Putative synaptojanin (N-terminal domain) (Putative inositol 5'-phosphatase)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

synaptojanin (N-terminal domain), putative

Species:

Leishmania mexicana

UniProt:

E9APZ7_LEIMU

TriTrypDb:

LmxM.14.1490

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9APZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APZ7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.447
CLV_C14_Caspase3-7	815	819	PF00656	0.649
CLV_NRD_NRD_1	627	629	PF00675	0.445
CLV_NRD_NRD_1	636	638	PF00675	0.434
CLV_NRD_NRD_1	695	697	PF00675	0.479
CLV_NRD_NRD_1	767	769	PF00675	0.558
CLV_PCSK_KEX2_1	24	26	PF00082	0.311
CLV_PCSK_KEX2_1	695	697	PF00082	0.508
CLV_PCSK_KEX2_1	74	76	PF00082	0.608
CLV_PCSK_KEX2_1	834	836	PF00082	0.662
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.321
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.608
CLV_PCSK_PC1ET2_1	834	836	PF00082	0.662
CLV_PCSK_SKI1_1	401	405	PF00082	0.348
CLV_PCSK_SKI1_1	478	482	PF00082	0.496
CLV_PCSK_SKI1_1	835	839	PF00082	0.625
CLV_Separin_Metazoa	348	352	PF03568	0.378
DEG_APCC_DBOX_1	400	408	PF00400	0.378
DEG_APCC_DBOX_1	41	49	PF00400	0.434
DEG_APCC_DBOX_1	636	644	PF00400	0.468
DEG_Kelch_actinfilin_1	576	580	PF01344	0.225
DEG_Nend_UBRbox_3	1	3	PF02207	0.668
DEG_SPOP_SBC_1	441	445	PF00917	0.480
DOC_CDC14_PxL_1	121	129	PF14671	0.511
DOC_CKS1_1	56	61	PF01111	0.739
DOC_CYCLIN_RxL_1	93	104	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	663	669	PF00134	0.385
DOC_MAPK_DCC_7	36	45	PF00069	0.588
DOC_MAPK_DCC_7	570	580	PF00069	0.423
DOC_MAPK_gen_1	16	23	PF00069	0.412
DOC_MAPK_gen_1	24	32	PF00069	0.421
DOC_MAPK_gen_1	36	45	PF00069	0.360
DOC_MAPK_gen_1	637	647	PF00069	0.399
DOC_MAPK_gen_1	768	777	PF00069	0.589
DOC_MAPK_MEF2A_6	25	34	PF00069	0.452
DOC_MAPK_MEF2A_6	259	268	PF00069	0.408
DOC_MAPK_MEF2A_6	36	45	PF00069	0.637
DOC_MAPK_MEF2A_6	638	647	PF00069	0.396
DOC_PP1_RVXF_1	715	722	PF00149	0.578
DOC_PP1_RVXF_1	94	101	PF00149	0.513
DOC_PP1_SILK_1	316	321	PF00149	0.383
DOC_PP2B_LxvP_1	679	682	PF13499	0.425
DOC_PP2B_LxvP_1	709	712	PF13499	0.357
DOC_PP4_FxxP_1	167	170	PF00568	0.378
DOC_PP4_FxxP_1	211	214	PF00568	0.408
DOC_USP7_MATH_1	10	14	PF00917	0.672
DOC_USP7_MATH_1	117	121	PF00917	0.430
DOC_USP7_MATH_1	241	245	PF00917	0.405
DOC_USP7_MATH_1	419	423	PF00917	0.445
DOC_USP7_MATH_1	460	464	PF00917	0.537
DOC_USP7_MATH_1	519	523	PF00917	0.518
DOC_USP7_MATH_1	713	717	PF00917	0.517
DOC_USP7_MATH_1	816	820	PF00917	0.664
DOC_WW_Pin1_4	175	180	PF00397	0.408
DOC_WW_Pin1_4	523	528	PF00397	0.607
DOC_WW_Pin1_4	55	60	PF00397	0.658
DOC_WW_Pin1_4	656	661	PF00397	0.482
DOC_WW_Pin1_4	756	761	PF00397	0.793
