C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger (CCCH type) protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQ11_LEIMU

TriTrypDb:

LmxM.15.0140

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ11

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5
GO:0003729	mRNA binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.592
CLV_PCSK_FUR_1	107	111	PF00082	0.702
CLV_PCSK_KEX2_1	109	111	PF00082	0.598
CLV_PCSK_SKI1_1	34	38	PF00082	0.398
CLV_PCSK_SKI1_1	86	90	PF00082	0.491
DOC_CKS1_1	98	103	PF01111	0.768
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.594
DOC_MAPK_gen_1	107	117	PF00069	0.604
DOC_MAPK_MEF2A_6	109	117	PF00069	0.619
DOC_PP2B_LxvP_1	172	175	PF13499	0.672
DOC_USP7_MATH_1	190	194	PF00917	0.576
DOC_WW_Pin1_4	126	131	PF00397	0.644
DOC_WW_Pin1_4	75	80	PF00397	0.705
DOC_WW_Pin1_4	97	102	PF00397	0.716
LIG_14-3-3_CanoR_1	109	114	PF00244	0.692
LIG_14-3-3_CanoR_1	187	197	PF00244	0.615
LIG_14-3-3_CanoR_1	86	95	PF00244	0.496
LIG_FHA_1	110	116	PF00498	0.673
LIG_FHA_1	150	156	PF00498	0.542
LIG_FHA_1	206	212	PF00498	0.660
LIG_FHA_1	76	82	PF00498	0.615
LIG_FHA_1	83	89	PF00498	0.595
LIG_FHA_2	120	126	PF00498	0.687
LIG_FHA_2	132	138	PF00498	0.705
LIG_IBAR_NPY_1	203	205	PF08397	0.589
LIG_LIR_Apic_2	124	130	PF02991	0.680
LIG_LIR_Apic_2	147	151	PF02991	0.679
LIG_LIR_Nem_3	137	143	PF02991	0.698
LIG_PCNA_yPIPBox_3	156	164	PF02747	0.467
LIG_REV1ctd_RIR_1	20	29	PF16727	0.444
LIG_SH2_CRK	127	131	PF00017	0.674
LIG_SH2_CRK	148	152	PF00017	0.677
LIG_SH2_NCK_1	143	147	PF00017	0.609
LIG_SH2_SRC	173	176	PF00017	0.553
LIG_SH2_STAP1	131	135	PF00017	0.420
LIG_SH2_STAT3	150	153	PF00017	0.694
LIG_SH2_STAT5	183	186	PF00017	0.699
LIG_SH3_1	148	154	PF00018	0.444
LIG_SH3_3	112	118	PF00018	0.650
LIG_SH3_3	148	154	PF00018	0.444
LIG_SH3_3	95	101	PF00018	0.741
LIG_SUMO_SIM_par_1	111	116	PF11976	0.614
MOD_CDK_SPxxK_3	100	107	PF00069	0.683
MOD_CK1_1	129	135	PF00069	0.635
MOD_CK1_1	168	174	PF00069	0.614
MOD_CK1_1	80	86	PF00069	0.730
MOD_CK1_1	87	93	PF00069	0.704
MOD_CK2_1	119	125	PF00069	0.691
MOD_CK2_1	131	137	PF00069	0.705
MOD_GlcNHglycan	131	134	PF01048	0.652
MOD_GlcNHglycan	188	191	PF01048	0.630
MOD_GlcNHglycan	82	85	PF01048	0.714
MOD_GSK3_1	10	17	PF00069	0.458
MOD_GSK3_1	109	116	PF00069	0.740
MOD_GSK3_1	164	171	PF00069	0.596
MOD_GSK3_1	186	193	PF00069	0.625
MOD_GSK3_1	71	78	PF00069	0.618
MOD_GSK3_1	80	87	PF00069	0.616
MOD_GSK3_1	89	96	PF00069	0.714
MOD_N-GLC_1	164	169	PF02516	0.691
MOD_NEK2_1	188	193	PF00069	0.569
MOD_NEK2_1	54	59	PF00069	0.498
MOD_NEK2_2	131	136	PF00069	0.420
MOD_OFUCOSY	186	192	PF10250	0.629
MOD_PIKK_1	149	155	PF00454	0.695
MOD_PIKK_1	190	196	PF00454	0.672
MOD_PIKK_1	89	95	PF00454	0.496
MOD_PKA_1	109	115	PF00069	0.693
MOD_PKA_2	109	115	PF00069	0.693
MOD_PKA_2	186	192	PF00069	0.635
MOD_PKB_1	107	115	PF00069	0.697
MOD_Plk_1	168	174	PF00069	0.613
MOD_Plk_4	131	137	PF00069	0.419
MOD_Plk_4	168	174	PF00069	0.609
MOD_ProDKin_1	126	132	PF00069	0.642
MOD_ProDKin_1	75	81	PF00069	0.705
MOD_ProDKin_1	97	103	PF00069	0.740
MOD_SUMO_rev_2	41	51	PF00179	0.578
TRG_ER_diArg_1	106	109	PF00400	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Y1	Leptomonas seymouri	69%	100%
A0A1X0NV29	Trypanosomatidae	43%	100%
A0A3S7WT90	Leishmania donovani	87%	100%
A0A422NSB0	Trypanosoma rangeli	38%	100%
A4H7Y4	Leishmania braziliensis	81%	100%
A4HWB1	Leishmania infantum	87%	100%
C9ZNU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QFH0	Leishmania major	87%	100%