Flavin-containing monooxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flavin-binding monooxygenase-like, putative

Species:

Leishmania mexicana

UniProt:

E9AQ07_LEIMU

TriTrypDb:

LmxM.15.0100

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ07

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004497	monooxygenase activity	3	11
GO:0004499	N,N-dimethylaniline monooxygenase activity	5	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	11
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0050661	NADP binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.395
CLV_NRD_NRD_1	188	190	PF00675	0.267
CLV_NRD_NRD_1	296	298	PF00675	0.565
CLV_NRD_NRD_1	333	335	PF00675	0.568
CLV_NRD_NRD_1	387	389	PF00675	0.435
CLV_NRD_NRD_1	552	554	PF00675	0.557
CLV_PCSK_KEX2_1	190	192	PF00082	0.299
CLV_PCSK_KEX2_1	209	211	PF00082	0.336
CLV_PCSK_KEX2_1	333	335	PF00082	0.588
CLV_PCSK_KEX2_1	387	389	PF00082	0.435
CLV_PCSK_KEX2_1	552	554	PF00082	0.557
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.313
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.386
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.557
CLV_PCSK_SKI1_1	104	108	PF00082	0.381
CLV_PCSK_SKI1_1	162	166	PF00082	0.256
CLV_PCSK_SKI1_1	387	391	PF00082	0.447
CLV_PCSK_SKI1_1	443	447	PF00082	0.419
CLV_PCSK_SKI1_1	45	49	PF00082	0.381
CLV_PCSK_SKI1_1	531	535	PF00082	0.485
CLV_PCSK_SKI1_1	62	66	PF00082	0.194
DEG_APCC_DBOX_1	534	542	PF00400	0.493
DEG_Nend_UBRbox_3	1	3	PF02207	0.465
DOC_CYCLIN_RxL_1	525	537	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	445	448	PF00134	0.398
DOC_MAPK_DCC_7	306	315	PF00069	0.573
DOC_MAPK_DCC_7	443	452	PF00069	0.430
DOC_MAPK_gen_1	123	132	PF00069	0.413
DOC_MAPK_gen_1	189	195	PF00069	0.302
DOC_MAPK_gen_1	297	307	PF00069	0.606
DOC_MAPK_gen_1	344	352	PF00069	0.716
DOC_MAPK_gen_1	552	560	PF00069	0.554
DOC_MAPK_MEF2A_6	123	132	PF00069	0.410
DOC_MAPK_MEF2A_6	301	309	PF00069	0.621
DOC_MAPK_MEF2A_6	443	452	PF00069	0.408
DOC_PP1_RVXF_1	320	327	PF00149	0.463
DOC_PP2B_LxvP_1	445	448	PF13499	0.413
DOC_PP4_FxxP_1	381	384	PF00568	0.499
DOC_USP7_MATH_1	236	240	PF00917	0.727
DOC_USP7_MATH_1	328	332	PF00917	0.611
DOC_USP7_MATH_1	355	359	PF00917	0.668
DOC_USP7_MATH_1	417	421	PF00917	0.629
DOC_USP7_MATH_1	432	436	PF00917	0.331
DOC_WW_Pin1_4	401	406	PF00397	0.628
DOC_WW_Pin1_4	52	57	PF00397	0.321
LIG_14-3-3_CanoR_1	333	340	PF00244	0.552
LIG_14-3-3_CanoR_1	535	539	PF00244	0.567
