOP1_diTrp_1	571	581	PF00928	0.441
LIG_EVH1_1	169	173	PF00568	0.698
LIG_FHA_1	49	55	PF00498	0.676
LIG_FHA_1	505	511	PF00498	0.633
LIG_FHA_1	545	551	PF00498	0.385
LIG_FHA_1	573	579	PF00498	0.426
LIG_FHA_1	635	641	PF00498	0.627
LIG_FHA_1	683	689	PF00498	0.518
LIG_FHA_2	288	294	PF00498	0.532
LIG_FHA_2	329	335	PF00498	0.648
LIG_FHA_2	582	588	PF00498	0.478
LIG_FHA_2	631	637	PF00498	0.630
LIG_FHA_2	822	828	PF00498	0.590
LIG_Integrin_RGD_1	151	153	PF01839	0.717
LIG_LIR_Gen_1	405	414	PF02991	0.626
LIG_LIR_Gen_1	528	538	PF02991	0.501
LIG_LIR_Gen_1	543	553	PF02991	0.412
LIG_LIR_Gen_1	735	740	PF02991	0.395
LIG_LIR_Nem_3	205	211	PF02991	0.608
LIG_LIR_Nem_3	253	259	PF02991	0.680
LIG_LIR_Nem_3	405	409	PF02991	0.622
LIG_LIR_Nem_3	528	534	PF02991	0.509
LIG_LIR_Nem_3	543	548	PF02991	0.415
LIG_LIR_Nem_3	735	739	PF02991	0.384
LIG_LYPXL_yS_3	256	259	PF13949	0.641
LIG_PDZ_Class_2	827	832	PF00595	0.580
LIG_Rb_LxCxE_1	723	744	PF01857	0.419
LIG_REV1ctd_RIR_1	20	28	PF16727	0.504
LIG_SH2_CRK	531	535	PF00017	0.470
LIG_SH2_CRK	545	549	PF00017	0.405
LIG_SH2_NCK_1	545	549	PF00017	0.405
LIG_SH2_SRC	226	229	PF00017	0.648
LIG_SH2_SRC	738	741	PF00017	0.438
LIG_SH2_STAT3	638	641	PF00017	0.595
LIG_SH2_STAT5	226	229	PF00017	0.598
LIG_SH2_STAT5	341	344	PF00017	0.742
LIG_SH2_STAT5	545	548	PF00017	0.402
LIG_SH2_STAT5	729	732	PF00017	0.404
LIG_SH2_STAT5	738	741	PF00017	0.410
LIG_SH3_2	699	704	PF14604	0.582
LIG_SH3_3	167	173	PF00018	0.655
LIG_SH3_3	186	192	PF00018	0.645
LIG_SH3_3	194	200	PF00018	0.565
LIG_SH3_3	218	224	PF00018	0.547
LIG_SH3_3	262	268	PF00018	0.615
LIG_SH3_3	333	339	PF00018	0.596
LIG_SH3_3	366	372	PF00018	0.669
LIG_SH3_3	377	383	PF00018	0.552
LIG_SH3_3	696	702	PF00018	0.576
LIG_SH3_3	734	740	PF00018	0.412
LIG_SUMO_SIM_par_1	645	652	PF11976	0.572
LIG_SUMO_SIM_par_1	653	658	PF11976	0.626
LIG_TRAF2_1	520	523	PF00917	0.672
LIG_TRAF2_1	824	827	PF00917	0.631
LIG_TRAF2_1	96	99	PF00917	0.536
LIG_WRC_WIRS_1	19	24	PF05994	0.424
LIG_WW_2	192	195	PF00397	0.605
MOD_CDC14_SPxK_1	417	420	PF00782	0.495
MOD_CDK_SPK_2	72	77	PF00069	0.523
MOD_CDK_SPxK_1	414	420	PF00069	0.495
MOD_CDK_SPxK_1	748	754	PF00069	0.700
MOD_CDK_SPxxK_3	748	755	PF00069	0.700
MOD_CK1_1	107	113	PF00069	0.690
MOD_CK1_1	122	128	PF00069	0.575
MOD_CK1_1	18	24	PF00069	0.421
MOD_CK1_1	255	261	PF00069	0.685
