Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQ04_LEIMU

TriTrypDb:

LmxM.15.0070

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQ04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.587
CLV_NRD_NRD_1	183	185	PF00675	0.837
CLV_NRD_NRD_1	284	286	PF00675	0.565
CLV_NRD_NRD_1	34	36	PF00675	0.614
CLV_NRD_NRD_1	354	356	PF00675	0.559
CLV_NRD_NRD_1	426	428	PF00675	0.568
CLV_PCSK_FUR_1	181	185	PF00082	0.762
CLV_PCSK_KEX2_1	183	185	PF00082	0.789
CLV_PCSK_KEX2_1	274	276	PF00082	0.584
CLV_PCSK_KEX2_1	284	286	PF00082	0.560
CLV_PCSK_KEX2_1	34	36	PF00082	0.614
CLV_PCSK_KEX2_1	354	356	PF00082	0.559
CLV_PCSK_KEX2_1	426	428	PF00082	0.568
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.385
DEG_SPOP_SBC_1	171	175	PF00917	0.533
DEG_SPOP_SBC_1	70	74	PF00917	0.488
DOC_CYCLIN_RxL_1	390	401	PF00134	0.667
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.673
DOC_MAPK_gen_1	354	361	PF00069	0.577
DOC_USP7_MATH_1	172	176	PF00917	0.715
DOC_USP7_MATH_1	193	197	PF00917	0.709
DOC_USP7_MATH_1	198	202	PF00917	0.680
DOC_USP7_MATH_1	2	6	PF00917	0.635
DOC_USP7_MATH_1	217	221	PF00917	0.630
DOC_USP7_MATH_1	237	241	PF00917	0.737
DOC_USP7_MATH_1	461	465	PF00917	0.732
DOC_WW_Pin1_4	144	149	PF00397	0.746
DOC_WW_Pin1_4	210	215	PF00397	0.663
DOC_WW_Pin1_4	449	454	PF00397	0.571
LIG_14-3-3_CanoR_1	224	233	PF00244	0.786
LIG_14-3-3_CanoR_1	236	242	PF00244	0.583
LIG_14-3-3_CanoR_1	34	42	PF00244	0.692
LIG_14-3-3_CanoR_1	68	77	PF00244	0.583
LIG_EVH1_1	414	418	PF00568	0.651
LIG_FHA_1	132	138	PF00498	0.520
LIG_FHA_1	14	20	PF00498	0.712
LIG_FHA_1	153	159	PF00498	0.630
LIG_FHA_1	256	262	PF00498	0.636
LIG_FHA_1	305	311	PF00498	0.651
LIG_FHA_1	319	325	PF00498	0.352
LIG_FHA_1	59	65	PF00498	0.735
LIG_FHA_1	72	78	PF00498	0.488
LIG_FHA_2	240	246	PF00498	0.612
LIG_FHA_2	27	33	PF00498	0.558
LIG_FHA_2	318	324	PF00498	0.518
LIG_FHA_2	71	77	PF00498	0.646
LIG_FHA_2	91	97	PF00498	0.587
LIG_IBAR_NPY_1	264	266	PF08397	0.595
LIG_LIR_Gen_1	90	95	PF02991	0.621
LIG_LIR_Nem_3	90	94	PF02991	0.642
LIG_RPA_C_Fungi	350	362	PF08784	0.668
LIG_SH2_NCK_1	443	447	PF00017	0.557
LIG_SH2_STAP1	102	106	PF00017	0.566
LIG_SH2_STAT5	266	269	PF00017	0.604
LIG_SH2_STAT5	44	47	PF00017	0.692
LIG_SH3_2	190	195	PF14604	0.604
LIG_SH3_2	216	221	PF14604	0.713
LIG_SH3_3	109	115	PF00018	0.692
LIG_SH3_3	142	148	PF00018	0.745
LIG_SH3_3	179	185	PF00018	0.769
LIG_SH3_3	187	193	PF00018	0.692