DOC_WW_Pin1_4	804	809	PF00397	0.259
LIG_14-3-3_CanoR_1	254	259	PF00244	0.480
LIG_14-3-3_CanoR_1	351	357	PF00244	0.376
LIG_14-3-3_CanoR_1	375	382	PF00244	0.250
LIG_14-3-3_CanoR_1	408	414	PF00244	0.356
LIG_14-3-3_CanoR_1	478	486	PF00244	0.532
LIG_14-3-3_CanoR_1	695	699	PF00244	0.543
LIG_14-3-3_CanoR_1	835	841	PF00244	0.680
LIG_Actin_WH2_2	626	643	PF00022	0.483
LIG_Actin_WH2_2	819	836	PF00022	0.697
LIG_BIR_III_4	786	790	PF00653	0.249
LIG_BRCT_BRCA1_1	357	361	PF00533	0.394
LIG_BRCT_BRCA1_1	449	453	PF00533	0.447
LIG_BRCT_BRCA1_1	658	662	PF00533	0.404
LIG_BRCT_BRCA1_1	96	100	PF00533	0.514
LIG_Clathr_ClatBox_1	367	371	PF01394	0.188
LIG_Clathr_ClatBox_1	425	429	PF01394	0.319
LIG_Clathr_ClatBox_1	48	52	PF01394	0.583
LIG_CSL_BTD_1	163	166	PF09270	0.447
LIG_CtBP_PxDLS_1	219	223	PF00389	0.480
LIG_FHA_1	143	149	PF00498	0.408
LIG_FHA_1	160	166	PF00498	0.335
LIG_FHA_1	178	184	PF00498	0.335
LIG_FHA_1	198	204	PF00498	0.368
LIG_FHA_1	320	326	PF00498	0.335
LIG_FHA_1	330	336	PF00498	0.335
LIG_FHA_1	471	477	PF00498	0.473
LIG_FHA_1	513	519	PF00498	0.512
LIG_FHA_1	685	691	PF00498	0.550
LIG_FHA_1	720	726	PF00498	0.471
LIG_FHA_1	736	742	PF00498	0.654
LIG_FHA_1	821	827	PF00498	0.738
LIG_FHA_2	255	261	PF00498	0.417
LIG_FHA_2	443	449	PF00498	0.417
LIG_FHA_2	457	463	PF00498	0.509
LIG_FHA_2	563	569	PF00498	0.469
LIG_FHA_2	728	734	PF00498	0.692
LIG_FHA_2	813	819	PF00498	0.623
LIG_GSK3_LRP6_1	55	60	PF00069	0.559
LIG_HCF-1_HBM_1	295	298	PF13415	0.335
LIG_Integrin_isoDGR_2	373	375	PF01839	0.266
LIG_LIR_Apic_2	807	812	PF02991	0.383
LIG_LIR_Gen_1	103	111	PF02991	0.438
LIG_LIR_Gen_1	134	144	PF02991	0.372
LIG_LIR_Gen_1	295	305	PF02991	0.335
LIG_LIR_Gen_1	355	364	PF02991	0.334
LIG_LIR_Gen_1	429	437	PF02991	0.398
LIG_LIR_Gen_1	483	491	PF02991	0.441
LIG_LIR_Nem_3	103	108	PF02991	0.433
LIG_LIR_Nem_3	119	124	PF02991	0.411
LIG_LIR_Nem_3	134	140	PF02991	0.254
LIG_LIR_Nem_3	162	167	PF02991	0.337
LIG_LIR_Nem_3	295	301	PF02991	0.335
LIG_LIR_Nem_3	358	364	PF02991	0.320
LIG_LIR_Nem_3	429	433	PF02991	0.335
LIG_LIR_Nem_3	483	488	PF02991	0.436
LIG_LIR_Nem_3	653	658	PF02991	0.490
LIG_LYPXL_yS_3	124	127	PF13949	0.428
LIG_LYPXL_yS_3	811	814	PF13949	0.519
LIG_Pex14_2	357	361	PF04695	0.355
LIG_Pex14_2	562	566	PF04695	0.442
LIG_Pex14_2	630	634	PF04695	0.448
LIG_SH2_CRK	809	813	PF00017	0.441
LIG_SH2_GRB2like	598	601	PF00017	0.425
LIG_SH2_NCK_1	544	548	PF00017	0.687
LIG_SH2_PTP2	137	140	PF00017	0.408
LIG_SH2_SRC	298	301	PF00017	0.335
LIG_SH2_SRC	809	812	PF00017	0.472
LIG_SH2_STAP1	199	203	PF00017	0.368
LIG_SH2_STAP1	298	302	PF00017	0.335
LIG_SH2_STAP1	544	548	PF00017	0.700
LIG_SH2_STAP1	598	602	PF00017	0.386