MOD_CK1_1	274	280	PF00069	0.616
MOD_CK1_1	313	319	PF00069	0.648
MOD_CK1_1	421	427	PF00069	0.621
MOD_CK1_1	428	434	PF00069	0.647
MOD_CK1_1	474	480	PF00069	0.604
MOD_CK1_1	485	491	PF00069	0.640
MOD_CK1_1	514	520	PF00069	0.619
MOD_CK1_1	543	549	PF00069	0.428
MOD_CK1_1	558	564	PF00069	0.543
MOD_CK1_1	642	648	PF00069	0.726
MOD_CK1_1	675	681	PF00069	0.742
MOD_CK1_1	741	747	PF00069	0.627
MOD_CK1_1	75	81	PF00069	0.661
MOD_CK1_1	794	800	PF00069	0.765
MOD_CK2_1	352	358	PF00069	0.763
MOD_CK2_1	364	370	PF00069	0.583
MOD_CK2_1	516	522	PF00069	0.702
MOD_CK2_1	557	563	PF00069	0.539
MOD_CK2_1	581	587	PF00069	0.458
MOD_CK2_1	630	636	PF00069	0.710
MOD_CK2_1	673	679	PF00069	0.653
MOD_CK2_1	815	821	PF00069	0.667
MOD_Cter_Amidation	752	755	PF01082	0.706
MOD_Cter_Amidation	812	815	PF01082	0.573
MOD_GlcNHglycan	103	107	PF01048	0.593
MOD_GlcNHglycan	143	146	PF01048	0.648
MOD_GlcNHglycan	147	150	PF01048	0.607
MOD_GlcNHglycan	204	207	PF01048	0.662
MOD_GlcNHglycan	235	238	PF01048	0.635
MOD_GlcNHglycan	276	279	PF01048	0.709
MOD_GlcNHglycan	328	331	PF01048	0.627
MOD_GlcNHglycan	383	386	PF01048	0.576
MOD_GlcNHglycan	430	433	PF01048	0.754
MOD_GlcNHglycan	446	449	PF01048	0.524
MOD_GlcNHglycan	462	465	PF01048	0.693
MOD_GlcNHglycan	480	483	PF01048	0.629
MOD_GlcNHglycan	513	516	PF01048	0.647
MOD_GlcNHglycan	535	538	PF01048	0.493
MOD_GlcNHglycan	557	560	PF01048	0.525
MOD_GlcNHglycan	595	598	PF01048	0.594
MOD_GlcNHglycan	641	644	PF01048	0.589
MOD_GlcNHglycan	722	725	PF01048	0.440
MOD_GlcNHglycan	740	743	PF01048	0.485
MOD_GlcNHglycan	86	89	PF01048	0.604
MOD_GSK3_1	10	17	PF00069	0.446
MOD_GSK3_1	115	122	PF00069	0.680
MOD_GSK3_1	137	144	PF00069	0.570
MOD_GSK3_1	18	25	PF00069	0.419
MOD_GSK3_1	198	205	PF00069	0.599
MOD_GSK3_1	251	258	PF00069	0.673
MOD_GSK3_1	269	276	PF00069	0.730
MOD_GSK3_1	313	320	PF00069	0.650
MOD_GSK3_1	398	405	PF00069	0.543
MOD_GSK3_1	414	421	PF00069	0.624
MOD_GSK3_1	428	435	PF00069	0.597
MOD_GSK3_1	438	445	PF00069	0.611
MOD_GSK3_1	460	467	PF00069	0.544
MOD_GSK3_1	474	481	PF00069	0.633
MOD_GSK3_1	511	518	PF00069	0.625
MOD_GSK3_1	540	547	PF00069	0.408
MOD_GSK3_1	555	562	PF00069	0.478
MOD_GSK3_1	61	68	PF00069	0.587
MOD_GSK3_1	613	620	PF00069	0.581
MOD_GSK3_1	623	630	PF00069	0.593
MOD_GSK3_1	80	87	PF00069	0.783
MOD_LATS_1	82	88	PF00433	0.537
MOD_N-GLC_1	326	331	PF02516	0.677
