Expression site-associated gene (ESAG-like) protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APZ9_LEIMU

TriTrypDb:

LmxM.15.0020

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9APZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.418
CLV_C14_Caspase3-7	530	534	PF00656	0.368
CLV_NRD_NRD_1	34	36	PF00675	0.324
CLV_NRD_NRD_1	477	479	PF00675	0.621
CLV_NRD_NRD_1	545	547	PF00675	0.592
CLV_NRD_NRD_1	561	563	PF00675	0.494
CLV_NRD_NRD_1	578	580	PF00675	0.573
CLV_NRD_NRD_1	92	94	PF00675	0.604
CLV_NRD_NRD_1	98	100	PF00675	0.582
CLV_PCSK_FUR_1	409	413	PF00082	0.565
CLV_PCSK_FUR_1	49	53	PF00082	0.368
CLV_PCSK_KEX2_1	34	36	PF00082	0.368
CLV_PCSK_KEX2_1	411	413	PF00082	0.575
CLV_PCSK_KEX2_1	477	479	PF00082	0.608
CLV_PCSK_KEX2_1	51	53	PF00082	0.338
CLV_PCSK_KEX2_1	545	547	PF00082	0.710
CLV_PCSK_KEX2_1	560	562	PF00082	0.605
CLV_PCSK_KEX2_1	578	580	PF00082	0.508
CLV_PCSK_KEX2_1	92	94	PF00082	0.563
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.565
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.279
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.618
CLV_PCSK_SKI1_1	401	405	PF00082	0.537
CLV_PCSK_SKI1_1	51	55	PF00082	0.383
CLV_PCSK_SKI1_1	520	524	PF00082	0.621
CLV_PCSK_SKI1_1	546	550	PF00082	0.658
CLV_PCSK_SKI1_1	579	583	PF00082	0.699
CLV_PCSK_SKI1_1	93	97	PF00082	0.582
CLV_Separin_Metazoa	36	40	PF03568	0.523
DEG_APCC_DBOX_1	33	41	PF00400	0.606
DEG_APCC_DBOX_1	477	485	PF00400	0.401
DOC_CKS1_1	357	362	PF01111	0.373
DOC_CKS1_1	512	517	PF01111	0.418
DOC_CYCLIN_RxL_1	49	57	PF00134	0.478
DOC_MAPK_DCC_7	265	275	PF00069	0.335
DOC_MAPK_gen_1	31	40	PF00069	0.596
DOC_MAPK_gen_1	448	458	PF00069	0.431
DOC_MAPK_gen_1	490	497	PF00069	0.430
DOC_MAPK_MEF2A_6	196	204	PF00069	0.321
DOC_MAPK_MEF2A_6	261	270	PF00069	0.345
DOC_MAPK_MEF2A_6	451	460	PF00069	0.424
DOC_PP1_RVXF_1	138	144	PF00149	0.385
DOC_PP4_FxxP_1	313	316	PF00568	0.362
DOC_PP4_FxxP_1	454	457	PF00568	0.322
DOC_PP4_FxxP_1	497	500	PF00568	0.377
DOC_PP4_FxxP_1	512	515	PF00568	0.324
DOC_PP4_FxxP_1	617	620	PF00568	0.355
DOC_USP7_MATH_1	320	324	PF00917	0.415
DOC_USP7_MATH_1	506	510	PF00917	0.402
DOC_USP7_MATH_1	556	560	PF00917	0.438
DOC_USP7_MATH_1	65	69	PF00917	0.253
DOC_WW_Pin1_4	223	228	PF00397	0.371
DOC_WW_Pin1_4	256	261	PF00397	0.372
DOC_WW_Pin1_4	312	317	PF00397	0.362
DOC_WW_Pin1_4	356	361	PF00397	0.464
DOC_WW_Pin1_4	511	516	PF00397	0.421
DOC_WW_Pin1_4	612	617	PF00397	0.375
DOC_WW_Pin1_4	75	80	PF00397	0.375
LIG_14-3-3_CanoR_1	167	171	PF00244	0.375
LIG_14-3-3_CanoR_1	308	314	PF00244	0.463
LIG_14-3-3_CanoR_1	52	62	PF00244	0.456
LIG_14-3-3_CanoR_1	6	15	PF00244	0.631
LIG_Actin_WH2_2	244	259	PF00022	0.265
LIG_Actin_WH2_2	385	403	PF00022	0.315
LIG_BRCT_BRCA1_1	427	431	PF00533	0.324
LIG_BRCT_BRCA1_1	508	512	PF00533	0.355
LIG_BRCT_BRCA1_1	55	59	PF00533	0.239
