AMP nucleosidase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

AMP nucleosidase

Gene product:

Possible lysine decarboxylase, putative

Species:

Leishmania mexicana

UniProt:

E9AQ01_LEIMU

TriTrypDb:

LmxM.15.0040

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQ01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQ01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.554
CLV_NRD_NRD_1	231	233	PF00675	0.321
CLV_NRD_NRD_1	322	324	PF00675	0.558
CLV_PCSK_KEX2_1	170	172	PF00082	0.650
CLV_PCSK_KEX2_1	322	324	PF00082	0.401
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.650
CLV_PCSK_SKI1_1	23	27	PF00082	0.474
CLV_PCSK_SKI1_1	75	79	PF00082	0.493
DOC_CYCLIN_RxL_1	217	225	PF00134	0.572
DOC_MAPK_DCC_7	263	273	PF00069	0.541
DOC_MAPK_gen_1	170	177	PF00069	0.604
DOC_MAPK_gen_1	263	273	PF00069	0.554
DOC_MAPK_MEF2A_6	266	275	PF00069	0.531
DOC_MIT_MIM_1	166	175	PF04212	0.642
DOC_PP1_RVXF_1	218	225	PF00149	0.572
DOC_PP4_FxxP_1	52	55	PF00568	0.483
DOC_USP7_UBL2_3	263	267	PF12436	0.589
DOC_WW_Pin1_4	154	159	PF00397	0.677
DOC_WW_Pin1_4	23	28	PF00397	0.526
DOC_WW_Pin1_4	325	330	PF00397	0.572
DOC_WW_Pin1_4	8	13	PF00397	0.663
LIG_14-3-3_CanoR_1	111	121	PF00244	0.510
LIG_14-3-3_CanoR_1	5	13	PF00244	0.734
LIG_14-3-3_CanoR_1	65	69	PF00244	0.415
LIG_14-3-3_CanoR_1	75	82	PF00244	0.452
LIG_Actin_WH2_2	249	265	PF00022	0.530
LIG_BIR_II_1	1	5	PF00653	0.732
LIG_BRCT_BRCA1_1	206	210	PF00533	0.530
LIG_BRCT_BRCA1_1	302	306	PF00533	0.554
LIG_BRCT_BRCA1_2	206	212	PF00533	0.491
LIG_CtBP_PxDLS_1	17	23	PF00389	0.456
LIG_deltaCOP1_diTrp_1	279	287	PF00928	0.606
LIG_FHA_1	217	223	PF00498	0.554
LIG_FHA_1	24	30	PF00498	0.612
LIG_FHA_1	263	269	PF00498	0.530
LIG_FHA_1	64	70	PF00498	0.438
LIG_FHA_2	155	161	PF00498	0.602
LIG_FHA_2	250	256	PF00498	0.521
LIG_FHA_2	83	89	PF00498	0.489
LIG_HP1_1	272	276	PF01393	0.541
LIG_LIR_Apic_2	51	55	PF02991	0.478
LIG_LIR_Gen_1	225	234	PF02991	0.531
LIG_LIR_Gen_1	254	262	PF02991	0.521
LIG_LIR_LC3C_4	174	177	PF02991	0.487
LIG_LIR_Nem_3	146	150	PF02991	0.531
LIG_LIR_Nem_3	152	156	PF02991	0.543
LIG_LIR_Nem_3	225	229	PF02991	0.519
LIG_LIR_Nem_3	254	260	PF02991	0.530
LIG_LIR_Nem_3	279	284	PF02991	0.527
LIG_LIR_Nem_3	292	296	PF02991	0.504
LIG_LIR_Nem_3	319	324	PF02991	0.575
LIG_MAD2	47	55	PF02301	0.480
LIG_NRBOX	255	261	PF00104	0.509
LIG_Pex14_2	226	230	PF04695	0.523
LIG_PTB_Apo_2	141	148	PF02174	0.435
LIG_PTB_Apo_2	31	38	PF02174	0.480
LIG_REV1ctd_RIR_1	227	237	PF16727	0.521
LIG_SH2_CRK	293	297	PF00017	0.595
LIG_SH2_CRK	321	325	PF00017	0.553
LIG_SH2_STAP1	238	242	PF00017	0.521