LIG_SH3_3	213	219	PF00018	0.661
LIG_SH3_3	264	270	PF00018	0.430
LIG_SH3_3	410	416	PF00018	0.604
LIG_SH3_3	61	67	PF00018	0.703
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.678
LIG_SUMO_SIM_par_1	444	452	PF11976	0.612
LIG_TRAF2_1	398	401	PF00917	0.575
LIG_TRAF2_1	83	86	PF00917	0.707
LIG_TRFH_1	266	270	PF08558	0.422
LIG_WRC_WIRS_1	88	93	PF05994	0.600
MOD_CK1_1	164	170	PF00069	0.789
MOD_CK1_1	220	226	PF00069	0.761
MOD_CK1_1	240	246	PF00069	0.416
MOD_CK1_1	46	52	PF00069	0.736
MOD_CK2_1	123	129	PF00069	0.770
MOD_CK2_1	144	150	PF00069	0.745
MOD_CK2_1	239	245	PF00069	0.623
MOD_CK2_1	461	467	PF00069	0.688
MOD_GlcNHglycan	108	111	PF01048	0.603
MOD_GlcNHglycan	200	203	PF01048	0.735
MOD_GlcNHglycan	254	258	PF01048	0.700
MOD_GlcNHglycan	422	425	PF01048	0.691
MOD_GlcNHglycan	444	447	PF01048	0.511
MOD_GlcNHglycan	462	466	PF01048	0.587
MOD_GlcNHglycan	49	52	PF01048	0.663
MOD_GSK3_1	13	20	PF00069	0.717
MOD_GSK3_1	152	159	PF00069	0.722
MOD_GSK3_1	161	168	PF00069	0.755
MOD_GSK3_1	172	179	PF00069	0.649
MOD_GSK3_1	194	201	PF00069	0.683
MOD_GSK3_1	219	226	PF00069	0.791
MOD_GSK3_1	237	244	PF00069	0.451
MOD_GSK3_1	315	322	PF00069	0.466
MOD_GSK3_1	43	50	PF00069	0.694
MOD_NEK2_1	13	18	PF00069	0.726
MOD_NEK2_1	442	447	PF00069	0.423
MOD_PIKK_1	176	182	PF00454	0.843
MOD_PKA_1	34	40	PF00069	0.626
MOD_PKA_2	191	197	PF00069	0.748
MOD_PKA_2	208	214	PF00069	0.756
MOD_PKA_2	217	223	PF00069	0.703
MOD_PKA_2	34	40	PF00069	0.704
MOD_PKA_2	374	380	PF00069	0.600
MOD_Plk_1	244	250	PF00069	0.630
MOD_Plk_2-3	123	129	PF00069	0.789
MOD_Plk_2-3	98	104	PF00069	0.563
MOD_Plk_4	161	167	PF00069	0.523
MOD_Plk_4	87	93	PF00069	0.585
MOD_ProDKin_1	144	150	PF00069	0.745
MOD_ProDKin_1	210	216	PF00069	0.662
MOD_ProDKin_1	449	455	PF00069	0.577
MOD_SUMO_for_1	302	305	PF00179	0.468
MOD_SUMO_for_1	7	10	PF00179	0.613
TRG_DiLeu_BaEn_3	86	92	PF01217	0.631
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.582
TRG_ER_diArg_1	181	184	PF00400	0.841
TRG_ER_diArg_1	275	278	PF00400	0.571
TRG_ER_diArg_1	284	286	PF00400	0.565
TRG_ER_diArg_1	33	35	PF00400	0.610
TRG_ER_diArg_1	425	427	PF00400	0.572
TRG_ER_diArg_1	66	69	PF00400	0.681
TRG_Pf-PMV_PEXEL_1	277	282	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C4	Leptomonas seymouri	41%	87%
A0A3Q8IIJ0	Leishmania donovani	85%	100%
A4H7X7	Leishmania braziliensis	66%	100%
A4HWA4	Leishmania infantum	85%	100%
Q4QFH7	Leishmania major	88%	100%