Expression site-associated gene (ESAG-like) protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9APZ9_LEIMU

TriTrypDb:

LmxM.15.0020

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

E9APZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APZ9

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.418
CLV_C14_Caspase3-7	530	534	PF00656	0.368
CLV_NRD_NRD_1	34	36	PF00675	0.324
CLV_NRD_NRD_1	477	479	PF00675	0.621
CLV_NRD_NRD_1	545	547	PF00675	0.592
CLV_NRD_NRD_1	561	563	PF00675	0.494
CLV_NRD_NRD_1	578	580	PF00675	0.573
CLV_NRD_NRD_1	92	94	PF00675	0.604
CLV_NRD_NRD_1	98	100	PF00675	0.582
CLV_PCSK_FUR_1	409	413	PF00082	0.565

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	33%	97%
A0A0N1PDD7	Leptomonas seymouri	25%	100%
A0A3Q8ID98	Leishmania donovani	90%	100%
A0A3Q8IM92	Leishmania donovani	33%	93%
A4H7X2	Leishmania braziliensis	75%	100%
A4HLI8	Leishmania braziliensis	33%	100%
A4HLJ0	Leishmania braziliensis	32%	100%
A4HLJ2	Leishmania braziliensis	30%	99%
A4HW99	Leishmania infantum	90%	100%
A4I8Z8	Leishmania infantum	34%	93%

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