LIG_BIR_III_4	411	415	PF00653	0.690
LIG_BRCT_BRCA1_1	114	118	PF00533	0.407
LIG_deltaCOP1_diTrp_1	139	142	PF00928	0.313
LIG_FHA_1	150	156	PF00498	0.425
LIG_FHA_1	239	245	PF00498	0.695
LIG_FHA_1	257	263	PF00498	0.682
LIG_FHA_1	334	340	PF00498	0.575
LIG_FHA_1	462	468	PF00498	0.298
LIG_FHA_1	521	527	PF00498	0.442
LIG_FHA_2	109	115	PF00498	0.386
LIG_FHA_2	26	32	PF00498	0.313
LIG_LIR_Gen_1	139	147	PF02991	0.329
LIG_LIR_Gen_1	214	224	PF02991	0.427
LIG_LIR_Nem_3	122	128	PF02991	0.317
LIG_LIR_Nem_3	139	145	PF02991	0.321
LIG_LIR_Nem_3	183	187	PF02991	0.332
LIG_LIR_Nem_3	214	219	PF02991	0.408
LIG_LIR_Nem_3	503	509	PF02991	0.381
LIG_LYPXL_S_1	57	61	PF13949	0.425
LIG_LYPXL_yS_3	379	382	PF13949	0.413
LIG_LYPXL_yS_3	58	61	PF13949	0.425
LIG_MYND_1	380	384	PF01753	0.493
LIG_PCNA_yPIPBox_3	286	300	PF02747	0.375
LIG_PCNA_yPIPBox_3	485	494	PF02747	0.489
LIG_Rb_LxCxE_1	428	444	PF01857	0.429
LIG_SH2_CRK	216	220	PF00017	0.434
LIG_SH2_GRB2like	506	509	PF00017	0.375
LIG_SH2_NCK_1	79	83	PF00017	0.386
LIG_SH2_STAP1	202	206	PF00017	0.425
LIG_SH2_STAP1	522	526	PF00017	0.513
LIG_SH2_STAT3	93	96	PF00017	0.352
LIG_SH2_STAT3	97	100	PF00017	0.360
LIG_SH2_STAT5	168	171	PF00017	0.307
LIG_SH2_STAT5	204	207	PF00017	0.332
LIG_SH2_STAT5	425	428	PF00017	0.351
LIG_SH2_STAT5	506	509	PF00017	0.375
LIG_SH2_STAT5	522	525	PF00017	0.440
LIG_SH3_3	152	158	PF00018	0.332
LIG_SH3_3	310	316	PF00018	0.500
LIG_SH3_3	464	470	PF00018	0.389
LIG_SH3_3	53	59	PF00018	0.346
LIG_TRAF2_1	389	392	PF00917	0.270
LIG_TRFH_1	30	34	PF08558	0.412
LIG_WRC_WIRS_1	184	189	PF05994	0.380
MOD_CK1_1	226	232	PF00069	0.694
MOD_CK1_1	238	244	PF00069	0.679
MOD_CK1_1	399	405	PF00069	0.725
MOD_CK1_1	407	413	PF00069	0.703
MOD_CK1_1	518	524	PF00069	0.515
MOD_CK2_1	108	114	PF00069	0.386
MOD_GlcNHglycan	114	117	PF01048	0.436
MOD_GlcNHglycan	199	202	PF01048	0.386
MOD_GlcNHglycan	22	25	PF01048	0.346
MOD_GlcNHglycan	225	228	PF01048	0.716
MOD_GlcNHglycan	353	356	PF01048	0.690
MOD_GlcNHglycan	357	360	PF01048	0.488
MOD_GlcNHglycan	406	409	PF01048	0.667
MOD_GlcNHglycan	494	497	PF01048	0.510
MOD_GlcNHglycan	502	505	PF01048	0.371
MOD_GSK3_1	104	111	PF00069	0.324
MOD_GSK3_1	222	229	PF00069	0.668
MOD_GSK3_1	230	237	PF00069	0.708
MOD_GSK3_1	256	263	PF00069	0.668
MOD_GSK3_1	328	335	PF00069	0.579
MOD_GSK3_1	351	358	PF00069	0.644
MOD_GSK3_1	395	402	PF00069	0.650
MOD_GSK3_1	514	521	PF00069	0.578
MOD_NEK2_1	14	19	PF00069	0.336
MOD_NEK2_1	20	25	PF00069	0.298
MOD_NEK2_1	235	240	PF00069	0.719