LIG_Clathr_ClatBox_1	460	464	PF01394	0.318
LIG_deltaCOP1_diTrp_1	151	154	PF00928	0.320
LIG_deltaCOP1_diTrp_1	569	575	PF00928	0.301
LIG_eIF4E_1	298	304	PF01652	0.320
LIG_EVH1_2	271	275	PF00568	0.316
LIG_FHA_1	129	135	PF00498	0.397
LIG_FHA_1	298	304	PF00498	0.319
LIG_FHA_1	470	476	PF00498	0.390
LIG_FHA_1	512	518	PF00498	0.406
LIG_FHA_1	55	61	PF00498	0.375
LIG_FHA_2	209	215	PF00498	0.389
LIG_FHA_2	347	353	PF00498	0.454
LIG_FHA_2	357	363	PF00498	0.306
LIG_FHA_2	496	502	PF00498	0.396
LIG_FHA_2	528	534	PF00498	0.462
LIG_FHA_2	587	593	PF00498	0.348
LIG_LIR_Apic_2	280	286	PF02991	0.360
LIG_LIR_Apic_2	312	316	PF02991	0.355
LIG_LIR_Apic_2	452	457	PF02991	0.381
LIG_LIR_Apic_2	494	500	PF02991	0.390
LIG_LIR_Apic_2	509	515	PF02991	0.324
LIG_LIR_Apic_2	615	620	PF02991	0.334
LIG_LIR_Gen_1	151	162	PF02991	0.318
LIG_LIR_Gen_1	174	183	PF02991	0.385
LIG_LIR_Gen_1	288	299	PF02991	0.416
LIG_LIR_Gen_1	551	557	PF02991	0.332
LIG_LIR_Gen_1	56	66	PF02991	0.407
LIG_LIR_Nem_3	151	157	PF02991	0.325
LIG_LIR_Nem_3	174	180	PF02991	0.357
LIG_LIR_Nem_3	288	294	PF02991	0.406
LIG_LIR_Nem_3	325	330	PF02991	0.442
LIG_LIR_Nem_3	551	555	PF02991	0.418
LIG_LIR_Nem_3	56	62	PF02991	0.407
LIG_NRBOX	3	9	PF00104	0.552
LIG_PCNA_PIPBox_1	118	127	PF02747	0.354
LIG_Pex14_2	218	222	PF04695	0.435
LIG_Pex14_2	527	531	PF04695	0.305
LIG_Pex14_2	55	59	PF04695	0.379
LIG_Pex14_2	571	575	PF04695	0.344
LIG_PTB_Apo_2	364	371	PF02174	0.295
LIG_SH2_CRK	283	287	PF00017	0.339
LIG_SH2_CRK	330	334	PF00017	0.395
LIG_SH2_GRB2like	379	382	PF00017	0.328
LIG_SH2_NCK_1	225	229	PF00017	0.359
LIG_SH2_NCK_1	85	89	PF00017	0.323
LIG_SH2_SRC	379	382	PF00017	0.324
LIG_SH2_SRC	83	86	PF00017	0.403
LIG_SH2_STAP1	177	181	PF00017	0.322
LIG_SH2_STAP1	427	431	PF00017	0.308
LIG_SH2_STAT3	124	127	PF00017	0.357
LIG_SH2_STAT3	244	247	PF00017	0.254
LIG_SH2_STAT3	282	285	PF00017	0.326
LIG_SH2_STAT5	124	127	PF00017	0.415
LIG_SH2_STAT5	186	189	PF00017	0.370
LIG_SH2_STAT5	298	301	PF00017	0.322
LIG_SH2_STAT5	379	382	PF00017	0.330
LIG_SH2_STAT5	488	491	PF00017	0.444
LIG_SH2_STAT5	83	86	PF00017	0.519
LIG_SH3_3	131	137	PF00018	0.326
LIG_SH3_3	265	271	PF00018	0.366
LIG_SH3_4	100	107	PF00018	0.329
LIG_SUMO_SIM_par_1	459	464	PF11976	0.295
LIG_SUMO_SIM_par_1	62	68	PF11976	0.388
LIG_WRC_WIRS_1	549	554	PF05994	0.328
MOD_CDK_SPK_2	256	261	PF00069	0.309
MOD_CK1_1	147	153	PF00069	0.336
MOD_CK1_1	226	232	PF00069	0.340
MOD_CK1_1	312	318	PF00069	0.398
MOD_CK1_1	486	492	PF00069	0.396
MOD_CK1_1	535	541	PF00069	0.365
MOD_CK2_1	346	352	PF00069	0.447
MOD_CMANNOS	570	573	PF00535	0.527
MOD_GlcNHglycan	440	443	PF01048	0.464
MOD_GlcNHglycan	508	511	PF01048	0.670
MOD_GlcNHglycan	540	543	PF01048	0.594
MOD_GlcNHglycan	584	587	PF01048	0.497
MOD_GlcNHglycan	67	70	PF01048	0.453
MOD_GSK3_1	128	135	PF00069	0.382
MOD_GSK3_1	252	259	PF00069	0.420
