C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytoskeleton associated protein, putative

Species:

Leishmania mexicana

UniProt:

E9APZ2_LEIMU

TriTrypDb:

LmxM.14.1440

Length:

966

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0030863	cortical cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9APZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9APZ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.528
CLV_C14_Caspase3-7	421	425	PF00656	0.417
CLV_NRD_NRD_1	325	327	PF00675	0.495
CLV_NRD_NRD_1	39	41	PF00675	0.579
CLV_NRD_NRD_1	538	540	PF00675	0.619
CLV_NRD_NRD_1	60	62	PF00675	0.679
CLV_NRD_NRD_1	65	67	PF00675	0.640
CLV_NRD_NRD_1	838	840	PF00675	0.609
CLV_NRD_NRD_1	887	889	PF00675	0.693
CLV_NRD_NRD_1	91	93	PF00675	0.636
CLV_NRD_NRD_1	948	950	PF00675	0.853
CLV_NRD_NRD_1	954	956	PF00675	0.650
CLV_PCSK_FUR_1	884	888	PF00082	0.722
CLV_PCSK_FUR_1	92	96	PF00082	0.500
CLV_PCSK_KEX2_1	38	40	PF00082	0.532
CLV_PCSK_KEX2_1	525	527	PF00082	0.540
CLV_PCSK_KEX2_1	60	62	PF00082	0.666
CLV_PCSK_KEX2_1	65	67	PF00082	0.652
CLV_PCSK_KEX2_1	838	840	PF00082	0.664
CLV_PCSK_KEX2_1	886	888	PF00082	0.709
CLV_PCSK_KEX2_1	91	93	PF00082	0.636
CLV_PCSK_KEX2_1	94	96	PF00082	0.619
CLV_PCSK_KEX2_1	948	950	PF00082	0.853
CLV_PCSK_KEX2_1	954	956	PF00082	0.650
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.540
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.506
CLV_PCSK_PC7_1	61	67	PF00082	0.682
CLV_PCSK_SKI1_1	31	35	PF00082	0.728
CLV_PCSK_SKI1_1	91	95	PF00082	0.590
DEG_APCC_DBOX_1	37	45	PF00400	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.578
DEG_SPOP_SBC_1	892	896	PF00917	0.571
DOC_CYCLIN_yCln2_LP_2	716	722	PF00134	0.710
DOC_CYCLIN_yCln2_LP_2	736	742	PF00134	0.675
DOC_CYCLIN_yCln2_LP_2	760	766	PF00134	0.653
DOC_CYCLIN_yCln2_LP_2	780	786	PF00134	0.652
DOC_CYCLIN_yCln2_LP_2	800	806	PF00134	0.625
DOC_MAPK_DCC_7	94	104	PF00069	0.563
DOC_MAPK_FxFP_2	150	153	PF00069	0.412
DOC_MAPK_gen_1	135	144	PF00069	0.370
DOC_MAPK_gen_1	267	276	PF00069	0.397
DOC_MAPK_gen_1	326	333	PF00069	0.530
DOC_MAPK_gen_1	38	46	PF00069	0.577
DOC_MAPK_gen_1	94	104	PF00069	0.644
DOC_MAPK_MEF2A_6	326	335	PF00069	0.531
DOC_MAPK_MEF2A_6	38	46	PF00069	0.577
DOC_MAPK_MEF2A_6	95	104	PF00069	0.657
DOC_MAPK_NFAT4_5	39	47	PF00069	0.585
DOC_PP2B_LxvP_1	181	184	PF13499	0.324
DOC_PP2B_LxvP_1	245	248	PF13499	0.564
DOC_PP2B_LxvP_1	527	530	PF13499	0.596
DOC_PP4_FxxP_1	150	153	PF00568	0.412
DOC_USP7_MATH_1	12	16	PF00917	0.619
DOC_USP7_MATH_1	203	207	PF00917	0.510
DOC_USP7_MATH_1	53	57	PF00917	0.599
DOC_USP7_MATH_1	700	704	PF00917	0.698
