Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ08_LEIMU

TriTrypDb:

LmxM.15.0110

Length:

795

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AQ08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.613
CLV_NRD_NRD_1	101	103	PF00675	0.757
CLV_NRD_NRD_1	220	222	PF00675	0.651
CLV_NRD_NRD_1	227	229	PF00675	0.693
CLV_NRD_NRD_1	253	255	PF00675	0.440
CLV_NRD_NRD_1	383	385	PF00675	0.470
CLV_NRD_NRD_1	757	759	PF00675	0.578
CLV_NRD_NRD_1	775	777	PF00675	0.588
CLV_PCSK_FUR_1	381	385	PF00082	0.541
CLV_PCSK_KEX2_1	101	103	PF00082	0.761
CLV_PCSK_KEX2_1	253	255	PF00082	0.446
CLV_PCSK_KEX2_1	383	385	PF00082	0.444
CLV_PCSK_KEX2_1	757	759	PF00082	0.578
CLV_PCSK_KEX2_1	775	777	PF00082	0.588
CLV_PCSK_SKI1_1	215	219	PF00082	0.621
CLV_PCSK_SKI1_1	228	232	PF00082	0.743
CLV_PCSK_SKI1_1	266	270	PF00082	0.458
CLV_PCSK_SKI1_1	384	388	PF00082	0.445
CLV_PCSK_SKI1_1	572	576	PF00082	0.683
CLV_PCSK_SKI1_1	612	616	PF00082	0.486
CLV_PCSK_SKI1_1	623	627	PF00082	0.487
CLV_Separin_Metazoa	772	776	PF03568	0.628
DEG_APCC_DBOX_1	302	310	PF00400	0.468
DEG_APCC_DBOX_1	611	619	PF00400	0.499
DEG_APCC_DBOX_1	774	782	PF00400	0.421
DEG_MDM2_SWIB_1	291	298	PF02201	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.695
DEG_SCF_FBW7_1	551	558	PF00400	0.662
DEG_SCF_FBW7_1	573	579	PF00400	0.602
DEG_SCF_TRCP1_1	201	206	PF00400	0.631
DEG_SPOP_SBC_1	23	27	PF00917	0.484
DOC_CKS1_1	376	381	PF01111	0.580
DOC_CKS1_1	573	578	PF01111	0.604
DOC_CYCLIN_RxL_1	609	616	PF00134	0.614
DOC_MAPK_HePTP_8	631	643	PF00069	0.613
DOC_MAPK_MEF2A_6	634	643	PF00069	0.593
DOC_PP1_RVXF_1	412	419	PF00149	0.462
DOC_PP1_RVXF_1	548	554	PF00149	0.559
DOC_PP2B_LxvP_1	507	510	PF13499	0.499
DOC_PP4_FxxP_1	389	392	PF00568	0.438
DOC_PP4_FxxP_1	733	736	PF00568	0.684
DOC_USP7_MATH_1	216	220	PF00917	0.676
DOC_USP7_MATH_1	22	26	PF00917	0.618
DOC_USP7_MATH_1	322	326	PF00917	0.703
DOC_USP7_MATH_1	543	547	PF00917	0.486
DOC_USP7_MATH_1	576	580	PF00917	0.651
DOC_USP7_MATH_1	592	596	PF00917	0.437
DOC_USP7_MATH_1	703	707	PF00917	0.631
DOC_USP7_MATH_1	780	784	PF00917	0.571
DOC_USP7_UBL2_3	682	686	PF12436	0.720
DOC_WW_Pin1_4	355	360	PF00397	0.731
DOC_WW_Pin1_4	375	380	PF00397	0.534
DOC_WW_Pin1_4	422	427	PF00397	0.453
DOC_WW_Pin1_4	446	451	PF00397	0.458
DOC_WW_Pin1_4	551	556	PF00397	0.515
DOC_WW_Pin1_4	564	569	PF00397	0.486
DOC_WW_Pin1_4	572	577	PF00397	0.571
DOC_WW_Pin1_4	671	676	PF00397	0.715
DOC_WW_Pin1_4	732	737	PF00397	0.694
LIG_14-3-3_CanoR_1	133	137	PF00244	0.586