LIG_SH2_STAP1	82	86	PF00017	0.556
LIG_SH2_STAT5	13	16	PF00017	0.603
LIG_SH2_STAT5	153	156	PF00017	0.537
LIG_SH2_STAT5	228	231	PF00017	0.552
LIG_SH3_1	266	272	PF00018	0.530
LIG_SH3_3	241	247	PF00018	0.554
LIG_SH3_3	266	272	PF00018	0.513
LIG_SUMO_SIM_par_1	270	277	PF11976	0.453
LIG_TRAF2_1	297	300	PF00917	0.556
LIG_TRAF2_1	309	312	PF00917	0.391
LIG_TRFH_1	154	158	PF08558	0.691
LIG_UBA3_1	256	263	PF00899	0.537
MOD_CDK_SPxxK_3	23	30	PF00069	0.585
MOD_CK1_1	7	13	PF00069	0.690
MOD_CK1_1	73	79	PF00069	0.549
MOD_CK2_1	133	139	PF00069	0.568
MOD_CK2_1	249	255	PF00069	0.521
MOD_CK2_1	294	300	PF00069	0.521
MOD_CK2_1	306	312	PF00069	0.391
MOD_Cter_Amidation	21	24	PF01082	0.584
MOD_GlcNHglycan	18	23	PF01048	0.654
MOD_GlcNHglycan	308	311	PF01048	0.427
MOD_GlcNHglycan	41	44	PF01048	0.568
MOD_GlcNHglycan	72	75	PF01048	0.449
MOD_GSK3_1	258	265	PF00069	0.530
MOD_GSK3_1	300	307	PF00069	0.612
MOD_GSK3_1	4	11	PF00069	0.753
MOD_GSK3_1	94	101	PF00069	0.607
MOD_N-GLC_1	143	148	PF02516	0.435
MOD_N-GLC_1	325	330	PF02516	0.612
MOD_NEK2_1	112	117	PF00069	0.514
MOD_NEK2_1	175	180	PF00069	0.439
MOD_NEK2_1	204	209	PF00069	0.530
MOD_NEK2_1	236	241	PF00069	0.538
MOD_NEK2_1	262	267	PF00069	0.530
MOD_NEK2_1	280	285	PF00069	0.534
MOD_NEK2_1	37	42	PF00069	0.553
MOD_NEK2_1	63	68	PF00069	0.497
MOD_NEK2_1	70	75	PF00069	0.444
MOD_PIKK_1	112	118	PF00454	0.518
MOD_PIKK_1	133	139	PF00454	0.610
MOD_PIKK_1	294	300	PF00454	0.569
MOD_PIKK_1	75	81	PF00454	0.617
MOD_PKA_2	4	10	PF00069	0.702
MOD_PKA_2	64	70	PF00069	0.409
MOD_Plk_1	143	149	PF00069	0.453
MOD_Plk_1	82	88	PF00069	0.544
MOD_Plk_4	300	306	PF00069	0.612
MOD_Plk_4	64	70	PF00069	0.409
MOD_ProDKin_1	154	160	PF00069	0.676
MOD_ProDKin_1	23	29	PF00069	0.518
MOD_ProDKin_1	325	331	PF00069	0.589
MOD_ProDKin_1	8	14	PF00069	0.659
TRG_DiLeu_BaEn_1	255	260	PF01217	0.522
TRG_DiLeu_BaEn_1	300	305	PF01217	0.612
TRG_ENDOCYTIC_2	153	156	PF00928	0.626
TRG_ENDOCYTIC_2	293	296	PF00928	0.595
TRG_ENDOCYTIC_2	32	35	PF00928	0.655
TRG_ENDOCYTIC_2	321	324	PF00928	0.552
TRG_ER_diArg_1	321	323	PF00400	0.385
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	322	327	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M2	Leptomonas seymouri	73%	100%
A0A0S4J0W4	Bodo saltans	41%	100%
A0A0S4KLV2	Bodo saltans	58%	98%
A0A1X0NU32	Trypanosomatidae	63%	100%
A0A3Q8IC52	Leishmania donovani	93%	100%
A0A422MT26	Trypanosoma rangeli	60%	100%
A4H7X4	Leishmania braziliensis	82%	100%
A4HWA1	Leishmania infantum	94%	100%
C9ZNT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
Q4QFI0	Leishmania major	94%	100%
V5AWJ3	Trypanosoma cruzi	61%	88%