DOC_USP7_MATH_1	740	744	PF00917	0.694
DOC_USP7_MATH_1	862	866	PF00917	0.647
DOC_USP7_MATH_1	953	957	PF00917	0.738
DOC_USP7_MATH_2	806	812	PF00917	0.607
DOC_USP7_UBL2_3	923	927	PF12436	0.588
DOC_USP7_UBL2_3	94	98	PF12436	0.579
DOC_WW_Pin1_4	298	303	PF00397	0.612
DOC_WW_Pin1_4	398	403	PF00397	0.524
DOC_WW_Pin1_4	621	626	PF00397	0.736
DOC_WW_Pin1_4	949	954	PF00397	0.716
DOC_WW_Pin1_4	959	964	PF00397	0.741
LIG_14-3-3_CanoR_1	119	123	PF00244	0.412
LIG_14-3-3_CanoR_1	486	491	PF00244	0.463
LIG_14-3-3_CanoR_1	948	953	PF00244	0.704
LIG_14-3-3_CanoR_1	954	963	PF00244	0.614
LIG_Actin_WH2_2	215	231	PF00022	0.455
LIG_APCC_ABBA_1	44	49	PF00400	0.597
LIG_BIR_III_2	168	172	PF00653	0.412
LIG_BRCT_BRCA1_1	408	412	PF00533	0.426
LIG_Clathr_ClatBox_1	41	45	PF01394	0.587
LIG_deltaCOP1_diTrp_1	377	388	PF00928	0.573
LIG_eIF4E_1	482	488	PF01652	0.476
LIG_FHA_1	131	137	PF00498	0.412
LIG_FHA_1	219	225	PF00498	0.324
LIG_FHA_1	242	248	PF00498	0.559
LIG_FHA_1	250	256	PF00498	0.467
LIG_FHA_1	686	692	PF00498	0.617
LIG_FHA_1	956	962	PF00498	0.734
LIG_FHA_2	441	447	PF00498	0.574
LIG_FHA_2	84	90	PF00498	0.638
LIG_LIR_Apic_2	147	153	PF02991	0.412
LIG_LIR_Apic_2	307	313	PF02991	0.662
LIG_LIR_Apic_2	7	12	PF02991	0.630
LIG_LIR_Apic_2	898	904	PF02991	0.629
LIG_LIR_Gen_1	357	362	PF02991	0.548
LIG_LIR_Gen_1	409	420	PF02991	0.480
LIG_LIR_Gen_1	429	440	PF02991	0.407
LIG_LIR_Gen_1	464	473	PF02991	0.533
LIG_LIR_LC3C_4	162	166	PF02991	0.412
LIG_LIR_Nem_3	151	155	PF02991	0.379
LIG_LIR_Nem_3	306	312	PF02991	0.553
LIG_LIR_Nem_3	357	361	PF02991	0.536
LIG_LIR_Nem_3	378	384	PF02991	0.574
LIG_LIR_Nem_3	408	414	PF02991	0.473
LIG_LIR_Nem_3	429	435	PF02991	0.503
LIG_LIR_Nem_3	464	470	PF02991	0.520
LIG_LIR_Nem_3	523	527	PF02991	0.530
LIG_MLH1_MIPbox_1	408	412	PF16413	0.426
LIG_MYND_1	298	302	PF01753	0.558
LIG_Pex14_1	146	150	PF04695	0.412
LIG_SH2_CRK	524	528	PF00017	0.572
LIG_SH2_CRK	64	68	PF00017	0.687
LIG_SH2_GRB2like	154	157	PF00017	0.412
LIG_SH2_PTP2	432	435	PF00017	0.492
LIG_SH2_SRC	154	157	PF00017	0.362
LIG_SH2_SRC	311	314	PF00017	0.528
LIG_SH2_STAT5	154	157	PF00017	0.362
LIG_SH2_STAT5	227	230	PF00017	0.540
LIG_SH2_STAT5	311	314	PF00017	0.561
LIG_SH2_STAT5	432	435	PF00017	0.567
LIG_SH2_STAT5	650	653	PF00017	0.924
LIG_SH2_STAT5	9	12	PF00017	0.630
LIG_SH3_1	310	316	PF00018	0.534
LIG_SH3_1	901	907	PF00018	0.726
LIG_SH3_3	139	145	PF00018	0.403
LIG_SH3_3	197	203	PF00018	0.452
LIG_SH3_3	310	316	PF00018	0.534
LIG_SH3_3	442	448	PF00018	0.659
LIG_SH3_3	75	81	PF00018	0.687
LIG_SH3_3	800	806	PF00018	0.666
LIG_SH3_3	816	822	PF00018	0.658
LIG_SH3_3	901	907	PF00018	0.730