LIG_SH2_STAP1	669	673	PF00017	0.527
LIG_SH2_STAT5	137	140	PF00017	0.368
LIG_SH2_STAT5	199	202	PF00017	0.207
LIG_SH2_STAT5	281	284	PF00017	0.335
LIG_SH2_STAT5	29	32	PF00017	0.478
LIG_SH2_STAT5	300	303	PF00017	0.335
LIG_SH2_STAT5	356	359	PF00017	0.335
LIG_SH2_STAT5	598	601	PF00017	0.431
LIG_SH2_STAT5	669	672	PF00017	0.528
LIG_SH3_2	37	42	PF14604	0.561
LIG_SH3_3	145	151	PF00018	0.447
LIG_SH3_3	202	208	PF00018	0.434
LIG_SH3_3	29	35	PF00018	0.420
LIG_SH3_3	524	530	PF00018	0.509
LIG_SH3_3	53	59	PF00018	0.697
LIG_SH3_3	555	561	PF00018	0.598
LIG_SH3_3	802	808	PF00018	0.470
LIG_SH3_CIN85_PxpxPR_1	37	42	PF14604	0.396
LIG_SUMO_SIM_anti_2	422	427	PF11976	0.411
LIG_SUMO_SIM_anti_2	770	776	PF11976	0.438
LIG_SUMO_SIM_par_1	721	726	PF11976	0.551
LIG_TRAF2_1	522	525	PF00917	0.513
LIG_TRAF2_1	750	753	PF00917	0.642
LIG_TRFH_1	662	666	PF08558	0.491
LIG_TYR_ITIM	27	32	PF00017	0.495
LIG_UBA3_1	127	135	PF00899	0.237
LIG_UBA3_1	360	365	PF00899	0.434
LIG_WRC_WIRS_1	118	123	PF05994	0.474
LIG_WRC_WIRS_1	520	525	PF05994	0.537
LIG_WW_3	39	43	PF00397	0.412
LIG_WW_3	765	769	PF00397	0.674
MOD_CDK_SPxxK_3	175	182	PF00069	0.408
MOD_CDK_SPxxK_3	761	768	PF00069	0.711
MOD_CK1_1	235	241	PF00069	0.474
MOD_CK1_1	463	469	PF00069	0.485
MOD_CK1_1	697	703	PF00069	0.466
MOD_CK1_1	726	732	PF00069	0.637
MOD_CK2_1	104	110	PF00069	0.399
MOD_CK2_1	117	123	PF00069	0.429
MOD_CK2_1	331	337	PF00069	0.335
MOD_CK2_1	442	448	PF00069	0.388
MOD_CK2_1	455	461	PF00069	0.438
MOD_CK2_1	519	525	PF00069	0.392
MOD_CK2_1	562	568	PF00069	0.406
MOD_CK2_1	727	733	PF00069	0.571
MOD_GlcNHglycan	234	237	PF01048	0.393
MOD_GlcNHglycan	352	355	PF01048	0.466
MOD_GlcNHglycan	376	379	PF01048	0.257
MOD_GlcNHglycan	393	396	PF01048	0.436
MOD_GlcNHglycan	4	7	PF01048	0.721
MOD_GlcNHglycan	551	554	PF01048	0.628
MOD_GlcNHglycan	600	603	PF01048	0.391
MOD_GlcNHglycan	725	728	PF01048	0.538
MOD_GlcNHglycan	90	93	PF01048	0.518
MOD_GSK3_1	100	107	PF00069	0.484
MOD_GSK3_1	325	332	PF00069	0.246
MOD_GSK3_1	369	376	PF00069	0.341
MOD_GSK3_1	456	463	PF00069	0.546
MOD_GSK3_1	490	497	PF00069	0.417
MOD_GSK3_1	50	57	PF00069	0.609
MOD_GSK3_1	519	526	PF00069	0.530
MOD_GSK3_1	719	726	PF00069	0.468
MOD_GSK3_1	737	744	PF00069	0.532
MOD_GSK3_1	74	81	PF00069	0.444
MOD_GSK3_1	795	802	PF00069	0.541
MOD_GSK3_1	812	819	PF00069	0.575
MOD_N-GLC_1	157	162	PF02516	0.305
MOD_N-GLC_1	761	766	PF02516	0.720
MOD_N-GLC_1	816	821	PF02516	0.659
MOD_N-GLC_1	88	93	PF02516	0.546
MOD_N-GLC_2	780	782	PF02516	0.483
MOD_NEK2_1	139	144	PF00069	0.348
MOD_NEK2_1	230	235	PF00069	0.349
MOD_NEK2_1	319	324	PF00069	0.335
MOD_NEK2_1	331	336	PF00069	0.335
MOD_NEK2_1	350	355	PF00069	0.193
MOD_NEK2_1	369	374	PF00069	0.269