LIG_14-3-3_CanoR_1	163	171	PF00244	0.463
LIG_14-3-3_CanoR_1	266	272	PF00244	0.433
LIG_14-3-3_CanoR_1	319	328	PF00244	0.644
LIG_14-3-3_CanoR_1	612	618	PF00244	0.566
LIG_14-3-3_CanoR_1	623	628	PF00244	0.598
LIG_Actin_WH2_2	119	135	PF00022	0.286
LIG_Actin_WH2_2	270	285	PF00022	0.465
LIG_Actin_WH2_2	306	321	PF00022	0.568
LIG_Actin_WH2_2	752	770	PF00022	0.498
LIG_AP2alpha_2	155	157	PF02296	0.501
LIG_Clathr_ClatBox_1	297	301	PF01394	0.237
LIG_CtBP_PxDLS_1	478	482	PF00389	0.556
LIG_deltaCOP1_diTrp_1	292	295	PF00928	0.437
LIG_deltaCOP1_diTrp_1	490	493	PF00928	0.641
LIG_FHA_1	184	190	PF00498	0.459
LIG_FHA_1	391	397	PF00498	0.463
LIG_FHA_1	460	466	PF00498	0.469
LIG_FHA_1	482	488	PF00498	0.574
LIG_FHA_1	502	508	PF00498	0.435
LIG_FHA_1	585	591	PF00498	0.544
LIG_FHA_1	710	716	PF00498	0.657
LIG_FHA_1	761	767	PF00498	0.567
LIG_FHA_1	80	86	PF00498	0.769
LIG_FHA_2	108	114	PF00498	0.652
LIG_FHA_2	233	239	PF00498	0.730
LIG_FHA_2	474	480	PF00498	0.480
LIG_FHA_2	498	504	PF00498	0.516
LIG_LIR_Gen_1	144	154	PF02991	0.572
LIG_LIR_Gen_1	155	165	PF02991	0.417
LIG_LIR_Gen_1	262	271	PF02991	0.500
LIG_LIR_Gen_1	292	300	PF02991	0.416
LIG_LIR_Gen_1	449	459	PF02991	0.431
LIG_LIR_Gen_1	514	523	PF02991	0.389
LIG_LIR_Gen_1	527	536	PF02991	0.561
LIG_LIR_Gen_1	587	592	PF02991	0.496
LIG_LIR_Nem_3	109	115	PF02991	0.619
LIG_LIR_Nem_3	144	149	PF02991	0.526
LIG_LIR_Nem_3	155	160	PF02991	0.423
LIG_LIR_Nem_3	292	298	PF02991	0.419
LIG_LIR_Nem_3	385	389	PF02991	0.408
LIG_LIR_Nem_3	425	431	PF02991	0.378
LIG_LIR_Nem_3	449	455	PF02991	0.419
LIG_LIR_Nem_3	514	518	PF02991	0.343
LIG_LIR_Nem_3	527	532	PF02991	0.618
LIG_LIR_Nem_3	538	544	PF02991	0.392
LIG_LIR_Nem_3	616	620	PF02991	0.475
LIG_LIR_Nem_3	640	645	PF02991	0.475
LIG_LIR_Nem_3	719	724	PF02991	0.452
LIG_LIR_Nem_3	783	788	PF02991	0.551
LIG_MAD2	414	422	PF02301	0.384
LIG_MYND_1	422	426	PF01753	0.520
LIG_Pex14_2	291	295	PF04695	0.489
LIG_SH2_CRK	529	533	PF00017	0.617
LIG_SH2_NCK_1	112	116	PF00017	0.594
LIG_SH2_PTP2	515	518	PF00017	0.483
LIG_SH2_SRC	112	115	PF00017	0.507
LIG_SH2_STAP1	547	551	PF00017	0.510
LIG_SH2_STAP1	58	62	PF00017	0.564
LIG_SH2_STAT3	431	434	PF00017	0.472
LIG_SH2_STAT5	305	308	PF00017	0.360
LIG_SH2_STAT5	394	397	PF00017	0.395
LIG_SH2_STAT5	452	455	PF00017	0.400
LIG_SH2_STAT5	515	518	PF00017	0.419
LIG_SH2_STAT5	565	568	PF00017	0.607
LIG_SH2_STAT5	61	64	PF00017	0.566
LIG_SH2_STAT5	724	727	PF00017	0.644
LIG_SH2_STAT5	784	787	PF00017	0.546
LIG_SH3_2	376	381	PF14604	0.580