LIG_SUMO_SIM_anti_2	118	124	PF11976	0.384
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.412
LIG_SUMO_SIM_anti_2	341	352	PF11976	0.695
LIG_SUMO_SIM_anti_2	496	506	PF11976	0.544
LIG_SUMO_SIM_par_1	162	168	PF11976	0.412
LIG_SUMO_SIM_par_1	220	225	PF11976	0.349
LIG_SUMO_SIM_par_1	367	373	PF11976	0.575
LIG_TRAF2_1	145	148	PF00917	0.412
LIG_TRAF2_1	18	21	PF00917	0.510
LIG_TRAF2_1	213	216	PF00917	0.509
LIG_TRAF2_1	336	339	PF00917	0.584
LIG_TRAF2_1	341	344	PF00917	0.637
LIG_TRAF2_1	543	546	PF00917	0.603
LIG_TRAF2_1	552	555	PF00917	0.652
LIG_TRAF2_1	610	613	PF00917	0.705
LIG_TRAF2_1	630	633	PF00917	0.645
LIG_TRAF2_1	661	664	PF00917	0.688
LIG_TRAF2_1	727	730	PF00917	0.678
LIG_TRAF2_1	742	745	PF00917	0.664
LIG_TRAF2_1	751	754	PF00917	0.625
LIG_TRAF2_1	771	774	PF00917	0.636
LIG_TRAF2_1	791	794	PF00917	0.631
LIG_TRAF2_1	811	814	PF00917	0.634
LIG_TRAF2_1	815	818	PF00917	0.647
LIG_TRAF2_1	822	825	PF00917	0.604
LIG_TRAF2_1	827	830	PF00917	0.591
LIG_TRAF2_2	83	88	PF00917	0.555
MOD_CDK_SPK_2	949	954	PF00069	0.716
MOD_CDK_SPxK_1	949	955	PF00069	0.721
MOD_CK1_1	15	21	PF00069	0.609
MOD_CK1_1	206	212	PF00069	0.526
MOD_CK1_1	434	440	PF00069	0.521
MOD_CK1_1	895	901	PF00069	0.593
MOD_CK2_1	15	21	PF00069	0.600
MOD_CK2_1	210	216	PF00069	0.503
MOD_CK2_1	338	344	PF00069	0.792
MOD_CK2_1	440	446	PF00069	0.596
MOD_CK2_1	509	515	PF00069	0.440
MOD_CK2_1	601	607	PF00069	0.765
MOD_CK2_1	627	633	PF00069	0.757
MOD_CK2_1	658	664	PF00069	0.752
MOD_CK2_1	695	701	PF00069	0.679
MOD_CK2_1	704	710	PF00069	0.687
MOD_CK2_1	724	730	PF00069	0.777
MOD_CK2_1	748	754	PF00069	0.668
MOD_CK2_1	768	774	PF00069	0.650
MOD_CK2_1	788	794	PF00069	0.651
MOD_CK2_1	808	814	PF00069	0.619
MOD_CK2_1	937	943	PF00069	0.702
MOD_DYRK1A_RPxSP_1	949	953	PF00069	0.708
MOD_GlcNHglycan	112	115	PF01048	0.412
MOD_GlcNHglycan	436	439	PF01048	0.488
MOD_GlcNHglycan	55	58	PF01048	0.629
MOD_GlcNHglycan	697	701	PF01048	0.612
MOD_GlcNHglycan	864	867	PF01048	0.646
MOD_GlcNHglycan	898	901	PF01048	0.727
MOD_GlcNHglycan	907	910	PF01048	0.782
MOD_GSK3_1	206	213	PF00069	0.532
MOD_GSK3_1	218	225	PF00069	0.416
MOD_GSK3_1	298	305	PF00069	0.557
MOD_GSK3_1	406	413	PF00069	0.507
MOD_GSK3_1	692	699	PF00069	0.615
MOD_GSK3_1	700	707	PF00069	0.601
MOD_GSK3_1	740	747	PF00069	0.670
MOD_GSK3_1	887	894	PF00069	0.712
MOD_GSK3_1	943	950	PF00069	0.668
MOD_GSK3_1	955	962	PF00069	0.735
MOD_N-GLC_1	110	115	PF02516	0.274
MOD_N-GLC_1	282	287	PF02516	0.591
MOD_N-GLC_1	339	344	PF02516	0.519
MOD_NEK2_1	102	107	PF00069	0.412
MOD_NEK2_1	249	254	PF00069	0.464
MOD_NEK2_1	370	375	PF00069	0.596
MOD_NEK2_1	410	415	PF00069	0.471