MOD_GSK3_1	438	445	PF00069	0.276
MOD_GSK3_1	482	489	PF00069	0.421
MOD_GSK3_1	534	541	PF00069	0.395
MOD_GSK3_1	582	589	PF00069	0.358
MOD_GSK3_1	612	619	PF00069	0.350
MOD_N-GLC_1	128	133	PF02516	0.612
MOD_N-GLC_1	147	152	PF02516	0.525
MOD_N-GLC_1	347	352	PF02516	0.635
MOD_N-GLC_1	600	605	PF02516	0.574
MOD_NEK2_1	252	257	PF00069	0.347
MOD_NEK2_1	346	351	PF00069	0.427
MOD_NEK2_1	384	389	PF00069	0.332
MOD_NEK2_1	438	443	PF00069	0.349
MOD_NEK2_1	469	474	PF00069	0.375
MOD_NEK2_1	504	509	PF00069	0.403
MOD_NEK2_1	527	532	PF00069	0.497
MOD_NEK2_1	53	58	PF00069	0.351
MOD_NEK2_1	64	69	PF00069	0.370
MOD_NEK2_1	7	12	PF00069	0.634
MOD_OFUCOSY	155	161	PF10250	0.501
MOD_PIKK_1	123	129	PF00454	0.339
MOD_PIKK_1	8	14	PF00454	0.555
MOD_PKA_2	166	172	PF00069	0.401
MOD_PKA_2	320	326	PF00069	0.475
MOD_PKA_2	450	456	PF00069	0.344
MOD_PKA_2	8	14	PF00069	0.634
MOD_Plk_1	150	156	PF00069	0.315
MOD_Plk_1	173	179	PF00069	0.374
MOD_Plk_1	347	353	PF00069	0.405
MOD_Plk_1	416	422	PF00069	0.314
MOD_Plk_1	493	499	PF00069	0.320
MOD_Plk_1	527	533	PF00069	0.349
MOD_Plk_1	600	606	PF00069	0.400
MOD_Plk_4	166	172	PF00069	0.424
MOD_Plk_4	247	253	PF00069	0.252
MOD_Plk_4	309	315	PF00069	0.362
MOD_Plk_4	416	422	PF00069	0.317
MOD_Plk_4	483	489	PF00069	0.373
MOD_Plk_4	527	533	PF00069	0.373
MOD_Plk_4	54	60	PF00069	0.514
MOD_Plk_4	548	554	PF00069	0.335
MOD_Plk_4	586	592	PF00069	0.323
MOD_ProDKin_1	223	229	PF00069	0.374
MOD_ProDKin_1	256	262	PF00069	0.371
MOD_ProDKin_1	312	318	PF00069	0.363
MOD_ProDKin_1	356	362	PF00069	0.459
MOD_ProDKin_1	511	517	PF00069	0.421
MOD_ProDKin_1	612	618	PF00069	0.359
MOD_ProDKin_1	75	81	PF00069	0.374
MOD_SUMO_for_1	410	413	PF00179	0.390
MOD_SUMO_for_1	594	597	PF00179	0.283
TRG_DiLeu_BaEn_2	351	357	PF01217	0.420
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.526
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.378
TRG_ENDOCYTIC_2	177	180	PF00928	0.379
TRG_ENDOCYTIC_2	330	333	PF00928	0.422
TRG_ENDOCYTIC_2	334	337	PF00928	0.304
TRG_ENDOCYTIC_2	427	430	PF00928	0.324
TRG_ENDOCYTIC_2	85	88	PF00928	0.368
TRG_ER_diArg_1	33	35	PF00400	0.577
TRG_ER_diArg_1	544	546	PF00400	0.386
TRG_ER_diArg_1	561	563	PF00400	0.286
TRG_ER_diArg_1	91	93	PF00400	0.375
TRG_NLS_Bipartite_1	545	564	PF00514	0.314
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	33%	97%
A0A0N1PDD7	Leptomonas seymouri	25%	100%
A0A3Q8ID98	Leishmania donovani	90%	100%
A0A3Q8IM92	Leishmania donovani	33%	93%
A4H7X2	Leishmania braziliensis	75%	100%
A4HLI8	Leishmania braziliensis	33%	100%
A4HLJ0	Leishmania braziliensis	32%	100%
A4HLJ2	Leishmania braziliensis	30%	99%
A4HW99	Leishmania infantum	90%	100%
A4I8Z8	Leishmania infantum	34%	93%
E9B3W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	93%
Q4Q457	Leishmania major	34%	100%
Q4QFI2	Leishmania major	86%	100%