LIG_SH3_2	401	406	PF14604	0.569
LIG_SH3_3	186	192	PF00018	0.523
LIG_SH3_3	205	211	PF00018	0.655
LIG_SH3_3	236	242	PF00018	0.598
LIG_SH3_3	328	334	PF00018	0.647
LIG_SH3_3	373	379	PF00018	0.547
LIG_SH3_3	398	404	PF00018	0.497
LIG_SH3_3	556	562	PF00018	0.599
LIG_SH3_3	616	622	PF00018	0.436
LIG_Sin3_3	405	412	PF02671	0.567
LIG_SUMO_SIM_anti_2	25	33	PF11976	0.689
LIG_SUMO_SIM_anti_2	514	520	PF11976	0.223
LIG_SUMO_SIM_par_1	246	252	PF11976	0.526
LIG_SUMO_SIM_par_1	296	301	PF11976	0.525
LIG_SUMO_SIM_par_1	305	310	PF11976	0.509
LIG_TRAF2_1	194	197	PF00917	0.543
LIG_TRAF2_1	286	289	PF00917	0.502
LIG_TYR_ITSM	108	115	PF00017	0.637
LIG_WRC_WIRS_1	452	457	PF05994	0.517
LIG_WRC_WIRS_1	614	619	PF05994	0.490
MOD_CDK_SPxK_1	375	381	PF00069	0.583
MOD_CDK_SPxxK_3	673	680	PF00069	0.565
MOD_CK1_1	141	147	PF00069	0.609
MOD_CK1_1	183	189	PF00069	0.549
MOD_CK1_1	27	33	PF00069	0.669
MOD_CK1_1	320	326	PF00069	0.722
MOD_CK1_1	355	361	PF00069	0.702
MOD_CK1_1	437	443	PF00069	0.481
MOD_CK1_1	451	457	PF00069	0.321
MOD_CK1_1	460	466	PF00069	0.517
MOD_CK1_1	499	505	PF00069	0.577
MOD_CK1_1	706	712	PF00069	0.517
MOD_CK2_1	232	238	PF00069	0.708
MOD_CK2_1	34	40	PF00069	0.659
MOD_CK2_1	458	464	PF00069	0.551
MOD_CK2_1	473	479	PF00069	0.373
MOD_CK2_1	699	705	PF00069	0.652
MOD_Cter_Amidation	99	102	PF01082	0.762
MOD_GlcNHglycan	145	149	PF01048	0.460
MOD_GlcNHglycan	15	18	PF01048	0.569
MOD_GlcNHglycan	200	204	PF01048	0.716
MOD_GlcNHglycan	211	214	PF01048	0.666
MOD_GlcNHglycan	218	221	PF01048	0.584
MOD_GlcNHglycan	308	312	PF01048	0.435
MOD_GlcNHglycan	319	322	PF01048	0.653
MOD_GlcNHglycan	359	362	PF01048	0.773
MOD_GlcNHglycan	4	7	PF01048	0.593
MOD_GlcNHglycan	446	449	PF01048	0.552
MOD_GlcNHglycan	623	626	PF01048	0.562
MOD_GlcNHglycan	690	694	PF01048	0.701
MOD_GlcNHglycan	701	704	PF01048	0.631
MOD_GSK3_1	132	139	PF00069	0.570
MOD_GSK3_1	183	190	PF00069	0.554
MOD_GSK3_1	199	206	PF00069	0.695
MOD_GSK3_1	216	223	PF00069	0.509
MOD_GSK3_1	23	30	PF00069	0.700
MOD_GSK3_1	267	274	PF00069	0.523
MOD_GSK3_1	307	314	PF00069	0.520
MOD_GSK3_1	322	329	PF00069	0.732
MOD_GSK3_1	433	440	PF00069	0.369
MOD_GSK3_1	444	451	PF00069	0.426
MOD_GSK3_1	497	504	PF00069	0.481
MOD_GSK3_1	551	558	PF00069	0.676
MOD_GSK3_1	572	579	PF00069	0.646
MOD_GSK3_1	667	674	PF00069	0.696
MOD_GSK3_1	699	706	PF00069	0.577
MOD_N-GLC_1	368	373	PF02516	0.607
MOD_NEK2_1	132	137	PF00069	0.449
MOD_NEK2_1	158	163	PF00069	0.536
MOD_NEK2_1	187	192	PF00069	0.623
MOD_NEK2_1	267	272	PF00069	0.529