MOD_NEK2_1	453	458	PF00069	0.475
MOD_NEK2_1	494	499	PF00069	0.367
MOD_NEK2_1	50	55	PF00069	0.659
MOD_NEK2_1	506	511	PF00069	0.345
MOD_NEK2_1	512	517	PF00069	0.389
MOD_NEK2_1	562	567	PF00069	0.453
MOD_NEK2_1	596	601	PF00069	0.433
MOD_NEK2_1	719	724	PF00069	0.467
MOD_NEK2_1	78	83	PF00069	0.450
MOD_NEK2_1	799	804	PF00069	0.461
MOD_NEK2_1	94	99	PF00069	0.540
MOD_NEK2_2	117	122	PF00069	0.382
MOD_NEK2_2	727	732	PF00069	0.397
MOD_PIKK_1	10	16	PF00454	0.710
MOD_PIKK_1	326	332	PF00454	0.370
MOD_PIKK_1	478	484	PF00454	0.506
MOD_PIKK_1	512	518	PF00454	0.469
MOD_PIKK_1	623	629	PF00454	0.431
MOD_PIKK_1	667	673	PF00454	0.514
MOD_PIKK_1	735	741	PF00454	0.495
MOD_PKA_1	74	80	PF00069	0.675
MOD_PKA_2	230	236	PF00069	0.188
MOD_PKA_2	270	276	PF00069	0.434
MOD_PKA_2	314	320	PF00069	0.344
MOD_PKA_2	350	356	PF00069	0.408
MOD_PKA_2	374	380	PF00069	0.294
MOD_PKA_2	407	413	PF00069	0.355
MOD_PKA_2	694	700	PF00069	0.544
MOD_PKA_2	74	80	PF00069	0.632
MOD_PKA_2	820	826	PF00069	0.658
MOD_Plk_1	224	230	PF00069	0.402
MOD_Plk_1	447	453	PF00069	0.419
MOD_Plk_1	460	466	PF00069	0.474
MOD_Plk_1	78	84	PF00069	0.302
MOD_Plk_2-3	104	110	PF00069	0.436
MOD_Plk_4	241	247	PF00069	0.346
MOD_Plk_4	314	320	PF00069	0.335
MOD_Plk_4	352	358	PF00069	0.337
MOD_Plk_4	442	448	PF00069	0.391
MOD_Plk_4	460	466	PF00069	0.450
MOD_Plk_4	836	842	PF00069	0.679
MOD_ProDKin_1	175	181	PF00069	0.408
MOD_ProDKin_1	523	529	PF00069	0.599
MOD_ProDKin_1	55	61	PF00069	0.661
MOD_ProDKin_1	656	662	PF00069	0.476
MOD_ProDKin_1	756	762	PF00069	0.793
MOD_ProDKin_1	804	810	PF00069	0.266
MOD_SUMO_rev_2	358	367	PF00179	0.305
MOD_SUMO_rev_2	631	640	PF00179	0.439
TRG_DiLeu_BaEn_1	363	368	PF01217	0.188
TRG_DiLeu_BaEn_1	715	720	PF01217	0.491
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.469
TRG_ENDOCYTIC_2	124	127	PF00928	0.375
TRG_ENDOCYTIC_2	137	140	PF00928	0.271
TRG_ENDOCYTIC_2	29	32	PF00928	0.480
TRG_ENDOCYTIC_2	298	301	PF00928	0.335
TRG_ENDOCYTIC_2	520	523	PF00928	0.565
TRG_ENDOCYTIC_2	811	814	PF00928	0.497
TRG_ER_diArg_1	182	185	PF00400	0.335
TRG_ER_diArg_1	694	696	PF00400	0.491
TRG_NES_CRM1_1	424	436	PF08389	0.335
TRG_NLS_Bipartite_1	628	642	PF00514	0.526
TRG_NLS_MonoExtN_4	637	642	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	581	585	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T7	Leptomonas seymouri	74%	99%
A0A1X0NNZ9	Trypanosomatidae	49%	100%
A0A3Q8I9X9	Leishmania donovani	90%	100%
A0A3R7LN11	Trypanosoma rangeli	48%	100%
A4H7W9	Leishmania braziliensis	76%	100%
A4HW96	Leishmania infantum	90%	100%
C9ZSR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4QFI4	Leishmania major	87%	100%
V5AVZ2	Trypanosoma cruzi	47%	100%