Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ05_LEIMU

TriTrypDb:

LmxM.15.0080

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ05

PDB structure(s): 7ane_p

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.405
CLV_NRD_NRD_1	2	4	PF00675	0.592
CLV_NRD_NRD_1	99	101	PF00675	0.400
CLV_PCSK_KEX2_1	144	146	PF00082	0.426
CLV_PCSK_KEX2_1	158	160	PF00082	0.328
CLV_PCSK_KEX2_1	2	4	PF00082	0.592
CLV_PCSK_KEX2_1	311	313	PF00082	0.689
CLV_PCSK_KEX2_1	35	37	PF00082	0.391
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.421
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.328
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.644
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.384
CLV_PCSK_SKI1_1	144	148	PF00082	0.367
CLV_PCSK_SKI1_1	159	163	PF00082	0.406
CLV_PCSK_SKI1_1	178	182	PF00082	0.391
CLV_PCSK_SKI1_1	91	95	PF00082	0.403
DEG_APCC_DBOX_1	118	126	PF00400	0.381
DEG_Nend_UBRbox_1	1	4	PF02207	0.561
DOC_CKS1_1	194	199	PF01111	0.426
DOC_MAPK_gen_1	7	17	PF00069	0.418
DOC_PP4_FxxP_1	45	48	PF00568	0.397
DOC_PP4_MxPP_1	57	60	PF00568	0.397
DOC_USP7_MATH_1	99	103	PF00917	0.414
DOC_USP7_UBL2_3	169	173	PF12436	0.569
DOC_WW_Pin1_4	193	198	PF00397	0.424
DOC_WW_Pin1_4	258	263	PF00397	0.700
DOC_WW_Pin1_4	296	301	PF00397	0.499
DOC_WW_Pin1_4	310	315	PF00397	0.545
LIG_14-3-3_CanoR_1	103	113	PF00244	0.390
LIG_14-3-3_CanoR_1	2	11	PF00244	0.571
LIG_14-3-3_CanoR_1	223	231	PF00244	0.442
LIG_APCC_ABBA_1	147	152	PF00400	0.476
LIG_deltaCOP1_diTrp_1	22	31	PF00928	0.399
LIG_deltaCOP1_diTrp_1	50	58	PF00928	0.400
LIG_FHA_1	223	229	PF00498	0.650
LIG_FHA_1	259	265	PF00498	0.450
LIG_FHA_1	82	88	PF00498	0.500
LIG_FHA_2	21	27	PF00498	0.497
LIG_FHA_2	251	257	PF00498	0.695
LIG_FHA_2	267	273	PF00498	0.482
LIG_FHA_2	78	84	PF00498	0.490
LIG_LIR_Apic_2	43	49	PF02991	0.393
LIG_LIR_Apic_2	6	12	PF02991	0.539
LIG_LIR_Gen_1	171	182	PF02991	0.411
LIG_LIR_Gen_1	29	37	PF02991	0.388
LIG_LIR_Gen_1	50	60	PF02991	0.401
LIG_LIR_Nem_3	126	132	PF02991	0.400
LIG_LIR_Nem_3	29	34	PF02991	0.504
LIG_LIR_Nem_3	50	55	PF02991	0.375
LIG_NRBOX	246	252	PF00104	0.611
LIG_Pex14_1	24	28	PF04695	0.399
LIG_Pex14_1	51	55	PF04695	0.366
LIG_SH2_CRK	9	13	PF00017	0.501
LIG_SH2_GRB2like	112	115	PF00017	0.403
LIG_SH2_PTP2	46	49	PF00017	0.379
LIG_SH2_SRC	46	49	PF00017	0.379
LIG_SH2_STAT5	174	177	PF00017	0.544
LIG_SH2_STAT5	295	298	PF00017	0.481
LIG_SH2_STAT5	46	49	PF00017	0.379
LIG_TYR_ITIM	149	154	PF00017	0.236
LIG_UBA3_1	183	192	PF00899	0.527
MOD_CDK_SPxxK_3	310	317	PF00069	0.780
MOD_CK1_1	243	249	PF00069	0.514
MOD_CK1_1	260	266	PF00069	0.399
MOD_CK1_1	77	83	PF00069	0.474
MOD_CK2_1	173	179	PF00069	0.413
MOD_CK2_1	243	249	PF00069	0.572
MOD_CK2_1	266	272	PF00069	0.577
MOD_GlcNHglycan	170	173	PF01048	0.453
MOD_GlcNHglycan	242	245	PF01048	0.512
MOD_GSK3_1	217	224	PF00069	0.491
MOD_GSK3_1	258	265	PF00069	0.571
MOD_GSK3_1	266	273	PF00069	0.484
MOD_GSK3_1	289	296	PF00069	0.645
MOD_GSK3_1	77	84	PF00069	0.508
MOD_N-GLC_1	74	79	PF02516	0.478
MOD_NEK2_1	1	6	PF00069	0.595
MOD_NEK2_1	257	262	PF00069	0.691
MOD_NEK2_1	286	291	PF00069	0.570
MOD_NEK2_1	40	45	PF00069	0.414
MOD_NEK2_2	266	271	PF00069	0.542
MOD_PIKK_1	185	191	PF00454	0.523
MOD_PIKK_1	77	83	PF00454	0.474
MOD_PKA_1	2	8	PF00069	0.581
MOD_PKA_2	1	7	PF00069	0.594
MOD_PKA_2	222	228	PF00069	0.596
MOD_PKA_2	99	105	PF00069	0.392
MOD_PKB_1	208	216	PF00069	0.317
MOD_Plk_1	137	143	PF00069	0.445
MOD_Plk_1	152	158	PF00069	0.433
MOD_Plk_1	178	184	PF00069	0.379
MOD_Plk_1	67	73	PF00069	0.469
MOD_Plk_2-3	85	91	PF00069	0.570
MOD_Plk_4	178	184	PF00069	0.380
MOD_Plk_4	198	204	PF00069	0.488
MOD_ProDKin_1	193	199	PF00069	0.425
MOD_ProDKin_1	258	264	PF00069	0.692
MOD_ProDKin_1	296	302	PF00069	0.504
MOD_ProDKin_1	310	316	PF00069	0.545
MOD_SUMO_rev_2	166	171	PF00179	0.420
TRG_DiLeu_BaEn_1	179	184	PF01217	0.517
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.525
TRG_ENDOCYTIC_2	112	115	PF00928	0.403
TRG_ENDOCYTIC_2	129	132	PF00928	0.401
TRG_ENDOCYTIC_2	151	154	PF00928	0.364
TRG_ENDOCYTIC_2	174	177	PF00928	0.544
TRG_ENDOCYTIC_2	52	55	PF00928	0.365
TRG_ER_diArg_1	1	3	PF00400	0.598
TRG_NLS_Bipartite_1	144	161	PF00514	0.392
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM8	Leptomonas seymouri	75%	99%
A0A0S4KJ11	Bodo saltans	53%	93%
A0A1X0NU97	Trypanosomatidae	64%	100%
A0A3S5H6T6	Leishmania donovani	94%	99%
A0A422NSE6	Trypanosoma rangeli	64%	100%
A4H7X8	Leishmania braziliensis	86%	100%
A4HWA5	Leishmania infantum	94%	99%
C9ZNU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
Q4QFH6	Leishmania major	92%	100%
V5DCQ2	Trypanosoma cruzi	66%	100%