MOD_NEK2_1	291	296	PF00069	0.544
MOD_NEK2_1	352	357	PF00069	0.501
MOD_NEK2_1	395	400	PF00069	0.371
MOD_NEK2_1	408	413	PF00069	0.436
MOD_NEK2_1	433	438	PF00069	0.350
MOD_NEK2_1	444	449	PF00069	0.540
MOD_NEK2_1	481	486	PF00069	0.572
MOD_NEK2_1	505	510	PF00069	0.529
MOD_NEK2_1	85	90	PF00069	0.738
MOD_NEK2_2	34	39	PF00069	0.682
MOD_NEK2_2	470	475	PF00069	0.447
MOD_OFUCOSY	589	594	PF10250	0.635
MOD_PIKK_1	164	170	PF00454	0.426
MOD_PIKK_1	352	358	PF00454	0.801
MOD_PIKK_1	479	485	PF00454	0.621
MOD_PIKK_1	576	582	PF00454	0.602
MOD_PIKK_1	653	659	PF00454	0.713
MOD_PIKK_1	703	709	PF00454	0.668
MOD_PKA_2	132	138	PF00069	0.328
MOD_PKA_2	220	226	PF00069	0.695
MOD_PKA_2	70	76	PF00069	0.683
MOD_PKA_2	86	92	PF00069	0.676
MOD_Plk_1	144	150	PF00069	0.539
MOD_Plk_1	291	297	PF00069	0.521
MOD_Plk_1	368	374	PF00069	0.512
MOD_Plk_1	750	756	PF00069	0.701
MOD_Plk_4	132	138	PF00069	0.290
MOD_Plk_4	203	209	PF00069	0.475
MOD_Plk_4	27	33	PF00069	0.688
MOD_Plk_4	34	40	PF00069	0.601
MOD_Plk_4	390	396	PF00069	0.432
MOD_Plk_4	448	454	PF00069	0.558
MOD_Plk_4	613	619	PF00069	0.548
MOD_Plk_4	780	786	PF00069	0.530
MOD_ProDKin_1	355	361	PF00069	0.731
MOD_ProDKin_1	375	381	PF00069	0.536
MOD_ProDKin_1	422	428	PF00069	0.452
MOD_ProDKin_1	446	452	PF00069	0.458
MOD_ProDKin_1	551	557	PF00069	0.529
MOD_ProDKin_1	564	570	PF00069	0.486
MOD_ProDKin_1	572	578	PF00069	0.567
MOD_ProDKin_1	671	677	PF00069	0.713
MOD_ProDKin_1	732	738	PF00069	0.694
TRG_DiLeu_BaEn_1	370	375	PF01217	0.617
TRG_DiLeu_BaEn_2	728	734	PF01217	0.687
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.568
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.699
TRG_ENDOCYTIC_2	112	115	PF00928	0.584
TRG_ENDOCYTIC_2	178	181	PF00928	0.350
TRG_ENDOCYTIC_2	264	267	PF00928	0.423
TRG_ENDOCYTIC_2	452	455	PF00928	0.403
TRG_ENDOCYTIC_2	515	518	PF00928	0.378
TRG_ENDOCYTIC_2	529	532	PF00928	0.531
TRG_ER_diArg_1	381	384	PF00400	0.480
TRG_ER_diArg_1	420	423	PF00400	0.540
TRG_ER_diArg_1	756	758	PF00400	0.574
TRG_ER_diArg_1	774	776	PF00400	0.584
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR8	Leptomonas seymouri	49%	98%
A0A0S4KHH2	Bodo saltans	30%	92%
A0A1X0NTL8	Trypanosomatidae	40%	100%
A0A3Q8IA12	Leishmania donovani	87%	100%
A0A422NS84	Trypanosoma rangeli	37%	100%
A4H7Y1	Leishmania braziliensis	73%	100%
A4HWA8	Leishmania infantum	88%	100%
C9ZNU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QFH3	Leishmania major	89%	100%
V5AWK1	Trypanosoma cruzi	34%	96%