MOD_N-GLC_1	334	339	PF02516	0.566
MOD_N-GLC_1	365	370	PF02516	0.736
MOD_N-GLC_1	666	671	PF02516	0.642
MOD_NEK2_1	1	6	PF00069	0.534
MOD_NEK2_1	123	128	PF00069	0.650
MOD_NEK2_1	250	255	PF00069	0.677
MOD_NEK2_1	317	322	PF00069	0.628
MOD_NEK2_1	352	357	PF00069	0.632
MOD_NEK2_1	473	478	PF00069	0.644
MOD_NEK2_1	572	577	PF00069	0.438
MOD_NEK2_1	713	718	PF00069	0.543
MOD_PIKK_1	697	703	PF00454	0.707
MOD_PIKK_1	788	794	PF00454	0.637
MOD_PK_1	815	821	PF00069	0.591
MOD_PKA_1	115	121	PF00069	0.647
MOD_PKA_1	682	688	PF00069	0.518
MOD_PKA_1	815	821	PF00069	0.591
MOD_PKA_2	115	121	PF00069	0.653
MOD_PKA_2	419	425	PF00069	0.663
MOD_PKA_2	485	491	PF00069	0.574
MOD_PKA_2	682	688	PF00069	0.518
MOD_Plk_1	123	129	PF00069	0.512
MOD_Plk_1	251	257	PF00069	0.496
MOD_Plk_1	365	371	PF00069	0.620
MOD_Plk_1	666	672	PF00069	0.643
MOD_Plk_2-3	821	827	PF00069	0.595
MOD_Plk_4	18	24	PF00069	0.424
MOD_Plk_4	391	397	PF00069	0.575
MOD_Plk_4	66	72	PF00069	0.631
MOD_Plk_4	732	738	PF00069	0.451
MOD_ProDKin_1	137	143	PF00069	0.546
MOD_ProDKin_1	195	201	PF00069	0.664
MOD_ProDKin_1	335	341	PF00069	0.597
MOD_ProDKin_1	353	359	PF00069	0.613
MOD_ProDKin_1	414	420	PF00069	0.649
MOD_ProDKin_1	432	438	PF00069	0.513
MOD_ProDKin_1	49	55	PF00069	0.605
MOD_ProDKin_1	599	605	PF00069	0.611
MOD_ProDKin_1	617	623	PF00069	0.615
MOD_ProDKin_1	72	78	PF00069	0.634
MOD_ProDKin_1	748	754	PF00069	0.643
MOD_ProDKin_1	794	800	PF00069	0.602
MOD_SUMO_rev_2	41	51	PF00179	0.598
MOD_SUMO_rev_2	773	778	PF00179	0.625
TRG_DiLeu_BaEn_2	731	737	PF01217	0.412
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.637
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.615
TRG_ENDOCYTIC_2	213	216	PF00928	0.628
TRG_ENDOCYTIC_2	256	259	PF00928	0.689
TRG_ENDOCYTIC_2	343	346	PF00928	0.586
TRG_ENDOCYTIC_2	531	534	PF00928	0.480
TRG_ENDOCYTIC_2	545	548	PF00928	0.402
TRG_ER_diArg_1	682	684	PF00400	0.690
TRG_ER_diArg_1	754	756	PF00400	0.658
TRG_NLS_MonoCore_2	813	818	PF00514	0.615
TRG_NLS_MonoExtC_3	114	119	PF00514	0.638
TRG_NLS_MonoExtN_4	115	120	PF00514	0.599
TRG_NLS_MonoExtN_4	812	819	PF00514	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y8	Leptomonas seymouri	42%	100%
A0A3Q8I906	Leishmania donovani	87%	99%
A4H7Y5	Leishmania braziliensis	58%	96%
A4HWB3	Leishmania infantum	86%	99%
Q4QFG8	Leishmania major	84%	100%