MOD_NEK2_1	440	445	PF00069	0.410
MOD_NEK2_1	568	573	PF00069	0.699
MOD_NEK2_1	73	78	PF00069	0.658
MOD_NEK2_1	919	924	PF00069	0.665
MOD_PIKK_1	314	320	PF00454	0.599
MOD_PIKK_1	426	432	PF00454	0.392
MOD_PIKK_1	590	596	PF00454	0.602
MOD_PIKK_1	658	664	PF00454	0.664
MOD_PK_1	486	492	PF00069	0.469
MOD_PKA_1	887	893	PF00069	0.709
MOD_PKA_1	948	954	PF00069	0.711
MOD_PKA_2	118	124	PF00069	0.412
MOD_PKA_2	277	283	PF00069	0.573
MOD_PKA_2	887	893	PF00069	0.872
MOD_PKA_2	947	953	PF00069	0.700
MOD_PKA_2	954	960	PF00069	0.605
MOD_Plk_1	203	209	PF00069	0.481
MOD_Plk_1	236	242	PF00069	0.657
MOD_Plk_1	382	388	PF00069	0.464
MOD_Plk_1	943	949	PF00069	0.668
MOD_Plk_2-3	236	242	PF00069	0.503
MOD_Plk_2-3	339	345	PF00069	0.652
MOD_Plk_2-3	441	447	PF00069	0.549
MOD_Plk_2-3	607	613	PF00069	0.656
MOD_Plk_2-3	653	659	PF00069	0.710
MOD_Plk_2-3	672	678	PF00069	0.622
MOD_Plk_2-3	724	730	PF00069	0.811
MOD_Plk_2-3	768	774	PF00069	0.650
MOD_Plk_2-3	788	794	PF00069	0.649
MOD_Plk_2-3	808	814	PF00069	0.614
MOD_Plk_2-3	840	846	PF00069	0.602
MOD_Plk_4	218	224	PF00069	0.470
MOD_Plk_4	249	255	PF00069	0.517
MOD_Plk_4	284	290	PF00069	0.572
MOD_Plk_4	406	412	PF00069	0.496
MOD_Plk_4	887	893	PF00069	0.718
MOD_ProDKin_1	298	304	PF00069	0.607
MOD_ProDKin_1	398	404	PF00069	0.518
MOD_ProDKin_1	621	627	PF00069	0.737
MOD_ProDKin_1	949	955	PF00069	0.721
MOD_ProDKin_1	959	965	PF00069	0.738
MOD_SUMO_for_1	336	339	PF00179	0.723
MOD_SUMO_rev_2	29	36	PF00179	0.573
MOD_SUMO_rev_2	452	458	PF00179	0.433
MOD_SUMO_rev_2	607	616	PF00179	0.737
TRG_DiLeu_BaEn_1	22	27	PF01217	0.596
TRG_DiLeu_BaEn_1	344	349	PF01217	0.742
TRG_DiLeu_BaEn_1	37	42	PF01217	0.457
TRG_DiLeu_BaEn_1	483	488	PF01217	0.532
TRG_DiLeu_BaEn_4	731	737	PF01217	0.627
TRG_DiLeu_BaEn_4	775	781	PF01217	0.615
TRG_DiLeu_BaEn_4	795	801	PF01217	0.623
TRG_DiLeu_LyEn_5	22	27	PF01217	0.596
TRG_ENDOCYTIC_2	2	5	PF00928	0.646
TRG_ENDOCYTIC_2	309	312	PF00928	0.657
TRG_ENDOCYTIC_2	432	435	PF00928	0.492
TRG_ENDOCYTIC_2	524	527	PF00928	0.530
TRG_ENDOCYTIC_2	64	67	PF00928	0.687
TRG_ER_diArg_1	38	40	PF00400	0.643
TRG_ER_diArg_1	50	53	PF00400	0.525
TRG_ER_diArg_1	59	61	PF00400	0.568
TRG_ER_diArg_1	64	66	PF00400	0.555
TRG_ER_diArg_1	884	887	PF00400	0.713
TRG_ER_diArg_1	90	92	PF00400	0.754
TRG_ER_diArg_1	947	949	PF00400	0.847
TRG_ER_diArg_1	953	955	PF00400	0.810
TRG_NES_CRM1_1	346	359	PF08389	0.570
TRG_NLS_Bipartite_1	525	543	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6T3	Leishmania donovani	77%	100%
A4H7W4	Leishmania braziliensis	66%	100%
A4HW91	Leishmania infantum	83%	96%
Q4QFI9	Leishmania major	80%	100%