MOD_NEK2_1	350	355	PF00069	0.633
MOD_NEK2_1	395	400	PF00069	0.665
MOD_NEK2_1	514	519	PF00069	0.575
MOD_NEK2_1	533	538	PF00069	0.495
MOD_NEK2_1	558	563	PF00069	0.625
MOD_PIKK_1	149	155	PF00454	0.386
MOD_PIKK_1	461	467	PF00454	0.463
MOD_PK_1	126	132	PF00069	0.393
MOD_PKA_1	333	339	PF00069	0.554
MOD_PKA_2	20	26	PF00069	0.332
MOD_PKA_2	332	338	PF00069	0.619
MOD_PKA_2	518	524	PF00069	0.515
MOD_PKA_2	534	540	PF00069	0.567
MOD_Plk_1	138	144	PF00069	0.386
MOD_Plk_4	15	21	PF00069	0.458
MOD_Plk_4	425	431	PF00069	0.347
MOD_Plk_4	534	540	PF00069	0.502
MOD_ProDKin_1	401	407	PF00069	0.631
MOD_ProDKin_1	52	58	PF00069	0.321
MOD_SUMO_rev_2	203	211	PF00179	0.425
TRG_DiLeu_BaEn_1	391	396	PF01217	0.615
TRG_ENDOCYTIC_2	216	219	PF00928	0.460
TRG_ENDOCYTIC_2	302	305	PF00928	0.358
TRG_ENDOCYTIC_2	379	382	PF00928	0.413
TRG_ENDOCYTIC_2	506	509	PF00928	0.392
TRG_ENDOCYTIC_2	58	61	PF00928	0.386
TRG_ER_diArg_1	189	192	PF00400	0.298
TRG_ER_diArg_1	332	334	PF00400	0.668
TRG_ER_diArg_1	386	388	PF00400	0.428
TRG_NES_CRM1_1	122	136	PF08389	0.340
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJM8	Leptomonas seymouri	70%	99%
A0A0S4KJK2	Bodo saltans	41%	93%
A0A1X0NTN1	Trypanosomatidae	51%	100%
A0A3S7WTA1	Leishmania donovani	93%	100%
A4H7Y0	Leishmania braziliensis	87%	100%
A4HWA7	Leishmania infantum	93%	100%
B8ANW0	Oryza sativa subsp. indica	24%	100%
C9ZNU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	90%
O60774	Homo sapiens	24%	100%
P17635	Oryctolagus cuniculus	24%	100%
P17636	Oryctolagus cuniculus	23%	100%
P31513	Homo sapiens	25%	100%
P32417	Oryctolagus cuniculus	25%	100%
P36366	Cavia porcellus	22%	100%
P49109	Cavia porcellus	23%	100%
P49326	Homo sapiens	24%	100%
P97501	Mus musculus	24%	100%
P97872	Mus musculus	23%	100%
Q01740	Homo sapiens	22%	100%
Q04799	Oryctolagus cuniculus	24%	100%
Q10RE2	Oryza sativa subsp. japonica	24%	100%
Q28505	Macaca mulatta	25%	100%
Q4QFH4	Leishmania major	93%	100%
Q5REK0	Pongo abelii	25%	100%
Q6IRI9	Rattus norvegicus	24%	100%
Q7YS44	Pan troglodytes	25%	100%
Q8HYJ9	Bos taurus	23%	100%
Q8HZ69	Gorilla gorilla gorilla	24%	100%
Q8HZ70	Pan troglodytes	23%	100%
Q8K2I3	Mus musculus	23%	100%
Q8K4C0	Rattus norvegicus	23%	100%
Q8SPQ7	Macaca mulatta	25%	100%
Q95LA1	Canis lupus familiaris	22%	100%
Q99518	Homo sapiens	24%	100%
Q9EQ76	Rattus norvegicus	25%	100%
Q9FWW9	Arabidopsis thaliana	24%	100%
Q9SVQ1	Arabidopsis thaliana	22%	100%
V5BBZ3	Trypanosoma cruzi	52%	100%